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Volumn 1012, Issue , 2004, Pages 193-208

The relevance of iron in the pathogenesis of Parkinson's disease

Author keywords

Dopamine; Iron; Lewy body; Neuromelanin; Oxidative stress; Parkinson's disease; Radicals; Substantia nigra; Transition metal; synuclein

Indexed keywords

ALPHA SYNUCLEIN; FERRITIN; IRON; NEUROMELANIN; REACTIVE OXYGEN METABOLITE;

EID: 11144353557     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1306.017     Document Type: Review
Times cited : (280)

References (129)
  • 1
    • 0036091142 scopus 로고    scopus 로고
    • Occupational and environmental risk factors for Parkinson's disease
    • LAI, B.C.L., S.A. MARION, K. TESCHKE et al. 2002. Occupational and environmental risk factors for Parkinson's disease. Parkinson's Rel. Dis. 8: 297-309.
    • (2002) Parkinson's Rel. Dis. , vol.8 , pp. 297-309
    • Lai, B.C.L.1    Marion, S.A.2    Teschke, K.3
  • 2
    • 0038454676 scopus 로고    scopus 로고
    • Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes
    • POWERS, K.M., T. SMITH-WELLER, G.M. FRANKLIN et al. 2003. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 60: 1761-1766.
    • (2003) Neurology , vol.60 , pp. 1761-1766
    • Powers, K.M.1    Smith-Weller, T.2    Franklin, G.M.3
  • 3
    • 0030940439 scopus 로고    scopus 로고
    • Occupational exposures to metals as risk factors for Parkinson's disease
    • GORELL, J.M., C.C. JOHNSON, B.A. RYBICKI et al. 1997. Occupational exposures to metals as risk factors for Parkinson's disease. Neurology 48: 650-658.
    • (1997) Neurology , vol.48 , pp. 650-658
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3
  • 4
    • 0033037034 scopus 로고    scopus 로고
    • Occupational exposure to manganese, copper, lead, iron, mercury, and zinc and the risk of Parkinson's disease
    • GORELL, J.M., C.C. JOHNSON, B.A. RYBICKI et al. 1999. Occupational exposure to manganese, copper, lead, iron, mercury, and zinc and the risk of Parkinson's disease. Neurotoxicology 20: 239-247.
    • (1999) Neurotoxicology , vol.20 , pp. 239-247
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3
  • 5
    • 0032794767 scopus 로고    scopus 로고
    • A family history of Parkinson's disease and its effect on other PD risk factors
    • RYBICKI, B.A., C.C. JOHNSON, E.L. PETERSON et al. 1999. A family history of Parkinson's disease and its effect on other PD risk factors. Neuroepidemiology 18: 270-278.
    • (1999) Neuroepidemiology , vol.18 , pp. 270-278
    • Rybicki, B.A.1    Johnson, C.C.2    Peterson, E.L.3
  • 6
    • 0025192139 scopus 로고
    • Facteurs environnementaux dans l'etiologie de la maladie de Parkinson
    • ZAYED, J., S. DUCIC, G. CAMPANELLA et al. 1990. Facteurs environnementaux dans l'etiologie de la maladie de Parkinson. Can. J. Neurol. Sci. 17: 286-291.
    • (1990) Can. J. Neurol. Sci. , vol.17 , pp. 286-291
    • Zayed, J.1    Ducic, S.2    Campanella, G.3
  • 7
    • 0024554150 scopus 로고
    • Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson's disease
    • NGIM, C.H. & G. DEVATHASAN, 1989. Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson's disease. Neuroepidemiology 8: 128-141.
    • (1989) Neuroepidemiology , vol.8 , pp. 128-141
    • Ngim, C.H.1    Devathasan, G.2
  • 8
    • 0030012558 scopus 로고    scopus 로고
    • Possible environmental, occupational, and other etiologic factors for Parkinson's disease: A case control study in Germany
    • SEIDLER, A., W. HELLENBRAND, B.P. ROBRA et al. 1996. Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case control study in Germany. Neurology 46: 1275-1284.
    • (1996) Neurology , vol.46 , pp. 1275-1284
    • Seidler, A.1    Hellenbrand, W.2    Robra, B.P.3
  • 9
    • 0031922955 scopus 로고    scopus 로고
    • Dietary iron, animal fats, and risk of Parkinson's disease
    • LOGROSCINO, G., K. MARDER, J. GRAZIANO et al. 1998. Dietary iron, animal fats, and risk of Parkinson's disease. Mov. Disord. 13(suppl. 1): 13-16.
    • (1998) Mov. Disord. , vol.13 , Issue.1 SUPPL. , pp. 13-16
    • Logroscino, G.1    Marder, K.2    Graziano, J.3
  • 10
    • 0017300939 scopus 로고
    • Biogenic monoamine metabolism and functional activity in iron-deficient rats: Behavioural correlates
    • YOUDIM, M.B. & A.R. GREEN. 1976. Biogenic monoamine metabolism and functional activity in iron-deficient rats: behavioural correlates. Ciba Found. Symp. 7-9: 201-225.
    • (1976) Ciba Found. Symp. , vol.7-9 , pp. 201-225
    • Youdim, M.B.1    Green, A.R.2
  • 11
    • 0000594895 scopus 로고
    • Brain iron metabolism: Biochemical and behavioural aspects of iron in relation to dopaminergic neurotransmission
    • Plenum. New York
    • YOUDIM, M.B.H. 1985. Brain iron metabolism: biochemical and behavioural aspects of iron in relation to dopaminergic neurotransmission. In Handbook of Neurochemistry. Volume 10, pp. 731-756. Plenum. New York.
    • (1985) Handbook of Neurochemistry , vol.10 , pp. 731-756
    • Youdim, M.B.H.1
  • 12
    • 84996111069 scopus 로고
    • Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?
    • YOUDIM, M.B., D. BEN-SHACHAR & P. RIEDERER. 1989. Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration? Acta Neurol. Scand. Suppl. 126: 47-54.
    • (1989) Acta Neurol. Scand. Suppl. , vol.126 , pp. 47-54
    • Youdim, M.B.1    Ben-Shachar, D.2    Riederer, P.3
  • 13
    • 0027497409 scopus 로고
    • The possible role of iron in the etiopathology of Parkinson's disease
    • YOUDIM, M.B., D. BEN-SHACHAR & P. RIEDERER. 1993. The possible role of iron in the etiopathology of Parkinson's disease. Mov. Disord. 8: 1-12.
    • (1993) Mov. Disord. , vol.8 , pp. 1-12
    • Youdim, M.B.1    Ben-Shachar, D.2    Riederer, P.3
  • 14
    • 0028492775 scopus 로고
    • Biochemistry of Parkinson's disease with special reference to the dopaminergic systems
    • HIRSCH, E.C. 1994. Biochemistry of Parkinson's disease with special reference to the dopaminergic systems. Mol. Neurobiol. 9: 135-142.
