Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

Molecular Cell

Volumn 2, Issue 2, 1998, Pages 275-281

  Gu, Long ^a   Okada, Yoshikatsu ^b   Clinton, Steven K ^a   Gerard, Craig ^c   Sukhova, Galina K ^b   Libby, Peter ^b   Rollins, Barrett J ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; PRIMER DNA;

ANIMAL; AORTA; ARTERIOSCLEROSIS; ARTICLE; ATHEROGENIC DIET; BLOOD; C57BL MOUSE; CELL MOTION; FEMALE; GENETICS; LIPID METABOLISM; MACROPHAGE; MALE; METABOLISM; MONOCYTE; MOUSE; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; AORTA; ARTERIOSCLEROSIS; BASE SEQUENCE; CELL MOVEMENT; CHEMOKINE CCL2; DIET, ATHEROGENIC; DNA PRIMERS; FEMALE; LIPID METABOLISM; LIPIDS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; POLYMERASE CHAIN REACTION; RECEPTORS, LDL;

EID: 0032134003     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80139-2     Document Type: Article

References (51)

1. Aqel, N.M., Ball, R.Y., Waldmann, H., and Mitchinson, M.J. (1985). Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies. J. Pathol. 146, 197-204.
2. Baggiolini, M. (1998). Chemokines and leukocyte traffic. Nature 392, 565-568.
3. Berliner, J.A., Territo, M.C., Sevanian, A., Ramin, S., Kim, J.A., Barnshad, B., Esterson, M., and Fogelman, A.M. (1990). Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J. Clin. Invest. 85, 1260-1266.
4. Boring, L., Gosling, J., Chensue, S.W., Kunkel, S.L., Farese, R.V.J., Broxmeyer, H.E., and Charo, I.F. (1997). Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100, 2552-2561.
5. Breslow, J.L. (1996). Mouse models of atherosclerosis. Science 272, 685-688.
6. Charo, I.F., Myers, S.J., Herman, A., Franci, C., Connolly, A.J., and Coughlin, S.R. (1994). Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA 91, 2752-2756.
7. Chensue, S.W., Warmington, K.S., Ruth, J.H., Sanghi, P.S., Lincoln, P., and Kunkel, S.L. (1996). Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J. Immunol. 157, 4602-4608.
8. Clinton, S.K., and Libby, P. (1992). Cytokines and growth factors in atherogenesis. Arch. Pathol. Lab. Med. 116, 1292-1300.
9. Combadiere, C., Ahuja, S.K., Van Damme, J., Tiffany, H.L., Gao, J.L., and Murphy, P.M. (1995). Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. J. Biol. Chem. 270, 29671-29675.
10. Cushing, S.D., Berliner, J.A., Valente, A.J., Territo, M.C., Navab, M., Parhami, F., Gerrity, R., Schwartz, C.J., and Fogelman, A.M. (1990). Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc. Natl Acad. Sci. USA 87, 5134-5138.
11. Franci, C., Wong, L.M., Van, D.J., Proost, P., and Charo, I.F. (1995). Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. J. Immunol. 154, 6511-6517.
12. Fuentes, M.E., Durham, S.K., Swerdel, M.R., Lewin, A.C., Barton, D.S., Megill, J.R., Bravo, R., and Lira, S.A. (1995). Controlled recruitment of monocytes/macrophages to specific organs through transgenic expression of MCP-1. J. Immunol. 155, 5769-5776.
13. Fuster, V., Badimon, L., Badimon, J.J., and Chesebro, J.H. (1992). The pathogenesis of coronary artery disease and the acute coronary syndromes. N. Engl. J. Med. 326, 310-318.
14. Garcia-Zepeda, E.A., Combadiere, C., Rothenberg, M.E., Sarafi, M.N., Lavigne, F., Hamid, Q., Murphy, P.M., and Luster, A.D. (1996). Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J. Immunol. 157, 5613-5626.
15. Gerrity, R.G. (1981). The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. Am. J. Pathol. 103, 181-190.
16. Goldberg, I.J. (1996). Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 37, 693-707.
17. Gown, A.M., Tsukuda, T., and Ross, R. (1986). Human atherosclerosis: II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am. J. Pathol. 125, 191-207.
18. Grewal, I.S., Rutledge, B.J., Fiorillo, J.A., Gu, L., Gladue, R.P., Flavell, R.A., and Rollins, B.J. (1997). Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1. J. Immunol. 159, 401-408.
19. Gunn, M.D., Nelken, N.A., Liao, X., and Williams, L.T. (1997). Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J. Immunol. 158, 376-383.
20. Ishibashi, S., Brown, M.S., Goldstein, J.L., Gerard, R.D., Hammer, R.E., and Herz, J. (1993). Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92, 883-893.
21. Ishibashi, S., Goldstein, J.L., Brown, M.S., Herz, J., and Burns, D.K. (1994). Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93, 1885-1893.
22. Jonasson, L., Holm, J., Skalli, O., Bondjers, G., and Hansson, G.K. (1986). Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 6, 131-138.
23. Kraal, G., Rep, M., and Janse, M. (1987). Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2. An immunohistochemical study. Scand. J. Immunol. 26, 653-661.
24. Kurihara, T., and Bravo, R. (1996). Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J. Biol. Chem. 271, 11603-11607.
25. Kurihara, T., Warr, G., Loy, J., and Bravo, R. (1997). Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J. Exp. Med. 186, 1757-1762.
