메뉴 건너뛰기




Volumn 97, Issue 11, 1996, Pages 2553-2561

Regulation of PPAR γ gene expression by nutrition and obesity in rodents

Author keywords

gene regulation; insulin; nutrition; obesity; peroxisome proliferator activated receptor

Indexed keywords

CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR;

EID: 0030000088     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118703     Document Type: Article
Times cited : (604)

References (45)
  • 1
    • 0028830080 scopus 로고
    • The adipocyte: Storage depot or node on the energy information superhighway
    • Flier, J.S. 1995. The adipocyte: storage depot or node on the energy information superhighway. Cell. 80:15-18.
    • (1995) Cell , vol.80 , pp. 15-18
    • Flier, J.S.1
  • 2
    • 0018616780 scopus 로고
    • Obesity: Adverse effects on health and longevity
    • Van Itali, T.B. 1979. Obesity: adverse effects on health and longevity. Am. J. Clin. Nutr. 32:2723-2733.
    • (1979) Am. J. Clin. Nutr. , vol.32 , pp. 2723-2733
    • Van Itali, T.B.1
  • 4
    • 0019332901 scopus 로고
    • Control of specific protein biosynthesis during the adipose conversion of 3T3 cells
    • Spiegelman, B., and H. Green. 1980. Control of specific protein biosynthesis during the adipose conversion of 3T3 cells. J. Biol. Chem. 255:8811-8818.
    • (1980) J. Biol. Chem. , vol.255 , pp. 8811-8818
    • Spiegelman, B.1    Green, H.2
  • 5
    • 0023811651 scopus 로고
    • Regulation of gene expression in the adipocyte: Implication for obesity and proto-oncogene function
    • Spiegelman, B.M. 1988. Regulation of gene expression in the adipocyte: implication for obesity and proto-oncogene function. Trends Genet. 4:203-207.
    • (1988) Trends Genet. , vol.4 , pp. 203-207
    • Spiegelman, B.M.1
  • 6
    • 0024728988 scopus 로고
    • Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte specific genes
    • Christy, R.J., V.W. Yang, J.M. Ntambi, D.E. Geiman, W.H. Landschulz, A.D. Friedman, Y. Nakabeppu, T.J. Kelly, and M.D. Lane. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte specific genes. Genes & Dev. 3:1323-1335.
    • (1989) Genes & Dev. , vol.3 , pp. 1323-1335
    • Christy, R.J.1    Yang, V.W.2    Ntambi, J.M.3    Geiman, D.E.4    Landschulz, W.H.5    Friedman, A.D.6    Nakabeppu, Y.7    Kelly, T.J.8    Lane, M.D.9
  • 7
    • 0028950216 scopus 로고
    • Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, delta genes in fully differentiated 3T3-L1 adipocytes
    • MacDougald, O.A., P. Cornelius, R. Liu, and M.D. Lane. 1995. Insulin regulates transcription of the CCAAT/enhancer binding protein (C/EBP) alpha, beta, delta genes in fully differentiated 3T3-L1 adipocytes. J. Biol. Chem. 270:647-654.
    • (1995) J. Biol. Chem. , vol.270 , pp. 647-654
    • MacDougald, O.A.1    Cornelius, P.2    Liu, R.3    Lane, M.D.4
  • 8
    • 0028564903 scopus 로고
    • CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program
    • Lin, F.T., and M.D. Lane. 1994. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. USA. 91:8757-8761.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8757-8761
    • Lin, F.T.1    Lane, M.D.2
  • 9
    • 0028180070 scopus 로고
    • mPPARγ2: Tissue-specific regulator of an adipocyte enhancer
    • Tontonoz, P., E. Hu, R. Graves, A. Budavari, and B. Spiegelman. 1994. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes & Dev. 8: 1224-1234.
    • (1994) Genes & Dev. , vol.8 , pp. 1224-1234
    • Tontonoz, P.1    Hu, E.2    Graves, R.3    Budavari, A.4    Spiegelman, B.5
  • 10
    • 0028593992 scopus 로고
    • Adipocyte-specific transcription factor ARF 6 is a heterodimeric complex of two nuclear hormone receptors, PPAR γ and RXR α
    • Tontonoz, P., R. Graves, A. Budavari, H. Erdjument-Bromage, M. Lui, E. Hu, P. Temps, and B. Spiegelman. 1994. Adipocyte-specific transcription factor ARF 6 is a heterodimeric complex of two nuclear hormone receptors, PPAR γ and RXR α. Nucleic Adds Res. 22:5628-5634.
