Peroxisome proliferator-activated receptor gene expression in human tissues: Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2416-2422

  Vidal Puig, Antonio J ^a,d   Considine, Robert V ^b   Jimenez Liñan, Mercedes ^a   Werman, Ariel ^a   Pories, Walter J ^c   Caro, Jose F ^b   Flier, Jeffrey S ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

gene regulation; hormones; nutrition; obesity; PPAR

Indexed keywords

GLUCOCORTICOID; INSULIN; PEROXISOME PROLIFERATOR; RECEPTOR PROTEIN; THIAZOLIDINE DERIVATIVE;

ADIPOCYTE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; LOW CALORY DIET; MALE; MOLECULAR CLONING; OBESITY; PRIORITY JOURNAL; RECEPTOR UPREGULATION; WEIGHT REDUCTION;

EID: 0030977450     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119424     Document Type: Article

References (44)

1. Flier, J.S. 1995. The adipocyte: storage depot or node on the energy information superhighway. Cell. 80:15-18.
2. Drenick, E.J., G.S. Bale, and F.E.A. Seltzer. 1980. Excessive mortality and causes of death in morbidly obese men. J. Am. Med. Assoc. 243:443-445.
3. Lin, F.T., and M.D. Lane. 1994. CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acad. Sci. USA. 91:8757-8761.
4. Tontonoz, P., E. Hu, and B.M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid activated transcription factor. Cell. 79:1147-1156.
5. Tontonoz, P., E. Hu, R. Graves, A. Budavari, and B. Spiegelman. 1994. mPPARgamma 2: tissue-specific regulator of an adipocyte enhancer. Genes & Dev. 8:1224-1234.
6. Kim, J., and B. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes & Dev. 10:1096-1107.
7. MacDougald, O.A., and M.D. Lane. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64:345-373.
8. Tontonoz. P., R. Graves, A. Budavari, H. Erdjument-Bromage, M. Lui, E. Hu, P. Temps, and B. Spiegelman. 1994. Adipocyte-specific transcription factor ARF 6 is a heterodimeric complex of two nuclear hormone receptors, PPARγ and RXR α. Nucleic Acids Res. 22:5628-5634.
9. Tontonoz, P., E. Hu, J. Devine, E. Beale, and B. Spiegelman. 1995. PPARγ2 regulates adipose expression of the phospoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15:351-357.
10. Sears, I., M. MacGinnitie, L. Kovacs, and R. Graves. 1996. Differentiation-dependent expression of brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-aclivaled receptor gamma. Mol. Cell. Biol. 16:3410-3419.
11. Hu, E., P. Tontonoz, and B.M. Spiegelman. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα. Proc. Natl. Acad. Sci. USA. 92:9856-9860.
12. Brun, R.P., P. Tontonoz, B.M. Forman, R. Ellis, J. Chen, R.M. Evans, and B.M. Spiegelman. 1996. Differential activation of adipogenesis by multiple PPAR isoforms. Genes & Dev. 10:974-984.
13. Greene, M., B. Blumberg, O. McBride, H. Yi, K. Kronquist, K. Kwan, L. Hsieh, G. Greene, and S. Nimer. 1995. Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr. 4:281-299.
14. Elbrecht, A., Y. Chen, C. Cullinan, N. Hayes, M.D. Leibowitz, D. Moller, and J. Berger. 1996. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem. Biophys. Res. Commun. 224:431-437.
15. Zhu, Y., C. Qi, J.R. Korenberg, X.N. Chen, D. Noya, M. Sambasiva Rao, and J.K. Reddy. 1995. Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPAR γ) gene: Alternative promoter use and different splicing yield two mPPAR γ isoforms. Proc. Natl. Acad. Sci. USA. 92:7921-7925.
16. Kliewer, S., J. Lenhard, T. Willson, I. Patel, D. Morris, and J. Lehmmann. 1995. A prostaglandin J2 metabolite binds peroxisome proliferator activated receptor γ and promotes adipocyte differentiation. Cell. 83:813-819.
17. Forman, B., P. Tontonoz, J. Chen, R. Brun, B. Spiegelman, and R. Evans. 1995. 15-deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 83:803-812.
18. Yu, K., W. Bayona, C.B. Kallen, H.H. Harding, C.P. Ravera, G. McMahon, M. Brown, and M.A. Lazar. 1995. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J. Biol. Chem. 270:23975-23983.
19. Nolan, J., B. Ludvik, P. Beerdesen, M. Joyce, and J. Olefsky. 1994. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331:1188-1193.
20. Spiegelman, B., and J. Flier. 1996. Adipogenesis and obesity: rounding out the big picture. Cell. 87:377-389.
21. NIH Technology Assessment Conference Panel. 1992. Methods for voluntary weight loss and control. Ann. Intern. Med. 116:942-949.
22. Kolaczynski, J.W., L.M. Morales, J.H. Moore, R.V. Considine, Z. Pietrzkowski, P.F. Noto, J. Colberg, and J.F. Caro. 1994. A new technique for biopsy of human abdominal fat under local anaesthesia with lidocaine. Int. J. Obesity. 18:161-166.
23. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
24. Considine, R.V., M.R. Nyce, L.M. Morales, S.A. Magosin, T.L. Bauer, E.L. Rosato, J. Colberg, and J.F. Caro. 1996. Paracrine stimulation of preadipocyte-enriched cell cultures by mature adipocytes. Am. J. Physiol. 270:E895-E899.
25. Baxa, C., R. Sha, M. Buelt, A. Smith, V. Matarese, L. Chinader, K. Boundy, and D. Bernlohr. 1989. Human adipocyte lipid binding protein: purification of the protein and cloning of its complementary DNA. Biochemistry. 28: 8683-8690.
26. Jakubowski, M., and J.L. Roberts. 1992. Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J. Neuroendocrinol. 4:79-89.
27. Jakubowski, M. 1995. Receptor mRNA Measurements by Multiplex Nuclease Protection Assay. In Methods in Neurosciences. Vol. 25. Academic Press, Inc., San Diego, CA. 470-491.
28. Vidal-Puig, A., M. Jimenez-Liñan, B.B. Lowell, A. Hamann, E. Hu, B.S. Spiegelman, J.S. Flier, and D.E. Moller. 1996. Regulation of PPAR γ gene expression by nutrition and obesity in rodents. J. Clin. Invest. 97:2553-2561.
29. Tyler White, R., D. Damm, D. Hanckock, B. Rosen, B. Lowell, P. Usher, J. Flier, and B. Spiegelman. 1992. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J. Biol. Chem. 267:9210-9213.
30. Hunt, C.R., J.H.S. Ro, D.E. Dobson, H.Y. Min, and B. Spiegelman. 1986. Adipocyte P2 gene developmental expression and homology of 5′-flanking sequences among fat cell-specific genes. Proc. Natl. Acad. Sci. USA. 83: 3786-3790.
31. Vidal-Puig, A., C. Mantzoros, M. Jimenez-Liñan, D.E. Moller, and J.S. Flier. 1996. PPAR γ isoforms and leptin are regulated in parallel in the insulin deficient streptozotocin (STZ) model. In 10th International Congress of Endocrinology, San Francisco. P-2.6. p. 406.
32. Braissant, O., F. Foufelle, C. Scotto, M. Dauca, and W. Wahli. 1996. Differential expression of peroxisome proliferator activated receptors (PPARs); tissue distribution of PPAR α, β, and γ in adult rat. Endocrinology. 137:354-366.
33. Kliewer, S., B. Forman, B. Blumberg, E. Ong, U. Borgmeyer, D. Mangelsdorf, K. Umesomo, and R. Evans. 1994. Differential expression and activation of a family of murine peroxisome proliferator activated receptor. Proc. Natl. Acad. Sci. USA. 91:7355-7359.
34. Chawla, A., E. Schwarz, D. Dimaculangan, and M. Lazar. 1994. Peroxisome proliferator activated receptor (PPAR) γ: adipose predominant expression and induction early in adipocyte differentiation. Endocrinology. 135:798-800.
35. Ibrahimi, A., L. Teboul, D. Gaillard, E. Amri, G. Ailhaud, P. Young, M. Cawthorne, and P. Grimaldi. 1994. Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells. Mol. Pharmacol. 46:1070-1076.
36. Lehmann, J.M., L.B. Moore, T.A. Smith-Oliver, W.O. Wilkinson, T.M. Willson, and S.A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma. J. Biol. Chem. 270:12953-12956.
37. Zhang, B., J. Berger, E. Hu, D. Szalkowski, S. White-Carrington, B. Spiegelman, and D. Moller. 1996. Negative regulation of peroxisome proliferator activated receptor γ gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α. Mol. Endocrinol. 10:1457-1466.
38. Tontonoz, P., S. Singer, B.M. Forman, P. Sarraf, J.A. Fletcher, C.D.M. Fletcher, R.P. Brun, E. Mueller, S. Altiok, H. Oppenheim, et al. 1997. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc. Natl. Acad. Sci. USA. 94:237-241.
39. Berger, J., P. Bailey, C. Biswas, C. Cullinan, T. Doebber, N. Hayes, R. Saperstein, R. Smith, and M. Leibowitz. 1996. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor γ: binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology. 137:4189-4195.
40. Tominaga, M., M. Igarashi, M. Daimon, H. Eguchi, and M. Matsumoto. 1993. Thiazolidinediones improve hepatic insulin resistance in streplozotocin-induced diabetic rats. Endocr. J. 40:343-349.
41. Weistein, S.P., A. Holand, E. O'Boyle, and R.S. Haber. 1993. Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT-4 glucose transporter expression in rat skeletal muscle. Metab. Clin. Exp. 42: 1365-1369.
42. Hotamisligil, G.S., N.S. Shargill, and B.M. Spiegelman. 1993. Adipose tissue expression of tumor necrosis factor alpha: direct role in obesity-linked insulin resistance. Science (Wash. DC). 259:87-90.
43. Spiegelman, B.M., and G.S. Hotamisligil. 1993. Through thick and thin: wasting, obesity, and TNF α. Cell. 73:625-627.
44. Orth, D., W. Kovacs, and C. De Bold. 1992. The adrenal cortex. In Williams Textbook of Endocrinology. 8th edition. J.D. Wilson and D.W. Foster, editors. W.B. Saunders Co., Philadelphia, 489-620.