Insulin-stimulated production of nitric oxide is inhibited by Wortmannin: Direct measurement in vascular endothelial cells

Journal of Clinical Investigation

Volumn 98, Issue 4, 1996, Pages 894-898

  Zeng, Guangyuan ^a   Quon, Michael J ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b Hypertension Endocrine Branch   (United States)

Author keywords

diabetes; hypertension; insulin resistance; obesity

Indexed keywords

GENISTEIN; GLUCOSE; INSULIN; INSULIN RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL KINASE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C RECEPTOR; WORTMANNIN;

AMPEROMETRY; ARTICLE; BLOOD PRESSURE REGULATION; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; INHIBITION KINETICS; INSULIN RESISTANCE; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 0029789432     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118871     Document Type: Article

References (37)

1. Reaven, G.M. 1995. Pathophysiology of insulin resistance in human disease. Physiol. Rev. 75:473-486.
2. DeFronzo, R.A., and E. Ferrannini. 1991. Insulin resistance. A multifaceted syndrome responsible for NIDDM. obesity, hypertension, dyslipidemia. and atherosclerotic cardiovascular disease. Diabetes Care. 14:173-194.
3. Reaven, G.M., H. Lithell, and L. Landsberg. 1996. Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N. Engl. J. Med. 334:374-381.
4. Ferrannini, E., G. Buzzigoli, R. Bonadunna, M.A. Giorico, M. Oleggini, L. Graziadei, R. Pedrinelli, L. Brandi, and S. Bevilacqua. 1987. Insulin resistance inessential hypertension. N. Engl. J. Med. 317:350-357.
5. Baron, A.D. 1994. Hemodynamic actions of insulin. Am. J. Physiol. 267: E187-202.
6. Ogihara, T., H. Rakugi, H. Ikegami, H. Mikami, and K. Masuo. 1995. Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives. Am. J. Hypertens. 8:316-320.
7. Giugliano, D., N. De Rosa, G. Di Maro, R. Marfella, R. Acampora, R. Buoninconti, and F. D'Onofrio. 1993. Metformin improves glucose, lipid metabolism, and reduces blood pressure in hypertensive, obese women. Diabetes Care. 16:1387-1390.
8. Lee, M.K., P.D. Miles, M. Khoursheed, K.M. Gao, A.R. Moossa, and J.M. Olefsky. 1994. Metabolic effects of troglilazone on fructose-induced insulin resistance in the rat. Diabetes. 43:1435-1439.
9. Buchanan, T.A., W.P. Meehan, Y.Y. Jeng, D. Yang, T.M. Chan, J.L. Nadler, S. Scott, R.K. Rude, and W.A. Hsueh. 1995. Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect. J. Clin. Invest. 96:354-360.
10. Laakso, M., S.V. Edelman, G. Brechtel, and A.D. Baron. 1990. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J. Clin. Invest. 85:1844-1852.
11. Laakso, M., S.V. Edelman, G. Brechtel, and A.D. Baron. 1992. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes. 41:1076-1083.
12. Baron, A.D., O. Brechtel-Hook, A. Johnson, and D. Hardin. 1993. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure [see comments]. Hypertension. 21:129-135.
13. Baron, A.D., and G. Brechtel. 1993. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am. J. Physiol. 265:E61-E67.
14. Steinberg, H.O., G. Brechtel, A. Johnson, N. Fineberg, and A.D. Baron. 1994. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J. Clin. Invest. 94:1172-1179.
15. Cama, A., M.J. Ouon, M. de la Luz Sierra, and S.I. Taylor. 1992. Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action. J. Biol. Chem. 267:8383-8389.
16. Wennstrom, S., P. Hawkins, F. Cooke, K. Hara, K. Yonezawa, M. Kasuga, T. Jackson, L. Claesson-Welsh, and L. Stephens. 1994. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol. 4:385-393.
