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Volumn 31, Issue 4, 2011, Pages 307-340

Mechanisms behind the anti-inflammatory actions of insulin

Author keywords

And diabetes mellitus; Inflammation; Insulin

Indexed keywords

C PEPTIDE; CYTOKINE; ENDOTOXIN; HORMONE; INSULIN; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEINASE ACTIVATED RECEPTOR 2; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR;

EID: 80052431104     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevimmunol.v31.i4.30     Document Type: Article
Times cited : (36)

References (244)
  • 1
    • 33750374137 scopus 로고    scopus 로고
    • The twentieth century struggle to decipher insulin signalling
    • Cohen P. The twentieth century struggle to decipher insulin signalling. Nat Rev Mol Cell Biol. 2006;7(11):867-873.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.11 , pp. 867-873
    • Cohen, P.1
  • 2
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006;7(2):85-96.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 3
    • 0025995364 scopus 로고
    • Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans
    • Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest. 1991;87(6):2246-2252.
    • (1991) J Clin Invest , vol.87 , Issue.6 , pp. 2246-2252
    • Anderson, E.A.1    Hoffman, R.P.2    Balon, T.W.3    Sinkey, C.A.4    Mark, A.L.5
  • 4
    • 0022367327 scopus 로고
    • Beta adrenergic-mediated vasodilator response to insulin in the human forearm
    • Creager MA, Liang CS, Coffman JD. Beta adrenergic-mediated vasodilator response to insulin in the human forearm. J Pharmacol Exp Ther. 1985;235(3):709-714.
    • (1985) J Pharmacol Exp Ther , vol.235 , Issue.3 , pp. 709-714
    • Creager, M.A.1    Liang, C.S.2    Coffman, J.D.3
  • 5
    • 27844578300 scopus 로고    scopus 로고
    • Insulin and cognitive function in humans: Experimental data and therapeutic considerations
    • Strachan MW. Insulin and cognitive function in humans: experimental data and therapeutic considerations. Biochem Soc Trans. 2005;33(Pt 5):1037-1040.
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 5 , pp. 1037-1040
    • Strachan, M.W.1
  • 6
    • 0017071570 scopus 로고
    • The effects of glucose and insulin on renal electrolyte transport
    • DeFronzo RA, Goldberg M, Agus ZS. The effects of glucose and insulin on renal electrolyte transport. J Clin Invest. 1976;58(1):83-90.
    • (1976) J Clin Invest , vol.58 , Issue.1 , pp. 83-90
    • Defronzo, R.A.1    Goldberg, M.2    Agus, Z.S.3
  • 7
    • 0017237005 scopus 로고
    • Effect of insulin and alloxan diabetes on carrageenin inflammation in rats
    • Ottlecz A, Koltai M, Dekov E. Effect of insulin and alloxan diabetes on carrageenin inflammation in rats. Int Arch Allergy Appl Immunol. 1976;50(5):548-554.
    • (1976) Int Arch Allergy Appl Immunol , vol.50 , Issue.5 , pp. 548-554
    • Ottlecz, A.1    Koltai, M.2    Dekov, E.3
  • 8
    • 0017695520 scopus 로고
    • Further studies on the anti-inflammatory effect of insulin
    • Ottlecz A, Koltai M, Gecse A. Further studies on the anti-inflammatory effect of insulin. Agents Actions. 1977;7(4):487-491.
    • (1977) Agents Actions , vol.7 , Issue.4 , pp. 487-491
    • Ottlecz, A.1    Koltai, M.2    Gecse, A.3
  • 9
    • 0021824732 scopus 로고
    • Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: Role of glucose, insulin, and macrophages
    • Satomi N, Sakurai A, Haranaka K. Relationship of hypoglycemia to tumor necrosis factor production and antitumor activity: role of glucose, insulin, and macrophages. J Natl Cancer Inst. 1985;74(6):1255-1260.
    • (1985) J Natl Cancer Inst , vol.74 , Issue.6 , pp. 1255-1260
    • Satomi, N.1    Sakurai, A.2    Haranaka, K.3
  • 10
    • 0024334738 scopus 로고
    • Reversal of the toxic effects of cachectin by concurrent insulin administration
    • Fraker DL, Merino MJ, Norton JA. Reversal of the toxic effects of cachectin by concurrent insulin administration. Am J Physiol. 1989;256 (6 Pt 1):E725-E731.
    • (1989) Am J Physiol , vol.256 , Issue.6 PART 1
    • Fraker, D.L.1    Merino, M.J.2    Norton, J.A.3
  • 13
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science. 1996;271(5249):665-668.
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 14
    • 0036632631 scopus 로고    scopus 로고
    • Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings
    • Marette A. Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings. Curr Opin Clin Nutr Metab Care. 2002;5(4):377-383.
    • (2002) Curr Opin Clin Nutr Metab Care , vol.5 , Issue.4 , pp. 377-383
    • Marette, A.1
  • 19
    • 0142088505 scopus 로고    scopus 로고
    • Glucose control and mortality in critically ill patients
    • Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA. 2003;290(15):2041-2047.
    • (2003) JAMA , vol.290 , Issue.15 , pp. 2041-2047
    • Finney, S.J.1    Zekveld, C.2    Elia, A.3    Evans, T.W.4
  • 20
    • 34548146116 scopus 로고    scopus 로고
    • Clinical experience with tight glucose control by intensive insulin therapy
    • Preiser JC, Devos P. Clinical experience with tight glucose control by intensive insulin therapy. Crit Care Med. 2007;35(9 Suppl):S503-S507.
    • (2007) Crit Care Med , vol.35 , Issue.SUPPL. 9
    • Preiser, J.C.1    Devos, P.2
  • 23
    • 50549176442 scopus 로고
    • Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report
    • Sodi-Pallares D, Testelli MR, Fishleder BL, Bisteni A, Medrano GA, Friedland C, De Micheli A. Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report. Am J Cardiol. 1962;9:166-181.
    • (1962) Am J Cardiol , vol.9 , pp. 166-181
    • Sodi-Pallares, D.1    Testelli, M.R.2    Fishleder, B.L.3    Bisteni, A.4    Medrano, G.A.5    Friedland, C.6    de Micheli, A.7
  • 25
    • 0029069020 scopus 로고
    • Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year
    • Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P, Waldenstrom A, Wedel H, Welin L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol. 1995;26(1):57-65.
    • (1995) J Am Coll Cardiol , vol.26 , Issue.1 , pp. 57-65
    • Malmberg, K.1    Ryden, L.2    Efendic, S.3    Herlitz, J.4    Nicol, P.5    Waldenstrom, A.6    Wedel, H.7    Welin, L.8
  • 26
    • 33746366222 scopus 로고    scopus 로고
    • The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: A randomized controlled trial of insulin infusion therapy for myocardial infarction
    • Cheung NW, Wong VW, McLean M. The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: a randomized controlled trial of insulin infusion therapy for myocardial infarction. Diabetes Care. 2006;29(4):765-770.
    • (2006) Diabetes Care , vol.29 , Issue.4 , pp. 765-770
    • Cheung, N.W.1    Wong, V.W.2    McLean, M.3
  • 28
    • 9444288107 scopus 로고    scopus 로고
    • C-reactive protein levels following acute myocardial infarction: Effect of insulin infusion and tight glycemic control
    • Wong VW, McLean M, Boyages SC, Cheung NW. C-reactive protein levels following acute myocardial infarction: effect of insulin infusion and tight glycemic control. Diabetes Care. 2004;27(12):2971-2973.
    • (2004) Diabetes Care , vol.27 , Issue.12 , pp. 2971-2973
    • Wong, V.W.1    McLean, M.2    Boyages, S.C.3    Cheung, N.W.4
  • 32
    • 26444588755 scopus 로고    scopus 로고
    • Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: Effects on inflammatory response during coronary artery surgery
    • Visser L, Zuurbier CJ, Hoek FJ, Opmeer BC, de JE, de Mol BA, van Wezel HB. Glucose, insulin and potassium applied as perioperative hyperinsulinaemic normoglycaemic clamp: effects on inflammatory response during coronary artery surgery. Br J Anaesth. 2005;95(4): 448-457.
    • (2005) Br J Anaesth , vol.95 , Issue.4 , pp. 448-457
    • Visser, L.1    Zuurbier, C.J.2    Hoek, F.J.3    Opmeer, B.C.4    De, J.E.5    de Mol, B.A.6    van Wezel, H.B.7
  • 34
    • 1842434301 scopus 로고    scopus 로고
    • Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events
    • Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation. 2004;109(12):1497-1502.