    • (1994) Nucleic Adds Res. , vol.22 , pp. 5628-5634
    • Tontonoz, P.1    Graves, R.2    Budavari, A.3    Erdjument-Bromage, H.4    Lui, M.5    Hu, E.6    Temps, P.7    Spiegelman, B.8
  • 11
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor
    • Tontonoz, P., E. Hu, and B.M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid activated transcription factor. Cell. 79: 1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 13
    • 0026785388 scopus 로고
    • Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acid
    • Schmidt, A., N. Endo, S. Rutledge, R. Vogel, D. Shinar, and G. Rodan. 1992. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acid. Mol. Endocrinol. 6:1634-1641.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 1634-1641
    • Schmidt, A.1    Endo, N.2    Rutledge, S.3    Vogel, R.4    Shinar, D.5    Rodan, G.6
  • 14
    • 0027749599 scopus 로고
    • Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver
    • Zhu, Y., K. Alvares, Q. Huang, M. Sambasiva Rao, and J. Reddy. 1993. Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 268:26817-26820.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26817-26820
    • Zhu, Y.1    Alvares, K.2    Huang, Q.3    Sambasiva Rao, M.4    Reddy, J.5
  • 15
    • 0028871780 scopus 로고
    • Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR γ and C/EBPα
    • Hu, E., P. Tontonoz, and B.M. Spiegelman. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR γ and C/EBPα. Proc. Natl. Acad. Sci. USA. 92:9856-9860.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9856-9860
    • Hu, E.1    Tontonoz, P.2    Spiegelman, B.M.3
  • 16
    • 0029102676 scopus 로고
    • Structural organization of mouse peroxisome proliferator-activated receptor γ (m PPAR γ) gene: Alternative promoter use and different splicing yield two m PPAR γ isoforms
    • Zhu, Y., C. Qi, J.R. Korenberg, X.N. Chen, D. Noya, M. Sambasiva Rao, and J.K. Reddy. 1995. Structural organization of mouse peroxisome proliferator-activated receptor γ (m PPAR γ) gene: alternative promoter use and different splicing yield two m PPAR γ isoforms. Proc. Natl. Acad. Sci. USA. 92: 7921-7925.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7921-7925
    • Zhu, Y.1    Qi, C.2    Korenberg, J.R.3    Chen, X.N.4    Noya, D.5    Sambasiva Rao, M.6    Reddy, J.K.7
  • 17
    • 0028015713 scopus 로고
    • Peroxisome proliferator activated receptor (PPAR) γ: Adipose predominant expression and induction early in adipocyte dfferentiation
    • Chawla, A., E. Schwarz, D. Dimaculangan, and M. Lazar. 1994. Peroxisome proliferator activated receptor (PPAR) γ: adipose predominant expression and induction early in adipocyte dfferentiation. Endocrinology. 135:798-800.
    • (1994) Endocrinology , vol.135 , pp. 798-800
    • Chawla, A.1    Schwarz, E.2    Dimaculangan, D.3    Lazar, M.4
  • 18
    • 0018227222 scopus 로고
    • Insulin binding and effects in isolated soleus muscle of lean and obese mice
    • Le Marchand-Brustel, Y., B. Jeanrenaud, and P. Freychet. 1978. Insulin binding and effects in isolated soleus muscle of lean and obese mice. Am. J. Physiol. 234:E348-E358.
    • (1978) Am. J. Physiol. , vol.234
    • Le Marchand-Brustel, Y.1    Jeanrenaud, B.2    Freychet, P.3
  • 20
    • 8944233469 scopus 로고
    • Synergistic effect of brown fat deficiency and western diet on the development of obesity, insulin resistance and hyperlipemia
    • Hamann, A., R.C. Frederich, J.S. Flier, and B. Lowell. 1995. Synergistic effect of brown fat deficiency and western diet on the development of obesity, insulin resistance and hyperlipemia. Endocrinology. 137:21-29.
    • (1995) Endocrinology , vol.137 , pp. 21-29
    • Hamann, A.1    Frederich, R.C.2    Flier, J.S.3    Lowell, B.4
  • 21
    • 0025609173 scopus 로고
    • Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes
    • Lowell, B.B., and J.S. Flier. 1990. Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes. Endocrinology. 127:2898-2906.
