Decreased IL-4 Production in New Onset Type I Insulin-Dependent Diabetes Mellitus

Journal of Immunology

Volumn 157, Issue 10, 1996, Pages 4690-4696

  Berman, Monique A ^a,b   Sandborg, Christy I ^a,b   Wang, Zengshun ^a   Imfeld, Karen L ^a,b   Zaldivar Jr , Frank ^a,b   Dadufalza, Violeta ^a   Buckingham, Bruce A ^a  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 4; MESSENGER RNA;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; CHILD; DRUG ANTAGONISM; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PRESCHOOL CHILD; T LYMPHOCYTE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; INFANT; INTERLEUKIN-1; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0030588554     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (74)

1. Castano, L., and G. S. Eisenbarth. 1990. Type-1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8:647.
2. Muir, A., D. A. Schatz, and N. K. Maclaren. 1992. The pathogenesis, prediction, and prevention of insulin-dependent diabetes mellitus. Endocrinol. Metab. Clin. North Am. 21:199.
3. Rossini, A. A., D. L. Greiner, H. P. Friedman, and J. P. Mordes. 1993. Immunopathogenesis of diabetes mellitus. Diabetes Rev. 1:43.
4. Rossini, A. A., E. S. Handler, D. L. Greiner, and J. P. Mordes. 1991. Insulin-dependent diabetes mellitus hypothesis of autoimmunity. Autoimmunity 8:221.
5. Wilson, K. and G. S. Eisenbarth. 1990. Immunopathogenesis and immunotherapy of type I diabetes. Annu. Rev. Med. 41:497.
6. Roep, B. O., S. D. Ardern, R. R. P. de Vries, and J. C. Hutton. 1990. T cell clones from a type I diabetes patient respond to insulin secretory granule proteins. Nature 345:632.
7. Harrison, L. C., H. DeAizpurpua, T. Loudovaris, I. L. Campbell, J. S. Cebon, B. D. Tait, and P. G. Colman. 1991. Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes. Diabetes 40:1128.
8. Atkinson, M. A., D. L. Kaufman, L. Campbell, K. A. Gibbs, S. C. Shah, D.-F. Bu, M. G. Erlander, A. J. Tobin, and N. K. Maclaren. 1992. Response of peripheral blood mononuclear cells to glutamine decarboxylase in insulin-dependent diabetes. Lancet 339:458.
9. Durinovic-Bello, I., A. Steinle, A. G. Ziegler, and D. J. Schendel. 1994. HLA-DR-restricted, islet-specific T-cell clones of a type I diabetic patient. Diabetes 43:1318.
10. Vetter, U., E. Heinze, A. Thon, W. Beischer, and W. Teller. 1983. The effect of glucose tolbutamide and arginine on C-peptide release during remission in type I diabetes mellitus. Eur. J. Pediatr. 140:305.
11. Ganda, O. M., S. Srikania, S. J. Brink, M. A. Morris, R. E. Gleason, J. S. Soeldner, and G. S. Eisenbarth. 1984. Differential sensitivity to beta cell secretagogues in "early" type I diabetes mellitus. Diabetes 33:516.
12. Sochett, E. B., D. Daneman, C. Clarson, and R. Ehrlich. 1987. Factors affecting and patterns of residual insulin secretion during the first year of type I (insulin dependent) diabetes mellitus in children. Diabetologia 30:453.
13. Wallenstein, M., G. Dahlquist, B. Persson, M. Landin-Olsson, A. Lernmark, G. Sundkvist, and B. Thalme. 1988. Factors influencing the magnitude, duration, and rate of fall of B-cell function in type I (insulin dependent) diabetic children followed for two years from their clinical diagnosis. Diabetologia 31:664.
14. Peig, M., R. Gomis, G. Ercilla, R. Casamitjana, G. F. Bottazzo, and R. Pujol-Borrell. 1989. Correlation between residual β-cell function and islet cell antibodies in newly diagnosed type I patients: follow-up study. Diabetes 38:1396.
