Proteinase-activated receptor-2 mediates arterial vasodilation in diabetes

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 25, Issue 11, 2005, Pages 2349-2354

  Roviezzo, Fiorentina ^a   Bucci, Mariarosaria ^a   Brancaleone, Vincenzo ^a   Di Lorenzo, Annarita ^a   Geppetti, Pierangelo ^c   Farneti, Silvana ^d   Parente, Luca ^b   Lungarella, Giuseppe ^e   Fiorucci, Stefano ^d   Cirino, Giuseppe ^a,f  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF PERUGIA   (Italy)

^e UNIVERSITY OF SIENA   (Italy)

^f Dipartimento di Farmacologia Sperimentale   (Italy)

Author keywords

Cyclooxygenase 2; Diabetes, type I; Proteinase activated receptor 2; Smooth muscle

Indexed keywords

ACETYLCHOLINE; CYCLOOXYGENASE 2; PROTEINASE ACTIVATED RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; EVALUATION; FEMALE; GLUCOSURIA; IMMUNOHISTOCHEMISTRY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 1; DIABETIC ANGIOPATHIES; FEMALE; MICE; MICE, INBRED NOD; MICE, INBRED STRAINS; MICE, TRANSGENIC; NITRIC OXIDE; PROSTAGLANDINS; RECEPTOR, PAR-2; UP-REGULATION; VASODILATION;

EID: 27644442717     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000184770.01494.2e     Document Type: Article

References (34)

