-
1
-
-
0031278034
-
A family of gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from gram-negative bacteria
-
Paulsen I.T., Park J.H., Choi P.S., and Saier M.H. A family of gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from gram-negative bacteria. FEMS Microbiol. Lett. 156 (1997) 1-8
-
(1997)
FEMS Microbiol. Lett.
, vol.156
, pp. 1-8
-
-
Paulsen, I.T.1
Park, J.H.2
Choi, P.S.3
Saier, M.H.4
-
2
-
-
0028318241
-
A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria
-
Dinh T., Paulsen I.T., and Saier M.H. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J. Bacteriol. 176 (1994) 3825-3831
-
(1994)
J. Bacteriol.
, vol.176
, pp. 3825-3831
-
-
Dinh, T.1
Paulsen, I.T.2
Saier, M.H.3
-
3
-
-
0027508337
-
Molecular cloning and characterization of acrA and acrE genes of Escherichia coli
-
Ma D., Cook D.N., Alberti M., Pon N.G., Nikaido H., and Hearst J.E. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175 (1993) 6299-6313
-
(1993)
J. Bacteriol.
, vol.175
, pp. 6299-6313
-
-
Ma, D.1
Cook, D.N.2
Alberti, M.3
Pon, N.G.4
Nikaido, H.5
Hearst, J.E.6
-
4
-
-
0028926676
-
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli
-
Ma D., Cook D.N., Alberti M., Pon N.G., Nikaido H., and Hearst J.E. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microbiol. 16 (1995) 45-55
-
(1995)
Mol. Microbiol.
, vol.16
, pp. 45-55
-
-
Ma, D.1
Cook, D.N.2
Alberti, M.3
Pon, N.G.4
Nikaido, H.5
Hearst, J.E.6
-
5
-
-
0029845913
-
Multidrug efflux pumps of gram-negative bacteria
-
Nikaido H. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178 (1996) 5853-5859
-
(1996)
J. Bacteriol.
, vol.178
, pp. 5853-5859
-
-
Nikaido, H.1
-
6
-
-
0027365548
-
Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium
-
Vaara M. Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium. Antimicrob. Agents Chemother. 37 (1993) 2255-2260
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 2255-2260
-
-
Vaara, M.1
-
7
-
-
0031720812
-
Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains
-
Nikaido H., Basina M., Nguyen V., and Rosenberg E.Y. Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains. J. Bacteriol. 180 (1998) 4686-4692
-
(1998)
J. Bacteriol.
, vol.180
, pp. 4686-4692
-
-
Nikaido, H.1
Basina, M.2
Nguyen, V.3
Rosenberg, E.Y.4
-
8
-
-
0037057652
-
Crystal structure of bacterial multidrug efflux transporter AcrB
-
Murakami S., Nakashima R., Yamashita E., and Yamaguchi A. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419 (2002) 587-593
-
(2002)
Nature
, vol.419
, pp. 587-593
-
-
Murakami, S.1
Nakashima, R.2
Yamashita, E.3
Yamaguchi, A.4
-
9
-
-
0029129966
-
Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa
-
Li X.Z., Nikaido H., and Poole K. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39 (1995) 1948-1953
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1948-1953
-
-
Li, X.Z.1
Nikaido, H.2
Poole, K.3
-
10
-
-
0028050605
-
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance
-
Li X.Z., Ma D., Livermore D.M., and Nikaido H. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance. Antimicrob. Agents Chemother. 38 (1994) 1742-1752
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1742-1752
-
-
Li, X.Z.1
Ma, D.2
Livermore, D.M.3
Nikaido, H.4
-
11
-
-
14644397893
-
Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli
-
Aires J.R., and Nikaido H. Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli. J. Bacteriol. 187 (2005) 1923-1929
-
(2005)