    • (2004) Circulation , vol.109 , Issue.12 , pp. 1497-1502
    • Lazar, H.L.1    Chipkin, S.R.2    Fitzgerald, C.A.3    Bao, Y.4    Cabral, H.5    Apstein, C.S.6
  • 36
    • 0034773026 scopus 로고    scopus 로고
    • Association of hyperglycemia with increased mortality after severe burn injury
    • Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma. 2001;51(3):540-544.
    • (2001) J Trauma , vol.51 , Issue.3 , pp. 540-544
    • Gore, D.C.1    Chinkes, D.2    Heggers, J.3    Herndon, D.N.4    Wolf, S.E.5    Desai, M.6
  • 38
    • 0033509630 scopus 로고    scopus 로고
    • A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns
    • Ferrando AA, Chinkes DL, Wolf SE, Matin S, Herndon DN, Wolfe RR. A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns. Ann Surg. 1999;229(1):11-18.
    • (1999) Ann Surg , vol.229 , Issue.1 , pp. 11-18
    • Ferrando, A.A.1    Chinkes, D.L.2    Wolf, S.E.3    Matin, S.4    Herndon, D.N.5    Wolfe, R.R.6
  • 41
    • 51449120477 scopus 로고    scopus 로고
    • Intensive insulin therapy is associated with reduced infectious complications in burn patients
    • Hemmila MR, Taddonio MA, Arbabi S, Maggio PM, Wahl WL. Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery. 2008;144(4): 629-635.
    • (2008) Surgery , vol.144 , Issue.4 , pp. 629-635
    • Hemmila, M.R.1    Taddonio, M.A.2    Arbabi, S.3    Maggio, P.M.4    Wahl, W.L.5
  • 43
    • 1642331710 scopus 로고    scopus 로고
    • Insulin treatment improves the systemic inflammatory reaction to severe trauma
    • Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004;239(4):553-560.
    • (2004) Ann Surg , vol.239 , Issue.4 , pp. 553-560
    • Jeschke, M.G.1    Klein, D.2    Herndon, D.N.3
  • 45
    • 3042702611 scopus 로고    scopus 로고
    • Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations
    • Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P. Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations. Am J Clin Nutr. 2004;80(1):51-57.
    • (2004) Am J Clin Nutr , vol.80 , Issue.1 , pp. 51-57
    • Aljada, A.1    Ghanim, H.2    Mohanty, P.3    Syed, T.4    Bandyopadhyay, A.5    Dandona, P.6
  • 46
    • 1842453995 scopus 로고    scopus 로고
    • Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappa B in mononuclear cells
    • Dhindsa S, Tripathy D, Mohanty P, Ghanim H, Syed T, Aljada A, Dandona P. Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappa B in mononuclear cells. Metabolism. 2004;53(3):330-334.
    • (2004) Metabolism , vol.53 , Issue.3 , pp. 330-334
    • Dhindsa, S.1    Tripathy, D.2    Mohanty, P.3    Ghanim, H.4    Syed, T.5    Aljada, A.6    Dandona, P.7
  • 49
  • 50
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
    • Du XL, Edelstein D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, Brownlee M. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci U S A. 2000;97(22): 12222-12226.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.22 , pp. 12222-12226
    • Du, X.L.1    Edelstein, D.2    Rossetti, L.3    Fantus, I.G.4    Goldberg, H.5    Ziyadeh, F.6    Wu, J.7    Brownlee, M.8
  • 51
    • 0034988657 scopus 로고    scopus 로고
    • Elevated ambient glucose induces acute inflammatory events in the microvasculature: Effects of insulin
    • Booth G, Stalker TJ, Lefer AM, Scalia R. Elevated ambient glucose induces acute inflammatory events in the microvasculature: effects of insulin. Am J Physiol Endocrinol Metab. 2001;280(6):E848-E856.
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , Issue.6
    • Booth, G.1    Stalker, T.J.2    Lefer, A.M.3    Scalia, R.4
  • 53
    • 0842284787 scopus 로고    scopus 로고
    • Glucose-induced regulation of COX-2 expression in human islets of Langerhans
    • Persaud SJ, Burns CJ, Belin VD, Jones PM. Glucose-induced regulation of COX-2 expression in human islets of Langerhans. Diabetes. 2004;53 Suppl 1:S190-S192.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Persaud, S.J.1    Burns, C.J.2    Belin, V.D.3    Jones, P.M.4
  • 54
    • 77953141964 scopus 로고    scopus 로고
    • The role of intensive insulin therapy in increasing superoxide dismutase (SOD. and normalizing hyperglycemia in critically ill patients
    • Wiryana M. The role of intensive insulin therapy in increasing superoxide dismutase (SOD. and normalizing hyperglycemia in critically ill patients. Acta Med Indones. 2009;41(2):59-65.
    • (2009) Acta Med Indones , vol.41 , Issue.2 , pp. 59-65
    • Wiryana, M.1
  • 55
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43(2):109-142.
    • (1991) Pharmacol Rev , vol.43 , Issue.2 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 56
    • 0029064593 scopus 로고
    • Nitric oxide in inflammation and immune response
    • Moilanen E, Vapaatalo H. Nitric oxide in inflammation and immune response. Ann Med 1995;27(3):359-367.
    • (1995) Ann Med , vol.27 , Issue.3 , pp. 359-367
    • Moilanen, E.1    Vapaatalo, H.2
  • 57
    • 0347993913 scopus 로고    scopus 로고
    • Nitric oxide and superoxide in inflammation and immune regulation
    • Guzik TJ, Korbut R, mek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 2003;54(4): 469-487.
    • (2003) J Physiol Pharmacol , vol.54 , Issue.4 , pp. 469-487
    • Guzik, T.J.1    Korbut, R.2    Mek-Guzik, T.3
  • 58
    • 0028367210 scopus 로고
    • Beneficial actions of S-nitroso-N-acetylpenicillamine, a nitric oxide donor, in murine traumatic shock
    • Christopher TA, Ma XL, Lefer AM. Beneficial actions of S-nitroso-N-acetylpenicillamine, a nitric oxide donor, in murine traumatic shock. Shock. 1994;1(1):19-24.
    • (1994) Shock , vol.1 , Issue.1 , pp. 19-24
    • Christopher, T.A.1    Ma, X.L.2    Lefer, A.M.3
  • 59
    • 0026630603 scopus 로고
    • Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase
    • Clancy RM, Leszczynska-Piziak J, Abramson SB. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest. 1992;90(3):1116-1121.
    • (1992) J Clin Invest , vol.90 , Issue.3 , pp. 1116-1121
    • Clancy, R.M.1    Leszczynska-Piziak, J.2    Abramson, S.B.3
  • 60
    • 0029957727 scopus 로고    scopus 로고
    • Nitric oxide regulation of superoxide-dependent lung injury: Oxidantprotective actions of endogenously produced and exogenously administered nitric oxide
    • Gutierrez HH, Nieves B, Chumley P, Rivera A, Freeman BA. Nitric oxide regulation of superoxide-dependent lung injury: oxidantprotective actions of endogenously produced and exogenously administered nitric oxide. Free Radic Biol Med. 1996;21(1):43-52.
    • (1996) Free Radic Biol Med , vol.21 , Issue.1 , pp. 43-52
    • Gutierrez, H.H.1    Nieves, B.2    Chumley, P.3    Rivera, A.4    Freeman, B.A.5
  • 61
    • 0025731835 scopus 로고
    • Nitric oxide: An endogenous modulator of leukocyte adhesion
    • Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991;88(11):4651-4655.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.11 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 62
    • 0036562261 scopus 로고    scopus 로고
    • Potential cardioprotective actions of no-releasing aspirin
    • Wallace JL, Ignarro LJ, Fiorucci S. Potential cardioprotective actions of no-releasing aspirin. Nat Rev Drug Discov. 2002;1(5):375-382.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.5 , pp. 375-382
    • Wallace, J.L.1    Ignarro, L.J.2    Fiorucci, S.3
  • 63
    • 0036285223 scopus 로고    scopus 로고
    • Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels
    • Guzik TJ, West NE, Pillai R, Taggart DP, Channon KM. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension. 2002;39(6):1088-1094.
    • (2002) Hypertension , vol.39 , Issue.6 , pp. 1088-1094
    • Guzik, T.J.1    West, N.E.2    Pillai, R.3    Taggart, D.P.4    Channon, K.M.5
  • 64
    • 29344465714 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2
    • Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005;310(5756): 1966-1970.