    • (1994) Mol. Neurobiol. , vol.9 , pp. 135-142
    • Hirsch, E.C.1
  • 15
    • 0032975570 scopus 로고    scopus 로고
    • The role of iron in neurodegeneration: Prospects for pharmacotherapy of Parkinson's disease
    • JELLINGER, K.A. 1999. The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease. Drugs Aging 14: 115-140.
    • (1999) Drugs Aging , vol.14 , pp. 115-140
    • Jellinger, K.A.1
  • 16
    • 0142010013 scopus 로고    scopus 로고
    • General aspects of neurodegeneration
    • JELLINGER, K.A. 2003. General aspects of neurodegeneration. J. Neural Transm. Suppl. 65: 101-144.
    • (2003) J. Neural Transm. Suppl. , vol.65 , pp. 101-144
    • Jellinger, K.A.1
  • 17
    • 0034776216 scopus 로고    scopus 로고
    • Brain iron pathways and their relevance to Parkinson's disease
    • BERG, D., M. GERLACH, M.B.H. YOUDIM et al. 2001. Brain iron pathways and their relevance to Parkinson's disease. J. Neurochem. 79: 225-236.
    • (2001) J. Neurochem. , vol.79 , pp. 225-236
    • Berg, D.1    Gerlach, M.2    Youdim, M.B.H.3
  • 18
    • 0036279410 scopus 로고    scopus 로고
    • Echogenicity of the substantia nigra: Association with increased iron content and marker for susceptibility to nigro-striatal injury
    • BERG, D., W. ROGGENDORF, U. SCHRÖDER et al. 2002. Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigro-striatal injury. Arch. Neurol. 59: 999-1005.
    • (2002) Arch. Neurol. , vol.59 , pp. 999-1005
    • Berg, D.1    Roggendorf, W.2    Schröder, U.3
  • 20
    • 0036719084 scopus 로고    scopus 로고
    • Influence of neuromelanin on oxidative pathways within the human substantia nigra
    • DOUBLE, K.L., D. BEN-SHACHAR, M.B.H. YOUDIM et al. 2002. Influence of neuromelanin on oxidative pathways within the human substantia nigra. Neurotoxicol. Teratol. 24: 621-628.
    • (2002) Neurotoxicol. Teratol. , vol.24 , pp. 621-628
    • Double, K.L.1    Ben-Shachar, D.2    Youdim, M.B.H.3
  • 21
    • 0028000825 scopus 로고
    • Altered brain metabolism of iron as a cause of neurodegenerative diseases
    • GERLACH, M., D. BEN-SIIACHAR, P. RIEDERER et al. 1994. Altered brain metabolism of iron as a cause of neurodegenerative diseases. J. Neurochem. 63: 793-807.
    • (1994) J. Neurochem. , vol.63 , pp. 793-807
    • Gerlach, M.1    Ben-Siiachar, D.2    Riederer, P.3
  • 22
    • 0642376484 scopus 로고    scopus 로고
    • Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease
    • GERLACH, M., K.L. DOUBLE, D. BEN-SHACHAR et al. 2003. Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotoxicol. Res. 5: 35-44.
    • (2003) Neurotoxicol. Res. , vol.5 , pp. 35-44
    • Gerlach, M.1    Double, K.L.2    Ben-Shachar, D.3
  • 23
    • 0036113819 scopus 로고    scopus 로고
    • The role of iron and copper in the aetiology of neurodegenerative disorders: Therapeutic implications
    • PERRY, G., L.M. SAYRE et al. 2002. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. CNS Drugs 16: 339-352.
    • (2002) CNS Drugs , vol.16 , pp. 339-352
    • Perry, G.1    Sayre, L.M.2
  • 24
    • 0036970185 scopus 로고    scopus 로고
    • Brain iron metabolism and neurodegenerative disorders
    • SIPE, J.C., P. LEE & E. BEUTLER. 2002. Brain iron metabolism and neurodegenerative disorders. Dev. Neurosci. 24: 188-196.
    • (2002) Dev. Neurosci. , vol.24 , pp. 188-196
    • Sipe, J.C.1    Lee, P.2    Beutler, E.3
  • 25
    • 0036152892 scopus 로고    scopus 로고
    • Iron and Parkinson's disease
    • WOLOZIN, B. & N. GOLTS. 2002. Iron and Parkinson's disease. Neuroscientist 8: 22-32.
    • (2002) Neuroscientist , vol.8 , pp. 22-32
    • Wolozin, B.1    Golts, N.2
  • 26
    • 0035224228 scopus 로고    scopus 로고
    • The current state of free radicals in Parkinson's disease: Nigral iron as a trigger of oxidative stress
    • Lippincott/Williams & Wilkins. Philadelphia
    • FRIEDMAN, A. & J. GALAZKA-FRIEDMAN. 2001. The current state of free radicals in Parkinson's disease: nigral iron as a trigger of oxidative stress. In Parkinson's Disease. Volume 86, pp. 137-142. Lippincott/Williams & Wilkins. Philadelphia.
    • (2001) Parkinson's Disease , vol.86 , pp. 137-142
    • Friedman, A.1    Galazka-Friedman, J.2
  • 27
    • 84961042345 scopus 로고
    • The effect of age on the non-haemin iron in the human brain
    • HALLGREN, B. & P. SOURANDER. 1958. The effect of age on the non-haemin iron in the human brain. J. Neurochem. 3: 41-51.
    • (1958) J. Neurochem. , vol.3 , pp. 41-51
    • Hallgren, B.1    Sourander, P.2
  • 28
    • 0024557734 scopus 로고
    • Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
    • RIEDERER, P., E. SOFIC, W-D. RAUSCH et al. 1989. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. J. Neurochem. 52: 515-520.
    • (1989) J. Neurochem. , vol.52 , pp. 515-520
    • Riederer, P.1    Sofic, E.2    Rausch, W.-D.3
  • 29
    • 0032898122 scopus 로고    scopus 로고
    • Iron in the basal ganglia in Parkinson's disease: An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy
    • GRIFFITHS, P.D., B.R. DOBSDN, G.R. JONES et al. 1999. Iron in the basal ganglia in Parkinson's disease: an in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy. Brain 122: 667-673.
    • (1999) Brain , vol.122 , pp. 667-673
    • Griffiths, P.D.1    Dobsdn, B.R.2    Jones, G.R.3
  • 30
    • 84906417439 scopus 로고
    • On the occurrence of abnormal deposits of iron in the brain in parkinsonism with special reference to its localisation
    • LHERMITTE, J., W.M. KRAUS & D. MCALPINE. 1924. On the occurrence of abnormal deposits of iron in the brain in parkinsonism with special reference to its localisation. J. Neurol. Psychopathol. 5: 195-208.
