Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine- 3',5'-cyclic monophosphate and adenosine-3',5'-cyclic monophosphate

Diabetes

Volumn 46, Issue 5, 1997, Pages 742-749

  Trovati, Mariella ^a   Anfossi, Giovanni ^a   Massucco, Paola ^a   Mattiello, Luigi ^a   Costamagna, Costanzo ^a   Piretto, Valentina ^a   Mularoni, Elena ^a   Cavalot, Franco ^a   Bosia, Amalia ^a   Ghigo, Dario ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC GMP; FORSKOLIN; ILOPROST; INSULIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ADULT; ARTICLE; ENZYME INHIBITION; FEMALE; HORMONE ACTION; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE AGGREGATION INHIBITION;

EID: 15444357865     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.5.742     Document Type: Article

References (45)

1. Falcon C, Pfliegler G, Deckmyn H, Vermylen J: The platelet insulin receptor: detection, partial characterization, and search for a function. Biochem Biophys Res Comm 157:1190-1196, 1988
2. Trovati M, Anfossi G, Cavalot F, Massucco P, Mularoni E, Schinco P, Tamponi G, Emanuelli G: Studies on mechanisms involved in hypoglycemia-induced platelet activation. Diabetes 35:818-825, 1986
3. Hiramatsu K, Nozaki H, Arimori A: Reduction of platelet aggregation induced by euglycaemic insulin clamp. Diabetologia 30:310-313, 1987
4. Trovati M, Anfossi G, Cavalot F, Massucco P, Mularoni E, Emanuelli G: Insulin directly reduces platelet sensitivity to aggregating agents: studies in vitro and in vivo. Diabetes 37:780-786, 1988
5. Trovati M, Anfossi G, Mularoni E, Massucco P, Bosia A, Emanuelli G: Insulin reduces platelet sensitivity to platelet activating factor in washed human platelets resuspended in a calcium-free medium. Diabetes Metab Nutr 2:151-153, 1989
6. Trovati M, Anfossi G, Cavalot F, Massucco P, Mularoni E, Emanuelli G: Physiological insulin concentrations reduce platelet sensitivity to adrenaline in vivo. In Frontiers in Diabetes. Vol. 10, Tissue-Specific Metabolic Alterations in Diabetes. Belfiore F, Molinatti GM, Reaven GM, Eds. Basel, Karger, 1990, p. 166-169
7. Trovati M, Massucco P, Mattiello L, Mularoni E, Cavalot F, Anfossi G: Insulin increases guanosine-3′,5′-cyclic monophosphate in human platelets: a mechanism involved in the insulin anti-aggregating effect. Diabetes 43:1015-1019, 1994
8. Trovati M, Mularoni E, Burzacca S, Ponziani MC, Massucco P, Mattiello L, Piretto V, Cavalot F, Anfossi G: Impaired insulin-induced platelet anti-aggregating effect in obesity and in obese non-insulin-dependent diabetes mellitus. Diabetes 44:1318-1322, 1995
9. Trovati M, Massucco P, Mattiello L, Piretto V, Cavalot F, Mularoni E, Anfossi G: The insulin-induced increase of guanosine-3′,5′-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes 45:768-770, 1996
10. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109-142, 1991
11. Radomski MW, Palmer RMJ, Moncada S: An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87:5193-5197, 1990
12. Trovati M, Massucco P, Mattiello L, Cavalot F, Mularoni E, Hahn A, Anfossi G: Insulin increases cyclic nucleotide content in human vascular smooth muscle cells: a mechanism potentially involved in insulin-induced modulation of vascular tone. Diabetologia 38:936-941, 1995
13. Trovati M, Massucco P, Mattiello L, Cavalot F, Mularoni E, Hahn A, Anfossi G: Studies on the insulin influence on cyclic adenosine monophosphate in human vascular smooth muscle cells: dependence on cyclic guanosine monophosphate and modulation of catecholamine effects. Diabetologia 39:1156-1164, 1996
14. Salzman EW, Weisenberger H: Role of cyclic AMP in platelet function. Adv Cyclic Nucleotide Res 1:231-247, 1972
15. Sheth SB, Colman RW: Regulatory and catalytic domains of platelet cAMP phosphodiesterases: targets for drug design. Semin Hematol 32:110-119, 1995
16. 1 binding to human blood platelet membrane by insulin and the activation of adenylate cyclase. J Biol Chem 9:4976-4981, 1990
17. Lopez-Aparicio P, Rascon A, Manganiello VC, Andersson KE, Belfrage P, Degerman E: Insulin induced phosphorylation and activation of the cGMP-inhibited cAMP phosphodiesterase in human platelets. Biochem Biophys Res Commun 186:517-523, 1992
18. Gryglewski RJ, Korbut R, Kalecinska A, Zembowicz A: Interaction between stimulators of adenylate and guanylate cyclases in human leukocytes, platelets and arteries. Int J Tiss React 11:269-274, 1989