15. Lernmark, A., G. Kloppel, D. Stenger, C. Vathanaprida, K. Falt, M. Landin-Olsson, D. G. Baskin, J. P. Palmer, A. M. Gown, J. S. Petersen, L. Li, H. Edenvall, and R. S. Mauseth. 1995. Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch. 425:631.
16. Somoza, N., F. Vargas, C. Roura-Mir, M. Vives-Pi, M. T. Fernandez-Figueras, A. Ariza, R. Gomis, R. Bragado, M. Marti, D. Jaraquemada, and R. Pujol-Borrell. 1994. Pancreas in recent onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor Vb usage, and cytokine profile. J. Immunol. 153:1360.
17. Huang, X., J. Yuan, A. Goddard, A. Foulis, R. F. L. James, A. Lernmark, R. Pujol-Borrell, A. Rabinovitch, N. Somoza, and T. A. Stewart. 1995. Interferon expression in the pancreas of patients With type I diabetes. Diabetes 44:658.
18. Mossmann, T. R., and A. Zlotnik. 1990. Multiple functions of interleukin 4 and its role in immune regulation. In Growth Factors, Differentiation Factors, and Cytokines. A. Habenicht, ed. Springer-Verlag, Berlin/Heidelberg, p. 129.
19. teVelde, A. A., J. F. Huijbens, K. Heije, J. E. deVries, and C. G. Figdor. 1990. Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor alpha, and IL-6 by human monocytes. Blood 76:1392.
20. Wong, H. L., G. L. Costa, M. T. Lotze, and S. M. Wahl. 1993. Interleukin (IL)-4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivo. J. Exp. Med. 177:775.
21. Mason, D., and D. Fowell. 1992. T-cell subsets in autoimmunity. Current Opin. Immunol. 4:728.
22. Scott, B., R. Liblau, S. Degermann, L. A. Marconi, L. Ogata, A. J. Caton, H. O. McDevitt, and D. Lo. 1994. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1:73.
23. Rapoport, M. J., A. Jaramillo, D. Zipris, A. H. Lazarus, D. V. Serreze, E. H. Leiter, P. Cyopick, J. S. Danska, and T. L. Delovitch. 1993. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:87.
24. Rabinovitch, A. 1994. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation. Diabetes 43: 613.
25. Shehadeh, N. N., F. La Rosa, and K. J. Lafferty. 1993. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 6:291.
26. Zipris, D., A. R. Lazarus, C. M. Hadziji, and T. L. Delovitch. 1991. Defective thymic T cell activation by Con A and anti-CD3 in autoimmune NOD mice: evidence for thymic T cell anergy that correlates with the onset of insulitis. J. Immunol. 146:3763.
27. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:627.
28. + T cells and their roles in the induction and prevention of autoimmunity. Immunol. Rev. 123:37.
29. + cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. Diabetes 45:71.
30. Katz, J. D., C. Benoist, D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268:1185.
31. Herold, K. C., V. Vezys, Q. Sun, D. Victora, E. Seung, S. Reiner, and D. R Brown. 1996. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 156:3527.
32. Drell, D. W., and A. L. Notkins. 1987. Multiple immunological abnormalities in patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30:132.
33. Prud'homme, G. J. Cytokines and autoimmunity. 1993. In The Molecular Pathology of Autoimmune Diseases. C. A. Bona, K. A. Siminovitch, M. Zanetti, and A. N. Theophilopoulos, eds. Harwood Academic Publishers, Chur, Switzerland, pp. 149-167.
34. Polak, M., and G. Eisenbarth. 1994. Human autoimmune diabetes. In Molecular Pathology of Autoimmune Diseases. C. A. Bona, K. A. Siminovitch, M. Zanetti, and A. N. Theophilopoulos, eds. Harwood Academic Publishers, Chur, Switzerland, pp. 601-618.
35. Boitard, C. 1992. The differentiation of the immune system towards anti-islet autoimmunity: clinical prospects. Diabetologia 35:1101.
