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Volumn 71, Issue 8, 2003, Pages 4333-4340

Mechanism of fluconazole resistance in Candida albicans biofilms: Phase-specific role of efflux pumps and membrane sterols

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE; STEROL;

EID: 0041764578     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.8.4333-4340.2003     Document Type: Article
Times cited : (439)

References (53)
  • 1
    • 0029853191 scopus 로고    scopus 로고
    • Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance
    • Albertson, G. D., M. Niimi, R. D. Cannon, and H. F. Jenkinson. 1996. Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance. Antimicrob. Agents Chemother. 40:2835-2841.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2835-2841
    • Albertson, G.D.1    Niimi, M.2    Cannon, R.D.3    Jenkinson, H.F.4
  • 2
    • 19244378525 scopus 로고    scopus 로고
    • Predictors of adverse outcome in cancer patients with candidemia
    • Anaissie, E. J., J. H. Rex, O. Uzun, and S. Vartivarian. 1998. Predictors of adverse outcome in cancer patients with candidemia. Am. J. Med. 104:238-245.
    • (1998) Am. J. Med. , vol.104 , pp. 238-245
    • Anaissie, E.J.1    Rex, J.H.2    Uzun, O.3    Vartivarian, S.4
  • 3
    • 0033930831 scopus 로고    scopus 로고
    • Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin
    • Anderi, J. N., M. J. Franklin, and P. S. Stewart. 2000. Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin. Antimicrob. Agents Chemother. 44:1818-1824.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 1818-1824
    • Anderi, J.N.1    Franklin, M.J.2    Stewart, P.S.3
  • 4
    • 0032749537 scopus 로고    scopus 로고
    • Candida biofilms and their susceptibility to antifungal agents
    • Baillie, G. S., and L. J. Douglas. 1999. Candida biofilms and their susceptibility to antifungal agents. Methods Enzymol. 310:644-656.
    • (1999) Methods Enzymol. , vol.310 , pp. 644-656
    • Baillie, G.S.1    Douglas, L.J.2
  • 5
    • 0034002551 scopus 로고    scopus 로고
    • A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms
    • Brooun, A., S. Liu, and K. Lewis. 2000. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob. Agents Chemother. 44:640-646.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 640-646
    • Brooun, A.1    Liu, S.2    Lewis, K.3
  • 6
    • 0025333930 scopus 로고
    • Etiology, pathogenesis, therapy, and prophylaxis of oral yeast infections
    • Budtz-Jorgensen, E. 1990. Etiology, pathogenesis, therapy, and prophylaxis of oral yeast infections. Acta Odontol. Scand. 48:61-69.
    • (1990) Acta Odontol. Scand. , vol.48 , pp. 61-69
    • Budtz-Jorgensen, E.1
  • 7
    • 0025372268 scopus 로고
    • Histopathology, immunology, and serology of oral yeast infections. Diagnosis of oral candidosis
    • Budtz-Jorgensen, E. 1990. Histopathology, immunology, and serology of oral yeast infections. Diagnosis of oral candidosis. Acta Odontol. Scand. 48:37-43.
    • (1990) Acta Odontol. Scand. , vol.48 , pp. 37-43
    • Budtz-Jorgensen, E.1
  • 9
    • 0034870709 scopus 로고    scopus 로고
    • Biofilm formation by the fungal pathogen Candida albicans: Development, architecture, and drug resistance
    • Chandra, J., D. M. Kuhn, P. K. Mukherjee, L. L. Hoyer, T. McCormick, and M. A. Ghannoum. 2001. Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance. J. Bacteriol. 183:5385-5394.
    • (2001) J. Bacteriol. , vol.183 , pp. 5385-5394
    • Chandra, J.1    Kuhn, D.M.2    Mukherjee, P.K.3    Hoyer, L.L.4    McCormick, T.5    Ghannoum, M.A.6
  • 11
    • 0025799513 scopus 로고
    • Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
    • Chaudhary, P. M., and I. B. Roninson. 1991. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66:85-94.