    • (1924) J. Neurol. Psychopathol. , vol.5 , pp. 195-208
    • Lhermitte, J.1    Kraus, W.M.2    McAlpine, D.3
  • 31
    • 0014240538 scopus 로고
    • Studies in Parkinson's disease including X-ray fluorescent spectroscopy of formalin-fixed tissues
    • EARLE, K.M. 1968. Studies in Parkinson's disease including X-ray fluorescent spectroscopy of formalin-fixed tissues. J. Neuropathol. Exp. Neurol. 27: 1-14.
    • (1968) J. Neuropathol. Exp. Neurol. , vol.27 , pp. 1-14
    • Earle, K.M.1
  • 33
    • 0023638828 scopus 로고
    • Increased nigral iron content in post-mortem parkinsonian brain
    • DEXTER, D.T., F.R. WELLS et al. 1987. Increased nigral iron content in post-mortem parkinsonian brain. Lancet 341: 1219-1220.
    • (1987) Lancet , vol.341 , pp. 1219-1220
    • Dexter, D.T.1    Wells, F.R.2
  • 34
    • 0023804321 scopus 로고
    • Increased iron(II) and total iron content in post-mortem substantia nigra of parkinsonian brain
    • SOFIC, E., P. RIEDERER, H. HEINSEN et al. 1988. Increased iron(II) and total iron content in post-mortem substantia nigra of parkinsonian brain. J. Neural Transm. 74: 199-205.
    • (1988) J. Neural Transm. , vol.74 , pp. 199-205
    • Sofic, E.1    Riederer, P.2    Heinsen, H.3
  • 35
    • 0028091176 scopus 로고
    • Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
    • DEXTER, D.T., J. SIAN, S. ROSE et al. 1994. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann. Neurol. 35: 38-44.
    • (1994) Ann. Neurol. , vol.35 , pp. 38-44
    • Dexter, D.T.1    Sian, J.2    Rose, S.3
  • 36
    • 0031283221 scopus 로고    scopus 로고
    • Indices of oxidative stress in Parkinson's disease, Alzheimer's disease, and dementia with Lewy bodies
    • OWEN, A.D., A.H.V. SCHAPIRA, P. JENNER et al. 1997. Indices of oxidative stress in Parkinson's disease, Alzheimer's disease, and dementia with Lewy bodies. J. Neural Transm. Suppl. 51: 167-173.
    • (1997) J. Neural Transm. Suppl. , vol.51 , pp. 167-173
    • Owen, A.D.1    Schapira, A.H.V.2    Jenner, P.3
  • 37
    • 0025963530 scopus 로고
    • Selective increase of iron in substantia nigra zona compacta of parkinsonian brains
    • SOFIC, E., W. PAULUS, K. JELLINGER et al. 1991. Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J. Neurochem. 56: 978-982.
    • (1991) J. Neurochem. , vol.56 , pp. 978-982
    • Sofic, E.1    Paulus, W.2    Jellinger, K.3
  • 38
    • 0000712898 scopus 로고
    • Microtechnical demonstration of iron
    • GOMORI, G. 1936. Microtechnical demonstration of iron. Am. J. Pathol. 12: 655-663.
    • (1936) Am. J. Pathol. , vol.12 , pp. 655-663
    • Gomori, G.1
  • 39
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • DEXTER, D.T., F.R. WELLS, A.J. LEES et al. 1989. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52: 1830-136.
    • (1989) J. Neurochem. , vol.52 , pp. 1830-2136
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3
  • 40
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin, and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
    • DEXTER, D.T., A. CARAYON, F. JAVOY-AGID et al. 1991. Alterations in the levels of iron, ferritin, and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114: 1953-1975.
    • (1991) Brain , vol.114 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3
  • 42
    • 0026666528 scopus 로고
    • Iron-melanin complex in substantia nigra of parkinsonian brains: An X-ray microanalysis
    • JELLINGER, K., E. KIENZL, G. RUMPELMAIR et al. 1992. Iron-melanin complex in substantia nigra of parkinsonian brains: an X-ray microanalysis. J. Neurochem. 59: 1168-1171.
    • (1992) J. Neurochem. , vol.59 , pp. 1168-1171
    • Jellinger, K.1    Kienzl, E.2    Rumpelmair, G.3
  • 43
    • 0027348681 scopus 로고
    • Iron and ferritin in substantia nigra in Parkinson's disease
    • Raven Press. New York
    • JELLINGER, K., E. KIENZL, G. RUMPELMAIR et al. 1993. Iron and ferritin in substantia nigra in Parkinson's disease. In Parkinson's Disease. Volume 60, pp. 267-272. Raven Press. New York.
    • (1993) Parkinson's Disease , vol.60 , pp. 267-272
    • Jellinger, K.1    Kienzl, E.2    Rumpelmair, G.3
  • 44
    • 0026034279 scopus 로고
    • Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An X-ray microanalysis
    • HIRSCH, E.C., J-P. BRANDEL, P. GALLE et al. 1991. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem. 56: 446-451.
    • (1991) J. Neurochem. , vol.56 , pp. 446-451
    • Hirsch, E.C.1    Brandel, J.-P.2    Galle, P.3
  • 45
    • 0024339772 scopus 로고
    • Regional metal concentrations in Parkinson's disease, other chronic neurological diseases, and control brains
    • UITTI, R.J., A.H. RAJPUT, B. ROZDILSKY et al. 1989. Regional metal concentrations in Parkinson's disease, other chronic neurological diseases, and control brains. Can. J. Neurol. Sci. 16: 310-314.
    • (1989) Can. J. Neurol. Sci. , vol.16 , pp. 310-314
    • Uitti, R.J.1    Rajput, A.H.2    Rozdilsky, B.3
  • 46
    • 0027995435 scopus 로고
    • Complex 1, iron, and ferritin in Parkinson's disease substantia nigra
    • MANN, V.M., J.M. COOPER, S.E. DANIEL et al. 1994. Complex 1, iron, and ferritin in Parkinson's disease substantia nigra. Ann. Neurol. 36: 876-881.
    • (1994) Ann. Neurol. , vol.36 , pp. 876-881
    • Mann, V.M.1    Cooper, J.M.2    Daniel, S.E.3
  • 47
    • 0029153619 scopus 로고
    • Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions
    • LOEFFLER, D.A., J.R. CONNOR et al. 1995. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J. Neurochem. 65: 710-716.
    • (1995) J. Neurochem. , vol.65 , pp. 710-716
    • Loeffler, D.A.1    Connor, J.R.2
  • 48
    • 0029671110 scopus 로고    scopus 로고
    • Iron in parkinsonian and control substantia nigra: A Mössbauer spectroscopy study
    • GALAZKA-FRIEDMAN, J., E.R. BAUMINGER, A. FRIEDMAN et al. 1996. Iron in parkinsonian and control substantia nigra: a Mössbauer spectroscopy study. Mov. Disord. 11: 8-16.
