메뉴 건너뛰기




Volumn 77 1, Issue , 2010, Pages 237-306

Xenobiotic efflux in bacteria and fungi: A genomics update

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CARRIER PROTEIN; XENOBIOTIC AGENT;

EID: 79960959945     PISSN: 0065258X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article
Times cited : (13)

References (321)
  • 1
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach, M. A., and Walsh, C. T. (2009) Antibiotics for emerging pathogens, Science 325, 1089-1093.
    • (2009) Science , vol.325 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 2
    • 0345515642 scopus 로고
    • Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli
    • McMurry, L., Petrucci, R., and Levy, S. (1980) Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli, Proc. Natl. Acad. Sci. USA 77, 3974-3977.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 3974-3977
    • McMurry, L.1    Petrucci, R.2    Levy, S.3
  • 3
    • 0242291983 scopus 로고    scopus 로고
    • Multidrug efflux pumps and resistance: regulation and evolution
    • Paulsen, I. T. (2003) Multidrug efflux pumps and resistance: regulation and evolution, Curr. Opin. Microbiol. 6, 446-451.
    • (2003) Curr. Opin. Microbiol , vol.6 , pp. 446-451
    • Paulsen, I.T.1
  • 4
    • 0033207021 scopus 로고    scopus 로고
    • Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin
    • Alonso, A., Rojo, F., and Martínez, J. L. (1999) Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin, Environ. Microbiol. 1, 421-430.
    • (1999) Environ. Microbiol. , vol.1 , pp. 421-430
    • Alonso, A.1    Rojo, F.2    Martínez, J.L.3
  • 8
    • 0032949426 scopus 로고    scopus 로고
    • The multidrug efflux protein NorM is a prototype of a new family of transporters
    • Brown, M. H., Paulsen, I. T., and Skurray, R. A. (1999) The multidrug efflux protein NorM is a prototype of a new family of transporters, Mol. Microbiol. 31, 394-395.
    • (1999) Mol. Microbiol , vol.31 , pp. 394-395
    • Brown, M.H.1    Paulsen, I.T.2    Skurray, R.A.3
  • 9
    • 0037337313 scopus 로고    scopus 로고
    • The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
    • Hvorup, R. N., Winnen, B., Chang, A. B., Jiang, Y., Zhou, X. F., and Saier, M. H., Jr. (2003) The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily, Eur. J. Biochem. 270, 799-813.
    • (2003) Eur. J. Biochem , vol.270 , pp. 799-813
    • Hvorup, R.N.1    Winnen, B.2    Chang, A.B.3    Jiang, Y.4    Zhou, X.F.5    Saier Jr., M.H.6
  • 10
    • 0027507306 scopus 로고
    • A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
    • Marger, M. D., and Saier, M. H., Jr. (1993) A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport, Trends Biochem. Sci. 18, 13-20.
    • (1993) Trends Biochem. Sci , vol.18 , pp. 13-20
    • Marger, M.D.1    Saier Jr., M.H.2
  • 11
    • 0028365952 scopus 로고
    • Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport
    • Saier, M. H., Jr., Tam, R., Reizer, A., and Reizer, J. (1994) Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport, Mol. Microbiol. 11, 841-847.
    • (1994) Mol. Microbiol , vol.11 , pp. 841-847
    • Saier Jr., M.H.1    Tam, R.2    Reizer, A.3    Reizer, J.4
  • 12
    • 34548724460 scopus 로고    scopus 로고
    • Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria
    • Lubelski, J., Konings, W. N., and Driessen, A. J. (2007) Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria, Microbiol. Mol. Biol. Rev. 71, 463-476.
    • (2007) Microbiol. Mol. Biol. Rev , vol.71 , pp. 463-476
    • Lubelski, J.1    Konings, W.N.2    Driessen, A.J.3
  • 14
    • 0343603660 scopus 로고    scopus 로고
    • A functional-phylogenetic classification system for transmembrane solute transporters
    • Saier, M. H., Jr. (2000) A functional-phylogenetic classification system for transmembrane solute transporters, Microbiol. Mol. Biol. Rev. 64, 354-411.
    • (2000) Microbiol. Mol. Biol. Rev , vol.64 , pp. 354-411
    • Saier Jr., M.H.1
  • 16
    • 0029845047 scopus 로고    scopus 로고
    • Proton-dependent multidrug efflux systems
    • Paulsen, I. T., Brown, M. H., and Skurray, R. A. (1996) Proton-dependent multidrug efflux systems, Microbiol. Rev. 60, 575-608.
    • (1996) Microbiol. Rev , vol.60 , pp. 575-608
    • Paulsen, I.T.1    Brown, M.H.2    Skurray, R.A.3
  • 18
    • 0442307441 scopus 로고    scopus 로고
    • Efflux-mediated drug resistance in bacteria
    • Li, X. Z., and Nikaido, H. (2004) Efflux-mediated drug resistance in bacteria, Drugs 64, 159-204.
    • (2004) Drugs , vol.64 , pp. 159-204
    • Li, X.Z.1    Nikaido, H.2
  • 19
    • 0034445202 scopus 로고    scopus 로고
    • Molecular properties of bacterial multidrug transporters
    • Putman, M., van Veen, H. W., and Konings, W. N. (2000) Molecular properties of bacterial multidrug transporters, Microbiol. Mol. Biol. Rev. 64, 672-693.
    • (2000) Microbiol. Mol. Biol. Rev , vol.64 , pp. 672-693
    • Putman, M.1    van Veen, H.W.2    Konings, W.N.3
  • 21
    • 0037648419 scopus 로고    scopus 로고
    • Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy
    • Van Bambeke, F., Glupczynski, Y., Plé, P., Pechere, J. C., and Tulkens, P. M. (2003) Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy, J. Antimicrob. Chemother. 51, 1055-1065.
    • (2003) J. Antimicrob. Chemother , vol.51 , pp. 1055-1065
    • Van Bambeke, F.1    Glupczynski, Y.2    Plésiat, P.3    Pechere, J.C.4    Tulkens, P.M.5
  • 22
    • 33644552115 scopus 로고    scopus 로고
    • Efflux systems in bacterial pathogens: an opportunity for therapeutic intervention? An industry view
    • Lynch, A. S. (2006) Efflux systems in bacterial pathogens: an opportunity for therapeutic intervention? An industry view, Biochem. Pharmacol. 71, 949-956.
    • (2006) Biochem. Pharmacol , vol.71 , pp. 949-956
    • Lynch, A.S.1
  • 23
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen, C. J., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells, Cell 47, 381-389.
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3    Clark, D.P.4    Pastan, I.5    Gottesman, M.M.6    Roninson, I.B.7
  • 28
    • 27644571508 scopus 로고    scopus 로고
    • Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents
    • Robertson, G. T., Doyle, T. B., and Lynch, A. S. (2005) Use of an efflux-deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic resistance to antimicrobial agents, Antimicrob. Agents Chemother. 49, 4781-4783.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 4781-4783
    • Robertson, G.T.1    Doyle, T.B.2    Lynch, A.S.3
  • 29
    • 33646251815 scopus 로고    scopus 로고
    • Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria
    • Piddock, L. J. (2006) Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria, Clin. Microbiol. Rev. 19, 382-402.
    • (2006) Clin. Microbiol. Rev , vol.19 , pp. 382-402
    • Piddock, L.J.1
  • 30
    • 0034212332 scopus 로고    scopus 로고
    • The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism
    • van Veen, H.W.,Margolles, A., Muller,M., Higgins, C. F., and Konings,W. N. (2000) The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism, EMBO J. 19, 2503-2514.
    • (2000) EMBO J , vol.19 , pp. 2503-2514
    • van Veen, H.W.1    Margolles, A.2    Muller, M.3    Higgins, C.F.4    Konings, W.N.5
  • 31
    • 0030971840 scopus 로고    scopus 로고
    • Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis
    • Rosenberg, M. F., Callaghan, R., Ford, R. C., and Higgins, C. F. (1997) Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis, J. Biol. Chem. 272, 10685-10694.
    • (1997) J. Biol. Chem , vol.272 , pp. 10685-10694
    • Rosenberg, M.F.1    Callaghan, R.2    Ford, R.C.3    Higgins, C.F.4
  • 32
    • 0035088361 scopus 로고    scopus 로고
    • Molecular basis of multidrug transport by ATP-binding cassette transporters: a proposed two-cylinder engine model
    • van Veen, H.W., Higgins, C. F., and Konings,W. N. (2001) Molecular basis of multidrug transport by ATP-binding cassette transporters: a proposed two-cylinder engine model, J. Mol. Microbiol. Biotechnol. 3, 185-192.
    • (2001) J. Mol. Microbiol. Biotechnol , vol.3 , pp. 185-192
    • van Veen, H.W.1    Higgins, C.F.2    Konings, W.N.3
  • 33
    • 70349333637 scopus 로고    scopus 로고
    • The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter
    • Procko, E., O'Mara, M. L., Bennett, W. F., Tieleman, D. P., and Gaudet, R. (2009) The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter, FASEB J. 23, 1287-1302.
    • (2009) FASEB J , vol.23 , pp. 1287-1302
    • Procko, E.1    O'Mara, M.L.2    Bennett, W.F.3    Tieleman, D.P.4    Gaudet, R.5
  • 34
    • 0042430540 scopus 로고    scopus 로고
    • Multidrug-exporting secondary transporters
    • Murakami, S., and Yamaguchi, A. (2003) Multidrug-exporting secondary transporters, Curr. Opin. Struct. Biol. 13, 443-452.
    • (2003) Curr. Opin. Struct. Biol , vol.13 , pp. 443-452
    • Murakami, S.1    Yamaguchi, A.2
  • 36
    • 0034040493 scopus 로고    scopus 로고
    • Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals
    • Schmitz, F. J., Sadurski, R., Kray, A., Boos, M., Geisel, R., Kohrer, K., Verhoef, J., and Fluit, A. C. (2000) Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals, J. Antimicrob. Chemother. 45, 891-894.
    • (2000) J. Antimicrob. Chemother , vol.45 , pp. 891-894
    • Schmitz, F.J.1    Sadurski, R.2    Kray, A.3    Boos, M.4    Geisel, R.5    Kohrer, K.6    Verhoef, J.7    Fluit, A.C.8
  • 39
    • 3843101620 scopus 로고    scopus 로고
    • Characterization and prevalence of MefA, MefE, and the associated msr(D) gene in Streptococcus pneumoniae clinical isolates
    • Daly, M. M., Doktor, S., Flamm, R., and Shortridge, D. (2004) Characterization and prevalence of MefA, MefE, and the associated msr(D) gene in Streptococcus pneumoniae clinical isolates, J. Clin. Microbiol. 42, 3570-3574.
    • (2004) J. Clin. Microbiol , vol.42 , pp. 3570-3574
    • Daly, M.M.1    Doktor, S.2    Flamm, R.3    Shortridge, D.4
  • 40
    • 0042835378 scopus 로고    scopus 로고
    • Msr(A) and relatedmacrolide/streptogramin resistance determinants: incomplete transporters? Int
    • Reynolds, E.,Ross, J. I., and Cove, J.H. (2003)Msr(A) and relatedmacrolide/streptogramin resistance determinants: incomplete transporters? Int. J. Antimicrob. Agents 22, 228-236.
    • (2003) J. Antimicrob. Agents , vol.22 , pp. 228-236
    • Reynolds, E.1    Ross, J.I.2    Cove, J.H.3
  • 41
    • 0037636475 scopus 로고    scopus 로고
    • Nonsense mutations in the lsa-like gene in Enterococcus faecalis isolates susceptible to lincosamides and streptogramins A
    • Dina, J., Malbruny, B., and Leclercq, R. (2003) Nonsense mutations in the lsa-like gene in Enterococcus faecalis isolates susceptible to lincosamides and streptogramins A, Antimicrob. Agents Chemother. 47, 2307-2309.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 2307-2309
    • Dina, J.1    Malbruny, B.2    Leclercq, R.3
  • 43
    • 8844239120 scopus 로고    scopus 로고
    • Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri
    • Kehrenberg, C., Ojo, K. K., and Schwarz, S. (2004) Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri, J. Antimicrob. Chemother. 54, 936-939.
    • (2004) J. Antimicrob. Chemother , vol.54 , pp. 936-939
    • Kehrenberg, C.1    Ojo, K.K.2    Schwarz, S.3
  • 44
    • 0034806355 scopus 로고    scopus 로고
    • Novel macrolide-specific ABC-type efflux transporter in Escherichia coli
    • Kobayashi, N., Nishino, K., and Yamaguchi, A. (2001) Novel macrolide-specific ABC-type efflux transporter in Escherichia coli, J. Bacteriol. 183, 5639-5644.
    • (2001) J. Bacteriol , vol.183 , pp. 5639-5644
    • Kobayashi, N.1    Nishino, K.2    Yamaguchi, A.3
  • 45
    • 0037055994 scopus 로고    scopus 로고
    • Multidrug transporters and antibiotic resistance in Lactococcus lactis
    • Poelarends, G. J., Mazurkiewicz, P., and Konings, W. N. (2002) Multidrug transporters and antibiotic resistance in Lactococcus lactis, Biochim. Biophys. Acta 1555, 1-7.
    • (2002) Biochim. Biophys. Acta , vol.1555 , pp. 1-7
    • Poelarends, G.J.1    Mazurkiewicz, P.2    Konings, W.N.3
  • 46
    • 0041767580 scopus 로고    scopus 로고
    • Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio cholerae
    • Huda, N., Lee, E. W., Chen, J., Morita, Y., Kuroda, T., Mizushima, T., and Tsuchiya, T. (2003) Molecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio cholerae, Antimicrob. Agents Chemother. 47, 2413-2417.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 2413-2417
    • Huda, N.1    Lee, E.W.2    Chen, J.3    Morita, Y.4    Kuroda, T.5    Mizushima, T.6    Tsuchiya, T.7
  • 48
    • 11244270751 scopus 로고    scopus 로고
    • Increased expression of two multidrug transporter-like genes is associated with ethidium bromide and ciprofloxacin resistance in Mycoplasma hominis
    • Raherison, S., Gonzalez, P., Renaudin, H., Charron, A., Bebear, C., and Bebear, C. M. (2005) Increased expression of two multidrug transporter-like genes is associated with ethidium bromide and ciprofloxacin resistance in Mycoplasma hominis, Antimicrob. Agents Chemother. 49, 421-424.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 421-424
    • Raherison, S.1    Gonzalez, P.2    Renaudin, H.3    Charron, A.4    Bebear, C.5    Bebear, C.M.6
  • 49
    • 0034677201 scopus 로고    scopus 로고
    • A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE
    • Muth, T. R., and Schuldiner, S. (2000) A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE, EMBO J. 19, 234-240.
