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Baba 2006 {published data only} Baba M, Kimura K-I, Suda T, Yagihashi S. Three-year inhibition of aldose reductase on development of symptomatic neuropathy in diabetic patients. Journal of the Peripheral Nervous System 2006;11(2):176-8. [MEDLINE: 62].
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Boulton 1989 {published data only} Boulton AJM, Atiea J, de Leeuw IH, Lemkes H, MacLeod AF, MacRury S, et al North European Tolrestat Study Group. The efficacy and safety of the aldose-reductase inhibitor tolrestat in the treatment of chronic sensorimotor diabetic neuropathy. Diabetologia 1989;32:469A. [MEDLINE: 13].
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Boulton 1989 {published data only} Boulton AJM, Atiea J, de Leeuw IH, Lemkes H, MacLeod AF, MacRury S, et al North European Tolrestat Study Group. The efficacy and safety of the aldose-reductase inhibitor tolrestat in the treatment of chronic sensorimotor diabetic neuropathy. Diabetologia 1989;32:469A. [MEDLINE: 13].
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Boulton 1990 {published data only} Boulton AJ, Levin S, Comstock J. A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy. Diabetologia 1990;33(7):431-7. [MEDLINE: 14].
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Boulton 1990 {published data only} Boulton AJ, Levin S, Comstock J. A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy. Diabetologia 1990;33(7):431-7. [MEDLINE: 14].
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Brown 2004 {published data only} Brown MJ, Bird SJ, Watling S, Kaleta H, Hayes L, Eckert S, et al.Natural progression of diabetic peripheral neuropathy in the Zenarestat study population. Diabetes Care 2004;27(5):1153-9. [MEDLINE: 35].
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Brown 2004 {published data only} Brown MJ, Bird SJ, Watling S, Kaleta H, Hayes L, Eckert S, et al.Natural progression of diabetic peripheral neuropathy in the Zenarestat study population. Diabetes Care 2004;27(5):1153-9. [MEDLINE: 35].
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Christensen 1987 {published data only} Christensen JE, Larsen AB, Gregersen G. [Diabetic neuropathy: treatment trial with an aldose reductase inhibitor (Sorbinil)]. [Danish] [Diabetisk neuropati: Behandlingsforsog med en aldosereduktasehaemmer (Sorbinil)]. Ugeskrift for Laeger 1987;149(46):3111-4. [MEDLINE: 19].
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Christensen 1987 {published data only} Christensen JE, Larsen AB, Gregersen G. [Diabetic neuropathy: treatment trial with an aldose reductase inhibitor (Sorbinil)]. [Danish] [Diabetisk neuropati: Behandlingsforsog med en aldosereduktasehaemmer (Sorbinil)]. Ugeskrift for Laeger 1987;149(46):3111-4. [MEDLINE: 19].
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Daniele 1995 {published data only} Daniele E, Coco MP. The therapy of diabetic peripheral neuropathy with tolrestat: Is this drug really useful? [Italian] [La terapia della neuropatia diabetica periferica con tolrestat: tale farmaco e realmente utile?]. Clinica Terapeutica 1995;146(12):793-9. [MEDLINE: 25].
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Daniele 1995 {published data only} Daniele E, Coco MP. The therapy of diabetic peripheral neuropathy with tolrestat: Is this drug really useful? [Italian] [La terapia della neuropatia diabetica periferica con tolrestat: tale farmaco e realmente utile?]. Clinica Terapeutica 1995;146(12):793-9. [MEDLINE: 25].
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Dietrich 1990 {published data only} Dietrich E, Stracke H, Federlin K. The effects of the aldose reductase inhibitor 'Statil' on diabetic peripheral neuropathy. Diabetologia 1990;33:A167. [MEDLINE: 28].
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Dietrich 1990 {published data only} Dietrich E, Stracke H, Federlin K. The effects of the aldose reductase inhibitor 'Statil' on diabetic peripheral neuropathy. Diabetologia 1990;33:A167. [MEDLINE: 28].
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8
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Fabiani 1995 {published data only} Fabiani F, De Vincentis N, Staffilano A. Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy. Diabete et Metabolisme 1995;21(5):360-4. [MEDLINE: 30].
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Fabiani 1995 {published data only} Fabiani F, De Vincentis N, Staffilano A. Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy. Diabete et Metabolisme 1995;21(5):360-4. [MEDLINE: 30].
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Faes 1993 {published data only} Faes TJ, Yff GA, DeWeerdt O, Lanting P, Heimans JJ, Bertelsmann FW. Treatment of diabetic autonomic neuropathy with an aldose reductase inhibitor. Journal of Neurology 1993;240(3):156-60. [MEDLINE: 31].