36. Hayward, A. R., and M. Herberger. 1984. Culture and phenotypes of activated T-cells from patients with type-1 diabetes mellitus. Diabetes 33:319.
37. Tomoda, T., T. Kurashige, and T. Taniguchi. 1994. Imbalance of the interleukin 2 system in children with IDDM. Diabetologia 37:476.
38. Mascart-Lemone, F., O. Delespesse, H. Dorchy, B. Lemiere, G. Servais. 1982. Characterization of immunoregulatory T lymphocytes in insulin-dependent diabetic children by means of monoclonal antibodies. Clin. Exp. Immunol. 47:296.
39. Jackson, R. A., M. A. Morris, F. B. Haynes, G. S. Eisenbarth. 1982. Increased circulating Ia-antigen-bearing T cells in type 1 diabetes mellitus. New Engl. J. Med. 306:785.
40. Ilonen, J., H.-M. Surcel, A. Mustonen, M.-L. Kaar, H. K. Akerblom. 1984. Lymphocytes subpopulations at the onset of type-1 (insulin-dependent) diabetes. Diabetologia 27:106.
41. Alviggi, L., P. J. Hoskins, D. A. Pyke, C. Johnston, D. E. H. Tee, R. D. G. Leslie, D. Vergani. 1984. Pathogenesis of insulin-dependent diabetes: a role for activated T lymphocytes. Lancet 2:4.
42. Zier, K. S., M. M. Leo, R. S. Spielman, L. Baker. 1984. Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. Diabetes 33:552.
43. Kaye, W. A., M. S. Adri, J. S. Soeldner, S. L. Rabinowe, A. Kaldany, C. R. Kahn, B. Bistrian, S. Srikanta, O. P. Ganda, and G. S. Eisenbarth. 1986. Acquired defect in interleukin-2 production in patients with type I diabetes mellitus. New Eng. J. Med. 315:920.
44. Giordano, C., F. Pantó, C. Caruso, M. A. Modica, A. M. Zambito, N. Sapienza, M. P. Amato, and A. Galluzzo. 1989. The interleukin 21 and soluble interleukin 2 receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes 38:310.
45. Shah, U., L. Karch, L. Baker, and K. S. Zier. 1991. Low interleukin-2 synthesis by type I diabetics is regulated at the pretranslational level. Clin. Immunol. Immunopathol. 61:177.
46. Luger, A., G. Schemthaner, A. Urbanski, and T. A. Luger. 1988. Cytokine production in patients with newly diagnosed insulin-dependent (type I) diabetes mellitus. Eur. J. Clin. Invest. 18:233.
47. Kinzer, C. A., A. D. Keegan, M. P. Beckmann, M. Widmer, G. H. Idelson, S. Z. Ben-Sasson, and W. E. Paul. 1994. CT.h4S cell, a murine cell line expressing human IL-4 receptors and capable of assaying human IL-4. Fed. Proc. 2924: (Abstr.).
48. Sandborg, C. I., K. L. Imfeld, F. Zaldivar, Jr., Z. Wang, B. A. Buckingham, and M. A. Berman. 1995. IL-4 expression in human T cell is selectively inhibited by IL-1α and IL-1β. J. Immunol. 155:5206.
49. r non IL-1 activity released by human mononuclear cells. J. Leukocyte Biol. 46:417.
50. Berman, M. A., C. I. Sandborg, K. L. Imfeld, J. S. Kenney, and F. J. Zaldivar. 1994. Selective sustained release of interleukin 1 a (IL-1α) and IL-6 by HIV-1 infected macrophages. AIDS Res. Hum. Retroviruses 10:529.
51. Sandborg, C. I., K. L. Imfeld, F. J. Zaldivar, and M. A. Berman. 1994. HIV-1 induction of IL-1 and IL-6 production by human thymic cultures. AIDS Res. Hum. Retroviruses 10:1221.