    • (2000) EMBO J , vol.19 , pp. 234-240
    • Muth, T.R.1    Schuldiner, S.2
  • 50
    • 0037507278 scopus 로고    scopus 로고
    • An amino acid cluster around the essential Glu-14 is part of the substrate- and proton-binding domain of EmrE, a multidrug transporter from Escherichia coli
    • Gutman, N., Steiner-Mordoch, S., and Schuldiner, S. (2003) An amino acid cluster around the essential Glu-14 is part of the substrate- and proton-binding domain of EmrE, a multidrug transporter from Escherichia coli, J. Biol. Chem. 278, 16082-16087.
    • (2003) J. Biol. Chem , vol.278 , pp. 16082-16087
    • Gutman, N.1    Steiner-Mordoch, S.2    Schuldiner, S.3
  • 51
    • 0038521734 scopus 로고    scopus 로고
    • Structure of the substrate binding pocket of the multidrug transporter EmrE: site-directed spin labeling of transmembrane segment 1
    • Koteiche, H. A., Reeves, M. D., and McHaourab, H. S. (2003) Structure of the substrate binding pocket of the multidrug transporter EmrE: site-directed spin labeling of transmembrane segment 1, Biochemistry 42, 6099-6105.
    • (2003) Biochemistry , vol.42 , pp. 6099-6105
    • Koteiche, H.A.1    Reeves, M.D.2    McHaourab, H.S.3
  • 53
    • 0037126033 scopus 로고    scopus 로고
    • Crosslinking of membraneembedded cysteines reveals contact points in the EmrE oligomer
    • Soskine, M., Steiner-Mordoch, S., and Schuldiner, S. (2002) Crosslinking of membraneembedded cysteines reveals contact points in the EmrE oligomer, Proc. Natl. Acad. Sci. USA 99, 12043-12048.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12043-12048
    • Soskine, M.1    Steiner-Mordoch, S.2    Schuldiner, S.3
  • 54
    • 0028206518 scopus 로고
    • Multidrug resistance to antiseptics and disinfectants in coagulase-negative. staphylococci
    • Leelaporn, A., Paulsen, I. T., Tennent, J. M., Littlejohn, T. G., and Skurray, R. A. (1994) Multidrug resistance to antiseptics and disinfectants in coagulase-negative. staphylococci, J. Med. Microbiol. 40, 214-220.
    • (1994) J. Med. Microbiol , vol.40 , pp. 214-220
    • Leelaporn, A.1    Paulsen, I.T.2    Tennent, J.M.3    Littlejohn, T.G.4    Skurray, R.A.5
  • 55
    • 0026553163 scopus 로고
    • A staphylococcal multidrug resistance gene product is a member of a new protein family
    • Grinius, L., Dreguniene, G., Goldberg, E. B., Liao, C. H., and Projan, S. J. (1992) A staphylococcal multidrug resistance gene product is a member of a new protein family, Plasmid 27, 119-129.
    • (1992) Plasmid , vol.27 , pp. 119-129
    • Grinius, L.1    Dreguniene, G.2    Goldberg, E.B.3    Liao, C.H.4    Projan, S.J.5
  • 57
    • 0028314541 scopus 로고
    • Multidrug resistance pumps in bacteria: variations on a theme
    • Lewis, K. (1994) Multidrug resistance pumps in bacteria: variations on a theme, Trends Biochem. Sci. 19, 119-123.
    • (1994) Trends Biochem. Sci , vol.19 , pp. 119-123
    • Lewis, K.1
  • 59
    • 0035930531 scopus 로고    scopus 로고
    • Functional analysis of novel multidrug transporters from human pathogens
    • Ninio, S., Rotem, D., and Schuldiner, S. (2001) Functional analysis of novel multidrug transporters from human pathogens, J. Biol. Chem. 276, 48250-48256.
    • (2001) J. Biol. Chem , vol.276 , pp. 48250-48256
    • Ninio, S.1    Rotem, D.2    Schuldiner, S.3
  • 60
    • 0035930510 scopus 로고    scopus 로고
    • In vitro monomer swapping in EmrE, a multidrug transporter from Escherichia coli, reveals that the oligomer is the functional unit
    • Rotem, D., Sal-man, N., and Schuldiner, S. (2001) In vitro monomer swapping in EmrE, a multidrug transporter from Escherichia coli, reveals that the oligomer is the functional unit, J. Biol. Chem. 276, 48243-48249.
    • (2001) J. Biol. Chem , vol.276 , pp. 48243-48249
    • Rotem, D.1    Sal-man, N.2    Schuldiner, S.3
  • 61
    • 10344220028 scopus 로고    scopus 로고
    • EmrE, a multidrug transporter from Escherichia coli, and transports monovalent and divalent substrates with the same stoichiometry
    • Rotem, D., and Schuldiner, S. (2004) EmrE, a multidrug transporter from Escherichia coli, and transports monovalent and divalent substrates with the same stoichiometry, J. Biol. Chem. 279, 48787-48793.
    • (2004) J. Biol. Chem , vol.279 , pp. 48787-48793
    • Rotem, D.1    Schuldiner, S.2
  • 62
    • 3042585064 scopus 로고    scopus 로고
    • Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis
    • Li,X. Z., Zhang, L., andNikaido,H. (2004) Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis, Antimicrob. Agents Chemother. 48, 2415-2423.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 2415-2423
    • Li, X.Z.1    Zhang, L.2    Nikaido, H.3
  • 64
    • 0034087478 scopus 로고    scopus 로고
    • A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins
    • Jack, D. L., Storms, M. L., Tchieu, J. H., Paulsen, I. T., and Saier, M. H., Jr. (2000) A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins, J. Bacteriol. 182, 2311-2313.
    • (2000) J. Bacteriol , vol.182 , pp. 2311-2313
    • Jack, D.L.1    Storms, M.L.2    Tchieu, J.H.3    Paulsen, I.T.4    Saier Jr., M.H.5
  • 65
    • 12244293832 scopus 로고    scopus 로고
    • Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes
    • Li, X. Z., Poole, K., and Nikaido, H. (2003) Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes, Antimicrob. Agents Chemother. 47, 27-33.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 27-33
    • Li, X.Z.1    Poole, K.2    Nikaido, H.3
  • 66
    • 0033621673 scopus 로고    scopus 로고
    • Association of qacE and qacEDelta1 with multiple resistance to antibiotics and antiseptics in clinical isolates of gram-negative bacteria FEMS
    • Kucken, D., Feucht, H., and Kaulfers, P. (2000) Association of qacE and qacEDelta1 with multiple resistance to antibiotics and antiseptics in clinical isolates of gram-negative bacteria, FEMS Microbiol. Lett. 183, 95-98.
    • (2000) Microbiol. Lett , vol.183 , pp. 95-98
    • Kucken, D.1    Feucht, H.2    Kaulfers, P.3
  • 67
    • 33749988040 scopus 로고    scopus 로고
    • The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations
    • Omote, H., Hiasa, M., Matsumoto, T., Otsuka, M., and Moriyama, Y. (2006) The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations, Trends Pharmacol. Sci. 27, 587-593.
    • (2006) Trends Pharmacol. Sci , vol.27 , pp. 587-593
    • Omote, H.1    Hiasa, M.2    Matsumoto, T.3    Otsuka, M.4    Moriyama, Y.5
  • 68
  • 69
    • 64649085938 scopus 로고    scopus 로고
    • Multidrug efflux transporters in the MATE family
    • Kuroda, T., and Tsuchiya, T. (2009) Multidrug efflux transporters in the MATE family, Biochim. Biophys. Acta 1794, 763-768.
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 763-768
    • Kuroda, T.1    Tsuchiya, T.2
  • 71
    • 18244403495 scopus 로고    scopus 로고
    • A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline
    • McAleese, F., Petersen, P., Ruzin, A., Dunman, P. M., Murphy, E., Projan, S. J., and Bradford, P. A. (2005) A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline, Antimicrob. Agents Chemother. 49, 1865-1871.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 1865-1871
    • McAleese, F.1    Petersen, P.2    Ruzin, A.3    Dunman, P.M.4    Murphy, E.5    Projan, S.J.6    Bradford, P.A.7
  • 72
    • 50949102768 scopus 로고    scopus 로고
    • Functional cloning and characterization of the multidrug efflux pumps NorMfrom Neisseria gonorrhoeae and YdhE from Escherichia coli
    • Long, F., Rouquette-Loughlin, C., Shafer,W. M., and Yu, E.W. (2008) Functional cloning and characterization of the multidrug efflux pumps NorMfrom Neisseria gonorrhoeae and YdhE from Escherichia coli, Antimicrob. Agents Chemother. 52, 3052-3060.
    • (2008) Antimicrob. Agents Chemother , vol.52 , pp. 3052-3060
    • Long, F.1    Rouquette-Loughlin, C.2    Shafer, W.M.3    Yu, E.W.4
  • 73
    • 0037309093 scopus 로고    scopus 로고
    • The NorM efflux pump of Neisseria gonorrhoeae and Neisseria meningitidis recognizes antimicrobial cationic compounds
    • Rouquette-Loughlin, C., Dunham, S. A., Kuhn, M., Balthazar, J. T., and Shafer, W. M. (2003) The NorM efflux pump of Neisseria gonorrhoeae and Neisseria meningitidis recognizes antimicrobial cationic compounds, J. Bacteriol. 185, 1101-1106.
    • (2003) J. Bacteriol , vol.185 , pp. 1101-1106
    • Rouquette-Loughlin, C.1    Dunham, S.A.2    Kuhn, M.3    Balthazar, J.T.4    Shafer, W.M.5
  • 74
    • 18244388696 scopus 로고    scopus 로고
    • Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein
    • Kaatz, G. W., McAleese, F., and Seo, S. M. (2005) Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein, Antimicrob. Agents Chemother. 49, 1857-1864.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 1857-1864
    • Kaatz, G.W.1    McAleese, F.2    Seo, S.M.3
  • 75
    • 0037342874 scopus 로고    scopus 로고
    • Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli
    • Yang, S., Clayton, S. R., and Zechiedrich, E. L. (2003) Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli, J. Antimicrob. Chemother. 51, 545-556.
    • (2003) J. Antimicrob. ChemotherS , vol.51 , pp. 545-556
    • Yang, S.1    Clayton, S.R.2    Zechiedrich, E.L.3
  • 76
    • 0035185526 scopus 로고    scopus 로고
    • A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron
    • Miyamae, S., Ueda, O., Yoshimura, F., Hwang, J., Tanaka, Y., and Nikaido, H. (2001) A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron, Antimicrob. Agents Chemother. 45, 3341-3346.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 3341-3346
    • Miyamae, S.1    Ueda, O.2    Yoshimura, F.3    Hwang, J.4    Tanaka, Y.5    Nikaido, H.6
  • 77
    • 0346734230 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd
    • Xu, X. J., Su, X. Z., Morita, Y., Kuroda, T., Mizushima, T., and Tsuchiya, T. (2003) Molecular cloning and characterization of the HmrM multidrug efflux pump from Haemophilus influenzae Rd, Microbiol. Immunol. 47, 937-943.
    • (2003) Microbiol. Immunol , vol.47 , pp. 937-943
    • Xu, X.J.1    Su, X.Z.2    Morita, Y.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 78
    • 0346991732 scopus 로고    scopus 로고
    • An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa
    • He, G. X., Kuroda, T., Mima, T., Morita, Y., Mizushima, T., and Tsuchiya, T. (2004) An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa, J. Bacteriol. 186, 262-265.
    • (2004) J. Bacteriol , vol.186 , pp. 262-265
    • He, G.X.1    Kuroda, T.2    Mima, T.3    Morita, Y.4    Mizushima, T.5    Tsuchiya, T.6
  • 79
    • 0036134936 scopus 로고    scopus 로고
    • VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus
    • Chen, J., Morita, Y., Huda, M. N., Kuroda, T., Mizushima, T., and Tsuchiya, T. (2002) VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus, J. Bacteriol. 184, 572-576.
    • (2002) J. Bacteriol , vol.184 , pp. 572-576
    • Chen, J.1    Morita, Y.2    Huda, M.N.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 80
    • 4644306334 scopus 로고    scopus 로고
    • CdeA of Clostridium difficile, a new multidrug efflux transporter of the MATE family
    • Dridi, L., Tankovic, J., and Petit, J. C. (2004) CdeA of Clostridium difficile, a new multidrug efflux transporter of the MATE family, Microb. Drug Resist. 10, 191-196.
    • (2004) Microb. Drug Resist , vol.10 , pp. 191-196
    • Dridi, L.1    Tankovic, J.2    Petit, J.C.3
  • 83
    • 28044441589 scopus 로고    scopus 로고
    • Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1
    • Begum, A., Rahman, M. M., Ogawa, W., Mizushima, T., Kuroda, T., and Tsuchiya, T. (2005) Gene cloning and characterization of four MATE family multidrug efflux pumps from Vibrio cholerae non-O1, Microbiol. Immunol. 49, 949-957.
    • (2005) Microbiol. Immunol , vol.49 , pp. 949-957
    • Begum, A.1    Rahman, M.M.2    Ogawa, W.3    Mizushima, T.4    Kuroda, T.5    Tsuchiya, T.6
  • 84
    • 33645062695 scopus 로고    scopus 로고
    • Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar typhimurium
    • Nishino, K., Latifi, T., and Groisman, E. A. (2006) Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar typhimurium, Mol. Microbiol. 59, 126-141.
