Decreased lesion formation in CCR2(-/-) mice reveals a role for chemokines in the initiation of atherosclerosis

Nature

Volumn 394, Issue 6696, 1998, Pages 894-897

  Boring, Landin ^a,b   Gosling, Jennifa ^a   Cleary, Michael ^a   Charo, Israel F ^a,b,c  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; HYPERCHOLESTEROLEMIA; INFLAMMATORY INFILTRATE; LIPID STORAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; CHEMOKINE CCL2; CHOLESTEROL; DIET, ATHEROGENIC; LIPOPROTEINS; MICE; MICE, INBRED C57BL; MYOCARDIUM; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; TRIGLYCERIDES;

EID: 0032572719     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/29788     Document Type: Article

References (17)

1. + T cells. Science 270, 1811-1815 (1995).
2. Choe, H. et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85, 1135-1148 (1996).
3. Nelken, N. A., Coughlin, S. R., Gordon, D. & Wilcox, J. N. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88, 1121-1127 (1991).
4. Yiä-Herttuala, S. et al. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl Acad. Sci. USA 88, 5252-5256 (1991).
5. Yu, X. et al. Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates. Proc. Natl Acad. Sci. USA 89, 6953-6957 (1992).
6. Cushing, S. D. et al. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc. Natl Acad. Sci. USA 87, 5134-5138 (1990).
7. Boring, L. et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100, 2552-2561 (1997).
8. Plump, A. S. et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombinant in ES cells. Cell 71, 343-353 (1992).
9. Zhang, S. H., Reddick, R. L., Piedrahita, J. A. & Maeda, N. Spontaneous hypercholsterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258, 468-471 (1992).
10. Plump, A. S., Scott, C. J. & Breslow, J. L. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc. Natl Acad. Sci. USA 91, 9607-9611 (1994).
11. Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L. & Ross, R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14, 133-140 (1994).
12. Kraal, G., Rep, M. & Janse, M. Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2. An immunohistochemical study. Scand. J. Immunol. 26, 653-661 (1987).
13. Gupta, S. et al. IFN-γ potentiates atherosclerosis in apoE knock-out mice. J. Clin. Invest. 99, 2752-2761 (1997).
14. Duverger, N. et al. Protection against atherogenesis in mice mediated by human apolipoprotein A-IV. Science 273, 966-968 (1996).
15. Suzuki, H. et al. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386, 292-296 (1997).
16. Purcell-Huynh, D. A. et al. Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet. J. Clin. Invest. 95, 2246-2257 (1995).
17. Véniant, M. M. et al. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J. Clin. Invest. 100, 180-188 (1997).