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Faes 1993 {published data only} Faes TJ, Yff GA, DeWeerdt O, Lanting P, Heimans JJ, Bertelsmann FW. Treatment of diabetic autonomic neuropathy with an aldose reductase inhibitor. Journal of Neurology 1993;240(3):156-60. [MEDLINE: 31].
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Fagius 1985 {published data only} Fagius J, Brattberg A, Jameson S, Berne C. Limited benefit of treatment of diabetic polyneuropathy with an aldose reductase inhibitor: A 24-week controlled trial. Diabetologia 1985;28(6):323-9. [MEDLINE: 32].
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Fagius 1985 {published data only} Fagius J, Brattberg A, Jameson S, Berne C. Limited benefit of treatment of diabetic polyneuropathy with an aldose reductase inhibitor: A 24-week controlled trial. Diabetologia 1985;28(6):323-9. [MEDLINE: 32].
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Florkowski 1990 * {published data only} Florkowski CM, Rowe BR, Nightingale S, Barnett AH. A six-month randomized placebo-controlled trial of the aldose reductase inhibitor ponalrestat in chronic symptomatic peripheral neuropathy. International Diabetes Federation Symposium on Diabetic Neuropathy , Sydney, Australia. Chichester: John Wiley and Sons, 1990:143-8.
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Florkowski 1990 * {published data only} Florkowski CM, Rowe BR, Nightingale S, Barnett AH. A six-month randomized placebo-controlled trial of the aldose reductase inhibitor ponalrestat in chronic symptomatic peripheral neuropathy. International Diabetes Federation Symposium on Diabetic Neuropathy , Sydney, Australia. Chichester: John Wiley and Sons, 1990:143-8.
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Florkowski 1991 {published data only} Florkowski CM, Rowe BR, Nightingale S, Harvey TC, Barnett AH. Clinical and neurophysiological studies of aldose reductase inhibitor ponalrestat in chronic symptomatic diabetic peripheral neuropathy. Diabetes 1991;40(1):129-133. [MEDLINE: 37].
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Florkowski 1991 {published data only} Florkowski CM, Rowe BR, Nightingale S, Harvey TC, Barnett AH. Clinical and neurophysiological studies of aldose reductase inhibitor ponalrestat in chronic symptomatic diabetic peripheral neuropathy. Diabetes 1991;40(1):129-133. [MEDLINE: 37].
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Giugliano 1993 {published data only} Giugliano D, Marfella R, Quatraro A, De Rosa N, Salvatore T, Cozzolino D, Ceriello A, Torella R. Tolrestat for mild diabetic neuropathy: A 52-week, randomized, placebo- controlled trial. Annals of Internal Medicine 1993;118(1):7-11. [MEDLINE: 44].
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Giugliano 1993 {published data only} Giugliano D, Marfella R, Quatraro A, De Rosa N, Salvatore T, Cozzolino D, Ceriello A, Torella R. Tolrestat for mild diabetic neuropathy: A 52-week, randomized, placebo- controlled trial. Annals of Internal Medicine 1993;118(1):7-11. [MEDLINE: 44].
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Giugliano 1995 {published data only} Giugliano D, Acampora R, Marfella R, Di Maro G, De Rosa N, Misso L, et al.Tolrestat in the primary prevention of diabetic neuropathy. Diabetes Care 1995;18(4):536- 41. [MEDLINE: 42].
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Giugliano 1995 {published data only} Giugliano D, Acampora R, Marfella R, Di Maro G, De Rosa N, Misso L, et al.Tolrestat in the primary prevention of diabetic neuropathy. Diabetes Care 1995;18(4):536- 41. [MEDLINE: 42].
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Greene 1999 {published data only} Greene DA, Arezzo JC, Brown MB, Zenarestat Study Group. Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy [erratum appears in Neurology 2001;56(8):1124]. Neurology 1999;53(3):580-91. [MEDLINE: 49].
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Greene 1999 {published data only} Greene DA, Arezzo JC, Brown MB, Zenarestat Study Group. Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy [erratum appears in Neurology 2001;56(8):1124]. Neurology 1999;53(3):580-91. [MEDLINE: 49].
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Guy 1988 {published data only} Guy RJ, Gilbey SG, Sheehy M, Asselman P, Watkins PJ. Diabetic neuropathy in the upper limb and the effect of twelve months sorbinil treatment. Diabetologia 1988;31(4):214-20. [MEDLINE: 53].
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Guy 1988 {published data only} Guy RJ, Gilbey SG, Sheehy M, Asselman P, Watkins PJ. Diabetic neuropathy in the upper limb and the effect of twelve months sorbinil treatment. Diabetologia 1988;31(4):214-20. [MEDLINE: 53].
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Hotta 2001 {published data only} Hotta N, Toyota T, Matsuoka K, Shigeta Y, Kikkawa R, Kaneko T, et al The SNK-860 Diabetic Neuropathy Study Group. Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care 2001;24(10):1776-82. [MEDLINE: 299].