17. Furchgott, R.F., and J.V. Zawadzki. 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (Lond.). 288:373-376.
18. Palmer, R.M., A.G. Ferrige, and S. Moncada. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond.). 327:524-526.
19. Ignarro, L.J., G.M. Buga, K.S. Wood, R.E. Byrns, and G. Chaudhuri. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA. 84:9265-9269.
20. Huang, P.L., Z. Huang, H. Mashimo, K.D. Bloch, M.A. Moskowitz, J.A. Bevan, and M.C. Fishman. 1995. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (Lond.). 377:239-242.
21. Bredt, D.S., and S.H. Snyder. 1994. Nitric oxide: a physiologic messenger molecule. Annu. Rev. Biochem. 63:175-195.
22. Tsukahara, H., D.V. Gordienko, B. Tonshoff, M.C. Gelato, and M.S. Goligorsky. 1994. Direct demonstration of insulin-like growth faclor-I-induced nitric oxide production by endothelial cells. Kidney Int. 45:598-604.
23. LeRoith, D., P.C. Sampson, and C.T. Roberts, Jr. 1994. How does the mitogenic insulin-like growth factor I receptor differ from the metabolic insulin receptor? Horm. Res. 41 Suppl 2:74-78.
24. Baron, A.D., H. Steinberg, G. Brechtel, and A. Johnson. 1994. Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake. Am. J. Physiol. 266:E248-E253.
25. Baron, A.D., H.O. Steinberg, H. Chaker, R. Learning, A. Johnson, and G. Brechtel. 1995. Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans. J. Clin. Invest. 96: 786-792.
26. Baron, A.D. 1996. The coupling of glucose metabolism and perfusion in human skeletal muscle. The potential role of endothelium-derived nitric oxide. Diabetes. 45 Suppl 1:S105-S109.
27. King, G.L., and S.M. Johnson. 1985. Receptor-mediated transport of insulin across endothelial cells. Science (Wash. DC). 227:1583-1586.
28. Bar, R.S., J.C. Hoak, and M.L. Peacock. 1978. Insulin receptors in human endothelial cells: identification and characterization. J. Clin. Endocrinoi Metab. 47:699-702.
29. Bar, R.S., M. Boes, B.L. Dake, B.A. Booth, S.A. Henley, and A. Sandra. 1988. Insulin, insulin-like growth factors, and vascular endothelium. Am. J. Med. 85:59-70.
30. Quon, M.J., M. Guerre-Millo, M.J. Zarnowski, A.J. Butte, M. Em, S.W. Cushman, and S.I. Taylor. 1994. Tyrosine kinase-deficient mutant human insulin receptors (Met1153-Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc. Natl. Acad. Sci. USA. 91:5587-5591.
31. De Meyts, P. 1994. The structural basis of insulin and insulin-like growth faclor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia. 37 Suppl 2:S135-S148.
32. Quon, M.J., H. Chen, B.L. Ing, M.L. Liu, M.J. Zarnowski, K. Yonezawa, M. Kasuga, S.W. Cushman, and S.I. Taylor. 1995. Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol. Cell. Biol. 15:5403-5411.
33. Quon, M.J., A.J. Butte, and S.I. Taylor. 1994. Insulin signal transduction pathways. Trends Endocrin. Metab. 5:369-376.
34. Claesson-Welsh, L. 1994. Platelet-derived growth factor receptor signals. J. Biol. Chem. 269:32023-32026.
35. Wennstrom, S., A. Siegbahn, K. Yokote, A.K. Arvidsson, C.H. Heldin, S. Mori, and L. Claesson-Welsh. 1994. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphalidylinosilol 3′ kinase. Oncogene. 9:651-660.
36. Isakoff, S.J., C. Taha, E. Rose, J. Marcusohn, A. Klip, and E.Y. Skolnik. 1995. The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake. Proc. Natl. Acad. Sci. USA. 92:10247-10256.
37. Valius, M., and A. Kazlauskas. 1993. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell. 73:321-334.