J. Bacteriol.
, vol.187
, pp. 1923-1929
-
-
Aires, J.R.1
Nikaido, H.2
-
12
-
-
0035162640
-
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy
-
Lomovskaya O., Warren M.S., Lee A., Galazzo J., Fronko R., Lee M., Blais J., Cho D., Chamberland S., Renau T., Leger R., Hecker S., Watkins W., Hoshino K., Ishida H., and Lee V.J. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob. Agents Chemother. 45 (2001) 105-116
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 105-116
-
-
Lomovskaya, O.1
Warren, M.S.2
Lee, A.3
Galazzo, J.4
Fronko, R.5
Lee, M.6
Blais, J.7
Cho, D.8
Chamberland, S.9
Renau, T.10
Leger, R.11
Hecker, S.12
Watkins, W.13
Hoshino, K.14
Ishida, H.15
Lee, V.J.16
-
13
-
-
0034115142
-
Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance
-
Lee A., Mao W., Warren M.S., Mistry A., Hoshino K., Okumura R., Ishida H., and Lomovskaya O. Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance. J. Bacteriol. 182 (2000) 3142-3150
-
(2000)
J. Bacteriol.
, vol.182
, pp. 3142-3150
-
-
Lee, A.1
Mao, W.2
Warren, M.S.3
Mistry, A.4
Hoshino, K.5
Okumura, R.6
Ishida, H.7
Lomovskaya, O.8
-
14
-
-
0142168992
-
+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach
-
+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach. Curr. Opin. Chem. Biol. 7 (2003) 570-579
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 570-579
-
-
Tamura, N.1
Konishi, S.2
Yamaguchi, A.3
-
15
-
-
0029872148
-
Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity
-
Paulsen I.T., Brown M.H., Littlejohn T.G., Mitchell B.A., and Skurray R.A. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 3630-3635
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 3630-3635
-
-
Paulsen, I.T.1
Brown, M.H.2
Littlejohn, T.G.3
Mitchell, B.A.4
Skurray, R.A.5
-
16
-
-
0033594886
-
Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
-
Zgurskaya H.I., and Nikaido H. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 7190-7195
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 7190-7195
-
-
Zgurskaya, H.I.1
Nikaido, H.2
-
17
-
-
34948849834
-
Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay
-
Su C.C., and Yu E.W. Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay. FEBS Lett. 581 (2007) 4972-4976
-
(2007)
FEBS Lett.
, vol.581
, pp. 4972-4976
-
-
Su, C.C.1
Yu, E.W.2
-
18
-
-
0030845301
-
Use of fluorescence probes to monitor function of the subunit proteins of the MexA-MexB-oprM drug extrusion machinery in Pseudomonas aeruginosa
-
Ocaktan A., Yoneyama H., and Nakae T. Use of fluorescence probes to monitor function of the subunit proteins of the MexA-MexB-oprM drug extrusion machinery in Pseudomonas aeruginosa. J. Biol. Chem. 272 (1997) 21964-21969
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21964-21969
-
-
Ocaktan, A.1
Yoneyama, H.2
Nakae, T.3
-
19
-
-
0942298094
-
Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport
-
Murakami S., Tamura N., Saito A., Hirata T., and Yamaguchi A. Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport. J. Biol. Chem. 279 (2004) 3743-3748
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3743-3748
-
-
Murakami, S.1
Tamura, N.2
Saito, A.3
Hirata, T.4
Yamaguchi, A.5
-
20
-
-
0033543578
-
Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family
-
Goldberg M., Pribyl T., Juhnke S., and Nies D.H. Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family. J. Biol. Chem. 274 (1999) 26065-26070
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 26065-26070
-
-
Goldberg, M.1
Pribyl, T.2
Juhnke, S.3
Nies, D.H.4
-
21
-
-
33749073795
-
Cholesterol sensing, trafficking, and esterification
-
Chang T.Y., Chang C.C., Ohgami N., and Yamauchi Y. Cholesterol sensing, trafficking, and esterification. Annu. Rev. Cell Dev. Biol. 22 (2006) 129-157
-
(2006)
Annu. Rev. Cell Dev. Biol.