26. Kuziel, W.A., Morgan, S.J., Dawson, T.C., Griffin, S., Smithies, O., Ley, K., and Maeda, N. (1997). Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc. Natl. Acad. Sci. USA 94, 12053-12058.
27. Leenen, P.J., de Bruijn, M.F., Voerman, J.S., Campbell, P.A., and van Ewijk, W. (1994). Markers of mouse macrophage development detected by monoclonal antibodies. J. Immunol. Methods 174, 5-19.
28. Libby, P., Schwartz, D., Brogi, E., Tanaka, H., and Clinton, S.K. (1992). A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 86, 47-52.
29. Lu, B., Rutledge, B.J., Gu, L., Fiorillo, J., Lukacs, N.W., Kunkel, S.L., North, R., Gerard, C., and Rollins, B.J. (1998). Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187, 601-608.
30. Moore, U.M., Kaplow, J.M., Pleass, R.D., Castro, S.W., Naik, K., Lynch, C.N., Daly, S., Roach, A.G., Jaye, M., and Williams, R.J. (1997). Monocyte chemoattractant protein-2 is a potent agonist of CCR2B. J. Leukoc. Biol. 62, 911-915.
31. Nakamura, K., Williams, I.R., and Kupper, T.S. (1995). Keratinocyte-derived monocyte chemoattractant protein 1 (MCP-1): analysis in a transgenic model demonstrates MCP-1 can recruit dendritic and Langerhans cells to skin. J. Invest. Dermatol. 105, 635-643.
32. Nakashima, Y., Plump, A.S., Raines, E.W., Breslow, J.L., and Ross, R. (1994). ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14, 133-140.
33. Nelken, N.A., Coughlin, S.R., Gordon, D., and Wilcox, J.N. (1991). Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88, 1121-1127.
34. Nibbs, R.J.B., Wylie, S.M., Pragnell, I.B., and Graham, G.J. (1997). Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1 alpha receptors, CCR-1, CCR-3, and CCR-5. J. Biol. Chem. 272, 12495-12504.
35. O'Brien, K.D., Gordon, D., Deeb, S., Ferguson, M., and Chait, A. (1992). Lipoprotein lipase is synthesized by macrophage-derived foam cells in human coronary atherosclerotic plaques. J. Clin. Invest. 89, 1544-1550.
36. Paigen, B., Morrow, A., Holmes, P.A., Mitchell, D., and Williams, R.A. (1987). Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68, 231-240.
37. Qiao, J.H., Tripathi, J., Mishra, N.K., Cai, Y., Tripathi, S., Wang, X.P., Imes, S., Fishbein, M.C., Clinton, S.K., Libby, P., et al. (1997). Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am. J. Pathol. 150, 1687-1699.
38. Rollins, B.J. (1997). Chemokines. Blood 90, 909-928.
39. Rollins, B.J., Yoshimura, T., Leonard, E.J., and Pober, J.S. (1990). Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol. 136, 1229-1233.
40. Ross, R. (1995). Cell biology of atherosclerosis. Annu. Rev. Physiol. 57, 791-804.
41. Sarafi, M.N., Garcia-Zepeda, E.A., MacLean, J.A., Charo, I.F., and Luster, A.D. (1997). Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J. Exp. Med. 185, 99-109.
42. Shyy, Y.J., Hsieh, H.J., Usami, S., and Chien, S. (1994). Fluid shear stress induces a biphasic response of human monocyte chemotactic protein 1 gene expression in vascular endothelium. Proc. Natl. Acad. Sci. USA 91, 4678-4682.
43. Smith, J.D., Trogan, E., Ginsberg, M., Grigaux, C., Tian, J., and Miyata, M. (1995). Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl. Acad. Sci. USA 92, 8264-8268.
44. Sozzani, S., Zhou, D., Locati, M., Rieppi, M., Proost, P., Magazin, M., Vita, N., van Damme, J., and Mantovani, A. (1994). Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J. Immunol. 152, 3615-3622.
45. Stellato, C., Collins, P., Ponath, P.D., Soler, D., Newman, W., La Rosa, G., Li, H., White, J., Schwiebert, L.M., Bickel, C., et al. (1997). Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. J. Clin. Invest. 99, 926-936.
46. Strieter, R.M., Wiggins, R., Phan, S.H., Wharram, B.L., Showell, H.J., Remick, D.G., Chensue, S.W., and Kunkel, S.L. (1989). Monocyte chemotactic protein gene expression by cytokine-treated human fibroblasts and endothelial cells. Biochem. Biophys. Res. Commun. 162, 694-700.
47. Tangirala, R.K., Rubin, E.M., and Palinski, W. (1995). Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid. Res. 36, 2320-2328.
48. Taubman, M.B., Rollins, B.J., Poon, M., Marmur, J., Green, R.S., Berk, B.C., and Nadal-Ginard, B. (1992). JE mRNA accumulates rapidly in aortic injury and in PDGF-stimulated vascular smooth muscle cells. Circ. Res. 70, 314-325.
49. Yla-Herttuala, S., Lipton, B.A., Rosenfeld, M.E., Sarkioja, T., Yoshimura, T., Leonard, E.J., Witztum, J.L., and Steinberg, D. (1991a). Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. USA 88, 5252-5256.
50. Yla-Herttuala, S., Lipton, B.A., Rosenfeld, M.E., Goldberg, I.J., Steinberg, D., and Witztum, J.L. (1991b). Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proc. Natl. Acad. Sci. USA 88, 10143-10147.
51. Yu, X., Dluz, S., Graves, D.T., Zhang, L., Antoniades, H.N., Hollander, W., Prusty, S., Valente, A.J., Schwartz, C.J., and Sonenshein, G.E. (1992). Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates. Proc. Natl. Acad. Sci. USA 89, 6953-6957.