1. Macfarlane SR, Scatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptors. Pharmacol Rev. 2001;53:245-282.
2. Hollenberg MD, Compton SJ. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev. 2002;54: 203-217.
3. Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev. 2004;84:579-621.
4. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
5. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease activated receptor-3 is a second thrombin receptor in humans. Nature. 1997;386:502-506.
6. Xu WF, Andersen H, Withmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC. Cloning and characterization of human protease activated receptor-4. Proc Natl Acad Sci USA. 1998;95: 6642-6646.
7. Cicala C. Protease activated receptor 2 and the cardiovascular system. Br J Pharmacol. 2002;135:14-20.
8. Hirano K, Kanaide H. Role of protease-activated receptors in the vascular system. J Atheroscler Thromb. 2003;10:211-236.
9. Cheung W, Andrade-Gordon P, Derian CK, Damiano BP. Receptor activating peptides distinguish thrombin receptor (PAR1) and protease activated receptor 2 (PAR-2) mediated hemodynamic responses in vivo. Can J Physiol Pharmacol. 1998;76:16-25.
10. Emilsson K, Wahlestedt C, Sun M, Nystedt S, Owman C, Sundelin J. Vascular effects of proteinase activated receptor 2 agonist peptide. J Vasc Res. 1998;34:267-272.
11. Cicala C, Morello S, Santagada V, Caliendo G, Sorrentino L, Cirino G. Pharmacological dissection of vascular effects caused by activation of protease-activated receptors 1 and 2 in anesthetized rats. FASEB J. 2001; 15:1433-1435.
12. Sobey CG, Cocks TM. Activation of protease activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo. Stroke. 1998;29:1439-1444.
13. Sobey CG, Moffatt JD, Cocks TM. Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease activated receptor-2 activation. Stroke. 1999;30:1933-1941.
14. D'Andrea MR, Derian CK, Leturcq D, Baker SM, Brunmark A, Ling P, Darrow A, Santulli RJ, Brass LF, Andrade-Gordon P. Characterization of protease activated receptor-2 immunoreactiviry in normal human tissues. J Hist Cytoch. 1998;46:157-164.
15. Molino, M. Raghunatah PN, Kuo A, Ahuja M, Hoxie JA, Brass LF, Barnathan ES. Differential expression of functional protease-activated-receptor-2 (PAR-2) in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1998; 18:825-832.
16. Cicala C, Pinto A, Bucci M, Sorrentino R, Walker B, Harriot P, Cruchley A, Kapas S, Howells GL, Cirino G. Proteinase activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo. Circulation. 1999;99:2590-2597.
17. Damiano BP, Cheung WM, Santulli RJ, Fung-Leung WP, Ngo K, Ye RD, Darrow AL, Derian CK, De Garavilla L, Anadrade-Gordon P. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther. 1999;288:671-678.
18. Robin J, Kharbanda R, Mclean P, Campbell R, Vallance P. Protease-activated receptor 2-mediated vasodilatation in humans in vivo: role of nitric oxide and prostanoids. Circulation. 2003;107:954-959.
19. Nystedt S, Ramakrishnan V, Sundelin J. The proteinase activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem. 1996;271: 14910-14915.
20. Cirino G, Cicala C. Upregulation of proteinase-activated receptors (PARs) and cardiovascular function. Drug Develop Res. 2003;60:20-23.
21. Cocks TM, Moffatt JD. Protease-activated receptors: sentries for inflammation? Trends Pharmacol Sci. 2000;21:103-108.
22. Morrish N, Stevens L, Fuller J, et al. "Risk factors for macrovascular disease in diabetes mellitus-the London follow-up to the WHO Multinational Study of Vascular Disease in Diabetics." Diabetologia. 1991;34: 590-594.
23. Hu FB, Stampfer MJ, Solomon CG, Liu S, Willett WC, Speizer FE, Nathan DM, Manson JE. The impact of diabetes mellitus on mortality from all causes and coronary heart disease in women-20 years of follow-up. Arch Intern Med. 2001;161:1717-1723.
24. Schmidlin F, Amadesi S, Dabbagh K, Lewis DE, Knott P, Bunnett NW, Gater PR, Geppetti P, Bertrand C, Stevens ME. Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol. 2002;169:5315-5321.
25. Bucci M, Roviezzo F, Brancaleone V, Lin MI, Di Lorenzo A, Cicala C, Pinto A, Sessa WC, Farneti S, Fiorucci S, Cirino G. Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arterioscler Thromb Vasc Biol. 2004;24:721-726.
26. Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A. 2001;98:13936-13941.
27. Vergnolle N, Cellars L, Mencarelli A, Rizzo G, Swaminathan S, Beck P, Steinhoff M, Andrade-Gordon P, Bunnett NW, Hollenberg MD, Wallace JL, Cirino G, Fiorucci S. A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest. 2004;114:1444-1456.
28. Gomes MB, Alfonso FS, Cailleaux S, Almeida AL, Pinto LF, Tibirica E. Glucose levels observed in daily clinical practice induce endothelial dysfunction in the rabbit macro- and microcirculation. Fundam Clin Pharmacol. 2004;18:339-346.
29. De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130: 963-974.
30. Cicala C, Morello S, Vellecco V, Severino B, Sorrentino L, Cirino G. Basal nitric oxide modulates vascular effects of a peptide activating protease-activated receptor 2. Cardiovasc Res. 2003;60:431-437.
31. Houllston RA, Keogh RJ, Sudgen D, Dudhla J, Carter TD, Wheeler-Jones CPD. Protease-activated receptors upregulate cycloxygenase-2 expression in human endothelial cells. Thromb Haemost. 2002;88: 321-328.
32. Hamilton JR, Frauman AG, Cocks TM. Increased expression of proteinase-activated receptor-2 (PAR2) and PAR4 in human coronary artery by inflammatory stimuli unveils endothelium dependent relaxations to PAR2 and PAR4 agonists. Circ Res. 2001;89:92-98.
33. Damiano BP, D'Andrea MR, de Garavilla L, Cheung WM, Andrade-Gordon P. Increased expression of proteinase activated receptor-2 (PAR-2) in balloon-injured rat carotid artery. Thromb Haemost. 1999;81: 808-814.
34. Milia AF, Salis MB, Stacca T, Pinna A, Madeddu P, Trevisani M, Geppetti P, Emanueli C. Proteinase-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia. Circ Res. 2002;91:346-352.