, vol.22
, pp. 129-157
-
-
Chang, T.Y.1
Chang, C.C.2
Ohgami, N.3
Yamauchi, Y.4
-
22
-
-
38149069055
-
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein
-
Infante R.E., Abi-Mosleh L., Radhakrishnan A., Dale J.D., Brown M.S., and Goldstein J.L. Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J. Biol. Chem. 283 (2008) 1052-1063
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1052-1063
-
-
Infante, R.E.1
Abi-Mosleh, L.2
Radhakrishnan, A.3
Dale, J.D.4
Brown, M.S.5
Goldstein, J.L.6
-
23
-
-
38149068309
-
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop
-
Infante R.E., Radhakrishnan A., Abi-Mosleh L., Kinch L.N., Wang M.L., Grishin N.V., Goldstein J.L., and Brown M.S. Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J. Biol. Chem. 283 (2008) 1064-1075
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1064-1075
-
-
Infante, R.E.1
Radhakrishnan, A.2
Abi-Mosleh, L.3
Kinch, L.N.4
Wang, M.L.5
Grishin, N.V.6
Goldstein, J.L.7
Brown, M.S.8
-
24
-
-
0036889033
-
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops
-
Elkins C.A., and Nikaido H. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. J. Bacteriol. 184 (2002) 6490-6498
-
(2002)
J. Bacteriol.
, vol.184
, pp. 6490-6498
-
-
Elkins, C.A.1
Nikaido, H.2
-
25
-
-
0036889445
-
Chimeric analysis of the multicomponent multidrug efflux transporters from Gram-negative bacteria
-
Tikhonova E.B., Wang Q., and Zgruskaya H. Chimeric analysis of the multicomponent multidrug efflux transporters from Gram-negative bacteria. J. Bacteriol. 184 (2002) 6499-6507
-
(2002)
J. Bacteriol.
, vol.184
, pp. 6499-6507
-
-
Tikhonova, E.B.1
Wang, Q.2
Zgruskaya, H.3
-
26
-
-
0037462824
-
An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space
-
Eda S., Maseda H., and Nakae T. An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space. J. Biol. Chem. 278 (2003) 2085-2088
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2085-2088
-
-
Eda, S.1
Maseda, H.2
Nakae, T.3
-
27
-
-
0036437057
-
On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition
-
Mao W., Warren M.S., Black D.S., Satou T., Murata T., Nishino T., Gotoh N., and Lomovskaya O. On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition. Mol. Microbiol. 46 (2002) 889-901
-
(2002)
Mol. Microbiol.
, vol.46
, pp. 889-901
-
-
Mao, W.1
Warren, M.S.2
Black, D.S.3
Satou, T.4
Murata, T.5
Nishino, T.6
Gotoh, N.7
Lomovskaya, O.8
-
28
-
-
34447534306
-
Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)
-
Bohnert J.A., Schuster S., Fähnrich E., Trittler R., and Kern W.V. Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF). J. Antimicrob. Chemother. 59 (2007) 1216-1222
-
(2007)
J. Antimicrob. Chemother.
, vol.59
, pp. 1216-1222
-
-
Bohnert, J.A.1
Schuster, S.2
Fähnrich, E.3
Trittler, R.4
Kern, W.V.5
-
29
-
-
1342325470
-
Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa
-
Middlemiss J.K., and Poole K. Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. J. Bacteriol. 186 (2004) 1258-1269
-
(2004)
J. Bacteriol.
, vol.186
, pp. 1258-1269
-
-
Middlemiss, J.K.1
Poole, K.2
-
30
-
-
0035110804
-
Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa
-
Guan L., and Nakae T. Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa. J. Bacteriol. 183 (2001) 1734-1739
-
(2001)
J. Bacteriol.
, vol.183
, pp. 1734-1739
-
-
Guan, L.1
Nakae, T.2
-
31
-
-
33749630424
-
Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network
-
Takatsuka Y., and Nikaido H. Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network. J. Bacteriol. 188 (2006) 7284-7289
-
(2006)
J. Bacteriol.
, vol.188
, pp. 7284-7289
-
-
Takatsuka, Y.1
Nikaido, H.2
-
32
-
-
0141615783
-
AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity
-
Yu E.W., Aires J.R., and Nikaido H. AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity. J. Bacteriol. 185 (2003) 5657-5664
-
(2003)