    • (2006) Mol. Microbiol , vol.59 , pp. 126-141
    • Nishino, K.1    Latifi, T.2    Groisman, E.A.3
  • 85
    • 0037783318 scopus 로고    scopus 로고
    • Tracing pathways of transport protein evolution
    • Saier, M. H., Jr. (2003) Tracing pathways of transport protein evolution, Mol. Microbiol. 48, 1145-1156.
    • (2003) Mol. Microbiol , vol.48 , pp. 1145-1156
    • Saier Jr., M.H.1
  • 86
    • 34250883333 scopus 로고    scopus 로고
    • Large-scale comparative genomic analyses of cytoplasmic membrane transport systems in prokaryotes
    • Ren, Q., and Paulsen, I. T. (2007) Large-scale comparative genomic analyses of cytoplasmic membrane transport systems in prokaryotes, J. Mol. Microbiol. Biotechnol. 12, 165-179.
    • (2007) J. Mol. Microbiol. Biotechnol , vol.12 , pp. 165-179
    • Ren, Q.1    Paulsen, I.T.2
  • 87
    • 27844587362 scopus 로고
    • Microbes and membrane biology
    • Maloney, P. C. (1990) Microbes and membrane biology, FEMS Microbiol. Rev. 7, 91-102.
    • (1990) FEMS Microbiol. Rev , vol.7 , pp. 91-102
    • Maloney, P.C.1
  • 88
    • 33646445156 scopus 로고    scopus 로고
    • Structure of the multidrug transporter EmrD from Escherichia coli
    • Yin, Y., He, X., Szewczyk, P., Nguyen, T., and Chang, G. (2006) Structure of the multidrug transporter EmrD from Escherichia coli, Science 312, 741-744.
    • (2006) Science , vol.312 , pp. 741-744
    • Yin, Y.1    He, X.2    Szewczyk, P.3    Nguyen, T.4    Chang, G.5
  • 89
    • 0041489951 scopus 로고    scopus 로고
    • Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli
    • Huang, Y., Lemieux, M. J., Song, J., Auer, M., and Wang, D. N. (2003) Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli, Science 301, 616-620.
    • (2003) Science , vol.301 , pp. 616-620
    • Huang, Y.1    Lemieux, M.J.2    Song, J.3    Auer, M.4    Wang, D.N.5
  • 90
    • 0041353145 scopus 로고    scopus 로고
    • Structure and mechanism of the lactose permease of Escherichia coli
    • Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., and Iwata, S. (2003) Structure and mechanism of the lactose permease of Escherichia coli, Science 301, 610-615.
    • (2003) Science , vol.301 , pp. 610-615
    • Abramson, J.1    Smirnova, I.2    Kasho, V.3    Verner, G.4    Kaback, H.R.5    Iwata, S.6
  • 92
    • 0031983410 scopus 로고    scopus 로고
    • Isolation and characterization of a putative multidrug resistance pump from Vibrio cholerae
    • Colmer, J. A., Fralick, J. A., and Hamood, A. N. (1998) Isolation and characterization of a putative multidrug resistance pump from Vibrio cholerae, Mol. Microbiol. 27, 63-72.
    • (1998) Mol. Microbiol , vol.27 , pp. 63-72
    • Colmer, J.A.1    Fralick, J.A.2    Hamood, A.N.3
  • 93
    • 0026686805 scopus 로고
    • Emr, an Escherichia coli locus for multidrug resistance
    • Lomovskaya, O., and Lewis, K. (1992) Emr, an Escherichia coli locus for multidrug resistance, Proc. Natl. Acad. Sci. USA 89, 8938-8942.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8938-8942
    • Lomovskaya, O.1    Lewis, K.2
  • 95
    • 6344291118 scopus 로고    scopus 로고
    • Molecular basis of bacterial resistance to chloramphenicol and florfenicol
    • Schwarz, S., Kehrenberg, C., Doublet, B., and Cloeckaert, A. (2004) Molecular basis of bacterial resistance to chloramphenicol and florfenicol,FEMSMicrobiol. Rev. 28, 519-542.
    • (2004) FEMSMicrobiol. Rev , vol.28 , pp. 519-542
    • Schwarz, S.1    Kehrenberg, C.2    Doublet, B.3    Cloeckaert, A.4
  • 96
    • 0037316581 scopus 로고    scopus 로고
    • Clonal diversity among streptogramin A-resistant Staphylococcus aureus isolates collected in French hospitals
    • Haroche, J., Morvan, A., Davi, M., Allignet, J., Bimet, F., and El Solh, N. (2003) Clonal diversity among streptogramin A-resistant Staphylococcus aureus isolates collected in French hospitals, J. Clin. Microbiol. 41, 586-591.
    • (2003) J. Clin. Microbiol , vol.41 , pp. 586-591
    • Haroche, J.1    Morvan, A.2    Davi, M.3    Allignet, J.4    Bimet, F.5    El Solh, N.6
  • 97
    • 0033798301 scopus 로고    scopus 로고
    • Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria
    • Poole, K. (2000) Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria, Antimicrob. Agents Chemother. 44, 2595-2599.
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 2595-2599
    • Poole, K.1
  • 98
    • 0032907704 scopus 로고    scopus 로고
    • Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae
    • Gill, M. J., Brenwald, N. P., and Wise, R. (1999) Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae, Antimicrob. Agents Chemother. 43, 187-189.
    • (1999) Antimicrob. Agents Chemother , vol.43 , pp. 187-189
    • Gill, M.J.1    Brenwald, N.P.2    Wise, R.3
  • 99
    • 1642422948 scopus 로고    scopus 로고
    • Efflux-mediated multiresistance in gram-negative bacteria
    • Poole, K. (2004) Efflux-mediated multiresistance in gram-negative bacteria, Clin. Microbiol. Infect. 10, 12-26.
    • (2004) Clin. Microbiol. Infect , vol.10 , pp. 12-26
    • Poole, K.1
  • 100
    • 24044514016 scopus 로고    scopus 로고
    • Efflux-mediated antimicrobial resistance
    • Poole, K. (2005) Efflux-mediated antimicrobial resistance, J. Antimicrob. Chemother. 56, 20-51.
    • (2005) J. Antimicrob. Chemother , vol.56 , pp. 20-51
    • Poole, K.1
  • 102
    • 0035180195 scopus 로고    scopus 로고
    • Characterization of emeA, a NorA homolog and multidrug resistance efflux pump, in Enterococcus faecalis
    • Jonas, B. M., Murray, B. E., and Weinstock, G. M. (2001) Characterization of emeA, a NorA homolog and multidrug resistance efflux pump, in Enterococcus faecalis, Antimicrob. Agents Chemother. 45, 3574-3579.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 3574-3579
    • Jonas, B.M.1    Murray, B.E.2    Weinstock, G.M.3
  • 103
    • 0043269351 scopus 로고    scopus 로고
    • Functional cloning and expression of emeA, and characterization of EmeA, a multidrug efflux pump from Enterococcus faecalis
    • Lee, E. W., Chen, J., Huda, M. N., Kuroda, T., Mizushima, T., and Tsuchiya, T. (2003) Functional cloning and expression of emeA, and characterization of EmeA, a multidrug efflux pump from Enterococcus faecalis, Biol. Pharm. Bull. 26, 266-270.
    • (2003) Biol. Pharm. Bull , vol.26 , pp. 266-270
    • Lee, E.W.1    Chen, J.2    Huda, M.N.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 105
    • 0031053662 scopus 로고    scopus 로고
    • bmr3, a third multidrug transporter gene of Bacillus subtilis
    • Ohki, R., and Murata, M. (1997) bmr3, a third multidrug transporter gene of Bacillus subtilis, J. Bacteriol. 179, 1423-1427.
    • (1997) J. Bacteriol , vol.179 , pp. 1423-1427
    • Ohki, R.1    Murata, M.2
  • 106
    • 0346887115 scopus 로고    scopus 로고
    • Structure and function of efflux pumps that confer resistance to drugs
    • Borges-Walmsley, M. I., McKeegan, K. S., and Walmsley, A. R. (2003) Structure and function of efflux pumps that confer resistance to drugs, Biochem. J. 376, 313-338.
    • (2003) Biochem. J , vol.376 , pp. 313-338
    • Borges-Walmsley, M.I.1    McKeegan, K.S.2    Walmsley, A.R.3
  • 107
    • 0025688065 scopus 로고
    • Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones
    • Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K., and Konno, M. (1990) Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones, J. Bacteriol. 172, 6942-6949.
    • (1990) J. Bacteriol , vol.172 , pp. 6942-6949
    • Yoshida, H.1    Bogaki, M.2    Nakamura, S.3    Ubukata, K.4    Konno, M.5
  • 108
  • 110
    • 0033524927 scopus 로고    scopus 로고
    • Bioenergetics of the staphylococcal multidrug export protein QacA: identification of distinct binding sites for monovalent and divalent cations
    • Mitchell, B. A., Paulsen, I. T., Brown, M. H., and Skurray, R. A. (1999) Bioenergetics of the staphylococcal multidrug export protein QacA: identification of distinct binding sites for monovalent and divalent cations, J. Biol. Chem. 274, 3541-3548.
    • (1999) J. Biol. Chem , vol.274 , pp. 3541-3548
    • Mitchell, B.A.1    Paulsen, I.T.2    Brown, M.H.3    Skurray, R.A.4
  • 111
    • 0035980157 scopus 로고    scopus 로고
    • Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin
    • Kim, H. J., Kim, Y., Lee, M. S., and Lee, H. S. (2001) Gene lmrB of Corynebacterium glutamicum confers efflux-mediated resistance to lincomycin, Mol. Cells 12, 112-116.
    • (2001) Mol. Cells , vol.12 , pp. 112-116
    • Kim, H.J.1    Kim, Y.2    Lee, M.S.3    Lee, H.S.4
  • 112
    • 0038355216 scopus 로고    scopus 로고
    • Multidrug resistant phenotype of Bacillus subtilis spontaneous mutants isolated in the presence of puromycin and lincomycin
    • Murata, M., Ohno, S., Kumano, M., Yamane, K., and Ohki, R. (2003) Multidrug resistant phenotype of Bacillus subtilis spontaneous mutants isolated in the presence of puromycin and lincomycin, Can. J. Microbiol. 49, 71-77.
    • (2003) Can. J. Microbiol , vol.49 , pp. 71-77
    • Murata, M.1    Ohno, S.2    Kumano, M.3    Yamane, K.4    Ohki, R.5
  • 113
    • 12244279068 scopus 로고    scopus 로고
    • Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants
    • Kumano, M., Fujita, M., Nakamura, K., Murata, M., Ohki, R., and Yamane, K. (2003) Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants, Antimicrob. Agents Chemother. 47, 432-435.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 432-435
    • Kumano, M.1    Fujita, M.2    Nakamura, K.3    Murata, M.4    Ohki, R.5    Yamane, K.6
  • 114
    • 4444293722 scopus 로고    scopus 로고
    • The cme gene of Clostridium difficile confers multidrug resistance in Enterococcus faecalis FEMS
    • Lebel, S., Bouttier, S., and Lambert, T. (2004) The cme gene of Clostridium difficile confers multidrug resistance in Enterococcus faecalis, FEMS Microbiol. Lett. 238, 93-100.
    • (2004) Microbiol. Lett , vol.238 , pp. 93-100
    • Lebel, S.1    Bouttier, S.2    Lambert, T.3
  • 115
    • 0030273002 scopus 로고    scopus 로고
    • Tetracycline resistance determinants: mechanisms of action, regulation of expression, geneticmobility, and distribution FEMS
    • Roberts, M. C. (1996) Tetracycline resistance determinants: mechanisms of action, regulation of expression, geneticmobility, and distribution,FEMSMicrobiol. Rev. 19, 1-24.
    • (1996) Microbiol. Rev , vol.19 , pp. 1-24
    • Roberts, M.C.1
  • 116
    • 0041833332 scopus 로고    scopus 로고
    • Mobile genes coding for effluxmediated antimicrobial resistance in gram-positive and gram-negative bacteria
    • Butaye, P., Cloeckaert, A., and Schwarz, S. (2003) Mobile genes coding for effluxmediated antimicrobial resistance in gram-positive and gram-negative bacteria, Int. J. Antimicrob. Agents 22, 205-210.
    • (2003) Int. J. Antimicrob. Agents , vol.22 , pp. 205-210
    • Butaye, P.1    Cloeckaert, A.2    Schwarz, S.3
  • 117
    • 17444415031 scopus 로고    scopus 로고
    • Identification of Tet 39, a novel class of tetracycline resistance determinant in Acinetobacter spp. of environmental and clinical origin
    • Agerso, Y., and Guardabassi, L. (2005) Identification of Tet 39, a novel class of tetracycline resistance determinant in Acinetobacter spp. of environmental and clinical origin, J. Antimicrob. Chemother. 55, 566-569.
    • (2005) J. Antimicrob. Chemother , vol.55 , pp. 566-569
    • Agerso, Y.1    Guardabassi, L.2
  • 118
    • 0031793411 scopus 로고    scopus 로고
    • Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacteriumfortuitumand Mycobacterium tuberculosis
    • Ainsa, J. A., Blokpoel, M. C., Otal, I., Young, D. B., De Smet, K. A., andMartin, C. (1998) Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacteriumfortuitumand Mycobacterium tuberculosis, J. Bacteriol. 180, 5836-5843.
    • (1998) J. Bacteriol , vol.180 , pp. 5836-5843
    • Ainsa, J.A.1    Blokpoel, M.C.2    Otal, I.3    Young, D.B.4    De Smet, K.A.5    Martin, C.6
  • 120
    • 0041332754 scopus 로고    scopus 로고
    • Mycobacterial efflux pumps and chemotherapeutic implications
    • Viveiros, M., Leandro, C., and Amaral, L. (2003) Mycobacterial efflux pumps and chemotherapeutic implications, Int. J. Antimicrob. Agents 22, 274-278.