    • (1991) Cell , vol.66 , pp. 85-94
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 12
    • 0030025637 scopus 로고    scopus 로고
    • Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: Possible role for drug efflux in drug resistance
    • Clark, F. S., T. Parkinson, C. A. Hitchcock, and N. A. Gow. 1996. Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance. Antimicrob. Agents Chemother. 40:419-425.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 419-425
    • Clark, F.S.1    Parkinson, T.2    Hitchcock, C.A.3    Gow, N.A.4
  • 13
    • 0033591467 scopus 로고    scopus 로고
    • Bacterial biofilms: A common cause of persistent infections
    • Costerton, J. W., P. S. Stewart, and E. P. Greenberg. 1999. Bacterial biofilms: a common cause of persistent infections. Science 284:1318-1322.
    • (1999) Science , vol.284 , pp. 1318-1322
    • Costerton, J.W.1    Stewart, P.S.2    Greenberg, E.P.3
  • 15
    • 0034327420 scopus 로고    scopus 로고
    • Role of biofilms in antimicrobial resistance
    • Donlan, R. M. 2000. Role of biofilms in antimicrobial resistance. ASAIO J. 46:S47-S52.
    • (2000) ASAIO J. , vol.46
    • Donlan, R.M.1
  • 16
    • 0036228505 scopus 로고    scopus 로고
    • Biofilms: Survival mechanisms of clinically relevant microorganisms
    • Donlan, R. M., and J. W. Costerton. 2002. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin. Microbiol. Rev. 15:167-193.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 167-193
    • Donlan, R.M.1    Costerton, J.W.2
  • 17
    • 0031905588 scopus 로고    scopus 로고
    • Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter
    • Egner, R., F. E. Rosenthal, A. Kralli, D. Sanglard, and K. Kuchler. 1998. Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. Mol. Biol. Cell 9:523-543.
    • (1998) Mol. Biol. Cell. , vol.9 , pp. 523-543
    • Egner, R.1    Rosenthal, F.E.2    Kralli, A.3    Sanglard, D.4    Kuchler, K.5
  • 18
    • 0026543284 scopus 로고
    • Subinhibitory concentration of octenidine and pirtenidine: Influence on the lipid and sterol contents of Candida albicans
    • Ghannoum, M. A., N. M. Moussa, P. Whittaker, I. Swairjo, and K. H. Abu-Elteen. 1992. Subinhibitory concentration of octenidine and pirtenidine: influence on the lipid and sterol contents of Candida albicans. Chemotherapy 38:46-56.
    • (1992) Chemotherapy , vol.38 , pp. 46-56
    • Ghannoum, M.A.1    Moussa, N.M.2    Whittaker, P.3    Swairjo, I.4    Abu-Elteen, K.H.5
  • 19
    • 0032882718 scopus 로고    scopus 로고
    • Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    • Ghannoum, M. A., and L. B. Rice. 1999. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 12:501-517.
    • (1999) Clin. Microbiol. Rev. , vol.12 , pp. 501-517
    • Ghannoum, M.A.1    Rice, L.B.2
  • 20
    • 0033016717 scopus 로고    scopus 로고
    • Correlation between protein and mRNA abundance in yeast
    • Gygi, S. P., Y. Rochon, B. R. Franza, and R. Aebersold. 1999. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19:1720-1730.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1720-1730
    • Gygi, S.P.1    Rochon, Y.2    Franza, B.R.3    Aebersold, R.4
  • 21
    • 0033740216 scopus 로고    scopus 로고
    • P-glycoprotein in cell cultures: A combined approach to study expression, localisation, and functionality in the confocal microscope
    • Hammerle, S. P., B. Rothen-Rutishauser, S. D. Kramer, M. Gunthert, and H. Wunderli-Allenspach. 2000. P-glycoprotein in cell cultures: a combined approach to study expression, localisation, and functionality in the confocal microscope. Eur. J. Pharm. Sci. 12:69-77.