52. Kamdar, S. J., and R. Evans. 1992. Modifications of the guanidine hydrochloride procedure for the extraction of RNA: Isolation from a variety of tissues and adherent/nonadherent cell types. Biotechniques 12:632.
53. Arai, N., D. Nomura, D. Villareet, R. D. Malefit, M. J. Seiki, M. Yoshida, S. Minoshima, R. Fukyyama, M. Maekawa, J. Kudoh, N. Shimikzu, K. Yokota, E. Abe, T. Yokita, Y. Yakebe, and K. Arai. 1989. Complete nucleotide sequence of the chromosomal gene for human and IL-4 and its expression. J. Immunol. 142:274.
54. + T cell through an effect on antigen-presenting cells. J. Immunol. 154:2578.
55. Todd, M. D., M. Grusby, J. A. Lederer, E. Lacy, A. H. Lichtman, and L. H. Glimcher. 1993. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J. Exp. Med. 177:1663.
56. Spits, H., ed. 1992. IL-4: Structure and Function. CRC Press, Boca Raton, FL.
57. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091.
58. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
59. Seder, R. A., W. E. Paul, S. Z. Ben-Sasson, G. Le Gros, A. Kagey-Sobotka, F. D. Finkelman, J. H. Pierce, and M. Plaut. 1991. Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils. Int. Arch. Allergy Appl. Immunol. 94:137.
60. McDowell, T. L., J. A. Symons, R. Ploski, O. Forre, and G. W. Duff. 1995. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 alpha polymorphism. Arthritis Rheum. 38:221.
61. Blakemore, A. I., P. R. Watson, A. P. Weetman, G. W. Duff. 1995. Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene. J. Clin. Endocrinol. Metab. 80:111.
62. Bailly, S., F. S. Di Giovane, A. I. Blakemore, G. W. Duff. 1993. Genetic polymorphism of human interleukin-1 alpha. Eur. J. Immunol. 23:1240.
63. Danis, V. A., M. Millington, V. J. Hyland. 1995. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1 Ra) gene polymorphism. Clin. Exp. Immunol. 99:303.
64. Marsh, D. G., J. D. Neely, D. R. Breazeale, B. Ghosh, L. R. Freidhoff, E. Ehrlich-Kautzky, C. Schou, G. Krishnaswarny, T. H. Beaty. 1994. Linkage analysis of IL-4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:1152.
65. Song, Z., V. Casolaro, R. Chen, S. N. Georas, D. Monos, and S. J. Ono. 1996. Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene. J. Immunol. 156:424.
66. Hashimoto, S., J. P. Michalski, M. A. Berman, and C. McCombs. 1990. Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3: role of interleukin-1. Clin. Exp. Immunol. 79:227.
67. Mu, H.-H., and W. A. Sewell. 1993. Enhancement of interleukin 4 production by pertussis toxin. Infect. Immun. 61:2834.
68. + T cells. Int. Immunol. 5:877.
69. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
70. Rapoport, M. J., A. Jaramillo, D. Zipris, A. H. Lazarus, D. V. Serreze, E. H. Leiter, P. Cyopick, J. S. Danska, and T. L. Delovitch. 1993. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:87.
71. Tanaka, T., S. Z. Ben-Sasson, and W. W. Paul. 1991. IL-4 increases IL-2 production by T cells in response to accessory cell-independent stimuli. J. Immunol. 146:3831.
72. Mitchell, L. C., L. S. David, and P. E. Lipsky. 1989. Promotion of human T lymphocyte proliferation by IL-4. J. Immunol. 142:1548.
73. Lorre, K., J. V. Damme, and J. L. Ceuppens. 1990. A bidirectional regulatory network involving IL-2 and IL-4 in the alternative CD2 pathway of T cell activation. Eur. J. Immunol. 20:1569.
74. Jones-Tiffany, L. A., P. T. Mehrotra, D. W. Horohov, J. Siegel, and W. R. Kozak. 1993. Low versus high density of immobilized anti-CD3 influences IL-4 regulation of T-cell immune responses. Cell Immunol. 147:425-437.