    • (2003) Int. J. Antimicrob. Agents , vol.22 , pp. 274-278
    • Viveiros, M.1    Leandro, C.2    Amaral, L.3
  • 121
    • 1842451933 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump
    • Siddiqi, N., Das, R., Pathak, N., Banerjee, S., Ahmed, N., Katoch, V. M., and Hasnain, S. E. (2004) Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump, Infection 32, 109-111.
    • (2004) Infection , vol.32 , pp. 109-111
    • Siddiqi, N.1    Das, R.2    Pathak, N.3    Banerjee, S.4    Ahmed, N.5    Katoch, V.M.6    Hasnain, S.E.7
  • 123
    • 0033543578 scopus 로고    scopus 로고
    • Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family
    • Goldberg, M., Pribyl, T., Juhnke, S., and Nies, D. H. (1999) Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family, J. Biol. Chem. 274, 26065-26070.
    • (1999) J. Biol. Chem , vol.274 , pp. 26065-26070
    • Goldberg, M.1    Pribyl, T.2    Juhnke, S.3    Nies, D.H.4
  • 124
    • 0033170990 scopus 로고    scopus 로고
    • The RND permease family: an ancient, ubiquitus and diverse family that includes human diseases and development proteins
    • Tseng, T. T., Gratwick, K. S., Kollman, J., Park, D., Niles, D. H., Goffeau, A., and Saier, M. H., Jr. (2003) The RND permease family: an ancient, ubiquitus and diverse family that includes human diseases and development proteins, Mol. Microbiol. Biotechnol. 1, 107-125.
    • (2003) Mol. Microbiol. Biotechnol , vol.1 , pp. 107-125
    • Tseng, T.T.1    Gratwick, K.S.2    Kollman, J.3    Park, D.4    Niles, D.H.5    Goffeau, A.6    Saier Jr., M.H.7
  • 125
    • 0037303355 scopus 로고    scopus 로고
    • 3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm
    • Elkins, C. A., and Nikaido, H. (2003) 3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm, Drug Resist. Update 6, 9-13.
    • (2003) Drug Resist. Update , vol.6 , pp. 9-13
    • Elkins, C.A.1    Nikaido, H.2
  • 126
    • 0036437057 scopus 로고    scopus 로고
    • On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition
    • Mao, W., Warren, M. S., Black, D. S., Satou, T., Murata, T., Nishino, T., Gotoh, N., and Lomovskaya, O. (2002) On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition, Mol. Microbiol. 46, 889-901.
    • (2002) Mol. Microbiol , vol.46 , pp. 889-901
    • Mao, W.1    Warren, M.S.2    Black, D.S.3    Satou, T.4    Murata, T.5    Nishino, T.6    Gotoh, N.7    Lomovskaya, O.8
  • 127
    • 0036794301 scopus 로고    scopus 로고
    • Purification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein
    • Pos, K. M., and Diederichs, K. (2002) Purification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein, Acta Crystallogr. 58, 1865-1867.
    • (2002) Acta Crystallogr , vol.58 , pp. 1865-1867
    • Pos, K.M.1    Diederichs, K.2
  • 128
    • 1942468183 scopus 로고    scopus 로고
    • Crystallographic analysis of AcrB FEBS
    • Pos, K. M., Schiefner, A., Seeger, M. A., and Diederichs, K. (2004) Crystallographic analysis of AcrB, FEBS Lett. 564, 333-339.
    • (2004) Lett , vol.564 , pp. 333-339
    • Pos, K.M.1    Schiefner, A.2    Seeger, M.A.3    Diederichs, K.4
  • 129
    • 0037057652 scopus 로고    scopus 로고
    • Crystal structure of bacterial multidrug efflux transporter AcrB
    • Murakami, S., Nakashima, R., Yamashita, E., and Yamaguchi, A. (2002) Crystal structure of bacterial multidrug efflux transporter AcrB, Nature 419, 587-593.
    • (2002) Nature , vol.419 , pp. 587-593
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Yamaguchi, A.4
  • 130
    • 0036889033 scopus 로고    scopus 로고
    • Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops
    • Elkins, C. A., and Nikaido, H. (2002) Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops, J. Bacteriol. 184, 6490-6498.
    • (2002) J. Bacteriol , vol.184 , pp. 6490-6498
    • Elkins, C.A.1    Nikaido, H.2
  • 131
    • 33748670458 scopus 로고    scopus 로고
    • Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
    • Murakami, S., Nakashima, R., Yamashita, E., Matsumoto, T., and Yamaguchi, A. (2006) Crystal structures of a multidrug transporter reveal a functionally rotating mechanism, Nature 443, 173-179.
    • (2006) Nature , vol.443 , pp. 173-179
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Matsumoto, T.4    Yamaguchi, A.5
  • 132
    • 33748310520 scopus 로고    scopus 로고
    • Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
    • Seeger, M. A., Schiefner, A., Eicher, T., Verrey, F., Diederichs, K., and Pos, K. M. (2006) Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism, Science 313, 1295-1298.
    • (2006) Science , vol.313 , pp. 1295-1298
    • Seeger, M.A.1    Schiefner, A.2    Eicher, T.3    Verrey, F.4    Diederichs, K.5    Pos, K.M.6
  • 134
    • 49549088341 scopus 로고    scopus 로고
    • Multidrug efflux transporter, AcrB-the pumping mechanism
    • Murakami, S. (2008) Multidrug efflux transporter, AcrB-the pumping mechanism, Curr. Opin. Struct. Biol. 18, 459-465.
    • (2008) Curr. Opin. Struct. Biol , vol.18 , pp. 459-465
    • Murakami, S.1
  • 135
    • 64649100965 scopus 로고    scopus 로고
    • Drug transport mechanism of the AcrB efflux pump
    • Pos, K. M. (2009) Drug transport mechanism of the AcrB efflux pump, Biochim. Biophys. Acta 1794, 782-793.
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 782-793
    • Pos, K.M.1
  • 136
    • 70349452052 scopus 로고    scopus 로고
    • Structural and functional aspects of the multidrug efflux pump AcrB
    • Eicher, T., Brandstatter, L., and Pos, K. M. (2009) Structural and functional aspects of the multidrug efflux pump AcrB, Biol. Chem. 390, 693-699.
    • (2009) Biol. Chem , vol.390 , pp. 693-699
    • Eicher, T.1    Brandstatter, L.2    Pos, K.M.3
  • 137
    • 0347479229 scopus 로고    scopus 로고
    • Molecular basis of bacterial outer membrane permeability revisited
    • Nikaido, H. (2003) Molecular basis of bacterial outer membrane permeability revisited, Microbiol. Mol. Biol. Rev. 67, 593-656.
    • (2003) Microbiol. Mol. Biol. Rev , vol.67 , pp. 593-656
    • Nikaido, H.1
  • 138
    • 64649096369 scopus 로고    scopus 로고
    • Mechanisms of RND multidrug efflux pumps
    • Nikaido, H., and Takatsuka, Y. (2009) Mechanisms of RND multidrug efflux pumps, Biochim. Biophys. Acta 1794, 769-781.
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 769-781
    • Nikaido, H.1    Takatsuka, Y.2
  • 139
    • 0028051714 scopus 로고
    • Additive effect of tolC and rfa mutations on the hydrophobic barrier of the outer membrane of Escherichia coli K-12
    • Fralick, J. A., and Burns-Keliher, L. L. (1994) Additive effect of tolC and rfa mutations on the hydrophobic barrier of the outer membrane of Escherichia coli K-12, J. Bacteriol. 176, 6404-6406.
    • (1994) J. Bacteriol , vol.176 , pp. 6404-6406
    • Fralick, J.A.1    Burns-Keliher, L.L.2
  • 141
    • 33644833626 scopus 로고    scopus 로고
    • Conformational flexibility in the multidrug efflux system protein AcrA
    • Mikolosko, J., Bobyk, K., Zgurskaya, H. I., and Ghosh, P. (2006) Conformational flexibility in the multidrug efflux system protein AcrA, Structure 14, 577-587.
    • (2006) Structure , vol.14 , pp. 577-587
    • Mikolosko, J.1    Bobyk, K.2    Zgurskaya, H.I.3    Ghosh, P.4
  • 142
    • 43049143527 scopus 로고    scopus 로고
    • Crystallization and preliminary X-ray crystallographic analysis of MacA from Actinobacillus actinomycetemcomitans
    • Piao, S., Xu, Y., and Ha, N. C. (2008) Crystallization and preliminary X-ray crystallographic analysis of MacA from Actinobacillus actinomycetemcomitans, Acta Crystallogr. 64, 391-393.
    • (2008) Acta Crystallogr , vol.64 , pp. 391-393
    • Piao, S.1    Xu, Y.2    Ha, N.C.3
  • 143
    • 34248359106 scopus 로고    scopus 로고
    • A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps
    • Lobedanz, S., Bokma, E., Symmons, M. F., Koronakis, E., Hughes, C., and Koronakis, V. (2007) A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps, Proc. Natl. Acad. Sci. USA 104, 4612-4617.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 4612-4617
    • Lobedanz, S.1    Bokma, E.2    Symmons, M.F.3    Koronakis, E.4    Hughes, C.5    Koronakis, V.6
  • 144
    • 33748638824 scopus 로고    scopus 로고
    • Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps
    • Stegmeier, J. F., Polleichtner, G., Brandes, N., Hotz, C., and Andersen, C. (2006) Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps, Biochemistry 45, 10303-10312.
    • (2006) Biochemistry , vol.45 , pp. 10303-10312
    • Stegmeier, J.F.1    Polleichtner, G.2    Brandes, N.3    Hotz, C.4    Andersen, C.5
  • 146
    • 0034702177 scopus 로고    scopus 로고
    • Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
    • Koronakis, V., Sharff, A., Koronakis, E., Luisi, B., and Hughes, C. (2000) Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export, Nature 405, 914-919.
    • (2000) Nature , vol.405 , pp. 914-919
    • Koronakis, V.1    Sharff, A.2    Koronakis, E.3    Luisi, B.4    Hughes, C.5
  • 147
    • 33646493526 scopus 로고    scopus 로고
    • Preliminary crystallographic analysis of the antibiotic discharge outer membrane lipoprotein OprM of Pseudomonas aeruginosa with an exceptionally long unit cell and complex lattice structure
    • Akama, H., Kanemaki, M., Tsukihara, T., Nakagawa, A., and Nakae, T. (2005) Preliminary crystallographic analysis of the antibiotic discharge outer membrane lipoprotein OprM of Pseudomonas aeruginosa with an exceptionally long unit cell and complex lattice structure, Acta Crystallogr. 61, 131-133.
    • (2005) Acta Crystallogr , vol.61 , pp. 131-133
    • Akama, H.1    Kanemaki, M.2    Tsukihara, T.3    Nakagawa, A.4    Nakae, T.5
  • 150
    • 10044231647 scopus 로고    scopus 로고
    • Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli
    • Husain, F., Humbard, M., and Misra, R. (2004) Interaction between the TolC and AcrA proteins of a multidrug efflux system of Escherichia coli, J. Bacteriol. 186, 8533-8536.
    • (2004) J. Bacteriol , vol.186 , pp. 8533-8536
    • Husain, F.1    Humbard, M.2    Misra, R.3
  • 151
    • 3542998054 scopus 로고    scopus 로고
    • AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex
    • Tikhonova, E. B., and Zgurskaya, H. I. (2004) AcrA, AcrB, and TolC of Escherichia coli form a stable intermembrane multidrug efflux complex, J. Biol. Chem. 279, 32116-32124.
    • (2004) J. Biol. Chem , vol.279 , pp. 32116-32124
    • Tikhonova, E.B.1    Zgurskaya, H.I.2
  • 152
    • 3242890387 scopus 로고    scopus 로고
    • Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system
    • Touzé, T., Eswaran, J., Bokma, E., Koronakis, E., Hughes, C., and Koronakis, V. (2004) Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system, Mol. Microbiol. 53, 697-706.
    • (2004) Mol. Microbiol , vol.53 , pp. 697-706
    • Touzé, T.1    Eswaran, J.2    Bokma, E.3    Koronakis, E.4    Hughes, C.5    Koronakis, V.6
  • 153
    • 14644397893 scopus 로고    scopus 로고
    • Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli
    • Aires, J. R., and Nikaido, H. (2005) Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli, J. Bacteriol. 187, 1923-1929.
    • (2005) J. Bacteriol , vol.187 , pp. 1923-1929
    • Aires, J.R.1    Nikaido, H.2
  • 154
    • 1542390499 scopus 로고    scopus 로고
    • Identification of protein- protein interaction sites from docking energy landscapes
    • Fernández-Recio, J., Totrov, M., and Abagyan, R. (2004) Identification of protein- protein interaction sites from docking energy landscapes, J. Mol. Biol. 335, 843-865.
    • (2004) J. Mol. Biol , vol.335 , pp. 843-865
    • Fernández-Recio, J.1    Totrov, M.2    Abagyan, R.3
  • 155
    • 64649089196 scopus 로고    scopus 로고
    • Assembly and transport mechanism of tripartite drug efflux systems
    • Misra, R., and Bavro, V. N. (2009) Assembly and transport mechanism of tripartite drug efflux systems, Biochim. Biophys. Acta 1794, 817-825.
    • (2009) Biochim. Biophys. Acta , vol.1794 , pp. 817-825
    • Misra, R.1    Bavro, V.N.2
  • 156
    • 9944247705 scopus 로고    scopus 로고
    • Three's company: component structures bring a closer view of tripartite drug efflux pumps
    • Eswaran, J., Koronakis, E., Higgins, M. K., Hughes, C., and Koronakis, V. (2004) Three's company: component structures bring a closer view of tripartite drug efflux pumps, Curr. Opin. Struct. Biol. 14, 741-747.