    • (2005) Science , vol.310 , Issue.5756 , pp. 1966-1970
    • Kim, S.F.1    Huri, D.A.2    Snyder, S.H.3
  • 65
    • 0026586461 scopus 로고
    • The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids
    • Palmer RM, Bridge L, Foxwell NA, Moncada S. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br J Pharmacol. 1992;105(1):11-12.
    • (1992) Br J Pharmacol , vol.105 , Issue.1 , pp. 11-12
    • Palmer, R.M.1    Bridge, L.2    Foxwell, N.A.3    Moncada, S.4
  • 66
    • 0028030813 scopus 로고
    • Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
    • Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94(3):1172-1179.
    • (1994) J Clin Invest , vol.94 , Issue.3 , pp. 1172-1179
    • Steinberg, H.O.1    Brechtel, G.2    Johnson, A.3    Fineberg, N.4    Baron, A.D.5
  • 67
    • 0033950472 scopus 로고    scopus 로고
    • Effect of insulin on human aortic endothelial nitric oxide synthase
    • Aljada A, Dandona P. Effect of insulin on human aortic endothelial nitric oxide synthase. Metabolism. 2000;49(2):147-150.
    • (2000) Metabolism , vol.49 , Issue.2 , pp. 147-150
    • Aljada, A.1    Dandona, P.2
  • 68
    • 0036020513 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells
    • Montagnani M, Ravichandran LV, Chen H, Esposito DL, Quon MJ. Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells. Mol Endocrinol. 2002;16(8):1931-1942.
    • (2002) Mol Endocrinol , vol.16 , Issue.8 , pp. 1931-1942
    • Montagnani, M.1    Ravichandran, L.V.2    Chen, H.3    Esposito, D.L.4    Quon, M.J.5
  • 69
    • 0029789432 scopus 로고    scopus 로고
    • Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells
    • Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest. 1996;98(4):894-898.
    • (1996) J Clin Invest , vol.98 , Issue.4 , pp. 894-898
    • Zeng, G.1
  • 70
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H, Quon MJ. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101(13):1539-1545.
    • (2000) Circulation , vol.101 , Issue.13 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3    Cong, L.N.4    Kirby, M.5    Mostowski, H.6    Quon, M.J.7
  • 71
    • 0031774262 scopus 로고    scopus 로고
    • Insulin inhibits inducible nitric oxide synthase in skeletal muscle cells
    • Bedard S, Marcotte B, Marette A. Insulin inhibits inducible nitric oxide synthase in skeletal muscle cells. Diabetologia. 1998;41(12):1523-1527.
    • (1998) Diabetologia , vol.41 , Issue.12 , pp. 1523-1527
    • Bedard, S.1    Marcotte, B.2    Marette, A.3
  • 72
    • 51149105270 scopus 로고    scopus 로고
    • Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages
    • Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar S. Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages. Cell Physiol Biochem. 2008;22(1-4):279-286.
    • (2008) Cell Physiol Biochem , vol.22 , Issue.1-4 , pp. 279-286
    • Martins, J.O.1    Ferracini, M.2    Ravanelli, N.3    Landgraf, R.G.4    Jancar, S.5
  • 74
    • 0034746443 scopus 로고    scopus 로고
    • Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells
    • Aljada A, Ghanim H, Saadeh R, Dandona P. Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells. J Clin Endocrinol Metab. 2001;86(1):450-453.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.1 , pp. 450-453
    • Aljada, A.1    Ghanim, H.2    Saadeh, R.3    Dandona, P.4
  • 75
    • 0027931376 scopus 로고
    • Insulin increases guanosine-3',5'-cyclic monophosphate in human platelets. A mechanism involved in the insulin anti-aggregating effect
    • Trovati M, Massucco P, Mattiello L, Mularoni E, Cavalot F, Anfossi G. Insulin increases guanosine-3',5'-cyclic monophosphate in human platelets. A mechanism involved in the insulin anti-aggregating effect. Diabetes. 1994;43(8):1015-1019.
    • (1994) Diabetes , vol.43 , Issue.8 , pp. 1015-1019
    • Trovati, M.1    Massucco, P.2    Mattiello, L.3    Mularoni, E.4    Cavalot, F.5    Anfossi, G.6
  • 76
    • 15444357865 scopus 로고    scopus 로고
    • Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3', 5'-cyclic monophosphate and adenosine-3', 5'-cyclic monophosphate
    • Trovati M, Anfossi G, Massucco P, Mattiello L, Costamagna C, Piretto V, Mularoni E, Cavalot F, Bosia A, Ghigo D. Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3', 5'-cyclic monophosphate and adenosine-3', 5'-cyclic monophosphate. Diabetes. 1997;46(5):742-749.
    • (1997) Diabetes , vol.46 , Issue.5 , pp. 742-749
    • Trovati, M.1    Anfossi, G.2    Massucco, P.3    Mattiello, L.4    Costamagna, C.5    Piretto, V.6    Mularoni, E.7    Cavalot, F.8    Bosia, A.9    Ghigo, D.10
  • 77
    • 0029926254 scopus 로고    scopus 로고
    • Platelet-dependent primary hemostasis promotes selectin-and integrin-mediated neutrophil adhesion to damaged endothelium under flow conditions
    • Kuijper PH, Gallardo Torres HI, van der Linden JA, Lammers JW, Sixma JJ, Koenderman L, Zwaginga JJ. Platelet-dependent primary hemostasis promotes selectin-and integrin-mediated neutrophil adhesion to damaged endothelium under flow conditions. Blood. 1996;87(8): 3271-3281.
    • (1996) Blood , vol.87 , Issue.8 , pp. 3271-3281
    • Kuijper, P.H.1    Torres, H.I.G.2    van der Linden, J.A.3    Lammers, J.W.4    Sixma, J.J.5    Koenderman, L.6    Zwaginga, J.J.7
  • 78
    • 0029947679 scopus 로고    scopus 로고
    • Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18
    • Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood. 1996;88(1):146-157.
    • (1996) Blood , vol.88 , Issue.1 , pp. 146-157
    • Diacovo, T.G.1    Roth, S.J.2    Buccola, J.M.3    Bainton, D.F.4    Springer, T.A.5
  • 79
    • 0034915177 scopus 로고    scopus 로고
    • Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: Evidence for an anti-inflammatory effect?
    • Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab. 2001;86(7):3257-3265.
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.7 , pp. 3257-3265
    • Dandona, P.1    Aljada, A.2    Mohanty, P.3    Ghanim, H.4    Hamouda, W.5    Assian, E.6    Ahmad, S.7
  • 81
    • 1842844426 scopus 로고    scopus 로고
    • Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase
    • Madonna R, Pandolfi A, Massaro M, Consoli A, De CR. Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase. Diabetologia. 2004;47(3):532-536.
    • (2004) Diabetologia , vol.47 , Issue.3 , pp. 532-536
    • Madonna, R.1    Pandolfi, A.2    Massaro, M.3    Consoli, A.4    De, C.R.5
  • 82
    • 67651177695 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells
    • Li G, Barrett EJ, Ko SH, Cao W, Liu Z. Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells. Endocrinology. 2009;150(8):3475-3482.
    • (2009) Endocrinology , vol.150 , Issue.8 , pp. 3475-3482
    • Li, G.1    Barrett, E.J.2    Ko, S.H.3    Cao, W.4    Liu, Z.5
  • 83
    • 0034456622 scopus 로고    scopus 로고
    • Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide
    • Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab. 2000;85(7): 2572-2575.
    • (2000) J Clin Endocrinol Metab , vol.85 , Issue.7 , pp. 2572-2575
    • Aljada, A.1    Saadeh, R.2    Assian, E.3    Ghanim, H.4    Dandona, P.5
  • 84
    • 26844548397 scopus 로고    scopus 로고
    • Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I. or insulin/IGF-I hybrid receptors in endothelial cells
    • Li G, Barrett EJ, Wang H, Chai W, Liu Z. Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I. or insulin/IGF-I hybrid receptors in endothelial cells. Endocrinology. 2005;146(11):4690-4696.
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4690-4696
    • Li, G.1    Barrett, E.J.2    Wang, H.3    Chai, W.4    Liu, Z.5
  • 85
  • 86
    • 0032928925 scopus 로고    scopus 로고
    • Insulin like growth factor-1 activates nuclear factorkappaB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells
    • Balaram SK, Agrawal DK, Edwards JD. Insulin like growth factor-1 activates nuclear factorkappaB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells. Cardiovasc Surg. 1999;7(1):91-97.