    • (1996) Mov. Disord. , vol.11 , pp. 8-16
    • Galazka-Friedman, J.1    Bauminger, E.R.2    Friedman, A.3
  • 49
    • 0030948515 scopus 로고    scopus 로고
    • Iron in the parkinsonian substantia nigra
    • GERLACH, M., K. DOUBLE, P. RIEDERER et al. 1997. Iron in the parkinsonian substantia nigra. Mov. Disord. 12: 258-260.
    • (1997) Mov. Disord. , vol.12 , pp. 258-260
    • Gerlach, M.1    Double, K.2    Riederer, P.3
  • 50
    • 0028990740 scopus 로고
    • Mössbauer spectroscopic studies of human neuromelanin isolated from the substantia nigra
    • GERLACH, M., A.X. TRAUTWEIN, L. ZECCA et al. 1995. Mössbauer spectroscopic studies of human neuromelanin isolated from the substantia nigra. J. Neurochem. 65: 923-926.
    • (1995) J. Neurochem. , vol.65 , pp. 923-926
    • Gerlach, M.1    Trautwein, A.X.2    Zecca, L.3
  • 51
    • 0026746512 scopus 로고
    • Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: A LAMMA study
    • GOOD, P., C.W. OLANOW & D.P. PERL. 1992. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study. Brain Res. 593: 343-346.
    • (1992) Brain Res. , vol.593 , pp. 343-346
    • Good, P.1    Olanow, C.W.2    Perl, D.P.3
  • 52
    • 0030069706 scopus 로고    scopus 로고
    • The application of laser microprobe mass analysis to the study of biological material
    • IANCU, T.C., D.P. PERL, I. STERNLIEB et al. 1996. The application of laser microprobe mass analysis to the study of biological material. Biometals 9: 57-65.
    • (1996) Biometals , vol.9 , pp. 57-65
    • Iancu, T.C.1    Perl, D.P.2    Sternlieb, I.3
  • 53
    • 0028998624 scopus 로고
    • Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease
    • GORELL, J.M., R.J. ORDIDGE, G.G. BROWN et al. 1995. Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology 45: 1138-1143.
    • (1995) Neurology , vol.45 , pp. 1138-1143
    • Gorell, J.M.1    Ordidge, R.J.2    Brown, G.G.3
  • 54
    • 0029054075 scopus 로고
    • Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease
    • RYVLIN, P., E. BROUSSOLLE, H. PIOLLET et al. 1995. Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease. Arch. Neurol. 52: 583-588.
    • (1995) Arch. Neurol. , vol.52 , pp. 583-588
    • Ryvlin, P.1    Broussolle, E.2    Piollet, H.3
  • 55
    • 0030005267 scopus 로고    scopus 로고
    • Basal ganglia iron content in Parkinson's disease measured with magnetic resonance
    • YE, F.Q., P.S. ALLEN & W.R.W. MARTIN. 1996. Basal ganglia iron content in Parkinson's disease measured with magnetic resonance. Mov. Disord. 11: 243-249.
    • (1996) Mov. Disord. , vol.11 , pp. 243-249
    • Ye, F.Q.1    Allen, P.S.2    Martin, W.R.W.3
  • 56
    • 0032895811 scopus 로고    scopus 로고
    • MRI evaluation of brain iron in earlier- and later-onset Parkinson's disease and normal subjects
    • BARTZOKIS, G., J.L. CUMMINGS, C.H. MARKHAM et al. 1999. MRI evaluation of brain iron in earlier-and later-onset Parkinson's disease and normal subjects. Magn. Reson. Imaging 17: 213-222.
    • (1999) Magn. Reson. Imaging , vol.17 , pp. 213-222
    • Bartzokis, G.1    Cummings, J.L.2    Markham, C.H.3
  • 57
    • 0035238049 scopus 로고    scopus 로고
    • Magnetic resonance imaging and spectroscopy in Parkinson's disease
    • Lippincott/Williams & Wilkins. Philadelphia
    • MARTIN, W.R.W. 2001. Magnetic resonance imaging and spectroscopy in Parkinson's disease. In Parkinson's Disease. Volume 86, pp. 197-203. Lippincott/Williams & Wilkins. Philadelphia.
    • (2001) Parkinson's Disease , vol.86 , pp. 197-203
    • Martin, W.R.W.1
  • 58
    • 0028869760 scopus 로고
    • Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography
    • BECKER, G., J. SEUFERT, U. BOGDAHN et al. 1995. Degeneration of substantia nigra in chronic Parkinson's disease visualized by transcranial color-coded real-time sonography. Neurology 45: 182-184.
    • (1995) Neurology , vol.45 , pp. 182-184
    • Becker, G.1    Seufert, J.2    Bogdahn, U.3
  • 59
    • 0033595447 scopus 로고    scopus 로고
    • Vulnerability of the nigrostriatal system as detected by transcranial ultrasound
    • BERG, D., G. BECKER, B. ZEILER et al. 1999. Vulnerability of the nigrostriatal system as detected by transcranial ultrasound. Neurology 53: 1026-1031.
    • (1999) Neurology , vol.53 , pp. 1026-1031
    • Berg, D.1    Becker, G.2    Zeiler, B.3
  • 60
    • 0035830425 scopus 로고    scopus 로고
    • Echo pattern of substantia nigra and its relevance for motor function and motility in elderly subjects
    • BERG, D., C. SIEFKER, P. RUPRECHT-DÖRFLER et al. 2001. Echo pattern of substantia nigra and its relevance for motor function and motility in elderly subjects. Neurology 56: 13-17.
    • (2001) Neurology , vol.56 , pp. 13-17
    • Berg, D.1    Siefker, C.2    Ruprecht-Dörfler, P.3
  • 61
    • 0036189212 scopus 로고    scopus 로고
    • Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders, but increased in Parkinson's disease
    • WALTER, U., M. WITTSTOCK, R. BENECKE et al. 2002. Substantia nigra echogenicity is normal in non-extrapyramidal cerebral disorders, but increased in Parkinson's disease. J. Neural Transm. 109: 191-196.
    • (2002) J. Neural Transm. , vol.109 , pp. 191-196
    • Walter, U.1    Wittstock, M.2    Benecke, R.3
  • 62
    • 1842620709 scopus 로고    scopus 로고
    • The in vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage
    • Submitted
    • ZECCA, L., D. BERQ, T. ARZBERGER et al. 2004. The in vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage. Neurology. Submitted.
    • (2004) Neurology
    • Zecca, L.1    Berq, D.2    Arzberger, T.3
  • 63
    • 0025648166 scopus 로고
    • The cellular distribution of transferrin, ferritin, and iron in the human brain
    • CONNOR J., S. MENZIES, S. ST. MARTIN et al. 1990. The cellular distribution of transferrin, ferritin, and iron in the human brain. J. Neurosci. Res. 27: 595-611.