    • (2004) Curr. Opin. Struct. Biol , vol.14 , pp. 741-747
    • Eswaran, J.1    Koronakis, E.2    Higgins, M.K.3    Hughes, C.4    Koronakis, V.5
  • 158
    • 34548491825 scopus 로고    scopus 로고
    • Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors
    • Nehme, D., and Poole, K. (2007) Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors, J. Bacteriol. 189, 6118-6127.
    • (2007) J. Bacteriol , vol.189 , pp. 6118-6127
    • Nehme, D.1    Poole, K.2
  • 159
    • 3943108216 scopus 로고    scopus 로고
    • Structure and function of TolC: the bacterial exit duct for proteins and drugs
    • Koronakis, V., Eswaran, J., and Hughes, C. (2004) Structure and function of TolC: the bacterial exit duct for proteins and drugs, Annu. Rev. Biochem. 73, 467-489.
    • (2004) Annu. Rev. Biochem , vol.73 , pp. 467-489
    • Koronakis, V.1    Eswaran, J.2    Hughes, C.3
  • 161
    • 4344612328 scopus 로고    scopus 로고
    • The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli
    • Chollet, R., Chevalier, J., Bryskier, A., and Pages, J. M. (2004) The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli, Antimicrob. Agents Chemother. 48, 3621-3624.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 3621-3624
    • Chollet, R.1    Chevalier, J.2    Bryskier, A.3    Pages, J.M.4
  • 162
    • 0028926676 scopus 로고
    • Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli
    • Ma, D., Cook, D. N., Alberti, M., Pon, N. G., Nikaido, H., and Hearst, J. E. (1995) Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli, Mol. Microbiol. 16, 45-55.
    • (1995) Mol. Microbiol , vol.16 , pp. 45-55
    • Ma, D.1    Cook, D.N.2    Alberti, M.3    Pon, N.G.4    Nikaido, H.5    Hearst, J.E.6
  • 163
    • 0025372570 scopus 로고
    • TolC, an Escherichia coli outer membrane protein required for hemolysin secretion
    • Wandersman, C., and Delepelaire, P. (1990) TolC, an Escherichia coli outer membrane protein required for hemolysin secretion, Proc. Natl. Acad. Sci. USA 87, 4776-4780.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4776-4780
    • Wandersman, C.1    Delepelaire, P.2
  • 164
    • 70349751622 scopus 로고    scopus 로고
    • Structure, function and inhibition of RND efflux pumps in gram-negative bacteria: an update
    • Blair, J. M., and Piddock, L. J. (2009) Structure, function and inhibition of RND efflux pumps in gram-negative bacteria: an update, Curr. Opin. Microbiol. 12, 512-519.
    • (2009) Curr. Opin. Microbiol , vol.12 , pp. 512-519
    • Blair, J.M.1    Piddock, L.J.2
  • 165
    • 0029796966 scopus 로고    scopus 로고
    • Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
    • Fralick, J. A. (1996) Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli, J. Bacteriol. 178, 5803-5805.
    • (1996) J. Bacteriol , vol.178 , pp. 5803-5805
    • Fralick, J.A.1
  • 167
    • 0035028431 scopus 로고    scopus 로고
    • Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants selected with a fluoroquinolone
    • Jellen-Ritter, A. S., and Kern, W. V. (2001) Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants selected with a fluoroquinolone, Antimicrob. Agents Chemother. 45, 1467-1472.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 1467-1472
    • Jellen-Ritter, A.S.1    Kern, W.V.2
  • 168
    • 0031918573 scopus 로고    scopus 로고
    • Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems
    • Schweizer, H. P. (1998) Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems, Antimicrob. Agents Chemother. 42, 394-398.
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 394-398
    • Schweizer, H.P.1
  • 169
    • 0035139556 scopus 로고    scopus 로고
    • Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ
    • Chuanchuen, R., Beinlich, K., Hoang, T. T., Becher, A., Karkhoff-Schweizer, R. R., and Schweizer, H. P. (2001) Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ, Antimicrob. Agents Chemother. 45, 428-432.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 428-432
    • Chuanchuen, R.1    Beinlich, K.2    Hoang, T.T.3    Becher, A.4    Karkhoff-Schweizer, R.R.5    Schweizer, H.P.6
  • 170
    • 0036723860 scopus 로고    scopus 로고
    • The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan
    • Chuanchuen, R., Narasaki, C. T., and Schweizer, H. P. (2002) The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan, J. Bacteriol. 184, 5036-5044.
    • (2002) J. Bacteriol , vol.184 , pp. 5036-5044
    • Chuanchuen, R.1    Narasaki, C.T.2    Schweizer, H.P.3
  • 171
    • 33644746633 scopus 로고    scopus 로고
    • Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibioticinducible PA5471 gene product
    • Morita, Y., Sobel, M. L., and Poole, K. (2006) Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibioticinducible PA5471 gene product, J. Bacteriol. 188, 1847-1855.
    • (2006) J. Bacteriol , vol.188 , pp. 1847-1855
    • Morita, Y.1    Sobel, M.L.2    Poole, K.3
  • 172
    • 0041421188 scopus 로고    scopus 로고
    • Functional cloning and characterization of amultidrug efflux pump,MexHI-OpmD, froma Pseudomonas aeruginosa mutant
    • Sekiya, H., Mima, T., Morita, Y., Kuroda, T., Mizushima, T., and Tsuchiya, T. (2003) Functional cloning and characterization of amultidrug efflux pump,MexHI-OpmD, froma Pseudomonas aeruginosa mutant, Antimicrob. Agents Chemother. 47, 2990-2992.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 2990-2992
    • Sekiya, H.1    Mima, T.2    Morita, Y.3    Kuroda, T.4    Mizushima, T.5    Tsuchiya, T.6
  • 174
    • 1642322821 scopus 로고    scopus 로고
    • Contribution of integrons and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia
    • Chang, L. L., Chen, H. F., Chang, C. Y., Lee, T. M., andWu,W. J. (2004) Contribution of integrons and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrophomonas maltophilia, J. Antimicrob. Chemother. 53, 518-521.
    • (2004) J. Antimicrob. Chemother , vol.53 , pp. 518-521
    • Chang, L.L.1    Chen, H.F.2    Chang, C.Y.3    Lee, T.M.4    Wu, W.J.5
  • 175
    • 4444336144 scopus 로고    scopus 로고
    • Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibioticresistant Campylobacter jejuni
    • Pumbwe, L., Randall, L. P., Woodward, M. J., and Piddock, L. J. (2004) Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibioticresistant Campylobacter jejuni, J. Antimicrob. Chemother. 54, 341-347.
    • (2004) J. Antimicrob. Chemother , vol.54 , pp. 341-347
    • Pumbwe, L.1    Randall, L.P.2    Woodward, M.J.3    Piddock, L.J.4
  • 176
    • 16244421361 scopus 로고    scopus 로고
    • Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens
    • Kumar, A., and Worobec, E. A. (2005) Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescens, Antimicrob. Agents Chemother. 49, 1495-1501.
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 1495-1501
    • Kumar, A.1    Worobec, E.A.2
  • 178
    • 0032842433 scopus 로고    scopus 로고
    • Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations
    • Zarantonelli, L., Borthagaray, G., Lee, E. H., and Shafer, W. M. (1999) Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations, Antimicrob. Agents Chemother. 43, 2468-2472.
    • (1999) Antimicrob. Agents Chemother , vol.43 , pp. 2468-2472
    • Zarantonelli, L.1    Borthagaray, G.2    Lee, E.H.3    Shafer, W.M.4
  • 179
    • 12244277396 scopus 로고    scopus 로고
    • Acquired macrolide resistance genes and the 1 bp deletion in the mtrR promoter in Neisseria gonorrhoeae
    • Cousin, S. L., Jr., Whittington, W. L., and Roberts, M. C. (2003) Acquired macrolide resistance genes and the 1 bp deletion in the mtrR promoter in Neisseria gonorrhoeae, J. Antimicrob. Chemother. 51, 131-133.
    • (2003) J. Antimicrob. Chemother , vol.51 , pp. 131-133
    • Cousin Jr., S.L.1    Whittington, W.L.2    Roberts, M.C.3
  • 180
    • 2542482572 scopus 로고    scopus 로고
    • High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinoloneresistant Neisseria gonorrhoeae
    • Dewi, B. E., Akira, S., Hayashi, H., and Ba-Thein, W. (2004) High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinoloneresistant Neisseria gonorrhoeae, Sex. Transm. Dis. 31, 353-359.
    • (2004) Sex. Transm. Dis , vol.31 , pp. 353-359
    • Dewi, B.E.1    Akira, S.2    Hayashi, H.3    Ba-Thein, W.4
  • 181
    • 1542287457 scopus 로고    scopus 로고
    • Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia)
    • Nair, B. M., Cheung, K. J., Jr., Griffith, A., and Burns, J. L. (2004) Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia), J. Clin. Invest. 113, 464-473.
    • (2004) J. Clin. Invest , vol.113 , pp. 464-473
    • Nair, B.M.1    Cheung Jr., K.J.2    Griffith, A.3    Burns, J.L.4
  • 182
    • 2142827105 scopus 로고    scopus 로고
    • Genetic and molecular characterization of beta-lactamase-negative ampicillinresistant Haemophilus influenzae with unusually high resistance to ampicillin
    • Kaczmarek, F. S., Gootz, T. D., Dib-Hajj, F., Shang, W., Hallowell, S., and Cronan, M. (2004) Genetic and molecular characterization of beta-lactamase-negative ampicillinresistant Haemophilus influenzae with unusually high resistance to ampicillin, Antimicrob. Agents Chemother. 48, 1630-1639.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 1630-1639
    • Kaczmarek, F.S.1    Gootz, T.D.2    Dib-Hajj, F.3    Shang, W.4    Hallowell, S.5    Cronan, M.6
  • 183
    • 0035178557 scopus 로고    scopus 로고
    • Resistance-nodulation-cell division--type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454
    • Magnet, S., Courvalin, P., and Lambert, T. (2001) Resistance-nodulation-cell division--type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454, Antimicrob. Agents Chemother. 45, 3375-3380.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 3375-3380
    • Magnet, S.1    Courvalin, P.2    Lambert, T.3
  • 184
    • 33644873454 scopus 로고    scopus 로고
    • TCDB: The transporter classification database for membrane transport protein analyses and information
    • Saier, M. H., Jr., Tran, C., and Barabote, R. D. (2006) TCDB: The transporter classification database for membrane transport protein analyses and information, Nucleic Acids Res. 34, D191-D186.
    • (2006) Nucleic Acids Res , vol.34
    • Saier Jr., M.H.1    Tran, C.2    Barabote, R.D.3
  • 185
    • 34548602442 scopus 로고    scopus 로고
    • Comprehensive analysis of transport proteins encoded within the genome of Bdellovibrio bacteriovorus
    • Barabote, R. D., Rendulic, S., Schuster, S. C., and Saier,M. H., Jr. (2007) Comprehensive analysis of transport proteins encoded within the genome of Bdellovibrio bacteriovorus, Genomics 90, 424-446.
    • (2007) Genomics , vol.90 , pp. 424-446
    • Barabote, R.D.1    Rendulic, S.2    Schuster, S.C.3    Saier Jr., M.H.4
  • 186
    • 29144518548 scopus 로고    scopus 로고
    • Comparative genomic analyses of the bacterial phosphotransferase system
    • Barabote, R. D., and Saier, M. H., Jr. (2005) Comparative genomic analyses of the bacterial phosphotransferase system, Microbiol. Mol. Biol. Rev. 69, 608-634.
    • (2005) Microbiol. Mol. Biol. Rev , vol.69 , pp. 608-634
    • Barabote, R.D.1    Saier Jr., M.H.2
  • 188
    • 37649023694 scopus 로고    scopus 로고
    • Parallel genomic evolution and metabolic interdependence in an ancient symbiosis
    • McCutcheon, J. P., and Moran, N. A. (2007) Parallel genomic evolution and metabolic interdependence in an ancient symbiosis, Proc. Natl. Acad. Sci. USA 104, 19392-19397.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19392-19397
    • McCutcheon, J.P.1    Moran, N.A.2
  • 190
    • 27644463879 scopus 로고    scopus 로고
    • Organization and localization of the dnaA and dnaK gene regions on themultichromosomal genome of Burkholderia multivorans ATCC 17616
    • Nagata, Y., Matsuda, M., Komatsu, H., Imura, Y., Sawada, H., Ohtsubo, Y., and Tsuda, M. (2005) Organization and localization of the dnaA and dnaK gene regions on themultichromosomal genome of Burkholderia multivorans ATCC 17616, J. Biosci. Bioeng. 99, 603-610.
    • (2005) J. Biosci. Bioeng , vol.99 , pp. 603-610
    • Nagata, Y.1    Matsuda, M.2    Komatsu, H.3    Imura, Y.4    Sawada, H.5    Ohtsubo, Y.6    Tsuda, M.7
  • 191
    • 0037980285 scopus 로고    scopus 로고
    • Cepacia-like syndrome caused by Burkholderia multivorans
    • Zahariadis, G., Levy, M. H., and Burns, J. L. (2003) Cepacia-like syndrome caused by Burkholderia multivorans, Can. J. Infect. Dis., 14, 123-125.
    • (2003) Can. J. Infect. Dis , vol.14 , pp. 123-125
    • Zahariadis, G.1    Levy, M.H.2    Burns, J.L.3
  • 192
    • 0035210546 scopus 로고    scopus 로고
    • Members of the Cytophaga-Flavobacterium-Bacteroides phylum as intracellularbacteria of acanthamoebae: proposal of " Candidatus amoebophilus asiaticus
    • Horn, M., Harzenetter, M. D., Linner, T., Schmid, E. N., Müller, K. D., Michel, R., and Wagner, M. (2001) Members of the Cytophaga-Flavobacterium-Bacteroides phylum as intracellularbacteria of acanthamoebae: proposal of " Candidatus amoebophilus asiaticus," Environ. Microbiol. 3, 440-449.