    • (2000) Eur. J. Pharm. Sci. , vol.12 , pp. 69-77
    • Hammerle, S.P.1    Rothen-Rutishauser, B.2    Kramer, S.D.3    Gunthert, M.4    Wunderli-Allenspach, H.5
  • 22
    • 84907123977 scopus 로고
    • The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans
    • Hitchcock, C. A., K. J. Barrett-Bee, and N. J. Russell. 1987. The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans. J. Med. Vet. Mycol. 25:29-37.
    • (1987) J. Med. Vet. Mycol. , vol.25 , pp. 29-37
    • Hitchcock, C.A.1    Barrett-Bee, K.J.2    Russell, N.J.3
  • 23
    • 0024344621 scopus 로고
    • The lipid composition and permeability to the triazole antifungal antibiotic ICI 153066 of serum-grown mycelial cultures of Candida albicans
    • Hitchcock, C. A., K. J. Barrett-Bee, and N. J. Russell. 1989. The lipid composition and permeability to the triazole antifungal antibiotic ICI 153066 of serum-grown mycelial cultures of Candida albicans. J. Gen. Microbiol. 135:1949-1955.
    • (1989) J. Gen. Microbiol. , vol.135 , pp. 1949-1955
    • Hitchcock, C.A.1    Barrett-Bee, K.J.2    Russell, N.J.3
  • 24
    • 0023515339 scopus 로고
    • Sterols in Candida albicans mutants resistant to polyene or azole antifungals, and of a double mutant C. albicans 6.4
    • Hitchcock, C. A., N. J. Russell, and K. J. Barrett-Bee. 1987. Sterols in Candida albicans mutants resistant to polyene or azole antifungals, and of a double mutant C. albicans 6.4. Crit. Rev. Microbiol. 15:111-115.
    • (1987) Crit. Rev. Microbiol. , vol.15 , pp. 111-115
    • Hitchcock, C.A.1    Russell, N.J.2    Barrett-Bee, K.J.3
  • 25
    • 0028931377 scopus 로고
    • Candida albicans ALS1: Domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif
    • Hoyer, L. L., S. Scherer, A. R. Shatzman, and G. P. Livi. 1995. Candida albicans ALS1: domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif. Mol. Microbiol. 15:39-54.
    • (1995) Mol. Microbiol. , vol.15 , pp. 39-54
    • Hoyer, L.L.1    Scherer, S.2    Shatzman, A.R.3    Livi, G.P.4
  • 26
    • 0002789172 scopus 로고    scopus 로고
    • Chromatographic analysis of lipids
    • R. Prasad (ed.), Springer-Verlag, New York, N.Y.
    • Ibrahim, A. S., and M. A. Ghannoum. 1996. Chromatographic analysis of lipids, p. 52-79. In R. Prasad (ed.), Manual on membrane lipids. Springer-Verlag, New York, N.Y.
    • (1996) Manual on Membrane Lipids , pp. 52-79
    • Ibrahim, A.S.1    Ghannoum, M.A.2
  • 27
    • 0036208102 scopus 로고    scopus 로고
    • In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry
    • Kohli, A., Smriti, K. Mukhopadhyay, A. Rattan, and R. Prasad. 2002. In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry. Antimicrob. Agents Chemother. 46:1046-1052.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1046-1052
    • Kohli, A.1    Smriti2    Mukhopadhyay, K.3    Rattan, A.4    Prasad, R.5
  • 28
    • 0033870569 scopus 로고    scopus 로고
    • Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae
    • Kontoyiannis, D. P. 2000. Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae. J. Antimicrob. Chemother. 46:199-203.
    • (2000) J. Antimicrob. Chemother. , vol.46 , pp. 199-203
    • Kontoyiannis, D.P.1
  • 29
    • 0036151240 scopus 로고    scopus 로고
    • Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces
    • Kuhn, D. M., J. Chandra, P. K. Mukherjee, and M. A. Ghannoum. 2002. Comparison of biofilms formed by Candida albicans and Candida parapsilosis on bioprosthetic surfaces. Infect. Immun. 70:878-888.