    • (1990) J. Neurosci. Res. , vol.27 , pp. 595-611
    • Connor, J.1    Menzies, S.2    St. Martin, S.3
  • 64
    • 0035103932 scopus 로고    scopus 로고
    • Iron, neuromelanin, and ferritin content in the substantia nigra of normal subjects at different ages: Consequences for iron storage and neurodegenerative processes
    • ZECCA, L., M. GALLORINI, V. SCHÜNEMANN et al. 2001. Iron, neuromelanin, and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J. Neurochem. 76: 1766-1773.
    • (2001) J. Neurochem. , vol.76 , pp. 1766-1773
    • Zecca, L.1    Gallorini, M.2    Schünemann, V.3
  • 65
    • 0023839271 scopus 로고
    • Biochemical fundamentals in Parkinson's disease
    • RIEDERER, P., W.D. RAUSCH, B. SCHMIDT et al. 1988. Biochemical fundamentals in Parkinson's disease. Mt. Sinai J. Med. 55: 21-28.
    • (1988) Mt. Sinai J. Med. , vol.55 , pp. 21-28
    • Riederer, P.1    Rausch, W.D.2    Schmidt, B.3
  • 66
    • 0024374737 scopus 로고
    • Release of iron from ferritin by semiquinone, anthracycline, bipyridyl, and nitroaromatic radicals
    • MONTEIRO, H., G. VILLE & C. WINTERBOURN. 1989. Release of iron from ferritin by semiquinone, anthracycline, bipyridyl, and nitroaromatic radicals. Free Radical Biol. Med. 6: 587-591.
    • (1989) Free Radical Biol. Med. , vol.6 , pp. 587-591
    • Monteiro, H.1    Ville, G.2    Winterbourn, C.3
  • 67
    • 0028938676 scopus 로고
    • Captopril induces iron release from ferritin and oxidative stress
    • LAPENNA, D., S. DEGIOIA, G. CIOFANI et al. 1995. Captopril induces iron release from ferritin and oxidative stress. J. Pharm. Pharmacol. 47: 1-6.
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 1-6
    • Lapenna, D.1    Degioia, S.2    Ciofani, G.3
  • 68
    • 0030598917 scopus 로고    scopus 로고
    • Dopamine, 6-hydroxydopamine, iron, and dioxygen: Their mutual interactions and possible implication in the development of Parkinson's disease
    • LINERT, W., E. HERLINGER, R.F. JAMESON et al. 1996. Dopamine, 6-hydroxydopamine, iron, and dioxygen: their mutual interactions and possible implication in the development of Parkinson's disease. Biochim. Biophys. Acta 1316: 160-168.
    • (1996) Biochim. Biophys. Acta , vol.1316 , pp. 160-168
    • Linert, W.1    Herlinger, E.2    Jameson, R.F.3
  • 69
    • 0031778102 scopus 로고    scopus 로고
    • In vitro studies of ferritin iron release and neurotoxicity
    • DOUBLE, K.L., M. MAYWALD, M. SCHMITTEL et al. 1997. In vitro studies of ferritin iron release and neurotoxicity. J. Neurochem. 70: 2492-2499.
    • (1997) J. Neurochem. , vol.70 , pp. 2492-2499
    • Double, K.L.1    Maywald, M.2    Schmittel, M.3
  • 70
    • 0024272271 scopus 로고
    • The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin
    • MONTEIRO, H. & C. WINTERBOURN. 1988. The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin. Biochem. J. 256: 923-928.
    • (1988) Biochem. J. , vol.256 , pp. 923-928
    • Monteiro, H.1    Winterbourn, C.2
  • 71
    • 0023787317 scopus 로고
    • Reactive release of ferritin iron: A kinetic assay
    • BOYER, R., T. GRABILL & R. PETROVICH. 1988. Reactive release of ferritin iron: a kinetic assay. Anal. Biochem. 174: 17-22.
    • (1988) Anal. Biochem. , vol.174 , pp. 17-22
    • Boyer, R.1    Grabill, T.2    Petrovich, R.3
  • 72
    • 13344264987 scopus 로고
    • Iron and free radical reactions: Two aspects of antioxidant protection
    • HALLIWELL, B. & J. GUTTERIDGE. 1986. Iron and free radical reactions: two aspects of antioxidant protection. Trends Biol. Sci. 11: 1372-1375-
    • (1986) Trends Biol. Sci. , vol.11 , pp. 1372-1375
    • Halliwell, B.1    Gutteridge, J.2
  • 73
    • 0027937548 scopus 로고
    • Oxidative stress: Free radical production in neural degeneration
    • GÖTZ, M.E., G. KÜNIG, P. RIEDERER et al. 1994. Oxidative stress: free radical production in neural degeneration. Pharmacol. Ther. 63: 37-122.
    • (1994) Pharmacol. Ther. , vol.63 , pp. 37-122
    • Götz, M.E.1    Künig, G.2    Riederer, P.3
  • 74
    • 0032609802 scopus 로고    scopus 로고
    • The role of iron in 6-hydroxydopamine neurotoxicity
    • DOUBLE, K.L., P. RIEDERER & M. GERLACH. 1998. The role of iron in 6-hydroxydopamine neurotoxicity. Adv. Neurol. 80: 287-296.
    • (1998) Adv. Neurol. , vol.80 , pp. 287-296
    • Double, K.L.1    Riederer, P.2    Gerlach, M.3
  • 75
    • 0026040282 scopus 로고
    • Iron-melanin interaction and lipid peroxidation: Implications for Parkinson's disease
    • BEN-SHACHAR, D., P. RIEDERER & M.B.H. YOUDIM. 1991. Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease. J. Neurochem. 57: 1609-1614.
    • (1991) J. Neurochem. , vol.57 , pp. 1609-1614
    • Ben-Shachar, D.1    Riederer, P.2    Youdim, M.B.H.3
  • 76
    • 0041695547 scopus 로고    scopus 로고
    • Iron-binding characteristics of neuromelanin of the human substantia nigra
    • DOUBLE, K.L., M. GERLACH, V. SCHÜNEMANN et al. 2003. Iron-binding characteristics of neuromelanin of the human substantia nigra. Biochem. Pharmacol. 66: 489-494.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 489-494
    • Double, K.L.1    Gerlach, M.2    Schünemann, V.3
  • 77
    • 0035662768 scopus 로고    scopus 로고
    • Substantia nigra neuromelanin: Structure, synthesis, and molecular behaviour
    • ZECCA, L., D. TAMPELLINI, M. GERLACH et al. 2001. Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour. Mol. Pathol. 54: 414-418.
    • (2001) Mol. Pathol. , vol.54 , pp. 414-418
    • Zecca, L.1    Tampellini, D.2    Gerlach, M.3
  • 78
    • 0033769320 scopus 로고    scopus 로고
    • Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins
    • DOUBLE, K.L., L. ZECCA et al. 2000. Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins. J. Neurochem. 75: 2583-2589.