    • (1999) Cardiovasc Surg , vol.7 , Issue.1 , pp. 91-97
    • Balaram, S.K.1    Agrawal, D.K.2    Edwards, J.D.3
  • 87
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappa B regulation in the immune system
    • Li Q, Verma IM. NF-kappa B regulation in the immune system. Nat Rev Immunol. 2002;2(10): 725-734.
    • (2002) Nat Rev Immunol , vol.2 , Issue.10 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 88
    • 0036964978 scopus 로고    scopus 로고
    • Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations
    • Aljada A, Ghanim H, Mohanty P, Kapur N, Dandona P. Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab. 2002;87(3):1419-1422.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.3 , pp. 1419-1422
    • Aljada, A.1    Ghanim, H.2    Mohanty, P.3    Kapur, N.4    Dandona, P.5
  • 89
    • 0036705908 scopus 로고    scopus 로고
    • Insulin attenuates the systemic inflammatory response to thermal trauma
    • Jeschke MG, Einspanier R, Klein D, Jauch KW. Insulin attenuates the systemic inflammatory response to thermal trauma. Mol Med. 2002;8(8):443-450.
    • (2002) Mol Med , vol.8 , Issue.8 , pp. 443-450
    • Jeschke, M.G.1    Einspanier, R.2    Klein, D.3    Jauch, K.W.4
  • 90
    • 33845899723 scopus 로고    scopus 로고
    • Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype
    • Viardot A, Grey ST, Mackay F, Chisholm D. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. Endocrinology. 2007;148(1): 346-353.
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 346-353
    • Viardot, A.1    Grey, S.T.2    Mackay, F.3    Chisholm, D.4
  • 92
    • 10344239898 scopus 로고    scopus 로고
    • Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand
    • Singh RA, Zhang JZ. Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. J Immunol. 2004;173(12):7299-7307.
    • (2004) J Immunol , vol.173 , Issue.12 , pp. 7299-7307
    • Singh, R.A.1    Zhang, J.Z.2
  • 93
    • 0029801283 scopus 로고    scopus 로고
    • Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice
    • Kusske AM, Rongione AJ, Ashley SW, McFadden DW, Reber HA. Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery. 1996;120(2):284-288.
    • (1996) Surgery , vol.120 , Issue.2 , pp. 284-288
    • Kusske, A.M.1    Rongione, A.J.2    Ashley, S.W.3    McFadden, D.W.4    Reber, H.A.5
  • 95
    • 34248208781 scopus 로고    scopus 로고
    • Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes
    • Andersson CX, Sopasakis VR, Wallerstedt E, Smith U. Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes. J Biol Chem. 2007;282(13):9430-9435.
    • (2007) J Biol Chem , vol.282 , Issue.13 , pp. 9430-9435
    • Andersson, C.X.1    Sopasakis, V.R.2    Wallerstedt, E.3    Smith, U.4
  • 97
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss IJ, Becker C, Yang Z, Groden C, Hornung RL, Heller F, Neurath MF, Strober W, Mannon PJ. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis. 2006;12(1):9-15.
    • (2006) Inflamm Bowel Dis , vol.12 , Issue.1 , pp. 9-15
    • Fuss, I.J.1    Becker, C.2    Yang, Z.3    Groden, C.4    Hornung, R.L.5    Heller, F.6    Neurath, M.F.7    Strober, W.8    Mannon, P.J.9
  • 98
    • 33646349199 scopus 로고    scopus 로고
    • Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: A two-year prospective study (the DAMAGE study cohort)
    • Kirkham BW, Lassere MN, Edmonds JP, Juhasz KM, Bird PA, Lee CS, Shnier R, Portek IJ. Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). Arthritis Rheum. 2006;54(4): 1122-1131.
    • (2006) Arthritis Rheum , vol.54 , Issue.4 , pp. 1122-1131
    • Kirkham, B.W.1    Lassere, M.N.2    Edmonds, J.P.3    Juhasz, K.M.4    Bird, P.A.5    Lee, C.S.6    Shnier, R.7    Portek, I.J.8
  • 100
    • 0030610685 scopus 로고    scopus 로고
    • Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils
    • McDonald PP, Bald A, Cassatella MA. Activation of the NF-kappaB pathway by inflammatory stimuli in human neutrophils. Blood. 1997;89(9):3421-3433.
    • (1997) Blood , vol.89 , Issue.9 , pp. 3421-3433
    • McDonald, P.P.1    Bald, A.2    Cassatella, M.A.3
  • 101
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1(2):135-145.
    • (2001) Nat Rev Immunol , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 102
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem. 1999;274(16):10689-10692.
    • (1999) J Biol Chem , vol.274 , Issue.16 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 103
    • 4344645520 scopus 로고    scopus 로고
    • Insulin attenuates the systemic inflammatory response in endotoxemic rats
    • Jeschke MG, Klein D, Bolder U, Einspanier R. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology. 2004;145(9):4084-4093.
    • (2004) Endocrinology , vol.145 , Issue.9 , pp. 4084-4093
    • Jeschke, M.G.1    Klein, D.2    Bolder, U.3    Einspanier, R.4
  • 104
    • 45749127808 scopus 로고    scopus 로고
    • Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice
    • Kidd LB, Schabbauer GA, Luyendyk JP, Holscher TD, Tilley RE, Tencati M, Mackman N. Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice. J Pharmacol Exp Ther. 2008;326(1):348-353.
    • (2008) J Pharmacol Exp Ther , vol.326 , Issue.1 , pp. 348-353
    • Kidd, L.B.1    Schabbauer, G.A.2    Luyendyk, J.P.3    Holscher, T.D.4    Tilley, R.E.5    Tencati, M.6    Mackman, N.7
  • 107
    • 39049157857 scopus 로고    scopus 로고
    • Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: Further evidence of a proinflammatory state
    • Devaraj S, Dasu MR, Rockwood J, Winter W, Griffen SC, Jialal I. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. J Clin Endocrinol Metab. 2008;93(2):578-583.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.2 , pp. 578-583
    • Devaraj, S.1    Dasu, M.R.2    Rockwood, J.3    Winter, W.4    Griffen, S.C.5    Jialal, I.6
  • 108
    • 0035094340 scopus 로고    scopus 로고
    • The pleiotropic functions of peroxisome proliferator-activated receptor gamma
    • Debril MB, Renaud JP, Fajas L, Auwerx J. The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med. 2001;79(1):30-47.
    • (2001) J Mol Med , vol.79 , Issue.1 , pp. 30-47
    • Debril, M.B.1    Renaud, J.P.2    Fajas, L.3    Auwerx, J.4
  • 109
    • 0034892766 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma: From adipogenesis to carcinogenesis
    • Fajas L, Debril MB, Auwerx J. Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. J Mol Endocrinol. 2001;27(1):1-9.
    • (2001) J Mol Endocrinol , vol.27 , Issue.1 , pp. 1-9
    • Fajas, L.1    Debril, M.B.2    Auwerx, J.3
  • 110
    • 34447093179 scopus 로고    scopus 로고
    • The integration of lipid-sensing and anti-inflammatory effects: How the PPARs play a role in metabolic balance
    • Nunn AV, Bell J, Barter P. The integration of lipid-sensing and anti-inflammatory effects: how the PPARs play a role in metabolic balance. Nucl Recept. 2007;5(1):1.
    • (2007) Nucl Recept , vol.5 , Issue.1 , pp. 1
    • Nunn, A.V.1    Bell, J.2    Barter, P.3
  • 111
    • 52749088120 scopus 로고    scopus 로고
    • The many faces of PPAR gamma: Anti-inflammatory by any means?
    • Szanto A, Nagy L. The many faces of PPAR gamma: anti-inflammatory by any means? Immunobiology. 2008;213(9-10):789-803.
    • (2008) Immunobiology , vol.213 , Issue.9-10 , pp. 789-803
    • Szanto, A.1    Nagy, L.2
  • 112
    • 0032847680 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyteendothelial cell interaction
    • Jackson SM, Parhami F, Xi XP, Berliner JA, Hsueh WA, Law RE, Demer LL. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyteendothelial cell interaction. Arterioscler Thromb Vasc Biol. 1999;19(9):2094-2104.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , Issue.9 , pp. 2094-2104
    • Jackson, S.M.1    Parhami, F.2    Xi, X.P.3    Berliner, J.A.4    Hsueh, W.A.5    Law, R.E.6    Demer, L.L.7
  • 113
    • 0034660182 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptorgamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells
    • Marx N, Mach F, Sauty A, Leung JH, Sarafi MN, Ransohoff RM, Libby P, Plutzky J, Luster AD. Peroxisome proliferator-activated receptorgamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000;164(12):6503-6508.