J. Bacteriol.
, vol.185
, pp. 5657-5664
-
-
Yu, E.W.1
Aires, J.R.2
Nikaido, H.3
-
33
-
-
25144504245
-
A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study
-
Yu E.W., Aires J.R., McDermott G., and Nikaido H. A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study. J. Bacteriol. 187 (2005) 6804-6815
-
(2005)
J. Bacteriol.
, vol.187
, pp. 6804-6815
-
-
Yu, E.W.1
Aires, J.R.2
McDermott, G.3
Nikaido, H.4
-
34
-
-
33644880275
-
Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a
-
Hearn E.M., Gray M.R., and Foght J.M. Mutations in the central cavity and periplasmic domain affect efflux activity of the resistance-nodulation-division pump EmhB from Pseudomonas fluorescens cLP6a. J. Bacteriol. 188 (2006) 115-123
-
(2006)
J. Bacteriol.
, vol.188
, pp. 115-123
-
-
Hearn, E.M.1
Gray, M.R.2
Foght, J.M.3
-
35
-
-
0037701544
-
Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli
-
Franke S., Grass G., Rensing C., and Nies D.H. Molecular analysis of the copper-transporting efflux system CusCFBA of Escherichia coli. J. Bacteriol. 185 (2003) 3804-3812
-
(2003)
J. Bacteriol.
, vol.185
, pp. 3804-3812
-
-
Franke, S.1
Grass, G.2
Rensing, C.3
Nies, D.H.4
-
36
-
-
34547621067
-
Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae
-
Dastidar V., Mao W., Lomovskaya O., and Zgurskaya H.I. Drug-induced conformational changes in multidrug efflux transporter AcrB from Haemophilus influenzae. J. Bacteriol. 189 (2007) 5550-5558
-
(2007)
J. Bacteriol.
, vol.189
, pp. 5550-5558
-
-
Dastidar, V.1
Mao, W.2
Lomovskaya, O.3
Zgurskaya, H.I.4
-
37
-
-
0028307550
-
Phosphatidylcholine translocase: a physiological role for the mdr2 gene
-
Ruetz S., and Gros P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77 (1994) 1071-1081
-
(1994)
Cell
, vol.77
, pp. 1071-1081
-
-
Ruetz, S.1
Gros, P.2
-
38
-
-
0034950853
-
MexXY-OprM efflux pump is required for antagonism of aminoglycosides by divalent cations in Pseudomonas aeruginosa
-
Mao W., Warren M.S., Lee A., Mistry A., and Lomovskaya O. MexXY-OprM efflux pump is required for antagonism of aminoglycosides by divalent cations in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 45 (2001) 2001-2007
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 2001-2007
-
-
Mao, W.1
Warren, M.S.2
Lee, A.3
Mistry, A.4
Lomovskaya, O.5
-
39
-
-
34250766201
-
The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins
-
Schmidt T.G., and Skerra A. The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins. Nature Protocols 2 (2007) 1528-1535
-
(2007)
Nature Protocols
, vol.2
, pp. 1528-1535
-
-
Schmidt, T.G.1
Skerra, A.2
-
40
-
-
0023887303
-
Purification and reconstitution of Escherichia coli proline carrier using a site specifically cleavable fusion protein
-
Hanada K., Yamato I., and Anraku Y. Purification and reconstitution of Escherichia coli proline carrier using a site specifically cleavable fusion protein. J. Biol. Chem. 263 (1988) 7181-7185
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 7181-7185
-
-
Hanada, K.1
Yamato, I.2
Anraku, Y.3
-
41
-
-
33846263341
-
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB
-
Tikhonova E.B., Devroy V.K., Lau S.Y., and Zgurskaya H.I. Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB. Mol. Microbiol. 63 (2007) 895-910
-
(2007)
Mol. Microbiol.