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Hotta 2001 {published data only} Hotta N, Toyota T, Matsuoka K, Shigeta Y, Kikkawa R, Kaneko T, et al The SNK-860 Diabetic Neuropathy Study Group. Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care 2001;24(10):1776-82. [MEDLINE: 299].
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Hotta 2006 {published data only} Hotta N, Akanuma Y, Kawamori R, Matsuoka K, Oka Y, Shichiri M, et al The ADCT Study Group. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic periheral neuropathy: The 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial. Diabetes Care 2006;29(7):1538-44.
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Hotta 2006 {published data only} Hotta N, Akanuma Y, Kawamori R, Matsuoka K, Oka Y, Shichiri M, et al The ADCT Study Group. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic periheral neuropathy: The 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial. Diabetes Care 2006;29(7):1538-44.
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Jennings 1990 {published data only} Jennings PE, Nightingale S, Le Guen C, Lawson N, Williamson JR, Hoffman P, et al.Prolonged aldose reductase inhibition in chronic peripheral diabetic neuropathy: effects on microangiopathy. Diabetic Medicine 1990;7(1):63-8. [MEDLINE: 332].
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Jennings 1990 {published data only} Jennings PE, Nightingale S, Le Guen C, Lawson N, Williamson JR, Hoffman P, et al.Prolonged aldose reductase inhibition in chronic peripheral diabetic neuropathy: effects on microangiopathy. Diabetic Medicine 1990;7(1):63-8. [MEDLINE: 332].
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Jespersen 1986 {published data only} Jespersen J, Gram J, Christensen JE. Neurophysiological variables and fibrinolysis in insulin-dependent diabetes treated with an aldose reductase inhibitor or placebo. A double-blind randomized study. Haemostasis 1986;16(6):453-7. [MEDLINE: 336].
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Jespersen 1986 {published data only} Jespersen J, Gram J, Christensen JE. Neurophysiological variables and fibrinolysis in insulin-dependent diabetes treated with an aldose reductase inhibitor or placebo. A double-blind randomized study. Haemostasis 1986;16(6):453-7. [MEDLINE: 336].
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Johnson 2004 {published data only} Johnson BF, Nesto RW, Pfeifer MA, Slater WR, Vinik AI, Chyun DA, Law G, Wackers FJ, Young LH. Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration. Diabetes Care 2004;27(2):448-54. [MEDLINE: 38].
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Johnson 2004 {published data only} Johnson BF, Nesto RW, Pfeifer MA, Slater WR, Vinik AI, Chyun DA, Law G, Wackers FJ, Young LH. Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration. Diabetes Care 2004;27(2):448-54. [MEDLINE: 38].
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Krentz 1992 {published data only} Krentz AJ, Honigsberger L, Ellis SH, Hardman M, Nattrass M. A 12-month randomized controlled study of the aldose reductase inhibitor ponalrestat in patients with chronic symptomatic diabetic neuropathy. Diabetic Medicine 1992;9(5):463-8. [MEDLINE: 376].
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Krentz 1992 {published data only} Krentz AJ, Honigsberger L, Ellis SH, Hardman M, Nattrass M. A 12-month randomized controlled study of the aldose reductase inhibitor ponalrestat in patients with chronic symptomatic diabetic neuropathy. Diabetic Medicine 1992;9(5):463-8. [MEDLINE: 376].
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Macleod 1992 {published data only} Macleod AF, Boulton AJ, Owens DR, Van Rooy P, van Gerven JM, MacRury S, et al North European Tolrestat Study Group. A multicentre trial of the aldose-reductase inhibitor tolrestat in patients with symptomatic diabetic peripheral neuropathy. Diabetes & Metabolism 1992;18(1):14-20. [MEDLINE: 405].
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Macleod 1992 {published data only} Macleod AF, Boulton AJ, Owens DR, Van Rooy P, van Gerven JM, MacRury S, et al North European Tolrestat Study Group. A multicentre trial of the aldose-reductase inhibitor tolrestat in patients with symptomatic diabetic peripheral neuropathy. Diabetes & Metabolism 1992;18(1):14-20. [MEDLINE: 405].
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Martyn 1987 {published data only} Martyn CN, Reid W, Young RJ, Ewing DJ, Clarke BF. Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function. Diabetes 1987;36(9):987-90. [MEDLINE: 417].
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Martyn 1987 {published data only} Martyn CN, Reid W, Young RJ, Ewing DJ, Clarke BF. Six-month treatment with sorbinil in asymptomatic diabetic neuropathy. Failure to improve abnormal nerve function. Diabetes 1987;36(9):987-90. [MEDLINE: 417].
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Nakayama 2001 {published data only} Nakayama M. Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy. Diabetes Care 2001;24(6):1093-1098. [MEDLINE: 438].