    • (2000) J Immunol , vol.164 , Issue.12 , pp. 6503-6508
    • Marx, N.1    Mach, F.2    Sauty, A.3    Leung, J.H.4    Sarafi, M.N.5    Ransohoff, R.M.6    Libby, P.7    Plutzky, J.8    Luster, A.D.9
  • 114
    • 0001297403 scopus 로고    scopus 로고
    • Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma. agonists. PPARgamma co-association with transcription factor NFAT
    • Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma. agonists. PPARgamma co-association with transcription factor NFAT. J Biol Chem. 2000;275(7):4541-4544.
    • (2000) J Biol Chem , vol.275 , Issue.7 , pp. 4541-4544
    • Yang, X.Y.1    Wang, L.H.2    Chen, T.3    Hodge, D.R.4    Resau, J.H.5    Dasilva, L.6    Farrar, W.L.7
  • 116
    • 0030977450 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
    • Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF, Flier JS. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest. 1997;99(10):2416-2422.
    • (1997) J Clin Invest , vol.99 , Issue.10 , pp. 2416-2422
    • Vidal-Puig, A.J.1    Considine, R.V.2    Jimenez-Linan, M.3    Werman, A.4    Pories, W.J.5    Caro, J.F.6    Flier, J.S.7
  • 117
    • 0032994523 scopus 로고    scopus 로고
    • Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes
    • Rieusset J, Andreelli F, Auboeuf D, Roques M, Vallier P, Riou JP, Auwerx J, Laville M, Vidal H. Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes. Diabetes. 1999;48(4):699-705.
    • (1999) Diabetes , vol.48 , Issue.4 , pp. 699-705
    • Rieusset, J.1    Andreelli, F.2    Auboeuf, D.3    Roques, M.4    Vallier, P.5    Riou, J.P.6    Auwerx, J.7    Laville, M.8    Vidal, H.9
  • 118
    • 0030877565 scopus 로고    scopus 로고
    • Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma) Differential activity of PPARgamma1 and-2 isoforms and influence of insulin
    • Werman A, Hollenberg A, Solanes G, Bjorbaek C, Vidal-Puig AJ, Flier JS. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma) Differential activity of PPARgamma1 and-2 isoforms and influence of insulin. J Biol Chem. 1997;272(32):20230-20235.
    • (1997) J Biol Chem , vol.272 , Issue.32 , pp. 20230-20235
    • Werman, A.1    Hollenberg, A.2    Solanes, G.3    Bjorbaek, C.4    Vidal-Puig, A.J.5    Flier, J.S.6
  • 119
    • 0029775642 scopus 로고    scopus 로고
    • Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma
    • Zhang B, Berger J, Zhou G, Elbrecht A, Biswas S, White-Carrington S, Szalkowski D, Moller DE. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 1996;271(50):31771-4
    • (1996) J Biol Chem , vol.271 , Issue.50 , pp. 31771-31774
    • Zhang, B.1    Berger, J.2    Zhou, G.3    Elbrecht, A.4    Biswas, S.5    White-Carrington, S.6    Szalkowski, D.7    Moller, D.E.8
  • 120
    • 0026572097 scopus 로고
    • Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase
    • Krieger-Brauer HI, Kather H. Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase. J Clin Invest. 1992;89(3):1006-1013.
    • (1992) J Clin Invest , vol.89 , Issue.3 , pp. 1006-1013
    • Krieger-Brauer, H.I.1    Kather, H.2
  • 121
    • 0030894971 scopus 로고    scopus 로고
    • Insulin-induced activation of NADPHdependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2
    • Krieger-Brauer HI, Medda PK, Kather H. Insulin-induced activation of NADPHdependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. J Biol Chem. 1997;272(15):10135-10143.
    • (1997) J Biol Chem , vol.272 , Issue.15 , pp. 10135-10143
    • Krieger-Brauer, H.I.1    Medda, P.K.2    Kather, H.3
  • 122
    • 0035877633 scopus 로고    scopus 로고
    • Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade
    • Mahadev K, Zilbering A, Zhu L, Goldstein BJ. Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem. 2001;276(24):21938-21942.
    • (2001) J Biol Chem , vol.276 , Issue.24 , pp. 21938-21942
    • Mahadev, K.1    Zilbering, A.2    Zhu, L.3    Goldstein, B.J.4
  • 124
    • 71049131085 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases expression of very low density lipoprotein receptor gene in adipocytes
    • Takazawa T, Yamauchi T, Tsuchida A, Takata M, Hada Y, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T. Peroxisome proliferator-activated receptor gamma agonist rosiglitazone increases expression of very low density lipoprotein receptor gene in adipocytes. J Biol Chem 209; 284(44): 30049-30057.
    • (2009) J Biol Chem , vol.284 , Issue.44 , pp. 30049-30057
    • Takazawa, T.1    Yamauchi, T.2    Tsuchida, A.3    Takata, M.4    Hada, Y.5    Iwabu, M.6    Okada-Iwabu, M.7    Ueki, K.8    Kadowaki, T.9
  • 127
    • 18844421596 scopus 로고    scopus 로고
    • Protease-activated receptors and inflammatory hyperalgesia
    • Vergnolle N. Protease-activated receptors and inflammatory hyperalgesia. Mem Inst Oswaldo Cruz. 2005;100(Suppl 1):173-176.
    • (2005) Mem Inst Oswaldo Cruz , vol.100 , Issue.SUPPL. 1 , pp. 173-176
    • Vergnolle, N.1
  • 128
    • 68049115469 scopus 로고    scopus 로고
    • Protease-activated receptors as drug targets in inflammation and pain
    • Vergnolle N. Protease-activated receptors as drug targets in inflammation and pain. Pharmacol Ther. 2009;123(3):292-309.
    • (2009) Pharmacol Ther , vol.123 , Issue.3 , pp. 292-309
    • Vergnolle, N.1
  • 129
    • 40349085619 scopus 로고    scopus 로고
    • Proteinases and signalling: Pathophysiological and therapeutic implications via PARs and more
    • Ramachandran R, Hollenberg MD. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol. 2008;153(Suppl 1):S263-S282.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Ramachandran, R.1    Hollenberg, M.D.2
  • 133
    • 0037372534 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 and human lung epithelial cells: Disarming by neutrophil serine proteinases
    • Dulon S, Cande C, Bunnett NW, Hollenberg MD, Chignard M, Pidard D. Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. Am J Respir Cell Mol Biol. 2003;28(3):339-346.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , Issue.3 , pp. 339-346
    • Dulon, S.1    Cande, C.2    Bunnett, N.W.3    Hollenberg, M.D.4    Chignard, M.5    Pidard, D.6
  • 136
    • 46249121366 scopus 로고    scopus 로고
    • Beta-arrestin multimers: Does a crowd help or hinder function?
    • Defea KA. Beta-arrestin multimers: does a crowd help or hinder function? Biochem J. 2008;413(1):e1-e3.
    • (2008) Biochem J , vol.413 , Issue.1
    • Defea, K.A.1
  • 138
    • 0032792955 scopus 로고    scopus 로고
    • Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw
    • Vergnolle N, Hollenberg MD, Sharkey KA, Wallace JL. Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br J Pharmacol. 1999;127(5):1083-1090.
    • (1999) Br J Pharmacol , vol.127 , Issue.5 , pp. 1083-1090
    • Vergnolle, N.1    Hollenberg, M.D.2    Sharkey, K.A.3    Wallace, J.L.4
  • 139
    • 0032708759 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo
    • Vergnolle N. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. J Immunol. 1999;163(9):5064-5069.
    • (1999) J Immunol , vol.163 , Issue.9 , pp. 5064-5069
    • Vergnolle, N.1
  • 144
    • 50249124682 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activation: A major actor in intestinal inflammation
    • Hyun E, Andrade-Gordon P, Steinhoff M, Vergnolle N. Protease-activated receptor-2 activation: a major actor in intestinal inflammation. Gut. 2008;57(9):1222-9.
    • (2008) Gut , vol.57 , Issue.9 , pp. 1222-1229
    • Hyun, E.1    Andrade-Gordon, P.2    Steinhoff, M.3    Vergnolle, N.4
  • 145
    • 77955657409 scopus 로고    scopus 로고
    • Contribution of bone marrowderived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis
    • Hyun E, Andrade-Gordon P, Steinhoff M, Beck PL, Vergnolle N. Contribution of bone marrowderived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis. Inflamm Res. 2010;59(9):699-709.