, vol.63
, pp. 895-910
-
-
Tikhonova, E.B.1
Devroy, V.K.2
Lau, S.Y.3
Zgurskaya, H.I.4
-
42
-
-
0034702177
-
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
-
Koronakis V., Sharff A., Koronakis E., Luisi B., and Hughes C. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405 (2000) 914-919
-
(2000)
Nature
, vol.405
, pp. 914-919
-
-
Koronakis, V.1
Sharff, A.2
Koronakis, E.3
Luisi, B.4
Hughes, C.5
-
43
-
-
11144222920
-
Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end
-
Akama H., Kanemaki M., Yoshimura M., Tsukihara T., Kashiwagi T., Yoneyama H., Narita S., Nakagawa A., and Nakae T. Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end. J. Biol. Chem. 279 (2004) 52816-52819
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 52816-52819
-
-
Akama, H.1
Kanemaki, M.2
Yoshimura, M.3
Tsukihara, T.4
Kashiwagi, T.5
Yoneyama, H.6
Narita, S.7
Nakagawa, A.8
Nakae, T.9
-
44
-
-
2942731519
-
Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa
-
Akama H., Matsuura T., Kashiwagi S., Yoneyama H., Narita S., Tsukihara T., Nakagawa A., and Nakae T. Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa. J. Biol. Chem. 279 (2004) 25939-25942
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 25939-25942
-
-
Akama, H.1
Matsuura, T.2
Kashiwagi, S.3
Yoneyama, H.4
Narita, S.5
Tsukihara, T.6
Nakagawa, A.7
Nakae, T.8
-
45
-
-
3042838743
-
Structure of the periplasmic component of a bacterial drug efflux pump
-
Higgins M.K., Bokma E., Koronakis E., Hughes C., and Koronakis V. Structure of the periplasmic component of a bacterial drug efflux pump. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 9994-9999
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 9994-9999
-
-
Higgins, M.K.1
Bokma, E.2
Koronakis, E.3
Hughes, C.4
Koronakis, V.5
-
46
-
-
33644833626
-
Conformational flexibility in the multidrug efflux system protein AcrA
-
Mikolosko J., Bobyk K., Zgurskaya H.I., and Ghosh P. Conformational flexibility in the multidrug efflux system protein AcrA. Structure 14 (2006) 577-587
-
(2006)
Structure
, vol.14
, pp. 577-587
-
-
Mikolosko, J.1
Bobyk, K.2
Zgurskaya, H.I.3
Ghosh, P.4
-
47
-
-
0033534373
-
AcrA is a highly asymmetric protein capable of spanning the periplasm
-
Zgurskaya H.I., and Nikaido H. AcrA is a highly asymmetric protein capable of spanning the periplasm. J. Mol. Biol. 285 (1999) 409-420
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 409-420
-
-
Zgurskaya, H.I.1
Nikaido, H.2
-
48
-
-
9944247705
-
Three's company: component structures bring a closer view of tripartite drug efflux pumps
-
Eswaran J., Koronakis E., Higgins M.K., Hughes C., and Koronakis V. Three's company: component structures bring a closer view of tripartite drug efflux pumps. Curr. Opin. Struct. Biol. 14 (2004) 741-747
-
(2004)
Curr. Opin. Struct. Biol.
, vol.14
, pp. 741-747
-
-
Eswaran, J.1
Koronakis, E.2
Higgins, M.K.3
Hughes, C.4
Koronakis, V.5
-
49
-
-
33748638824
-
Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps
-
Stegmeier J.F., Polleichtner G., Brandes N., Hotz C., and Andersen C. Importance of the adaptor (membrane fusion) protein hairpin domain for the functionality of multidrug efflux pumps. Biochemistry 45 (2006) 10303-10312
-
(2006)
Biochemistry
, vol.45
, pp. 10303-10312
-
-
Stegmeier, J.F.1
Polleichtner, G.2
Brandes, N.3
Hotz, C.4
Andersen, C.5
-
50
-
-
34248359106
-
A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps
-
Lobedanz S., Bokma E., Symmons M.F., Koronakis E., Hughes C., and Koronakis V. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug efflux pumps. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 4612-4617
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 4612-4617
-
-
Lobedanz, S.1
Bokma, E.2
Symmons, M.F.3
Koronakis, E.4
Hughes, C.5
Koronakis, V.6
-
51
-
-
0042838181
-
Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump
-
Elkins C.A., and Nikaido H. Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. J. Bacteriol. 185 (2003) 5349-5356
-
(2003)