    • (1990) Endocrinology , vol.127 , pp. 2898-2906
    • Lowell, B.B.1    Flier, J.S.2
  • 22
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 23
    • 0038024793 scopus 로고
    • Receptor mRNA measurements by multiplex nuclease protection assay
    • Academic Press, Inc., San Diego, CA
    • Jakubowki, M. 1995. Receptor mRNA measurements by multiplex nuclease protection assay. In Methods in Neurosciences. Academic Press, Inc., San Diego, CA. 470-491.
    • (1995) Methods in Neurosciences , pp. 470-491
    • Jakubowki, M.1
  • 26
    • 0026508835 scopus 로고
    • Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonudeic acid transcripts from snap-frozen neuroendocrine tissues of individual animals
    • Jakubowski, M., and J.L. Roberts. 1992. Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonudeic acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J. Neuroendocrinol. 4:79-89.
    • (1992) J. Neuroendocrinol. , vol.4 , pp. 79-89
    • Jakubowski, M.1    Roberts, J.L.2
  • 27
    • 0027525576 scopus 로고
    • The peroxisome proliferator activated receptor: Retinoid X receptor heterodimer is activated by fatty acid and fibrate hypolipidaemic drugs
    • Issemann, I., R. Prince, J. Tugwood, and S. Green. 1993. The peroxisome proliferator activated receptor: retinoid X receptor heterodimer is activated by fatty acid and fibrate hypolipidaemic drugs. J. Mol. Endocrinol. 11:37-47.
    • (1993) J. Mol. Endocrinol. , vol.11 , pp. 37-47
    • Issemann, I.1    Prince, R.2    Tugwood, J.3    Green, S.4
  • 28
    • 0028142522 scopus 로고
    • Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily
    • Gearing, K., M. Gottlicher, E. Widmark, C. Banner, P. Tollet, M. Stromstedt, J. Rafter, R. Berge, and J. Gustafsson. 1994. Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily. J. Nutr. 124:1284-1288.
    • (1994) J. Nutr. , vol.124 , pp. 1284-1288
    • Gearing, K.1    Gottlicher, M.2    Widmark, E.3    Banner, C.4    Tollet, P.5    Stromstedt, M.6    Rafter, J.7    Berge, R.8    Gustafsson, J.9
  • 29
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (Lond.). 347:545-649.
    • (1990) Nature (Lond.) , vol.347 , pp. 545-649
    • Issemann, I.1    Green, S.2
  • 30
    • 0026517010 scopus 로고
    • Control of the peroxisomal B oxidation pathway by a novel family of nuclear hormone receptor
    • Dreyer, C., G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli. 1992. Control of the peroxisomal B oxidation pathway by a novel family of nuclear hormone receptor. Cell. 68:879-887.
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3    Givel, F.4    Helftenbein, G.5    Wahli, W.6
  • 32
    • 0028909362 scopus 로고
    • Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes
    • Amri, E., F. Bonino, G. Ailhaud, N. Abumrad, and P. Grimaldi. 1995. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. J. Biol. Chem. 270:2367-2371.
    • (1995) J. Biol. Chem. , vol.270 , pp. 2367-2371
    • Amri, E.1    Bonino, F.2    Ailhaud, G.3    Abumrad, N.4    Grimaldi, P.5
  • 34
    • 0027304282 scopus 로고
    • Thiazolidinediones improve hepatic insulin resistance in streptozotocin-induced diabetic rats
    • Tominaga, M., M. Igarashi, M. Daimon, H. Eguchi, and M. Matsumoto. 1993. Thiazolidinediones improve hepatic insulin resistance in streptozotocin-induced diabetic rats. Endocr J. 40:343-349.
    • (1993) Endocr J. , vol.40 , pp. 343-349
    • Tominaga, M.1    Igarashi, M.2    Daimon, M.3    Eguchi, H.4    Matsumoto, M.5
  • 35
    • 0027484069 scopus 로고
    • Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT-4 glucose transporter expression in rat skeletal muscle
    • Weinstein, S.P., A. Holand, E. O'Boyle, and R.S. Haber. 1993. Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT-4 glucose transporter expression in rat skeletal muscle. Metab. Clin. Exp. 42:1365-1369.
    • (1993) Metab. Clin. Exp. , vol.42 , pp. 1365-1369