    • (2010) Inflamm Res , vol.59 , Issue.9 , pp. 699-709
    • Hyun, E.1    Andrade-Gordon, P.2    Steinhoff, M.3    Beck, P.L.4    Vergnolle, N.5
  • 151
    • 0032484196 scopus 로고    scopus 로고
    • Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of betaadrenergic receptors with Grb2 via tyrosine 350
    • Karoor V, Wang L, Wang HY, Malbon CC. Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of betaadrenergic receptors with Grb2 via tyrosine 350. J Biol Chem. 1998;273(49):33035-33041.
    • (1998) J Biol Chem , vol.273 , Issue.49 , pp. 33035-33041
    • Karoor, V.1    Wang, L.2    Wang, H.Y.3    Malbon, C.C.4
  • 153
    • 61349130027 scopus 로고    scopus 로고
    • Deficiency of a betaarrestin-2 signal complex contributes to insulin resistance
    • Luan B, Zhao J, Wu H, Duan B, Shu G, Wang X, Li D, Jia W, Kang J, Pei G. Deficiency of a betaarrestin-2 signal complex contributes to insulin resistance. Nature. 2009;457(7233):1146-1149.
    • (2009) Nature , vol.457 , Issue.7233 , pp. 1146-1149
    • Luan, B.1    Zhao, J.2    Wu, H.3    Duan, B.4    Shu, G.5    Wang, X.6    Li, D.7    Jia, W.8    Kang, J.9    Pei, G.10
  • 154
    • 0039843091 scopus 로고    scopus 로고
    • Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor
    • Dery O, Thoma MS, Wong H, Grady EF, Bunnett NW. Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor. J Biol Chem. 1999;274(26):18524-18535.
    • (1999) J Biol Chem , vol.274 , Issue.26 , pp. 18524-18535
    • Dery, O.1    Thoma, M.S.2    Wong, H.3    Grady, E.F.4    Bunnett, N.W.5
  • 155
    • 34547120459 scopus 로고    scopus 로고
    • Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2
    • Kumar P, Lau CS, Mathur M, Wang P, Defea KA. Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. Am J Physiol Cell Physiol. 2007;293(1):C346-C357.
    • (2007) Am J Physiol Cell Physiol , vol.293 , Issue.1
    • Kumar, P.1    Lau, C.S.2    Mathur, M.3    Wang, P.4    Defea, K.A.5
  • 156
  • 157
    • 0017576691 scopus 로고
    • Proinsulin and C-peptide: A review
    • Kitabchi AE. Proinsulin and C-peptide: a review. Metabolism. 1977;26(5):547-587.
    • (1977) Metabolism , vol.26 , Issue.5 , pp. 547-587
    • Kitabchi, A.E.1
  • 159
    • 0032523926 scopus 로고    scopus 로고
    • Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus
    • Forst T, Kunt T, Pohlmann T, Goitom K, Engelbach M, Beyer J, Pfutzner A. Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus. J Clin Invest. 1998;101(10):2036-2041.
    • (1998) J Clin Invest , vol.101 , Issue.10 , pp. 2036-2041
    • Forst, T.1    Kunt, T.2    Pohlmann, T.3    Goitom, K.4    Engelbach, M.5    Beyer, J.6    Pfutzner, A.7
  • 161
    • 0026488266 scopus 로고
    • Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients
    • Johansson BL, Linde B, Wahren J. Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of type 1 (insulin-dependent) diabetic patients. Diabetologia. 1992;35(12):1151-8.
    • (1992) Diabetologia , vol.35 , Issue.12 , pp. 1151-1158
    • Johansson, B.L.1    Linde, B.2    Wahren, J.3
  • 163
    • 0033746038 scopus 로고    scopus 로고
    • C-peptide inhibits leukocyteendothelium interaction in the microcirculation during acute endothelial dysfunction
    • Scalia R, Coyle KM, Levine BJ, Booth G, Lefer AM. C-peptide inhibits leukocyteendothelium interaction in the microcirculation during acute endothelial dysfunction. FASEB J. 2000;14(14):2357-2364.
    • (2000) FASEB J , vol.14 , Issue.14 , pp. 2357-2364
    • Scalia, R.1    Coyle, K.M.2    Levine, B.J.3    Booth, G.4    Lefer, A.M.5
  • 164
    • 0036681940 scopus 로고    scopus 로고
    • Characterization of thrombin-induced leukocyte rolling and adherence: A potential proinflammatory role for proteinase-activated receptor-4
    • Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P. Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4. J Immunol. 2002;169(3):1467-1473.
    • (2002) J Immunol , vol.169 , Issue.3 , pp. 1467-1473
    • Vergnolle, N.1    Derian, C.K.2    D'andrea, M.R.3    Steinhoff, M.4    Andrade-Gordon, P.5
  • 165
    • 27644557524 scopus 로고    scopus 로고
    • Neutrophils and the kallikreinkinin system in proteinase-activated receptor 4-mediated inflammation in rodents
    • Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N. Neutrophils and the kallikreinkinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol. 2005;146(5):670-678.
    • (2005) Br J Pharmacol , vol.146 , Issue.5 , pp. 670-678
    • Houle, S.1    Papez, M.D.2    Ferazzini, M.3    Hollenberg, M.D.4    Vergnolle, N.5
  • 166
    • 48149103214 scopus 로고    scopus 로고
    • Human C-peptide antagonises high glucoseinduced endothelial dysfunction through the nuclear factor-kappaB pathway
    • Luppi P, Cifarelli V, Tse H, Piganelli J, Trucco M. Human C-peptide antagonises high glucoseinduced endothelial dysfunction through the nuclear factor-kappaB pathway. Diabetologia. 2008;51(8):1534-1543.
    • (2008) Diabetologia , vol.51 , Issue.8 , pp. 1534-1543
    • Luppi, P.1    Cifarelli, V.2    Tse, H.3    Piganelli, J.4    Trucco, M.5
  • 168
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116(7): 1793-1801.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 169
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature. 1997;389(6651):610-614.
    • (1997) Nature , vol.389 , Issue.6651 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 170
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem. 2003;278(46):45777-15784.
    • (2003) J Biol Chem , vol.278 , Issue.46 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 171
    • 0038809142 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 in obesity and insulin resistance
    • Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2003;100(12):7265-7270.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.12 , pp. 7265-7270
    • Sartipy, P.1    Loskutoff, D.J.2
  • 172
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem. 2001;276(20):16683-16689.
    • (2001) J Biol Chem , vol.276 , Issue.20 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 173
    • 37549013749 scopus 로고    scopus 로고
    • Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle
    • Radin MS, Sinha S, Bhatt BA, Dedousis N, O'Doherty RM. Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle. Diabetologia. 2008;51(2):336-346.
    • (2008) Diabetologia , vol.51 , Issue.2 , pp. 336-346
    • Radin, M.S.1    Sinha, S.2    Bhatt, B.A.3    Dedousis, N.4    O'Doherty, R.M.5
  • 176
    • 8744259926 scopus 로고    scopus 로고
    • Uncoupling insulin signalling by serine/ threonine phosphorylation: A molecular basis for insulin resistance
    • Zick Y. Uncoupling insulin signalling by serine/ threonine phosphorylation: a molecular basis for insulin resistance. Biochem Soc Trans. 2004;32(Pt 5):812-6.
    • (2004) Biochem Soc Trans , vol.32 , Issue.PART 5 , pp. 812-816
    • Zick, Y.1
  • 177
    • 70349129382 scopus 로고    scopus 로고
    • Independent anti-inflammatory effect of insulin in newly diagnosed type 2 diabetes
    • Mao XM, Liu H, Tao XJ, Yin GP, Li Q, Wang SK. Independent anti-inflammatory effect of insulin in newly diagnosed type 2 diabetes. Diabetes Metab Res Rev. 2009;25(5):435-441.
    • (2009) Diabetes Metab Res Rev , vol.25 , Issue.5 , pp. 435-441
    • Mao, X.M.1    Liu, H.2    Tao, X.J.3    Yin, G.P.4    Li, Q.5    Wang, S.K.6
  • 178
    • 70349132651 scopus 로고    scopus 로고
    • Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: The LANCET randomized trial
    • Pradhan AD, Everett BM, Cook NR, Rifai N, Ridker PM. Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial. JAMA. 2009;302(11):1186-1194.