J. Bacteriol.
, vol.185
, pp. 5349-5356
-
-
Elkins, C.A.1
Nikaido, H.2
-
52
-
-
38749137423
-
Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB
-
Krishnamoorthy G., Tikhonova E.B., and Zgurskaya H.I. Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB. J. Bacteriol. 190 (2007) 691-698
-
(2007)
J. Bacteriol.
, vol.190
, pp. 691-698
-
-
Krishnamoorthy, G.1
Tikhonova, E.B.2
Zgurskaya, H.I.3
-
53
-
-
0038670226
-
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
-
Yu E.W., McDermott G., Zgurskaya H.I., Nikaido H., and Koshland D.E. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 300 (2003) 976-980
-
(2003)
Science
, vol.300
, pp. 976-980
-
-
Yu, E.W.1
McDermott, G.2
Zgurskaya, H.I.3
Nikaido, H.4
Koshland, D.E.5
-
54
-
-
36749071555
-
Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist
-
Törnroth-Horsefield S., Gourdon P., Horsefield R., Brive L., Yamamoto N., Mori H., Snijder A., and Neutze R. Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist. Structure 15 (2007) 1663-1673
-
(2007)
Structure
, vol.15
, pp. 1663-1673
-
-
Törnroth-Horsefield, S.1
Gourdon, P.2
Horsefield, R.3
Brive, L.4
Yamamoto, N.5
Mori, H.6
Snijder, A.7
Neutze, R.8
-
55
-
-
33749632749
-
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway
-
Su C.C., Li M., Gu R., Takatsuka Y., McDermott G., Nikaido H., and Yu E.W. Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway. J. Bacteriol. 188 (2006) 7290-7296
-
(2006)
J. Bacteriol.
, vol.188
, pp. 7290-7296
-
-
Su, C.C.1
Li, M.2
Gu, R.3
Takatsuka, Y.4
McDermott, G.5
Nikaido, H.6
Yu, E.W.7
-
56
-
-
33748670458
-
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
-
Murakami S., Nakashima R., Yamashita E., Matsumoto T., and Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature 443 (2006) 173-179
-
(2006)
Nature
, vol.443
, pp. 173-179
-
-
Murakami, S.1
Nakashima, R.2
Yamashita, E.3
Matsumoto, T.4
Yamaguchi, A.5
-
57
-
-
33748310520
-
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
-
Seeger M.A., Schiefner A., Eicher T., Verrey F., Diederichs K., and Pos K.M. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science 313 (2006) 1295-1298
-
(2006)
Science
, vol.313
, pp. 1295-1298
-
-
Seeger, M.A.1
Schiefner, A.2
Eicher, T.3
Verrey, F.4
Diederichs, K.5
Pos, K.M.6
-
58
-
-
33846363597
-
Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors
-
Sennhauser G., Amstutz P., Briand C., Storchenegger O., and Grutter M.G. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 5 (2007) e7
-
(2007)
PLoS Biol.
, vol.5
-
-
Sennhauser, G.1
Amstutz, P.2
Briand, C.3
Storchenegger, O.4
Grutter, M.G.5
-
59
-
-
14644397894
-
Vacuuming the periplasm
-
Lomovskaya O., and Totrov M. Vacuuming the periplasm. J. Bacteriol. 187 (2005) 1879-1883
-
(2005)
J. Bacteriol.
, vol.187
, pp. 1879-1883
-
-
Lomovskaya, O.1
Totrov, M.2
-
60
-
-
36749045119
-
Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli
-
Takatsuka Y., and Nikaido H. Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli. J. Bacteriol. 189 (2007) 8677-8684
-
(2007)