    • (2002) Infect. Immun. , vol.70 , pp. 878-888
    • Kuhn, D.M.1    Chandra, J.2    Mukherjee, P.K.3    Ghannoum, M.A.4
  • 30
    • 0036096359 scopus 로고    scopus 로고
    • Antifungal susceptibility of Candida biofilms: Unique efficacy of amphotericin B lipid formulations and echinocandins
    • Kuhn, D. M., T. George, J. Chandra, P. K. Mukherjee, and M. A. Ghannoum. 2002. Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins. Antimicrob. Agents Chemother. 46:1773-1780.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1773-1780
    • Kuhn, D.M.1    George, T.2    Chandra, J.3    Mukherjee, P.K.4    Ghannoum, M.A.5
  • 31
    • 0029977087 scopus 로고    scopus 로고
    • Resistance of Streptococcus sanguis biofilms to antimicrobial agents
    • Larsen, T., and N. E. Fiehn. 1996. Resistance of Streptococcus sanguis biofilms to antimicrobial agents. APMIS 104:280-284.
    • (1996) APMIS , vol.104 , pp. 280-284
    • Larsen, T.1    Fiehn, N.E.2
  • 32
    • 0033836088 scopus 로고    scopus 로고
    • Transcriptional analyses of antifungal drug resistance in Candida albicans
    • Lyons, C. N., and T. C. White. 2000. Transcriptional analyses of antifungal drug resistance in Candida albicans. Antimicrob. Agents Chemother, 44:2296-2303.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2296-2303
    • Lyons, C.N.1    White, T.C.2
  • 33
    • 0035014383 scopus 로고    scopus 로고
    • Mechanisms of biofilm resistance to antimicrobial agents
    • Mah, T. F., and G. A. O'Toole. 2001, Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 9:34-39.
    • (2001) Trends Microbiol. , vol.9 , pp. 34-39
    • Mah, T.F.1    O'Toole, G.A.2
  • 34
    • 0034079907 scopus 로고    scopus 로고
    • An evaluation of the potential of the multiple antibiotic resistance operon (mar) and the multidrug efflux pump acrAB to moderate resistance towards ciprofloxacin in Escherichia coli biofilms
    • Maira-Litran, T., D. G. Allison, and P. Gilbert. 2000. An evaluation of the potential of the multiple antibiotic resistance operon (mar) and the multidrug efflux pump acrAB to moderate resistance towards ciprofloxacin in Escherichia coli biofilms. J. Antimicrob. Chemother. 45:789-795.
    • (2000) J. Antimicrob. Chemother. , vol.45 , pp. 789-795
    • Maira-Litran, T.1    Allison, D.G.2    Gilbert, P.3
  • 35
    • 0030788865 scopus 로고    scopus 로고
    • Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts
    • Millard, P. J., B. L. Roth, H. P. Thi, S. T. Yue, and R. P. Haugland, 1997. Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts. Appl. Environ. Microbiol. 63:2897-2905.
    • (1997) Appl. Environ. Microbiol. , vol.63 , pp. 2897-2905
    • Millard, P.J.1    Roth, B.L.2    Thi, H.P.3    Yue, S.T.4    Haugland, R.P.5
  • 36
    • 0036894215 scopus 로고    scopus 로고
    • Drug susceptibilities of yeast cells are affected by membrane lipid composition
    • Mukhopadhyay, K., A. Kohli, and R. Prasad. 2002. Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrob. Agents Chemother. 46:3695-3705.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3695-3705
    • Mukhopadhyay, K.1    Kohli, A.2    Prasad, R.3
  • 41
    • 0028928549 scopus 로고
    • Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
    • Prasad, R., P. De Wergifosse, A. Goffeau, and E. Balzi, 1995. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27:320-329.