    • (2001) " Environ. Microbiol. , vol.3 , pp. 440-449
    • Horn, M.1    Harzenetter, M.D.2    Linner, T.3    Schmid, E.N.4    Müller, K.D.5    Michel, R.6    Wagner, M.7
  • 194
    • 0014652762 scopus 로고
    • Ectothiorhodospirahalophila: a new species of the genus
    • Raymond, J. C., and Sistrom, W. R. (1969) Ectothiorhodospirahalophila: a new species of the genus, Ectothiorhodospira Arch. Mikrobiol. 69, 121-126.
    • (1969) Ectothiorhodospira Arch. Mikrobiol , vol.69 , pp. 121-126
    • Raymond, J.C.1    Sistrom, W.R.2
  • 196
    • 0029853191 scopus 로고    scopus 로고
    • Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
    • Albertson, G. D., Niimi, M., Cannon, R. D., and Jenkinson, H. F. (1996) Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance, Antimicrob. Agents Chemother. 40, 2835-2841.
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 2835-2841
    • Albertson, G.D.1    Niimi, M.2    Cannon, R.D.3    Jenkinson, H.F.4
  • 197
    • 34447579240 scopus 로고    scopus 로고
    • Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae
    • Lamping, E., Monk, B. C., Niimi, K., Holmes, A. R., Tsao, S., Tanabe, K., Niimi, M., Uehara, Y., and Cannon, R. D. (2007) Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae, Eukaryot. Cell 6, 1150-1165.
    • (2007) Eukaryot. Cell , vol.6 , pp. 1150-1165
    • Lamping, E.1    Monk, B.C.2    Niimi, K.3    Holmes, A.R.4    Tsao, S.5    Tanabe, K.6    Niimi, M.7    Uehara, Y.8    Cannon, R.D.9
  • 199
    • 0142216110 scopus 로고    scopus 로고
    • Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    • Saville, S. P., Lazzell, A. L., Monteagudo, C., and Lopez-Ribot, J. L. (2003) Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection, Eukaryot. Cell 2, 1053-1060.
    • (2003) Eukaryot. Cell , vol.2 , pp. 1053-1060
    • Saville, S.P.1    Lazzell, A.L.2    Monteagudo, C.3    Lopez-Ribot, J.L.4
  • 200
    • 0037170796 scopus 로고    scopus 로고
    • Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism
    • Kim, S., Kim, E., Shin, D. S., Kang, H., and Oh, K. B. (2002) Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism, Bioorg. Med. Chem. Lett. 12, 895-898.
    • (2002) Bioorg. Med. Chem. Lett , vol.12 , pp. 895-898
    • Kim, S.1    Kim, E.2    Shin, D.S.3    Kang, H.4    Oh, K.B.5
  • 202
    • 54249101880 scopus 로고    scopus 로고
    • Evidence for the role of calcineurin in morphogenesis and calcium homeostasis during mycelium-to-yeast dimorphism of Paracoccidioides brasiliensis
    • Campos, C. B., Di Benedette, J. P., Morais, F. V., Ovalle, R., and Nobrega, M. P. (2008) Evidence for the role of calcineurin in morphogenesis and calcium homeostasis during mycelium-to-yeast dimorphism of Paracoccidioides brasiliensis, Eukaryot. Cell 7, 1856-1864.
    • (2008) Eukaryot. Cell , vol.7 , pp. 1856-1864
    • Campos, C.B.1    Di Benedette, J.P.2    Morais, F.V.3    Ovalle, R.4    Nobrega, M.P.5
  • 203
    • 45149119133 scopus 로고    scopus 로고
    • Chemotaxis of the amphibian pathogen Batrachochytrium dendrobatidis and its response to a variety of attractants
    • Moss, A. S., Reddy, N. S., Dortaj, I. M., and San Francisco, M. J. (2008) Chemotaxis of the amphibian pathogen Batrachochytrium dendrobatidis and its response to a variety of attractants, Mycologia 100, 1-5.
    • (2008) Mycologia , vol.100 , pp. 1-5
    • Moss, A.S.1    Reddy, N.S.2    Dortaj, I.M.3    San Francisco, M.J.4
  • 204
    • 5444272819 scopus 로고    scopus 로고
    • Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus
    • Pfaller, M. A., and Diekema, D. J. (2004) Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus, J. Clin. Microbiol. 42, 4419-4431.
    • (2004) J. Clin. Microbiol , vol.42 , pp. 4419-4431
    • Pfaller, M.A.1    Diekema, D.J.2
  • 206
    • 0032949482 scopus 로고    scopus 로고
    • Batrachochytrium dendrobatidis gen et sp nov, a chytrid pathogenic to amphibians
    • Longcore, J. E., Pessier, A. P., and Nichols, D. K. (1999) Batrachochytrium dendrobatidis gen et sp nov, a chytrid pathogenic to amphibians, Mycologia 91, 219-227.
    • (1999) Mycologia , vol.91 , pp. 219-227
    • Longcore, J.E.1    Pessier, A.P.2    Nichols, D.K.3
  • 207
    • 36849043112 scopus 로고    scopus 로고
    • Multidrug resistance in fungi
    • Gulshan, K., and Moye-Rowley, W. S. (2007) Multidrug resistance in fungi, Eukaryot. Cell 6, 1933-1942.
    • (2007) Eukaryot. Cell , vol.6 , pp. 1933-1942
    • Gulshan, K.1    Moye-Rowley, W.S.2
  • 208
    • 21344451158 scopus 로고    scopus 로고
    • Evolution of antifungal-drug resistance: mechanisms and pathogen fitness
    • Anderson, J. B. (2005) Evolution of antifungal-drug resistance: mechanisms and pathogen fitness, Nat. Rev. Microbiol. 3, 547-556.
    • (2005) Nat. Rev. Microbiol , vol.3 , pp. 547-556
    • Anderson, J.B.1
  • 210
    • 0033093008 scopus 로고    scopus 로고
    • Three-dimensional quantitative structure- activity relationship (QSAR) and receptor mapping of cytochrome P-450 (14 alpha DM) inhibiting azole antifungal agents
    • Talele, T. T., and Kulkarni, V. M. (1999) Three-dimensional quantitative structure- activity relationship (QSAR) and receptor mapping of cytochrome P-450 (14 alpha DM) inhibiting azole antifungal agents, J. Chem. Inf. Comput. Sci. 39, 204-210.
    • (1999) J. Chem. Inf. Comput. Sci , vol.39 , pp. 204-210
    • Talele, T.T.1    Kulkarni, V.M.2
  • 213
    • 47049090269 scopus 로고    scopus 로고
    • Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance
    • Cowen, L. E., and Steinbach, W. J. (2008) Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance, Eukaryot. Cell 7, 747-764.
    • (2008) Eukaryot. Cell , vol.7 , pp. 747-764
    • Cowen, L.E.1    Steinbach, W.J.2
  • 214
    • 33748702265 scopus 로고    scopus 로고
    • Clinical efficacy of new antifungal agents
    • Kauffman, C. A. (2006) Clinical efficacy of new antifungal agents, Curr. Opin. Microbiol. 9, 483-488.
    • (2006) Curr. Opin. Microbiol , vol.9 , pp. 483-488
    • Kauffman, C.A.1
  • 215
    • 0038341642 scopus 로고    scopus 로고
    • Antifungal agents: mechanisms of action
    • Odds, F. C., Brown, A. J., and Gow, N. A. (2003) Antifungal agents: mechanisms of action, Trends Microbiol. 11, 272-279.
    • (2003) Trends Microbiol , vol.11 , pp. 272-279
    • Odds, F.C.1    Brown, A.J.2    Gow, N.A.3
  • 216
  • 217
    • 4644311383 scopus 로고    scopus 로고
    • Antimicrobial peptides from marine invertebrates
    • Tincu, J. A., and Taylor, S. W. (2004) Antimicrobial peptides from marine invertebrates, Antimicrob. Agents Chemother. 48, 3645-3654.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 3645-3654
    • Tincu, J.A.1    Taylor, S.W.2
  • 219
    • 0032882718 scopus 로고    scopus 로고
    • Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    • Ghannoum, M. A., and Rice, L. B. (1999) Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance, Clin. Microbiol. Rev. 12, 501-517.
    • (1999) Clin. Microbiol. Rev , vol.12 , pp. 501-517
    • Ghannoum, M.A.1    Rice, L.B.2
  • 220
    • 33846040629 scopus 로고    scopus 로고
    • TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels
    • Ren, Q., Chen, K., and Paulsen, I. T. (2007) TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels, Nucleic Acids Res. 35, D274-D279.
    • (2007) Nucleic Acids Res , vol.35
    • Ren, Q.1    Chen, K.2    Paulsen, I.T.3
  • 221
    • 0032883207 scopus 로고    scopus 로고
    • Fungal resistance to plant antibiotics as a mechanism of pathogenesis
    • Morrissey, J. P., and Osbourn, A. E. (1999) Fungal resistance to plant antibiotics as a mechanism of pathogenesis, Microbiol. Mol. Biol. Rev. 63, 708-724.
    • (1999) Microbiol. Mol. Biol. Rev , vol.63 , pp. 708-724
    • Morrissey, J.P.1    Osbourn, A.E.2
  • 222
    • 0031733149 scopus 로고    scopus 로고
    • Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya
    • Saier, M. H., Jr. (1998) Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya, Adv. Microb. Physiol. 40, 81-136.
    • (1998) Adv. Microb. Physiol , vol.40 , pp. 81-136
    • Saier Jr., M.H.1
  • 223
    • 33747849236 scopus 로고    scopus 로고
    • ELM1 is required for multidrug resistance in Saccharomyces cerevisiae
    • Souid, A. K., Gao, C.,Wang, L., Milgrom, E., and Shen,W. C. (2006) ELM1 is required for multidrug resistance in Saccharomyces cerevisiae, Genetics 173, 1919-1937.
    • (2006) Genetics , vol.173 , pp. 1919-1937
    • Souid, A.K.1    Gao, C.2    Wang, L.3    Milgrom, E.4    Shen, W.C.5
  • 224
    • 0036909285 scopus 로고    scopus 로고
    • Structure and mechanism of ABC transporters
    • Schmitt, L., and Tampe, R. (2002) Structure and mechanism of ABC transporters, Curr. Opin. Struct. Biol. 12, 754-760.
    • (2002) Curr. Opin. Struct. Biol , vol.12 , pp. 754-760
    • Schmitt, L.1    Tampe, R.2
  • 225
    • 31844436264 scopus 로고    scopus 로고
    • Yeast ABC transporters-a tale of sex, stress, drugs and aging
    • Jungwirth, H., and Kuchler, K. (2006) Yeast ABC transporters-a tale of sex, stress, drugs and aging, FEBS Lett. 580, 1131-1138.
    • (2006) FEBS Lett , vol.580 , pp. 1131-1138
    • Jungwirth, H.1    Kuchler, K.2
  • 226
    • 33747154459 scopus 로고    scopus 로고
    • Multidrug-resistance efflux pumps-not just for resistance
    • Piddock, L. J. (2006) Multidrug-resistance efflux pumps-not just for resistance, Nat. Rev. Microbiol. 4, 629-636.
    • (2006) Nat. Rev. Microbiol , vol.4 , pp. 629-636
    • Piddock, L.J.1
  • 227
    • 0001607723 scopus 로고
    • Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
    • Walker, J. E., Saraste, M., Runswick, M. J., and Gay, N. J. (1982) Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold, EMBO J. 1, 945-951.
    • (1982) EMBO J , vol.1 , pp. 945-951
    • Walker, J.E.1    Saraste, M.2    Runswick, M.J.3    Gay, N.J.4
  • 228
    • 0031056684 scopus 로고    scopus 로고
    • Complete inventory of the yeast ABC proteins
    • Decottignies, A., and Goffeau, A. (1997) Complete inventory of the yeast ABC proteins, Nat. Genet. 15, 137-145.
    • (1997) Nat. Genet , vol.15 , pp. 137-145
    • Decottignies, A.1    Goffeau, A.2
  • 229
    • 67651065004 scopus 로고    scopus 로고
    • Efflux in fungi: la pi_ece de r_esistance
    • Coleman, J. J., and Mylonakis, E. (2009) Efflux in fungi: la pi_ece de r_esistance, PLoS Pathog. 5, e1000486.
    • (2009) PLoS Pathog , vol.5
    • Coleman, J.J.1    Mylonakis, E.2
  • 230
    • 33646049086 scopus 로고    scopus 로고
    • Fungal ATP-binding cassette (ABC) transporters in drug resistance and detoxification
    • Sipos, G., and Kuchler, K. (2006) Fungal ATP-binding cassette (ABC) transporters in drug resistance and detoxification, Curr. Drug Targets 7, 471-481.
    • (2006) Curr. Drug Targets , vol.7 , pp. 471-481
    • Sipos, G.1    Kuchler, K.2
  • 232
    • 33747142301 scopus 로고    scopus 로고
    • A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant
    • Iwaki, T., Giga-Hama, Y., and Takegawa, K. (2006) A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant, Microbiology 152, 2309-2321.
    • (2006) Microbiology , vol.152 , pp. 2309-2321
    • Iwaki, T.1    Giga-Hama, Y.2    Takegawa, K.3
  • 233
    • 34248222428 scopus 로고    scopus 로고
    • Plant ATP-binding cassette transporters
    • Rea, P. A. (2007) Plant ATP-binding cassette transporters, Annu. Rev. Plant Biol. 58, 347-375.
    • (2007) Annu. Rev. Plant Biol , vol.58 , pp. 347-375
    • Rea, P.A.1
  • 234
    • 0032720231 scopus 로고    scopus 로고
    • Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance
    • Bauer, B. E., Wolfger, H., and Kuchler, K. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance, Biochim. Biophys. Acta 1461, 217-236.
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 217-236
    • Bauer, B.E.1    Wolfger, H.2    Kuchler, K.3
  • 236
    • 0029013333 scopus 로고
    • LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones
    • Kralli, A., Bohen, S. P., and Yamamoto, K. R. (1995) LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones, Proc. Natl. Acad. Sci. USA 92, 4701-4705.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4701-4705
    • Kralli, A.1    Bohen, S.P.2    Yamamoto, K.R.3
  • 237
    • 0028111508 scopus 로고
    • Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product: a yeast ABC transporter conferring mycotoxin resistance
    • Bissinger, P. H., and Kuchler, K. (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product: a yeast ABC transporter conferring mycotoxin resistance, J. Biol. Chem. 269, 4180-4186.