    • (2000) J. Neurochem. , vol.75 , pp. 2583-2589
    • Double, K.L.1    Zecca, L.2
  • 79
    • 0027260711 scopus 로고
    • Total and paramagnetic metals in human substantia nigra and its neuromelanin
    • ZECCA, L. & H.M. SWARTZ. 1993. Total and paramagnetic metals in human substantia nigra and its neuromelanin. J. Neural Transm. Parkinson's Dis. Dementia Sect 5: 203-213.
    • (1993) J. Neural Transm. Parkinson's Dis. Dementia Sect , vol.5 , pp. 203-213
    • Zecca, L.1    Swartz, H.M.2
  • 80
    • 0030012587 scopus 로고    scopus 로고
    • Interaction of neuromelanin and iron in substantia nigra and other areas of human brain
    • ZECCA, L., T. SHIMA, A. STROPPOLO et al. 1996. Interaction of neuromelanin and iron in substantia nigra and other areas of human brain. Neuroscience 73: 407-415.
    • (1996) Neuroscience , vol.73 , pp. 407-415
    • Zecca, L.1    Shima, T.2    Stroppolo, A.3
  • 81
    • 17044461766 scopus 로고    scopus 로고
    • Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: An electron paramagnetic resonance spectroscopy study
    • SHIMA, T., T. SARNA, A. STROPPOLO et al. 1997. Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study. Free Radical Biol. Med. 23: 110-119.
    • (1997) Free Radical Biol. Med. , vol.23 , pp. 110-119
    • Shima, T.1    Sarna, T.2    Stroppolo, A.3
  • 82
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • HIRSCH, E.C., A.M. GRAYBIEL & Y.A. AGID. 1988. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334: 345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.C.1    Graybiel, A.M.2    Agid, Y.A.3
  • 83
    • 0037116582 scopus 로고    scopus 로고
    • The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
    • ZECCA, L., R. FARIELLO, P. RIEDERER et al. 2002. The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease. FEBS Lett. 510: 216-220.
    • (2002) FEBS Lett. , vol.510 , pp. 216-220
    • Zecca, L.1    Fariello, R.2    Riederer, P.3
  • 84
    • 0026662141 scopus 로고
    • Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?
    • KASTNER, A., E. HIRSCH, O. LEJEUNE et al. 1992. Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? J. Neurochem. 59: 1080-1089.
    • (1992) J. Neurochem. , vol.59 , pp. 1080-1089
    • Kastner, A.1    Hirsch, E.2    Lejeune, O.3
  • 85
    • 0026638825 scopus 로고
    • Melanin, tyrosine hydroxylase, calbindin, and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuron susceptibility in Parkinson's disease
    • GIBB, W. 1992. Melanin, tyrosine hydroxylase, calbindin, and substance P in the human midbrain and substantia nigra in relation to nigrostriatal projections and differential neuron susceptibility in Parkinson's disease. Brain Res. 581: 283-291.
    • (1992) Brain Res. , vol.581 , pp. 283-291
    • Gibb, W.1
  • 86
    • 0032813648 scopus 로고    scopus 로고
    • The significance of neuromelanin in Parkinson's disease
    • DOUBLE, K.L., P. RIEDERER & M. GERLACH. 1999. The significance of neuromelanin in Parkinson's disease. Drug News Dev. 12: 333-340.
    • (1999) Drug News Dev. , vol.12 , pp. 333-340
    • Double, K.L.1    Riederer, P.2    Gerlach, M.3
  • 87
    • 0023884694 scopus 로고
    • The effect of melanin on iron associated decomposition of hydrogen peroxide
    • PILAS, B., T. SARNA, B. KALYANARAMAN et al. 1988. The effect of melanin on iron associated decomposition of hydrogen peroxide. Free Radical Biol. Med. 4: 285-293.
    • (1988) Free Radical Biol. Med. , vol.4 , pp. 285-293
    • Pilas, B.1    Sarna, T.2    Kalyanaraman, B.3
  • 88
    • 0033947467 scopus 로고    scopus 로고
    • Sequestration of iron by Lewy bodies in Parkinson's disease
    • CASTELLANI, R., S. SIEDLAK, G. PERRY et al. 2000. Sequestration of iron by Lewy bodies in Parkinson's disease. Acta Neuropathol. 100: 111-114.
    • (2000) Acta Neuropathol. , vol.100 , pp. 111-114
    • Castellani, R.1    Siedlak, S.2    Perry, G.3
  • 89
    • 0033626283 scopus 로고    scopus 로고
    • 13C-NMR characterization of an insoluble proteinaceous fraction from substantia nigra of patients with Parkinson's disease
    • 13C-NMR characterization of an insoluble proteinaceous fraction from substantia nigra of patients with Parkinson's disease. Mov. Disord. 15: 977-981.
    • (2000) Mov. Disord. , vol.15 , pp. 977-981
    • Aime, S.1    Bergamasco, B.2    Casu, M.3
  • 90
    • 0034049587 scopus 로고    scopus 로고
    • Q-band EPR investigations of neuromelanin in control and Parkinson's disease patients
    • LOPIANO, L., M. CHIESA, D. DIGILIO et al. 2000. Q-band EPR investigations of neuromelanin in control and Parkinson's disease patients. Biochim. Biophys. Acta 1500: 306-312.
    • (2000) Biochim. Biophys. Acta , vol.1500 , pp. 306-312
    • Lopiano, L.1    Chiesa, M.2    Digilio, D.3
  • 91
    • 0042433192 scopus 로고    scopus 로고
    • Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease
    • FAUCHEUX, B.A., M.E. MARTIN, C. BEAUMONT et al. 2003. Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease. J. Neurochem. 86: 1142-1148.
    • (2003) J. Neurochem. , vol.86 , pp. 1142-1148
    • Faucheux, B.A.1    Martin, M.E.2    Beaumont, C.3
  • 92
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • POLYMEROPOULOS, M., C. LAVEDAN, E. LEROY et al. 1997. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.1    Lavedan, C.2    Leroy, E.3
  • 93
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
    • KRÜGER, R., W. KUHN, T. MÜLLER et al. 1998. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18: 106-108.
    • (1998) Nat. Genet. , vol.18 , pp. 106-108
    • Krüger, R.1    Kuhn, W.2    Müller, T.3
  • 94
    • 17044447638 scopus 로고    scopus 로고
    • Familial Parkinson's disease, α-synuclein, and parkin
    • Lippincott/ Williams & Wilkins. Philadelphia
    • MIZUNO, Y., N. HATTORI, T. KITADA et al. 2001. Familial Parkinson's disease, α-synuclein, and parkin. In Parkinson's Disease. Volume 86, pp. 13-21. Lippincott/ Williams & Wilkins. Philadelphia.