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Nakayama 2001 {published data only} Nakayama M. Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy. Diabetes Care 2001;24(6):1093-1098. [MEDLINE: 438].
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O'Hare 1988 {published data only} O'Hare JP, Morgan MH, Alden P, Chissel S, O'Brien IA, Corrall RJ. Aldose reductase inhibition in diabetic neuropathy: clinical and neurophysiological studies of one year's treatment with sorbinil. Diabetic Medicine 1988;5(6):537-42. [MEDLINE: 453].
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O'Hare 1988 {published data only} O'Hare JP, Morgan MH, Alden P, Chissel S, O'Brien IA, Corrall RJ. Aldose reductase inhibition in diabetic neuropathy: clinical and neurophysiological studies of one year's treatment with sorbinil. Diabetic Medicine 1988;5(6):537-42. [MEDLINE: 453].
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Salmon 1991 {published data only} Salmon P, Perkins CM, Tomkin GH. Diabetic neuropathy and aldose reductase inhibition. Diabetes, Nutrition & Metabolism - Clinical & Experimental 1991;4(2):135-39. [MEDLINE: 516].
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Salmon 1991 {published data only} Salmon P, Perkins CM, Tomkin GH. Diabetic neuropathy and aldose reductase inhibition. Diabetes, Nutrition & Metabolism - Clinical & Experimental 1991;4(2):135-39. [MEDLINE: 516].
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Sima 1988 {published data only} Sima AAF, Bril V, Nathaniel V, McEwen TAJ, Brown MB, Lattimer SA, et al.Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil. New England Journal of Medicine 1988;319(9):548-55. [MEDLINE: 557].
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Sima 1988 {published data only} Sima AAF, Bril V, Nathaniel V, McEwen TAJ, Brown MB, Lattimer SA, et al.Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil. New England Journal of Medicine 1988;319(9):548-55. [MEDLINE: 557].
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SRG 1993 {published data only} Sorbinil Retinopathy Trial Research Group. The sorbinil retinopathy trial: neuropathy results. Neurology 1993;43(6):1141-9. [MEDLINE: 6].
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SRG 1993 {published data only} Sorbinil Retinopathy Trial Research Group. The sorbinil retinopathy trial: neuropathy results. Neurology 1993;43(6):1141-9. [MEDLINE: 6].
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Stracke 1994 {published data only} Stracke H, Dietrich E. Influence of Ponalrestat, an aldose-reductase inhibitor, on diabetic polyneuropathy. [German] [Der Einfluss des Aldose-Reduktase-Inhibitors Ponalrestat auf die diabetische Polyneuropathie]. Medizinische Welt 1994;45(3):84-89. [MEDLINE: 560].
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Stracke 1994 {published data only} Stracke H, Dietrich E. Influence of Ponalrestat, an aldose-reductase inhibitor, on diabetic polyneuropathy. [German] [Der Einfluss des Aldose-Reduktase-Inhibitors Ponalrestat auf die diabetische Polyneuropathie]. Medizinische Welt 1994;45(3):84-89. [MEDLINE: 560].
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Sundkvist 1992 {published data only} Sundkvist G, Armstrong FM, Bradbury JE, Chaplin C, Ellis SH, Owens DR, et al.Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. Journal of Diabetes and its Complications 1992;6(2):123-30. [MEDLINE: 561].
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van Gerven 1992 {published data only} van Gerven JM, Lemkes HH, van Dijk JG. Long-term effects of tolrestat on symptomatic diabetic sensory polyneuropathy. Journal of Diabetes and its Complications 1992;6(1):45-8. [MEDLINE: 566].
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van Gerven 1993 * {published data only} van Gerven JM. Further clinical studies with an aldose reductase inhibitor in diabetic neuropathy. Diabetic Medicine 1993;10(Suppl):38S. [MEDLINE: 567].
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Ziegler 1991 {published data only} Ziegler D, Mayer P, Rathmann W, Gries FA. One-year treatment with the aldose reductase inhibitor, ponalrestat, in diabetic neuropathy. Diabetes Research and Clinical Practice 1991;14(1):63-73. [MEDLINE: 22].
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Bertelsmann 1991 Bertelsmann FW, Faes ThJC, de Weerdt O, Yff GA, Heimans JJ, Lanting P. Treatment of diabetic autonomic neuropathy with the aldose reductase inhibitor statil. Diabetologia 1991;34(Suppl 2):A37. [MEDLINE: 12].
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Bril 2006 Bril V, Buchanan RA. Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy. Diabetes Care 2006;29(1):68-72.
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Canal 1984 Canal N, Comi G, Marchettini P, Pozza G. Effects of cyclandelate on diabetic peripheral neuropathy. British Journal of Clinical Practice. Supplement 1984;34:62-8. [MEDLINE: 17].
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