19. Maurice DH, Haslam RJ: Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 37:671-681, 1990
20. Anfossi G, Massucco P, Mularoni E, Cavalot F, Mattiello L, Trovati M: Organic nitrates and compounds that increase intraplatelet cyclic guanosine monophosphate (cGMP) levels enhance the antiaggregating effects of the stable prostacyclin analogue iloprost. Prostaglandins Leukot Essent Fatty Acids 49:839-845, 1993
21. Anfossi G, Massucco P, Mularoni E, Cavalot F, Mattiello L, Trovati M: Effects of forskolin and organic nitrate on aggregation and intracellular cyclic nucleotide content in human platelets. Gen Pharmacol 25:1093-1100, 1994
22. Reimers HJ, Baker RK, Joist JH: Impaired thromboxane synthesis in preactivated human blood platelets: agonist-specific, irreversible desensitization to thrombin. Thromb Res 48:535-542, 1987
23. Bredt DS, Snyder SH: Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033, 1989
24. Ghigo D, Alessio P, Foco A, Bussolino F, Costamagna C, Heller R, Garbarino G, Pescarmona GP, Bosia A: Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells. Am J Physiol 265:C728-C732, 1993
25. Palmer RMJ, Ferrige AG, Moncada S: A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells. Biochem Biophys Res Commun 158:348-352, 1989
26. Born GVR: Aggregation of blood platelets by adenosine and its reversal. Nature 194:927-929, 1962
27. Weiss HJ, Rogers J: Thrombocytopenia due to abnormalities in platelet release reaction. Blood 39:2-8, 1972
28. Zeng G, Quon MJ: Insulin-stimulated production of nitric oxide is inhibited by wortmannin: direct measurement in vascular endothelial cells. J Clin Invest 98:894-898, 1996
29. 2 adrenergic receptor numbers in platelets by insulin. Biochim Biophys Acta 1134:292-296, 1992
30. Katsuki S, Arnold WP, Mittal CK, Murad F: Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin, and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res 3:23-35, 1977
31. Griscavage JM, Fukuto JM, Komori Y, Ignarro LJ: Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. J Biol Chem 269:21644-21649, 1994
32. Mittal KC, Murad F: Formation of adenosine 3′,5′-monophosphate by preparations of guanylate cyclase from rat liver and other tissues. J Biol Chem 252:3136-3140, 1977
33. Illiano G, Tell GPE, Siegel MI, Cuatrecasas P: Guanosine 3′-5′ cyclic monophosphate and the action of insulin and acetylcholine. Proc Natl Acad Sci USA 70:2443-2447, 1973
34. Glass DG, Frey W, Carr DW, Goldberg ND: Stimulation of human platelet guanylate cyclase by fatty acids. J Biol Chem 252:1279-1285, 1977
35. Axelsson KL, Andersson RGG: Tolerance towards nitroglycerin, induced in vivo, is correlated to a cGMP response and an alteration in cGMP turnover Eur J Pharmacol 88:71-79, 1983
36. Waldman SA, Rapoport RM, Murad F: Desensitization to nitroglycerin in vascular smooth muscle from rat and human. Biochem Pharmacol 35:3525-3531, 1987
37. Lewicki JA, Brandwein HJ, Mittal CK, Arnold WP, Murad F: Properties of purified soluble guanylate cyclase activated by nitric oxide and sodium nitroprusside. J Cyclic Nucleotide Res 8:17-25, 1982
38. Arnold WP, Mittal CK, Katsuki S, Murad F: Nitric oxide activates guanylate cyclase and increases guanosine 3′,5′-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci USA 74:3203-3207, 1977
39. Conti M, Jin S-L C, Monaco L, Repaske DR, Swinnen JV: Hormonal regulation of cyclic phosphodiesterases. Endocr Rev 12:218-234, 1991
40. Tateson J, Moncada S, Vane JR: Effects of prostacyclin on cyclic AMP concentrations in human platelets. Prostaglandins 13:343-399, 1977
41. Seamon KB, Daly JW: Forskolin, cyclic AMP and cellular physiology. Trend Pharmacol Sci 4:120-132, 1983
42. Hwang DL, Yen CF, Nadler JL: Insulin increases intracellular magnesium transport in human platelets. J Clin Endocrinol Metab 76:549-553, 1993
43. Hardy E, Glenn J, Heptinstall S, Rubin PC, Horn EH: Magnesium modifies the responses of platelets to inhibitory agents which acts via cAMP. Thromb Haemos 74:1132-1137, 1995
44. Radomski MW, Palmer RMJ, Moncada S: The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 92:639-646, 1987
45. Colwell JA, Gisinger C, Klein R: Altered platelet function in diabetes mellitus: effect of glycemic regulation and antiplatelet agents. In Hyperglycemia, Diabetes, and Vascular Diseases. Ruderman N, Williamson J, Brownlee M, Eds. New York, Oxford University Press, 1992, p. 30-47