    • (2001) Parkinson's Disease , vol.86 , pp. 13-21
    • Mizuno, Y.1    Hattori, N.2    Kitada, T.3
  • 96
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • SPILLANTINI, M.G., R.A. CROWTHER, R. JAKES et al. 1998. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95: 6469-6473.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3
  • 97
    • 0032835781 scopus 로고    scopus 로고
    • Reduced expression of the G209A α-synuclein allele in familial parkinsonism
    • MARKOPOULOU, K., Z. WSZOLEK, R. PFEIFFER et al. 1999. Reduced expression of the G209A α-synuclein allele in familial parkinsonism. Ann. Neurol. 46: 374-381.
    • (1999) Ann. Neurol. , vol.46 , pp. 374-381
    • Markopoulou, K.1    Wszolek, Z.2    Pfeiffer, R.3
  • 98
    • 0034663039 scopus 로고    scopus 로고
    • The A53T α-synuclein mutation increases iron-dependent aggregation and toxicity
    • OSTREROVA-GOLTS, N., L. PETRUCELLI et al. 2000. The A53T α-synuclein mutation increases iron-dependent aggregation and toxicity. J. Neurosci. 20: 6048-6054.
    • (2000) J. Neurosci. , vol.20 , pp. 6048-6054
    • Ostrerova-Golts, N.1    Petrucelli, L.2
  • 99
    • 0035873812 scopus 로고    scopus 로고
    • α-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro
    • TURNBULL, S., B.J. TABNER, O.M.A. EL-AGNAF et al. 2001. α-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro. Free Radical Biol. Med. 30: 1163-1170.
    • (2001) Free Radical Biol. Med. , vol.30 , pp. 1163-1170
    • Turnbull, S.1    Tabner, B.J.2    El-Agnaf, O.M.A.3
  • 100
    • 0035933898 scopus 로고    scopus 로고
    • 2+ binding to α-synuclein regulates ligand binding and oligomerization
    • 2+ binding to α-synuclein regulates ligand binding and oligomerization. J. Biol. Chem. 276: 22680-22684.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22680-22684
    • Nielsen, M.S.1    Vorum, H.2    Lindersson, E.3
  • 101
    • 0033577159 scopus 로고    scopus 로고
    • Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro
    • HASHIMOTO, M., L.J. HSU, Y. XIA et al. 1999. Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro. Neuroreport 10: 717-721.
    • (1999) Neuroreport , vol.10 , pp. 717-721
    • Hashimoto, M.1    Hsu, L.J.2    Xia, Y.3
  • 103
    • 0033564726 scopus 로고    scopus 로고
    • Copper(II)-induced self oligomerization of α-synuclein
    • PAIK, S.R., H. SHIN, J. LEE et al. 1999. Copper(II)-induced self oligomerization of α-synuclein. Biochem. J. 340: 821-828.
    • (1999) Biochem. J. , vol.340 , pp. 821-828
    • Paik, S.R.1    Shin, H.2    Lee, J.3
  • 104
    • 0037468467 scopus 로고    scopus 로고
    • Oxidized glutathione stimulated the amyloid formation of α-synuclein
    • PAIK, S.R., D.Y. LEE, H.J. CHO et al. 2003. Oxidized glutathione stimulated the amyloid formation of α-synuclein. FEBS Lett. 537: 63-67.
    • (2003) FEBS Lett. , vol.537 , pp. 63-67
    • Paik, S.R.1    Lee, D.Y.2    Cho, H.J.3
  • 105
    • 0036591852 scopus 로고    scopus 로고
    • Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease
    • TABNER, B.J., S. TURNBULL, O.M.A. EL-AGNAF et al. 2002. Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radical Biol. Med. 32: 1076-1083.
    • (2002) Free Radical Biol. Med. , vol.32 , pp. 1076-1083
    • Tabner, B.J.1    Turnbull, S.2    El-Agnaf, O.M.A.3
  • 106
    • 0034468706 scopus 로고    scopus 로고
    • Crosslinking of α-synuclein by advanced glycation endproducts - An early pathophysiological step in Lewy body formation?
    • MÜNCH, G., H.J. LÜTH, A. WONG et al. 2000. Crosslinking of α-synuclein by advanced glycation endproducts - an early pathophysiological step in Lewy body formation? J. Chem. Neuroanat. 20: 253-257.
    • (2000) J. Chem. Neuroanat. , vol.20 , pp. 253-257
    • Münch, G.1    Lüth, H.J.2    Wong, A.3
  • 107
    • 0141906286 scopus 로고    scopus 로고
    • Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease
    • MÜNCH, G., J, GASIC-MILENKOVIC & T. ARENDT. 2003. Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease. J. Neural Transm. Suppl. 65: 63-71.
    • (2003) J. Neural Transm. Suppl. , vol.65 , pp. 63-71
    • Münch, G.1    Gasic-Milenkovic, J.2    Arendt, T.3
  • 108
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine alpha-synuclein adduct
    • CONWAY, K.A., J.C. ROCHET, R.M. BIEGANSKI et al. 2001. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine alpha-synuclein adduct. Science 294: 1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3
  • 109
    • 0034326816 scopus 로고    scopus 로고
    • Expression of mutant α-synuclein causes increased susceptibility to dopamine toxicity
    • TABRIZI, S.J., M. ORTH, J.M. WILKINSON et al. 2001. Expression of mutant α-synuclein causes increased susceptibility to dopamine toxicity. Hum. Mol. Genet. 9: 2683-2689.
    • (2001) Hum. Mol. Genet. , vol.9 , pp. 2683-2689
    • Tabrizi, S.J.1    Orth, M.2    Wilkinson, J.M.3
  • 110
    • 0033890821 scopus 로고    scopus 로고
    • α-Synuclein promotes mitochondrial deficit and oxidative stress
    • HSU, L.J., Y. SAGARRA, A. ARROYO et al. 2001. α-Synuclein promotes mitochondrial deficit and oxidative stress. Am. J. Pathol. 157: 401-410.
    • (2001) Am. J. Pathol. , vol.157 , pp. 401-410
    • Hsu, L.J.1    Sagarra, Y.2    Arroyo, A.3
  • 111
    • 0033821703 scopus 로고    scopus 로고
    • Induction of neuronal death by α-synuclein
    • SAHA, A.R., N.N. NINKINA, D.P. HANGER et al. 2001. Induction of neuronal death by α-synuclein. Eur. J. Neurosci. 12: 3073-3077.
    • (2001) Eur. J. Neurosci. , vol.12 , pp. 3073-3077
    • Saha, A.R.1    Ninkina, N.N.2    Hanger, D.P.3
  • 112
    • 0037087150 scopus 로고    scopus 로고
    • Aggregation of α-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system
    • KIM, K.S., S.Y. CHOI, H.Y. KWON et al. 2002. Aggregation of α-synuclein induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system. Free Radical Biol. Med. 32: 544-550.