    • (1994) J. Biol. Chem , vol.269 , pp. 4180-4186
    • Bissinger, P.H.1    Kuchler, K.2
  • 240
    • 0030776089 scopus 로고    scopus 로고
    • Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus
    • Tobin, M. B., Peery, R. B., and Skatrud, P. L. (1997) Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus, Gene 200, 11-23.
    • (1997) Gene , vol.200 , pp. 11-23
    • Tobin, M.B.1    Peery, R.B.2    Skatrud, P.L.3
  • 242
    • 0036197005 scopus 로고    scopus 로고
    • Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay
    • Semighini, C. P., Marins, M., Goldman, M. H., and Goldman, G. H. (2002) Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay, Appl. Environ. Microbiol. 68, 1351-1357.
    • (2002) Appl. Environ. Microbiol , vol.68 , pp. 1351-1357
    • Semighini, C.P.1    Marins, M.2    Goldman, M.H.3    Goldman, G.H.4
  • 243
    • 0042331368 scopus 로고    scopus 로고
    • A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients
    • and NIAID Mycoses Study Group
    • Pappas, P. G., Rex, J. H., Lee, J., Hamill, R. J., Larsen, R. A., Powderly,W., Kauffman, C. A., Hyslop, N., Mangino, J. E., Chapman, S., et al., and NIAID Mycoses Study Group (2003) A prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients, Clin. Infect. Dis. 37, 634-643.
    • (2003) Clin. Infect. Dis , vol.37 , pp. 634-643
    • Pappas, P.G.1    Rex, J.H.2    Lee, J.3    Hamill, R.J.4    Larsen, R.A.5    Powderly, W.6    Kauffman, C.A.7    Hyslop, N.8    Mangino, J.E.9    Chapman, S.10
  • 244
    • 84867113149 scopus 로고    scopus 로고
    • Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study
    • Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H.,Wenzel, R. P., and Edmond, M. B. (2009) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study, Clin. Infect. Dis. 49, 699-701.
    • (2009) Clin. Infect. Dis , vol.49 , pp. 699-701
    • Wisplinghoff, H.1    Bischoff, T.2    Tallent, S.M.3    Seifert, H.4    Wenzel, R.P.5    Edmond, M.B.6
  • 245
    • 65749096905 scopus 로고    scopus 로고
    • Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance
    • Tsao, S., Rahkhoodaee, F., and Raymond, M. (2009) Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance, Antimicrob. Agents Chemother. 53, 1344-1352.
    • (2009) Antimicrob. Agents Chemother , vol.53 , pp. 1344-1352
    • Tsao, S.1    Rahkhoodaee, F.2    Raymond, M.3
  • 246
    • 55849083537 scopus 로고    scopus 로고
    • ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates
    • Holmes, A. R., Lin, Y. H., Niimi, K., Lamping, E., Keniya, M., Niimi, M., Tanabe, K., Monk, B. C., and Cannon, R. D. (2008) ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates, Antimicrob. Agents and Chemother. 52, 3851-3862.
    • (2008) Antimicrob. Agents and Chemother , vol.52 , pp. 3851-3862
    • Holmes, A.R.1    Lin, Y.H.2    Niimi, K.3    Lamping, E.4    Keniya, M.5    Niimi, M.6    Tanabe, K.7    Monk, B.C.8    Cannon, R.D.9
  • 247
    • 0000501296 scopus 로고    scopus 로고
    • Multidrug resistance: an emerging threat
    • Prasad, R. K. S., Prasad, R., Gupta, V., and Lata, S. (1996) Multidrug resistance: an emerging threat, Curr. Sci. 71, 205-213.
    • (1996) Curr. Sci , vol.71 , pp. 205-213
    • Prasad, R.K.S.1    Prasad, R.2    Gupta, V.3    Lata, S.4
  • 248
    • 0347694571 scopus 로고    scopus 로고
    • Functional characterization of Candida albicans. ABC transporter Cdr1p
    • Shukla, S., Saini, P., Smriti, Jha, S., Ambudkar, S. V., and Prasad, R. (2003) Functional characterization of Candida albicans. ABC transporter Cdr1p, Eukaryot. Cell 2, 1361-1375.
    • (2003) Eukaryot. Cell , vol.2 , pp. 1361-1375
    • Shukla, S.1    Saini, P.2    Smritijha, S.3    Ambudkar, S.V.4    Prasad, R.5
  • 249
    • 0141868865 scopus 로고    scopus 로고
    • Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump
    • Jha, S., Karnani, N., Lynn, A. M., and Prasad, R. (2003) Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump, Biochem. Biophys. Res. Commun. 310, 869-875.
    • (2003) Biochem. Biophys. Res. Commun , vol.310 , pp. 869-875
    • Jha, S.1    Karnani, N.2    Lynn, A.M.3    Prasad, R.4
  • 250
    • 4744371579 scopus 로고    scopus 로고
    • ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry FEMS
    • Jha, S., Dabas, N., Karnani, N., Saini, P., and Prasad, R. (2004) ABC multidrug transporter Cdr1p of Candida albicans has divergent nucleotide-binding domains which display functional asymmetry, FEMS Yeast Res. 5, 63-72.
    • (2004) Yeast Res , vol.5 , pp. 63-72
    • Jha, S.1    Dabas, N.2    Karnani, N.3    Saini, P.4    Prasad, R.5
  • 252
    • 35648977496 scopus 로고    scopus 로고
    • Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system
    • Shukla, S., Rai, V., Saini, P., Banerjee, D., Menon, A. K., and Prasad, R. (2007) Candida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system, Biochemistry 46, 12081-12090.
    • (2007) Biochemistry , vol.46 , pp. 12081-12090
    • Shukla, S.1    Rai, V.2    Saini, P.3    Banerjee, D.4    Menon, A.K.5    Prasad, R.6
  • 253
    • 0030025637 scopus 로고    scopus 로고
    • Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance
    • Clark, F. S., Parkinson, T., Hitchcock, C. A., and Gow, N. A. (1996) Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance, Antimicrob. Agents Chemother. 40, 419-425.
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 419-425
    • Clark, F.S.1    Parkinson, T.2    Hitchcock, C.A.3    Gow, N.A.4
  • 254
    • 33645785596 scopus 로고    scopus 로고
    • Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility
    • Niimi, K., Maki, K., Ikeda, F., Holmes, A. R., Lamping, E., Niimi, M., Monk, B. C., and Cannon, R. D. (2006) Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility, Antimicrob. Agents Chemother. 50, 1148-1155.
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1148-1155
    • Niimi, K.1    Maki, K.2    Ikeda, F.3    Holmes, A.R.4    Lamping, E.5    Niimi, M.6    Monk, B.C.7    Cannon, R.D.8
  • 255
    • 0036720765 scopus 로고    scopus 로고
    • The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance
    • Moran, G., Sullivan, D., Morschhauser, J., and Coleman, D. (2002) The Candida dubliniensis CdCDR1 gene is not essential for fluconazole resistance, Antimicrob. Agents Chemother. 46, 2829-2841.
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 2829-2841
    • Moran, G.1    Sullivan, D.2    Morschhauser, J.3    Coleman, D.4
  • 257
    • 20444394677 scopus 로고    scopus 로고
    • Inhibition of efflux transporter-mediated fungicide resistance in Pyrenophora tritici-repentis by a derivative of 40-hydroxyflavone and enhancement of fungicide activity
    • Reimann, S., and Deising, H. B. (2005) Inhibition of efflux transporter-mediated fungicide resistance in Pyrenophora tritici-repentis by a derivative of 40-hydroxyflavone and enhancement of fungicide activity, Appl. Environ. Microbiol. 71, 3269-3275.
    • (2005) Appl. Environ. Microbiol , vol.71 , pp. 3269-3275
    • Reimann, S.1    Deising, H.B.2
  • 259
    • 0033081463 scopus 로고    scopus 로고
    • An ATP-driven efflux pump is a novel pathogenicity factor in rice blast disease
    • Urban, M., Bhargava, T., and Hamer, J. E. (1999) An ATP-driven efflux pump is a novel pathogenicity factor in rice blast disease, EMBO J. 18, 512-521.
    • (1999) EMBO J , vol.18 , pp. 512-521
    • Urban, M.1    Bhargava, T.2    Hamer, J.E.3
  • 260
    • 33947502268 scopus 로고    scopus 로고
    • A multidrug resistance transporter in Magnaporthe is required for host penetration and for survival during oxidative stress
    • Sun, C. B., Suresh, A., Deng, Y. Z., and Naqvi, N. I. (2006) A multidrug resistance transporter in Magnaporthe is required for host penetration and for survival during oxidative stress, Plant Cell 18, 3686-3705.
    • (2006) Plant Cell , vol.18 , pp. 3686-3705
    • Sun, C.B.1    Suresh, A.2    Deng, Y.Z.3    Naqvi, N.I.4
  • 261
    • 67650572854 scopus 로고    scopus 로고
    • Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans
    • Chen, C. G., Yang, Y. L., Tseng, K. Y., Shih, H. I., Liou, C. H., Lin, C. C., and Lo, H. J. (2009) Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans, Fungal Genet. Biol. 46, 714-720.
    • (2009) Fungal Genet. Biol , vol.46 , pp. 714-720
    • Chen, C.G.1    Yang, Y.L.2    Tseng, K.Y.3    Shih, H.I.4    Liou, C.H.5    Lin, C.C.6    Lo, H.J.7
  • 262
    • 0036894102 scopus 로고    scopus 로고
    • ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola
    • Zwiers, L. H., Stergiopoulos, I., Van Nistelrooy, J. G., and DeWaard, M. A. (2002) ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola, Antimicrob. Agents Chemother. 46, 3900-3906.
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 3900-3906
    • Zwiers, L.H.1    Stergiopoulos, I.2    Van Nistelrooy, J.G.3    DeWaard, M.A.4
  • 263
    • 0035042746 scopus 로고    scopus 로고
    • The ABC transporter BcatrB from Botrytis cinerea is a determinant of the activity of the phenylpyrrole fungicide fludioxonil
    • Vermeulen, T., Schoonbeek, H., and De Waard, M. A. (2001) The ABC transporter BcatrB from Botrytis cinerea is a determinant of the activity of the phenylpyrrole fungicide fludioxonil. Pest Mang. Sci. 57, 393-402.
    • (2001) Pest Mang. Sci , vol.57 , pp. 393-402
    • Vermeulen, T.1    Schoonbeek, H.2    De Waard, M.A.3
  • 264
    • 0034779263 scopus 로고    scopus 로고
    • Critical annotations to the use of azole antifungals for plant protection
    • Hof, H. (2001) Critical annotations to the use of azole antifungals for plant protection, Antimicrob. Agents Chemother. 45, 2987-2990.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 2987-2990
    • Hof, H.1
  • 265
    • 84867123768 scopus 로고    scopus 로고
    • Diagnosis of chytridiomycosis in amphibians by histologic examination
    • Queensland Museum, Brisbane, Australia
    • Berger, L., Speare, R., and Kent, A. (1999) Diagnosis of chytridiomycosis in amphibians by histologic examination. Proc. Frog Symposium: Frogs in the Community, Queensland Museum, Brisbane, Australia.
    • (1999) Proc. Frog Symposium: Frogs in the Community
    • Berger, L.1    Speare, R.2    Kent, A.3
  • 266
    • 84867131053 scopus 로고
    • The Comparative Method in Evolutionary Biology, Oxford University Press, Oxford, UK
    • Harvey, P. H., and Pagel, M. D. (1991). The Comparative Method in Evolutionary Biology, Oxford University Press, Oxford, UK.
    • (1991)
    • Harvey, P.H.1    Pagel, M.D.2
  • 268
    • 0034237772 scopus 로고    scopus 로고
    • Adaptation and the comparative method
    • Martins, E. (2000) Adaptation and the comparative method, Trends Ecol. Evol. 15, 296-299.
    • (2000) Trends Ecol. Evol , vol.15 , pp. 296-299
    • Martins, E.1
  • 270
    • 34247577123 scopus 로고    scopus 로고
    • Phylogenetics of Saccharomycetales, the ascomycete yeasts
    • Suh, S. O., Blackwell, M., Kurtzman, C. P., and Lachance, M. A. (2006) Phylogenetics of Saccharomycetales, the ascomycete yeasts, Mycologia 98, 1006-1017.
    • (2006) Mycologia , vol.98 , pp. 1006-1017
    • Suh, S.O.1    Blackwell, M.2    Kurtzman, C.P.3    Lachance, M.A.4
  • 272
    • 33845452848 scopus 로고    scopus 로고
    • A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis
    • Fitzpatrick, D. A., Logue, M. E., Stajich, J. E., and Butler, G. (2006) A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis, BMC Evol. Biol. 6, 99.
    • (2006) BMC Evol. Biol , vol.6 , pp. 99
    • Fitzpatrick, D.A.1    Logue, M.E.2    Stajich, J.E.3    Butler, G.4
  • 273
    • 37849022824 scopus 로고    scopus 로고
    • Insights from sequencing fungal and oomycete genomes: What can we learn about plant disease and the evolution of pathogenicity?
    • Soanes, D. M., Richards, T. A., and Talbot, N. J. (2007) Insights from sequencing fungal and oomycete genomes: What can we learn about plant disease and the evolution of pathogenicity? Plant Cell 19, 3318-3326.
    • (2007) Plant Cell , vol.19 , pp. 3318-3326
    • Soanes, D.M.1    Richards, T.A.2    Talbot, N.J.3
  • 274
    • 67249089901 scopus 로고    scopus 로고
    • Multilevel comparison of dendrograms: a new method with an application for genetic classifications
    • Podani, J., Engloner, A., and Major, A. (2009) Multilevel comparison of dendrograms: a new method with an application for genetic classifications, Stat. Appl. Genet. Mol. Biol. 8, 1-14.