    • (1995) Curr. Genet. , vol.27 , pp. 320-329
    • Prasad, R.1    De Wergifosse, P.2    Goffeau, A.3    Balzi, E.4
  • 43
    • 0035992139 scopus 로고    scopus 로고
    • Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms
    • Ramage, G., S. Bachmann, T. F. Patterson, B. L. Wickes, and J. L. Lopez-Ribot. 2002. Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms. J. Antimicrob. Chemother. 49:973-980.
    • (2002) J. Antimicrob. Chemother. , vol.49 , pp. 973-980
    • Ramage, G.1    Bachmann, S.2    Patterson, T.F.3    Wickes, B.L.4    Lopez-Ribot, J.L.5
  • 44
    • 0034863427 scopus 로고    scopus 로고
    • Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms
    • Ramage, G., W. K. Vande, B. L. Wickes, and J. L. Lopez-Ribot. 2001. Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob. Agents Chemother. 45:2475-2479.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2475-2479
    • Ramage, G.1    Vande, W.K.2    Wickes, B.L.3    Lopez-Ribot, J.L.4
  • 45
    • 0035431077 scopus 로고    scopus 로고
    • Biofilms of Candida albicans and their associated resistance to antifungal agents
    • Ramage, G., B. L. Wickes, and J. L. Lopez-Ribot. 2001. Biofilms of Candida albicans and their associated resistance to antifungal agents. Am. Clin. Lab 20:42-44.
    • (2001) Am. Clin. Lab. , vol.20 , pp. 42-44
    • Ramage, G.1    Wickes, B.L.2    Lopez-Ribot, J.L.3
  • 46
    • 0036839691 scopus 로고    scopus 로고
    • Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis
    • Rogers, P. D., and K. S. Barker. 2002, Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis. Antimicrob. Agents Chemother. 46:3412-3417.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3412-3417
    • Rogers, P.D.1    Barker, K.S.2
  • 47
    • 0030704329 scopus 로고    scopus 로고
    • A new triazole, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei
    • Sanati, H., P. Belanger, R. Fratti, and M. Ghannoum. 1997. A new triazole, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei. Antimicrob. Agents Chemother. 41:2492-2496.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2492-2496
    • Sanati, H.1    Belanger, P.2    Fratti, R.3    Ghannoum, M.4
  • 48
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1996. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40:2300-2305.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 49
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard, D., K. Kuchler, F. Ischer, J. L. Pagani, M. Monod, and J. Bille. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
    • (1995) Antimicrob. Agents Chemother. , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 50
    • 0035992362 scopus 로고    scopus 로고
    • Mechanisms of antibiotic resistance in bacterial biofilms
    • Stewart, P. S. 2002. Mechanisms of antibiotic resistance in bacterial biofilms. Int. J. Med. Microbiol. 292:107-113.
    • (2002) Int. J. Med. Microbiol. , vol.292 , pp. 107-113
    • Stewart, P.S.1
  • 51
    • 0035859467 scopus 로고    scopus 로고
    • Antibiotic resistance of bacteria in biofilms
    • Stewart, P. S., and J. W. Costerton. 2001. Antibiotic resistance of bacteria in biofilms. Lancet 358:135-138.
    • (2001) Lancet , vol.358 , pp. 135-138
    • Stewart, P.S.1    Costerton, J.W.2
  • 52
    • 0014421717 scopus 로고
    • Reference high-efficiency nonpolar packed columns for the gas-liquid chromatography of nanogram amounts of steroids. I. Retention time data
    • Vandenheuvel, F. A., and A. S. Court. 1968. Reference high-efficiency nonpolar packed columns for the gas-liquid chromatography of nanogram amounts of steroids. I. Retention time data. J. Chromatogr. 38:439-459.
    • (1968) J. Chromatogr. , vol.38 , pp. 439-459
    • Vandenheuvel, F.A.1    Court, A.S.2
  • 53
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White, T. C. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 41:1482-1487.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1482-1487
    • White, T.C.1


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