    • (2009) JAMA , vol.302 , Issue.11 , pp. 1186-1194
    • Pradhan, A.D.1    Everett, B.M.2    Cook, N.R.3    Rifai, N.4    Ridker, P.M.5
  • 179
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
    • Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med. 2003;81(8):455-470.
    • (2003) J Mol Med , vol.81 , Issue.8 , pp. 455-470
    • Donath, M.Y.1    Storling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 181
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: A sensor for metabolic danger?
    • Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010;327(5963):296-300.
    • (2010) Science , vol.327 , Issue.5963 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 183
    • 0031127355 scopus 로고    scopus 로고
    • Monokineproducing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase
    • Pilstrom B, Bjork L, Bohme J. Monokineproducing cells predominate in the recruitment phase of NOD insulitis while cells producing Th1-type cytokines characterize the effector phase. J Autoimmun. 1997;10(2):147-155.
    • (1997) J Autoimmun , vol.10 , Issue.2 , pp. 147-155
    • Pilstrom, B.1    Bjork, L.2    Bohme, J.3
  • 184
    • 0029810079 scopus 로고    scopus 로고
    • Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10
    • Faust A, Rothe H, Schade U, Lampeter E, Kolb H. Primary nonfunction of islet grafts in autoimmune diabetic nonobese diabetic mice is prevented by treatment with interleukin-4 and interleukin-10. Transplantation. 1996;62(5):648-652.
    • (1996) Transplantation , vol.62 , Issue.5 , pp. 648-652
    • Faust, A.1    Rothe, H.2    Schade, U.3    Lampeter, E.4    Kolb, H.5
  • 185
    • 0029896602 scopus 로고    scopus 로고
    • IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity
    • Lee MS, Mueller R, Wicker LS, Peterson LB, Sarvetnick N. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med. 1996;183(6):2663-2668.
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2663-2668
    • Lee, M.S.1    Mueller, R.2    Wicker, L.S.3    Peterson, L.B.4    Sarvetnick, N.5
  • 186
    • 0030742237 scopus 로고    scopus 로고
    • T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
    • Pakala SV, Kurrer MO, Katz JD. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J Exp Med. 1997;186(2):299-306.
    • (1997) J Exp Med , vol.186 , Issue.2 , pp. 299-306
    • Pakala, S.V.1    Kurrer, M.O.2    Katz, J.D.3
  • 187
    • 0028882673 scopus 로고
    • Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and-10, transforming growth factor-beta, and prostaglandin-E
    • Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL. Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and-10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol. 1995;147(5):1193-1199.
    • (1995) Am J Pathol , vol.147 , Issue.5 , pp. 1193-1199
    • Hancock, W.W.1    Polanski, M.2    Zhang, J.3    Blogg, N.4    Weiner, H.L.5
  • 189
    • 0025806641 scopus 로고
    • An interleukin-1 receptor antagonist protein protects insulin-producing beta cells against suppressive effects of interleukin-1 beta
    • Eizirik DL, Tracey DE, Bendtzen K, Sandler S. An interleukin-1 receptor antagonist protein protects insulin-producing beta cells against suppressive effects of interleukin-1 beta. Diabetologia. 1991;34(6):445-448.
    • (1991) Diabetologia , vol.34 , Issue.6 , pp. 445-448
    • Eizirik, D.L.1    Tracey, D.E.2    Bendtzen, K.3    Sandler, S.4
  • 196
    • 0027370108 scopus 로고
    • The Diabetes Control and Complications Trial Research Group
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329(14):977-986.
    • (1993) N Engl J Med , vol.329 , Issue.14 , pp. 977-986
  • 197
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS. Group. Lancet. 1998;352(9131):837-853.
    • (1998) Group. Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 200
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414 (6865):813-820.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 201
    • 0028074327 scopus 로고
    • Renal and microvascular effects of an aldose reductase inhibitor in experimental diabetes. Biochemical, functional and ultrastructural studies
    • Kassab JP, Guillot R, Andre J, Claperon N, Bellon G, Feldmann G, Peyroux J, Sternberg M. Renal and microvascular effects of an aldose reductase inhibitor in experimental diabetes. Biochemical, functional and ultrastructural studies. Biochem Pharmacol. 1994;48(5):1003-1008.
    • (1994) Biochem Pharmacol , vol.48 , Issue.5 , pp. 1003-1008
    • Kassab, J.P.1    Guillot, R.2    Andre, J.3    Claperon, N.4    Bellon, G.5    Feldmann, G.6    Peyroux, J.7    Sternberg, M.8
  • 202
    • 0031975643 scopus 로고    scopus 로고
    • High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
    • Kolm-Litty V, Sauer U, Nerlich A, Lehmann R, Schleicher ED. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. J Clin Invest. 1998;101(1):160-169.
    • (1998) J Clin Invest , vol.101 , Issue.1 , pp. 160-169
    • Kolm-Litty, V.1    Sauer, U.2    Nerlich, A.3    Lehmann, R.4    Schleicher, E.D.5
  • 205
    • 0026323337 scopus 로고
    • Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy
    • Hammes HP, Martin S, Federlin K, Geisen K, Brownlee M. Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy. Proc Natl Acad Sci U S A. 1991;88(24):11555-11558.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , Issue.24 , pp. 11555-11558
    • Hammes, H.P.1    Martin, S.2    Federlin, K.3    Geisen, K.4    Brownlee, M.5
  • 206
    • 0027176945 scopus 로고
    • Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products
    • Schmidt AM, Yan SD, Brett J, Mora R, Nowygrod R, Stern D. Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for advanced glycation end products. J Clin Invest. 1993;91(5):2155-2168.
    • (1993) J Clin Invest , vol.91 , Issue.5 , pp. 2155-2168
    • Schmidt, A.M.1    Yan, S.D.2    Brett, J.3    Mora, R.4    Nowygrod, R.5    Stern, D.6
  • 207
    • 0030888393 scopus 로고    scopus 로고
    • What's the RAGE? The receptor for advanced glycation end products (RAGE. and the dark side of glucose
    • Yan SD, Stern D, Schmidt AM. What's the RAGE? The receptor for advanced glycation end products (RAGE. and the dark side of glucose. Eur J Clin Invest. 1997;27(3):179-181.
    • (1997) Eur J Clin Invest , vol.27 , Issue.3 , pp. 179-181
    • Yan, S.D.1    Stern, D.2    Schmidt, A.M.3
  • 209
    • 79952707168 scopus 로고    scopus 로고
    • Role of advanced glycation end products (AGEs. and receptor for AGEs (RAGE. in vascular damage in diabetes
    • Yamagishi S. Role of advanced glycation end products (AGEs. and receptor for AGEs (RAGE. in vascular damage in diabetes. Exp Gerontol. 2011;46(4):217-224.
    • (2011) Exp Gerontol , vol.46 , Issue.4 , pp. 217-224
    • Yamagishi, S.1
  • 210
    • 64649104157 scopus 로고    scopus 로고
    • FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats
    • Behl Y, Krothapalli P, Desta T, Roy S, Graves DT. FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes. 2009;58(4):917-925.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 917-925
    • Behl, Y.1    Krothapalli, P.2    Desta, T.3    Roy, S.4    Graves, D.T.5
  • 211
    • 0037213986 scopus 로고    scopus 로고
    • Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy dur ing diabetes
    • DiPetrillo K, Coutermarsh B, Gesek FA. Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy dur ing diabetes. Am J Physiol Renal Physiol. 2003;284(1):F113-F121.
    • (2003) Am J Physiol Renal Physiol , vol.284 , Issue.1
    • Dipetrillo, K.1    Coutermarsh, B.2    Gesek, F.A.3
  • 212
    • 0030007350 scopus 로고    scopus 로고
    • Impaired nitric oxide-mediated vasodilation in patients with non-insulindependent diabetes mellitus
    • Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA. Impaired nitric oxide-mediated vasodilation in patients with non-insulindependent diabetes mellitus. J Am Coll Cardiol. 1996;27(3):567-574.
    • (1996) J Am Coll Cardiol , vol.27 , Issue.3 , pp. 567-574
    • Williams, S.B.1    Cusco, J.A.2    Roddy, M.A.3    Johnstone, M.T.4    Creager, M.A.5
  • 215
    • 34447625374 scopus 로고    scopus 로고
    • Uncoupling of the VEGFendothelial nitric oxide axis in diabetic nephropathy: An explanation for the paradoxical effects of VEGF in renal disease
    • Nakagawa T. Uncoupling of the VEGFendothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Am J Physiol Renal Physiol. 2007;292(6):F1665-F1672.