    • (2009) Stat. Appl. Genet. Mol. Biol. , vol.8 , pp. 1-14
    • Podani, J.1    Engloner, A.2    Major, A.3
  • 275
    • 0027968068 scopus 로고
    • CLUSTALW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) CLUSTALW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice, Nucleic Acids Res. 22, 4673-4680.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 277
    • 0000461280 scopus 로고
    • Confidence limits on phylogenies: an approach using the bootstrap
    • Felsenstein, J. (1985) Confidence limits on phylogenies: an approach using the bootstrap, Evolution 39, 783-791.
    • (1985) Evolution , vol.39 , pp. 783-791
    • Felsenstein, J.1
  • 278
    • 0003552989 scopus 로고
    • National Biomedical Research Foundation, Silver Springs, MD a.M.O.D.
    • Eck, R. V. a. M. O. D. (1966) Atlas of Protein Sequences and Structure, National Biomedical Research Foundation, Silver Springs, MD.
    • (1966) Atlas of Protein Sequences and Structure
    • Eck, R.V.1
  • 279
    • 34547781750 scopus 로고    scopus 로고
    • MEGA4: Molecular Evolutionary genetics analysis (MEGA), software version 4.0
    • Tamura, K., Dudley, J., Nei, M., and Kumar, S. (2007) MEGA4: Molecular Evolutionary genetics analysis (MEGA), software version 4.0, Mol. Biol. Evol. 24, 1596-1599.
    • (2007) Mol. Biol. Evol , vol.24 , pp. 1596-1599
    • Tamura, K.1    Dudley, J.2    Nei, M.3    Kumar, S.4
  • 280
    • 58149316028 scopus 로고    scopus 로고
    • Dos Santos, S. C., Teixeira, M. C., Cabrito, T. R., and Mira, N. P
    • + antiporters in chemical stress response in yeast, Trends Microbiol. 17, 22-31.
    • (2009) , vol.17 , pp. 22-31
    • Sa-Correia, I.1
  • 281
    • 0028067604 scopus 로고
    • The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily
    • Ehrenhofer-Murray, A. E., Wurgler, F. E., and Sengstag, C. (1994) The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily, Mol. Gen. Genet. 244, 287-294.
    • (1994) Mol. Gen. Genet , vol.244 , pp. 287-294
    • Ehrenhofer-Murray, A.E.1    Wurgler, F.E.2    Sengstag, C.3
  • 282
    • 0036777749 scopus 로고    scopus 로고
    • Dtrlp, a multidrug resistance transporter of the major facilitator superfamily plays an essential role in spore wall maturation in Saccharomyces cerevisiae
    • Felder, T., Bogengruber, E., Tenreiro, S., Ellinger, A., Sa-Correia, I., and Briza, P. (2002) Dtrlp, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae, Eukaryot. Cell 1, 799-810.
    • (2002) Eukaryot. Cell , vol.1 , pp. 799-810
    • Felder, T.1    Bogengruber, E.2    Tenreiro, S.3    Ellinger, A.4    Sa-Correia, I.5    Briza, P.6
  • 288
    • 0025774660 scopus 로고
    • Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate
    • Fling, M. E., Kopf, J., Tamarkin, A., Gorman, J. A., Smith, H. A., and Koltin, Y. (1991) Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate, Mol. Gen. Genet. 227, 318-329.
    • (1991) Mol. Gen. Genet , vol.227 , pp. 318-329
    • Fling, M.E.1    Kopf, J.2    Tamarkin, A.3    Gorman, J.A.4    Smith, H.A.5    Koltin, Y.6
  • 289
    • 0028293750 scopus 로고
    • Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene
    • Ben-Yaacov, R., Knoller, S., Caldwell, G. A., Becker, J. M., and Koltin, Y. (1994) Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene, Antimicrob. Agents Chemother. 38, 648-652.
    • (1994) Antimicrob. Agents Chemother , vol.38 , pp. 648-652
    • Ben-Yaacov, R.1    Knoller, S.2    Caldwell, G.A.3    Becker, J.M.4    Koltin, Y.5
  • 291
    • 34248398758 scopus 로고    scopus 로고
    • A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole
    • Cheng, S., Clancy, C. J., Nguyen, K. T., Clapp,W., and Nguyen, M. H. (2007) A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole, Antimicrob. Agents Chemother. 51, 1855-1858.
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 1855-1858
    • Cheng, S.1    Clancy, C.J.2    Nguyen, K.T.3    Clapp, W.4    Nguyen, M.H.5
  • 292
    • 0028844181 scopus 로고
    • Reduced virulence of Candida albicans mutants affected in multidrug resistance
    • Becker, J. M., Henry, L. K., Jiang, W., and Koltin, Y. (1995) Reduced virulence of Candida albicans mutants affected in multidrug resistance, Infect. Immun. 63, 4515-4518.
    • (1995) Infect. Immun , vol.63 , pp. 4515-4518
    • Becker, J.M.1    Henry, L.K.2    Jiang, W.3    Koltin, Y.4
  • 294
    • 0033677649 scopus 로고    scopus 로고
    • A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole
    • Calabrese, D., Bille, J., and Sanglard, D. (2000) A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole, Microbiology 146(Pt. 11), 2743-2754.
    • (2000) Microbiology , vol.146 , Issue.PART 11 , pp. 2743-2754
    • Calabrese, D.1    Bille, J.2    Sanglard, D.3
  • 295
    • 0037459113 scopus 로고    scopus 로고
    • Two membrane proteins located in the Nag regulon of Candida albicans confer multidrug resistance
    • Sengupta, M., and Datta, A. (2003) Two membrane proteins located in the Nag regulon of Candida albicans confer multidrug resistance, Biochem. Biophys. Res. Commun. 301, 1099-1108.
    • (2003) Biochem. Biophys. Res. Commun , vol.301 , pp. 1099-1108
    • Sengupta, M.1    Datta, A.2
  • 297
    • 0036795786 scopus 로고    scopus 로고
    • Bcmfs1, a novel major facilitator superfamily transporter from Botrytis cinerea, provides tolerance towards the natural toxic compounds camptothecin and cercosporin and towards fungicides
    • Hayashi, K., Schoonbeek, H. J., and De Waard, M. A. (2002) Bcmfs1, a novel major facilitator superfamily transporter from Botrytis cinerea, provides tolerance towards the natural toxic compounds camptothecin and cercosporin and towards fungicides, Appl. Environ. Microbiol. 68, 4996-5004.
    • (2002) Appl. Environ. Microbiol , vol.68 , pp. 4996-5004
    • Hayashi, K.1    Schoonbeek, H.J.2    De Waard, M.A.3
  • 298
    • 33947591073 scopus 로고    scopus 로고
    • MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides
    • Roohparvar, R., De Waard, M. A., Kema, G. H., and Zwiers, L. H. (2007) MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides, Fungal Genet. Biol. 44, 378-388.
    • (2007) Fungal Genet. Biol , vol.44 , pp. 378-388
    • Roohparvar, R.1    De Waard, M.A.2    Kema, G.H.3    Zwiers, L.H.4
  • 299
    • 46849107922 scopus 로고    scopus 로고
    • The drug transporter MgMfs1 can modulate sensitivity of field strains of the fungal wheat pathogen Mycosphaerella graminicola to the strobilurin fungicide trifloxystrobin
    • Roohparvar, R., Mehrabi, R., Van Nistelrooy, J. G., Zwiers, L. H., and De Waard, M. A. (2008) The drug transporter MgMfs1 can modulate sensitivity of field strains of the fungal wheat pathogen Mycosphaerella graminicola to the strobilurin fungicide trifloxystrobin, Pest Mang. Sci. 64, 685-693.
    • (2008) Pest Mang. Sci , vol.64 , pp. 685-693
    • Roohparvar, R.1    Mehrabi, R.2    Van Nistelrooy, J.G.3    Zwiers, L.H.4    De Waard, M.A.5
  • 300
    • 33646171879 scopus 로고    scopus 로고
    • A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    • Coste, A., Turner, V., Ischer, F., Morschhauser, J., Forche, A., Selmecki, A., Berman, J., Bille, J., and Sanglard, D. (2006) A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans, Genetics 172, 2139-2156.
    • (2006) Genetics , vol.172 , pp. 2139-2156
    • Coste, A.1    Turner, V.2    Ischer, F.3    Morschhauser, J.4    Forche, A.5    Selmecki, A.6    Berman, J.7    Bille, J.8    Sanglard, D.9
  • 302
    • 68549123451 scopus 로고    scopus 로고
    • Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans
    • Sellam, A., Tebbji, F., and Nantel, A. (2009) Role of Ndt80p in sterol metabolism regulation and azole resistance in Candida albicans, Eukaryot. Cell 8, 1174-1183.
    • (2009) Eukaryot. Cell , vol.8 , pp. 1174-1183
    • Sellam, A.1    Tebbji, F.2    Nantel, A.3
  • 303
    • 37349095258 scopus 로고    scopus 로고
    • The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans
    • Morschhauser, J., Barker, K. S., Liu, T. T., Bla, B.W. J., Homayouni, R., and Rogers, P. D. (2007) The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans, PLoS Pathog. 3, e164.
    • (2007) PLoS Pathog , vol.3
    • Morschhauser, J.1    Barker, K.S.2    Liu, T.T.3    Bla, B.W.J.4    Homayouni, R.5    Rogers, P.D.6
  • 305
    • 33845632497 scopus 로고    scopus 로고
    • Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site
    • Riggle, P. J., and Kumamoto, C. A. (2006) Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site, Eukaryot. Cell 5, 1957-1968.
    • (2006) Eukaryot. Cell , vol.5 , pp. 1957-1968
    • Riggle, P.J.1    Kumamoto, C.A.2
  • 308
    • 40149095880 scopus 로고    scopus 로고
    • Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae
    • Kolaczkowska, A., Kolaczkowski, M., Goffeau, A., and Moye-Rowley, W. S. (2008) Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae, FEBS Lett. 582, 977-983.
    • (2008) FEBS Lett , vol.582 , pp. 977-983
    • Kolaczkowska, A.1    Kolaczkowski, M.2    Goffeau, A.3    Moye-Rowley, W.S.4
  • 310
    • 65749086262 scopus 로고    scopus 로고
    • Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps
    • Zhang, H., Gao, A., Li, F., Zhang, G., Ho, H. I., and Liao,W. (2009) Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps, Yakugaku Zasshi 129, 623-630.
    • (2009) Yakugaku Zasshi , vol.129 , pp. 623-630
    • Zhang, H.1    Gao, A.2    Li, F.3    Zhang, G.4    Ho, H.I.5    Liao, W.6
  • 311
    • 62549089176 scopus 로고    scopus 로고
    • Cerulenin analogues as inhibitors of efflux pumps in drug-resistant Candida albicans
    • Diwischek, F., Morschhauser, J., and Holzgrabe, U. (2009) Cerulenin analogues as inhibitors of efflux pumps in drug-resistant Candida albicans, Arch. Pharm. (Weinheim) 342, 150-164.
    • (2009) Arch. Pharm. (Weinheim) , vol.342 , pp. 150-164
    • Diwischek, F.1    Morschhauser, J.2    Holzgrabe, U.3
  • 312
  • 314
    • 55849115646 scopus 로고    scopus 로고
    • Aspergillus fumigatus forms biofilms with reduced antifungal drug susceptibility on bronchial epithelial cells
    • Seidler, M. J., Salvenmoser, S., and Muller, F. M. (2008) Aspergillus fumigatus forms biofilms with reduced antifungal drug susceptibility on bronchial epithelial cells, Antimicrob. Agents Chemother. 52, 4130-4136.
    • (2008) Antimicrob. Agents Chemother , vol.52 , pp. 4130-4136
    • Seidler, M.J.1    Salvenmoser, S.2    Muller, F.M.3
  • 317
    • 33646068777 scopus 로고    scopus 로고
    • Biofilms and their role in the resistance of pathogenic Candida to antifungal agents
    • d'Enfert, C. (2006) Biofilms and their role in the resistance of pathogenic Candida to antifungal agents, Curr. Drug Targets 7, 465-670.
    • (2006) Curr. Drug Targets , vol.7 , pp. 465-670
    • d'Enfert, C.1
  • 318
    • 0041764578 scopus 로고    scopus 로고
    • Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols
    • Mukherjee, P.K., Chandra, J., Kuhn, D. M., and Ghannoum, M. A. (2003) Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols, Infect. Immun. 71, 4333-4340.
    • (2003) Infect. Immun , vol.71 , pp. 4333-4340
    • Mukherjee, P.K.1    Chandra, J.2    Kuhn, D.M.3    Ghannoum, M.A.4
  • 319
    • 0035992139 scopus 로고    scopus 로고
    • Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms
    • Ramage, G., Bachmann, S., Patterson, T. F.,Wickes, B. L., and López-Ribot, J. L. (2002) Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms, J. Antimicrob. Chemother. 49, 973-980.
    • (2002) J. Antimicrob. Chemother , vol.49 , pp. 973-980
    • Ramage, G.1    Bachmann, S.2    Patterson, T.F.3    Wickes, B.L.4    López-Ribot, J.L.5
  • 320
    • 34447277349 scopus 로고    scopus 로고
    • Role for cell density in antifungal drug resistance in Candida albicans biofilms
    • Perumal, P., Mekala, S., and Chaffin,W. L. (2007) Role for cell density in antifungal drug resistance in Candida albicans biofilms, Antimicrob. Agents Chemother. 51, 2454-2463.
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 2454-2463
    • Perumal, P.1    Mekala, S.2    Chaffin, W.L.3
  • 321
    • 51949116049 scopus 로고    scopus 로고
    • Candida albicans cell wall proteins
    • Chaffin,W. L. (2008) Candida albicans cell wall proteins, Microbiol. Mol. Biol. Rev. 72, 495-544.
    • (2008) Microbiol. Mol. Biol. Rev , vol.72 , pp. 495-544
    • Chaffin, W.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.