Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor γ (PPARγ). Differential activity of PPARγ1 and -2 isoforms and influence of insulin

Journal of Biological Chemistry

Volumn 272, Issue 32, 1997, Pages 20230-20235

  Werman, Ariel ^a   Hollenberg, Anthony ^a   Solanes, Gemma ^a   Bjørbæk, Christian ^a   Vidal Puig, Antonio J ^a   Flier, Jeffrey S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CELL NUCLEUS RECEPTOR; HORMONE RECEPTOR; INSULIN; LIGAND; LUCIFERASE; PEROXISOME PROLIFERATOR; PROSTAGLANDIN J2;

ADIPOCYTE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; GENETIC TRANSCRIPTION; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; TRANSACTIVATION;

ADIPOCYTES; ANIMALS; DNA; DNA-BINDING PROTEINS; INSULIN; LIGANDS; MALE; MICROBODIES; NUCLEAR PROTEINS; PROSTAGLANDIN D2; PROSTAGLANDINS, SYNTHETIC; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0030877565     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.32.20230     Document Type: Article

References (36)

1. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Cell 79, 1147-1156
2. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1995) Curr. Opin. Genet. Dev. 5, 571-576
3. Brun, R. P., Tontonoz, P, Forman, B. B., Ellis, R., Chen, J., Evans, R. M., and Spiegelman, B. M. (1996) Genes & Dev. 10, 974-984
4. Chawla, A., Schwartz, E. J., Dimaculangan, D. D., and Lazar, M. A. (1994) Endocrinology 135, 798-800
5. Hu, E., Tontonoz, P., and Spiegelman, B. M. (1995) Proc. Natl. Acad. Sci U. S. A. 92, 9856-9860
6. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Cell 79, 1147-1156
7. Forman, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., and Evans, R. M. (1995) Cell 83, 803-812
8. Kliewer, S., Lenhard, J., Willson, T., Patel, I., Morris, D., and Lehmmann, J. (1995) Cell 83, 813-819
9. Tontonoz, P, Hu, E., Graves, R., Budavari, A., and Spiegelman, B. M. (1994) Genes & Dev. 8, 1224-1234
10. Tontonoz, P., Hu, E., Devine, J., Beale, E. G., and Spiegelman, B. M. (1995) Mol. Cell Biol. 15, 351-357
11. Sears, I., MacGinnitie, M, Kovacs, L., and Graves, R. (1996) Mol. Cell. Biol. 16, 3410-3419
12. Zhu, Y., Qi, C., Korenberg, J. R., Chen, X. N., Noya, D, Rao, M. S., and Reddy, J. K. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7921-7925
13. Vidal-Puig A., Jimenez-Lian, M., Lowell, B. B., Hamann, A., Hu, E., Spiegelman, B. M., Flier, J. S., and Moller, D. E. (1996) J. Clin. Invest. 97, 2553-2561
14. Mukherjee, R., Jow, L., Croston, G. E., and Paterniti, J. R., Jr. (1997) J. Biol. Chem. 272, 8071-8076
15. Vidal-Puig, P., Considine, R., Jimenez-Linan, M., Werman, A., Pories, W. J., Caro, J. F, and Flier J. S. (1997) J. Clin. Invest. 99, 2416-2422
16. Hollenberg, A. N., Susulic, V. S., Madura, J. P., Zhang, B., Moller, D. E., Tontonoz, P., Sarraf, P., Spiegelman, B. M., and Lowell, B. B. (1997) J. Biol. Chem. 272, 5283-5290
17. Moghal, N., and Neel, B. G. (1995) Mol. Cell. Biol. 15, 3945-3959
18. Rodbell, M. (1964) J Biol. Chem. 239, 375-380
19. Quon, M. J., Zarnowski, M. J., Guerre-Millo, M., de la Luz Sierra, M., Taylor, S. I., and Cushman, S. W. (1993) Biochem. Biophys. Res. Commun. 194, 338-346
20. Markham, B. E., Tsika, R. W., Bahl, J. J., Anderson, P. G., and Morkin, E. (1990) J. Biol. Chem. 265, 6489-6493
21. Laemmli, U. K. (1970) Nature 227, 680-685
22. Towbin, H., Staehlin, T., and Gordon, J. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 4350-4354
23. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K, Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) Cell 83, 835-839
24. Mangelsdorf, D., and Evans, R. M. (1995) Cell 83, 841-850
25. O'Malley, B. W., Schrader, W. T., Mani, S., Smith, C., Weigel, N. L., Conneely, O. M., and Clark, J. H. (1995) Rec. Prog. Horm. Res. 50, 333-347
26. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., Metzger, D., and Chambon, P. (1995) Science 270, 1491-1494
27. Tora, L., White, J., Brou, C., Tassat, D., Webster, N., Scheer, E., and Chambon, P. (1989) Cell 59, 477-487
28. Dicken, E. S., and Miesfeld, R. L. (1992) Mol. Cell. Biol. 12, 589-597
29. Helmberg, A., Auphan, N., Caelles, C., and Karin, M. (1995) EMBO J. 14, 452-460.
30. Hsieh, J. C., Jurutka, P. W., Galligan, M. A., Terpening, C. M., Haussler, C. A., Samuels, D. S., Shimizu, Y., Shimizu, N., and Haussler, M. R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9315-9319
31. Shalev, A., Siegrist-Kaiser, C., Yen, P., Wahli, W., Burger, A., Chin, W., and Meier, C. (1996) Endocrinology 137, 4499-4502
32. Zhang, B., Berger, J., Zhou, G., Elbrecht, A., Biswas, S., White-Carrington, S., Szalkowski, D., and Moller, D. E. (1996) J. Biol. Chem. 271, 31771-31774
33. Hu, E., Kim, J. B., Sarraf, P., and Spiegelman, B. M. (1996) Science 274, 2100-2103
34. Adams, M., Reginato, M. J., Shao, D., Lazar, M. A., and Chatterjee, V. K. (1997) J. Biol. Chem. 272, 5128-5132
35. Guller, S., Corin, K. E., Mynarcik, D. C., London, B. M., and Sonenberg, M. (1988) Endocrinology 122, 2084-2089
36. Lowell, B. B., and Flier, J. S. (1990) Endocrinology 127, 2898-2906