    • (2007) Am J Physiol Renal Physiol , vol.292 , Issue.6
    • Nakagawa, T.1
  • 216
    • 0034810383 scopus 로고    scopus 로고
    • Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus
    • Abu El-Asrar AM, Desmet S, Meersschaert A, Dralands L, Missotten L, Geboes K. Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus. Am J Ophthalmol. 2001;132(4):551-556.
    • (2001) Am J Ophthalmol , vol.132 , Issue.4 , pp. 551-556
    • Abu El-Asrar, A.M.1    Desmet, S.2    Meersschaert, A.3    Dralands, L.4    Missotten, L.5    Geboes, K.6
  • 217
    • 0033986071 scopus 로고    scopus 로고
    • L-Arginine-nitric oxide pathwayrelated metabolites in the aqueous humor of diabetic patients
    • Hattenbach LO, Allers A, Klais C, Koch F, Hecker M. L-Arginine-nitric oxide pathwayrelated metabolites in the aqueous humor of diabetic patients. Invest Ophthalmol Vis Sci. 2000;41(1):213-217.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , Issue.1 , pp. 213-217
    • Hattenbach, L.O.1    Allers, A.2    Klais, C.3    Koch, F.4    Hecker, M.5
  • 218
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    • Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 1998;2(2):275-281.
    • (1998) Mol Cell , vol.2 , Issue.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3    Gerard, C.4    Sukhova, G.K.5    Libby, P.6    Rollins, B.J.7
  • 219
    • 0032572719 scopus 로고    scopus 로고
    • Decreased lesion formation in CCR2-/-mice reveals a role for chemokines in the initiation of atherosclerosis
    • Boring L, Gosling J, Cleary M, Charo IF. Decreased lesion formation in CCR2-/-mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 1998;394(6696): 894-897.
    • (1998) Nature , vol.394 , Issue.6696 , pp. 894-897
    • Boring, L.1    Gosling, J.2    Cleary, M.3    Charo, I.F.4
  • 220
    • 0029079926 scopus 로고
    • Decreased atherosclerosis in mice deficient in both macrophage colonystimulating factor (op) and apolipoprotein
    • Smith JD, Trogan E, Ginsberg M, Grigaux C, Tian J, Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colonystimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A. 1995;92(18):8264-8268.
    • (1995) E. Proc Natl Acad Sci U S A , vol.92 , Issue.18 , pp. 8264-8268
    • Smith, J.D.1    Trogan, E.2    Ginsberg, M.3    Grigaux, C.4    Tian, J.5    Miyata, M.6
  • 222
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340(2):115-126.
    • (1999) N Engl J Med , vol.340 , Issue.2 , pp. 115-126
    • Ross, R.1
  • 223
    • 0036637538 scopus 로고    scopus 로고
    • Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: The San Antonio Heart Study
    • Hanley AJ, Williams K, Stern MP, Haffner SM. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care. 2002;25(7):1177-1184.
    • (2002) Diabetes Care , vol.25 , Issue.7 , pp. 1177-1184
    • Hanley, A.J.1    Williams, K.2    Stern, M.P.3    Haffner, S.M.4
  • 227
    • 2442507928 scopus 로고    scopus 로고
    • Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions
    • Napoli C, de NF, Wallace JL, Hollenberg MD, Tajana G, De RG, Sica V, Cirino G. Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions. J Clin Pathol. 2004;57(5):513-516.
    • (2004) J Clin Pathol , vol.57 , Issue.5 , pp. 513-516
    • Napoli, C.1    De, N.F.2    Wallace, J.L.3    Hollenberg, M.D.4    Tajana, G.5    De, R.G.6    Sica, V.7    Cirino, G.8
  • 228
    • 0037449723 scopus 로고    scopus 로고
    • Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    • Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum JL. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003;278(3):1561-1568.
    • (2003) J Biol Chem , vol.278 , Issue.3 , pp. 1561-1568
    • Miller, Y.I.1    Viriyakosol, S.2    Binder, C.J.3    Feramisco, J.R.4    Kirkland, T.N.5    Witztum, J.L.6
  • 229
    • 0035800883 scopus 로고    scopus 로고
    • Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation
    • Sasu S, LaVerda D, Qureshi N, Golenbock DT, Beasley D. Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. Circ Res. 2001;89(3):244-250.
    • (2001) Circ Res , vol.89 , Issue.3 , pp. 244-250
    • Sasu, S.1    Laverda, D.2    Qureshi, N.3    Golenbock, D.T.4    Beasley, D.5
  • 231
    • 0026504343 scopus 로고
    • Acute and remitting painful diabetic polyneuropathy: A comparison of peripheral nerve fibre pathology
    • Britland ST, Young RJ, Sharma AK, Clarke BF. Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fibre pathology. Pain. 1992;48(3):361-370.
    • (1992) Pain , vol.48 , Issue.3 , pp. 361-370
    • Britland, S.T.1    Young, R.J.2    Sharma, A.K.3    Clarke, B.F.4
  • 233
    • 44949089602 scopus 로고    scopus 로고
    • Aldose reductase inhibitors for the treatment of diabetic polyneuropathy
    • CD004572
    • Chalk C, Benstead TJ, Moore F. Aldose reductase inhibitors for the treatment of diabetic polyneuropathy. Cochrane Database Syst Rev. 2007;(4):CD004572.
    • (2007) Cochrane Database Syst Rev , Issue.4
    • Chalk, C.1    Benstead, T.J.2    Moore, F.3
  • 235
    • 33750010094 scopus 로고    scopus 로고
    • Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats
    • Romanovsky D, Cruz NF, Dienel GA, Dobretsov M. Mechanical hyperalgesia correlates with insulin deficiency in normoglycemic streptozotocin-treated rats. Neurobiol Dis. 2006;24(2):384-394.
    • (2006) Neurobiol Dis , vol.24 , Issue.2 , pp. 384-394
    • Romanovsky, D.1    Cruz, N.F.2    Dienel, G.A.3    Dobretsov, M.4
  • 237
    • 34047262030 scopus 로고    scopus 로고
    • The effect of low-dose insulin on mechanical sensitivity and allodynia in type I diabetes neuropathy
    • Hoybergs YM, Meert TF. The effect of low-dose insulin on mechanical sensitivity and allodynia in type I diabetes neuropathy. Neurosci Lett. 2007;417(2):149-154.
    • (2007) Neurosci Lett , vol.417 , Issue.2 , pp. 149-154
    • Hoybergs, Y.M.1    Meert, T.F.2
  • 238
    • 0036129522 scopus 로고    scopus 로고
    • Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord
    • Sugimoto K, Murakawa Y, Sima AA. Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord. J Peripher Nerv Syst. 2002;7(1):44-53.
    • (2002) J Peripher Nerv Syst , vol.7 , Issue.1 , pp. 44-53
    • Sugimoto, K.1    Murakawa, Y.2    Sima, A.A.3
  • 239
    • 3042785971 scopus 로고    scopus 로고
    • Direct insulin signaling of neurons reverses diabetic neuropathy
    • Brussee V, Cunningham FA, Zochodne DW. Direct insulin signaling of neurons reverses diabetic neuropathy. Diabetes. 2004;53(7):1824-1830.
    • (2004) Diabetes , vol.53 , Issue.7 , pp. 1824-1830
    • Brussee, V.1    Cunningham, F.A.2    Zochodne, D.W.3
  • 241
    • 0022884726 scopus 로고
    • Acute painful diabetic neuropathy precipitated by strict glycaemic control
    • Llewelyn JG, Thomas PK, Fonseca V, King RH, Dandona P. Acute painful diabetic neuropathy precipitated by strict glycaemic control. Acta Neuropathol. 1986;72(2):157-163.
    • (1986) Acta Neuropathol , vol.72 , Issue.2 , pp. 157-163
    • Llewelyn, J.G.1    Thomas, P.K.2    Fonseca, V.3    King, R.H.4    Dandona, P.5
  • 243
    • 34248176762 scopus 로고    scopus 로고
    • Insulin and insulinlike growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1. in stably TRPV1-expressing SH-SY5Y neuroblastoma cells
    • Lilja J, Laulund F, Forsby A. Insulin and insulinlike growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1. in stably TRPV1-expressing SH-SY5Y neuroblastoma cells. J Neurosci Res. 2007;85(7):1413-1419.
    • (2007) J Neurosci Res , vol.85 , Issue.7 , pp. 1413-1419
    • Lilja, J.1    Laulund, F.2    Forsby, A.3


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