    • (2002) Free Radical Biol. Med. , vol.32 , pp. 544-550
    • Kim, K.S.1    Choi, S.Y.2    Kwon, H.Y.3
  • 114
    • 0034017710 scopus 로고    scopus 로고
    • α-Synuclein and Parkinson's disease: Selective neurodegenerative effect of α-synuclein fragment on dopaminergic neurons in vitro and in vivo
    • FORLONI, G., I. BERTANI, A.M. CALELLA et al. 2001. α-Synuclein and Parkinson's disease: selective neurodegenerative effect of α-synuclein fragment on dopaminergic neurons in vitro and in vivo. Ann. Neurol. 47: 632-640.
    • (2001) Ann. Neurol. , vol.47 , pp. 632-640
    • Forloni, G.1    Bertani, I.2    Calella, A.M.3
  • 115
    • 0036679197 scopus 로고    scopus 로고
    • α-Synucleinopathy and selective dopaminergic loss in a rat lentiviral-based model of Parkinson's disease
    • LO BIANCO, C., J.L. RIDET, B.L. SCHNEIDER et al. 2002. α-Synucleinopathy and selective dopaminergic loss in a rat lentiviral-based model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 99: 10813-10818.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.L.2    Schneider, B.L.3
  • 116
    • 0035800097 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar α-synuclein: Implications for the pathogenesis and treatment of Parkinson's disease
    • VOLLES, M.J., S.J. LEE, J-C. ROCHET et al. 2001. Vesicle permeabilization by protofibrillar α-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40: 7812-7819.
    • (2001) Biochemistry , vol.40 , pp. 7812-7819
    • Volles, M.J.1    Lee, S.J.2    Rochet, J.-C.3
  • 117
    • 0037046163 scopus 로고    scopus 로고
    • Vesicle permeabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
    • VOLLES, M.J. & P.T. LANSBURY, JR. 2002. Vesicle permeabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism. Biochemistry 41: 4595-4602.
    • (2002) Biochemistry , vol.41 , pp. 4595-4602
    • Volles, M.J.1    Lansbury Jr., P.T.2
  • 118
    • 0038386274 scopus 로고    scopus 로고
    • Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
    • VOLLES, M.J. & P.T. LANSBURY, JR. 2003. Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry 42: 7871-7878.
    • (2003) Biochemistry , vol.42 , pp. 7871-7878
    • Volles, M.J.1    Lansbury Jr., P.T.2
  • 119
    • 0141940629 scopus 로고    scopus 로고
    • What have we leamt from cDNA microarray gene expression studies about the role of iron in MPTP-induced neurodegeneration and Parkinson's disease
    • YOUDIM, M.B.H. 2003. What have we leamt from cDNA microarray gene expression studies about the role of iron in MPTP-induced neurodegeneration and Parkinson's disease. J. Neural Transm. Suppl. 65: 73-88.
    • (2003) J. Neural Transm. Suppl. , vol.65 , pp. 73-88
    • Youdim, M.B.H.1
  • 121
    • 0027991538 scopus 로고
    • Degeneration of nigro-striatal dopaminergic neurons increases iron within the substantia nigra: A histochemical and neurochemical study
    • OESTREICHER, E., G.J. SENGSTOCK, P. RIEDERER et al. 1994. Degeneration of nigro-striatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain Res. 660: 8-18.
    • (1994) Brain Res. , vol.660 , pp. 8-18
    • Oestreicher, E.1    Sengstock, G.J.2    Riederer, P.3
  • 122
    • 0030727141 scopus 로고    scopus 로고
    • Intranigral iron infusion in the rat: Acute elevations in nigral lipid peroxidation and striatal dopaminergic markers with ensuing nigral degeneration
    • SENGSTOCK, G.J., N.H. ZAWIA, C.W. OLANOW et al. 1997. Intranigral iron infusion in the rat: acute elevations in nigral lipid peroxidation and striatal dopaminergic markers with ensuing nigral degeneration. Biol. Trace Elem. Res. 58: 177-195.
    • (1997) Biol. Trace Elem. Res. , vol.58 , pp. 177-195
    • Sengstock, G.J.1    Zawia, N.H.2    Olanow, C.W.3
  • 123
    • 0025980955 scopus 로고
    • The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine- induced degeneration of nigrostriatal dopamine neurons
    • BEN-SHACHAR, D., G. ESHEL, J.P. FINBERG et al. 1991. The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J. Neurochem. 56: 1441-1444.
    • (1991) J. Neurochem. , vol.56 , pp. 1441-1444
    • Ben-Shachar, D.1    Eshel, G.2    Finberg, J.P.3
  • 124
    • 0346849912 scopus 로고    scopus 로고
    • Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats
    • BEN-SHACHAR, D., N. KAHANA, L. KAMPEL et al. 2004. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats. Neuropharmacology 46: 254-263.
    • (2004) Neuropharmacology , vol.46 , pp. 254-263
    • Ben-Shachar, D.1    Kahana, N.2    Kampel, L.3
  • 125
    • 0025824668 scopus 로고
    • Intranigral iron injection induces behavioural and biochemical "parkinsonism" in rats
    • BEN-SHACHAR, D. & M.B. YOUDIM. 1991. Intranigral iron injection induces behavioural and biochemical "parkinsonism" in rats. J. Neurochem. 57: 2133-2135.
    • (1991) J. Neurochem. , vol.57 , pp. 2133-2135
    • Ben-Shachar, D.1    Youdim, M.B.2
  • 126
    • 0034979314 scopus 로고    scopus 로고
    • Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter
    • MATSUOKA, Y., M. VILA, S. LINCOLN et al. 2001. Lack of nigral pathology in transgenic mice expressing human α-synuclein driven by the tyrosine hydroxylase promoter. Neurobiol. Dis. 8: 535-539.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 535-539
    • Matsuoka, Y.1    Vila, M.2    Lincoln, S.3
  • 127
    • 0036787779 scopus 로고    scopus 로고
    • Overexpression of Parkinson's disease associated alpha-synuclein A53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP
    • DONG, Z., B. FERGER, J. FELDON et al. 2002. Overexpression of Parkinson's disease associated alpha-synuclein A53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP. J. Neurobiol. 53: 1-10.
    • (2002) J. Neurobiol. , vol.53 , pp. 1-10
    • Dong, Z.1    Ferger, B.2    Feldon, J.3
  • 128
    • 0038015531 scopus 로고    scopus 로고
    • Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors
    • BJÖRKLUND, A. & D. KIRIK. 2003. Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors. TINS 26: 386-392,
    • (2003) TINS , vol.26 , pp. 386-392
    • Björklund, A.1    Kirik, D.2
  • 129
    • 0027193251 scopus 로고
    • Distribution of iron in the basal ganglia and neocortex in postmortem tissue in Parkinson's disease and Alzheimer's disease
    • GRIFFITHS, P.D. & A.R. CROSSMAN. 1993. Distribution of iron in the basal ganglia and neocortex in postmortem tissue in Parkinson's disease and Alzheimer's disease. Dementia 4: 61-65.
    • (1993) Dementia , vol.4 , pp. 61-65
    • Griffiths, P.D.1    Crossman, A.R.2


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