J. Bacteriol.
, vol.189
, pp. 8677-8684
-
-
Takatsuka, Y.1
Nikaido, H.2
-
61
-
-
38849185972
-
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB
-
Seeger M.A., von Ballmoos C., Eicher T., Brandstatter L., Verrey F., Diederichs K., and Pos K.M. Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat. Struct. Mol. Biol. 15 (2008) 199-205
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, pp. 199-205
-
-
Seeger, M.A.1
von Ballmoos, C.2
Eicher, T.3
Brandstatter, L.4
Verrey, F.5
Diederichs, K.6
Pos, K.M.7
-
62
-
-
0036066806
-
The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate
-
Baranova N., and Nikaido H. The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J. Bacteriol. 184 (2002) 4168-4176
-
(2002)
J. Bacteriol.
, vol.184
, pp. 4168-4176
-
-
Baranova, N.1
Nikaido, H.2
-
63
-
-
0036064516
-
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC
-
Nagakubo S., Nishino K., Hirata T., and Yamaguchi A. The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC. J. Bacteriol. 184 (2002) 4161-4167
-
(2002)
J. Bacteriol.
, vol.184
, pp. 4161-4167
-
-
Nagakubo, S.1
Nishino, K.2
Hirata, T.3
Yamaguchi, A.4
-
64
-
-
37249081439
-
Substrate-linked conformational change in the periplasmic component of a Cu(I)/Ag(I) efflux system
-
Bagai I., Liu W., Rensing C., Blackburn N.J., and McEvoy M.M. Substrate-linked conformational change in the periplasmic component of a Cu(I)/Ag(I) efflux system. J. Biol. Chem. 282 (2007) 35695-35702
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35695-35702
-
-
Bagai, I.1
Liu, W.2
Rensing, C.3
Blackburn, N.J.4
McEvoy, M.M.5
-
65
-
-
55249109759
-
Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone
-
e-published 10/11/2008
-
Bagai I., Liu W., Rensing C., Blackburn N.J., and McEvoy M.M. Direct metal transfer between periplasmic proteins identifies a bacterial copper chaperone. Biochemistry (2008) e-published 10/11/2008
-
(2008)
Biochemistry
-
-
Bagai, I.1
Liu, W.2
Rensing, C.3
Blackburn, N.J.4
McEvoy, M.M.5
-
66
-
-
46249116233
-
Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump
-
Jeannot K., Elsen S., Kohler T., Attree I., van Delden C., and Plesiat P. Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. Antimicrob. Agents Chemother. 52 (2008) 2455-2462
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 2455-2462
-
-
Jeannot, K.1
Elsen, S.2
Kohler, T.3
Attree, I.4
van Delden, C.5
Plesiat, P.6
-
67
-
-
0031691275
-
Influence of the TonB energy-coupling protein on efflux-mediated multidrug resistance in Pseudomonas aeruginosa
-
Zhao Q., Li X.Z., Mistry A., Srikumar R., Zhang L., Lomovskaya O., and Poole K. Influence of the TonB energy-coupling protein on efflux-mediated multidrug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 42 (1998) 2225-2231
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 2225-2231
-
-
Zhao, Q.1
Li, X.Z.2
Mistry, A.3
Srikumar, R.4
Zhang, L.5
Lomovskaya, O.6
Poole, K.7
-
68
-
-
0036208645
-
Differential effects of mutations in tonB1 on intrinsic multidrug resistance and iron acquisition in Pseudomonas aeruginosa
-
Zhao Q., and Poole K. Differential effects of mutations in tonB1 on intrinsic multidrug resistance and iron acquisition in Pseudomonas aeruginosa. J. Bacteriol. 184 (2002) 2045-2049
-
(2002)
J. Bacteriol.
, vol.184
, pp. 2045-2049
-
-
Zhao, Q.1
Poole, K.2
-
69
-
-
4444221565
-
UCSF Chimera-a visualization system for exploratory research and analysis
-
Pettersen E.F., Goddard T.D., Huang C.C., Couch G.S., Greenblatt D.M., Meng E.C., and Ferrin T.E. UCSF Chimera-a visualization system for exploratory research and analysis. J. Comput. Chem. 25 (2004) 1605-1612
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
|