    • Weinstein, S.P.1    Holand, A.2    O'Boyle, E.3    Haber, R.S.4
  • 36
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma
    • Lehmann, J.M., L.B. Moore, T.A. Smith-Oliver, W.O. Wilkinson, T.M. Willson, and S.A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma. J. Biol. Chem. 270:12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkinson, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 37
    • 0026635508 scopus 로고
    • Cellular and molecular aspects of adipose tissue development
    • Ailhaud, G., P. Grimaldi, and R. Negrel. 1992. Cellular and molecular aspects of adipose tissue development. Annu. Rev. Nutr. 12:207-233.
    • (1992) Annu. Rev. Nutr. , vol.12 , pp. 207-233
    • Ailhaud, G.1    Grimaldi, P.2    Negrel, R.3
  • 38
    • 0028988487 scopus 로고
    • PPARγ2 regulates adipose expression of the phospoenolpyruvate carboxykinase gene
    • Tontonoz, P., E. Hu, J. Devine, E. Beale, and B. Spiegelman. 1995. PPARγ2 regulates adipose expression of the phospoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15:351-357.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 351-357
    • Tontonoz, P.1    Hu, E.2    Devine, J.3    Beale, E.4    Spiegelman, B.5
  • 39
    • 0028131951 scopus 로고
    • Dexamethasone and insulin demonstrate marked and opposite regulation of the steady state mRNA level of the peroxisomal proliferator activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty acid induced transcription
    • Steineger, H., H. Sorensen, J. Tugwood, S. Skrede, O. Spydevold, and K. Gautvik. 1994. Dexamethasone and insulin demonstrate marked and opposite regulation of the steady state mRNA level of the peroxisomal proliferator activated receptor (PPAR) in hepatic cells. Hormonal modulation of fatty acid induced transcription. Eur. J. Biochem. 25:967-974.
    • (1994) Eur. J. Biochem. , vol.25 , pp. 967-974
    • Steineger, H.1    Sorensen, H.2    Tugwood, J.3    Skrede, S.4    Spydevold, O.5    Gautvik, K.6
  • 40
    • 0028276397 scopus 로고
    • Peroxisome proliferator activated receptor mediates induction of the mitochondrial 3 hydroxy methylglutaryl-CoA synthase gene by fatty acids
    • Rodriguez, J., G. Gil-Gomez, F. Hegardt, and D. Haro. 1994. Peroxisome proliferator activated receptor mediates induction of the mitochondrial 3 hydroxy methylglutaryl-CoA synthase gene by fatty acids. J. Biol. Chem. 269: 18767-18772.
    • (1994) J. Biol. Chem. , vol.269 , pp. 18767-18772
    • Rodriguez, J.1    Gil-Gomez, G.2    Hegardt, F.3    Haro, D.4
  • 41
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
    • MacDougald, O.A., C.S. Hwang, H. Fan, and M.D. Lane. 1995. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci USA. 92:9034-9037.
    • (1995) Proc. Natl. Acad. Sci USA , vol.92 , pp. 9034-9037
    • MacDougald, O.A.1    Hwang, C.S.2    Fan, H.3    Lane, M.D.4
  • 43
    • 0028033268 scopus 로고
    • The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression
    • Gulic, T., S. Cresci, T. Caira, D. Moore, and D. Kelly. 1994. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. USA. 91:11012-11016.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 11012-11016
    • Gulic, T.1    Cresci, S.2    Caira, T.3    Moore, D.4    Kelly, D.5
  • 44
    • 0027324558 scopus 로고
    • Through thick and thin: Wasting, obesity, and TNF α
    • Spiegelman, B.M., and G.S. Hotamisligil. 1993. Through thick and thin: wasting, obesity, and TNF α. Cell. 73:625-627.
    • (1993) Cell , vol.73 , pp. 625-627
    • Spiegelman, B.M.1    Hotamisligil, G.S.2
  • 45
    • 0026549669 scopus 로고
    • Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
    • Lang, C.H., C. Dobrescu, and G.J. Bagby. 1992. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology. 130:43-52.
    • (1992) Endocrinology , vol.130 , pp. 43-52
    • Lang, C.H.1    Dobrescu, C.2    Bagby, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.