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Volumn 51, Issue 5, 2003, Pages 1055-1065

Antibiotic efflux pumps in prokaryotic cells: Occurence, impact on resistance and strategies for the future of antimicrobial therapy

Author keywords

Antibiotic; Efflux; Prokaryotes; Resistance; Transporters

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CARBAPENEM; CARBENICILLIN; CEFALORIDINE; CEFALOTIN; CEFAZOLIN; CEFOTAXIME; CEFTRIAXONE; CEPHALOSPORIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLOXACILLIN; GLYCYLCYCLINE DERIVATIVE; IMIPENEM; KETOLIDE; LEVOFLOXACIN; MACROLIDE; MEMBRANE PROTEIN; MEROPENEM; MINOCYCLINE; NAFCILLIN; NORFLOXACIN; OFLOXACIN; PENICILLIN BINDING PROTEIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE; UNINDEXED DRUG;

EID: 0037648419     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg224     Document Type: Article
Times cited : (169)

References (118)
  • 1
    • 0032560586 scopus 로고    scopus 로고
    • Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae
    • Paulsen, I. T., Sliwinski, M. K., Nelissen, B., Goffeau, A. & Saier, M. H., Jr (1998). Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. FEBS Letters 430, 116-25.
    • (1998) FEBS Letters , vol.430 , pp. 116-125
    • Paulsen, I.T.1    Sliwinski, M.K.2    Nelissen, B.3    Goffeau, A.4    Saier M.H., Jr.5
  • 2
    • 0037987124 scopus 로고    scopus 로고
    • [Online.] (19 January 2003, date last accessed)
    • Saier, M. H., Jr (2002). [Online.] http://www-biology.ucsd.edu/~msaier/transport/ (19 January 2003, date last accessed).
    • (2002)
    • Saier M.H., Jr.1
  • 3
    • 0033836084 scopus 로고    scopus 로고
    • Efflux-mediated resistance to fluoroquinolones in Gram-negative bacteria
    • Poole, K. (2000). Efflux-mediated resistance to fluoroquinolones in Gram-negative bacteria. Antimicrobial Agents and Chemotherapy 44, 2233-41.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 2233-2241
    • Poole, K.1
  • 4
    • 0038323939 scopus 로고    scopus 로고
    • Antibiotic efflux pumps in eukaryotic cells: Occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics
    • Van Bambeke, F., Michot, J.-M. & Tulkens, P. M. (2003). Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics. Journal of Antimicrobial Chemotherapy 51, 1067-77.
    • (2003) Journal of Antimicrobial Chemotherapy , vol.51 , pp. 1067-1077
    • Van Bambeke, F.1    Michot, J.-M.2    Tulkens, P.M.3
  • 5
    • 0345515642 scopus 로고
    • Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli
    • McMurry, L., Petrucci, R. E., Jr & Levy, S. B. (1980). Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli. Proceedings of the National Academy of Sciences, USA 77, 3974-7.
    • (1980) Proceedings of the National Academy of Sciences, USA , vol.77 , pp. 3974-3977
    • McMurry, L.1    Petrucci R.E., Jr.2    Levy, S.B.3
  • 6
    • 0025456967 scopus 로고
    • Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family
    • Ross, J. I., Eady, E. A., Cove, J. H., Cunliffe, W. J., Baumberg, S. & Wootton, J. C. (1990). Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family. Molecular Microbiology 4, 1207-14.
    • (1990) Molecular Microbiology , vol.4 , pp. 1207-1214
    • Ross, J.I.1    Eady, E.A.2    Cove, J.H.3    Cunliffe, W.J.4    Baumberg, S.5    Wootton, J.C.6
  • 7
    • 0025688065 scopus 로고
    • Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones
    • Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K. & Konno, M. (1990). Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. Journal of Bacteriology 172, 6942-9.
    • (1990) Journal of Bacteriology , vol.172 , pp. 6942-6949
    • Yoshida, H.1    Bogaki, M.2    Nakamura, S.3    Ubukata, K.4    Konno, M.5
  • 8
    • 0028050605 scopus 로고
    • Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: Active efflux as a contributing factor to beta-lactam resistance
    • Li, X. Z., Ma, D., Livermore, D. M. & Nikaido, H. (1994). Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance. Antimicrobial Agents and Chemotherapy 38, 1742-52.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 1742-1752
    • Li, X.Z.1    Ma, D.2    Livermore, D.M.3    Nikaido, H.4
  • 9
    • 0345466364 scopus 로고    scopus 로고
    • Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides
    • Aires, J. R., Kohler, T., Nikaido, H. & Plesiat, P. (1999). Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrobial Agents and Chemotherapy 43, 2624-8.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 2624-2628
    • Aires, J.R.1    Kohler, T.2    Nikaido, H.3    Plesiat, P.4
  • 10
    • 0036045104 scopus 로고    scopus 로고
    • Mechanisms of bacterial biocide and antibiotic resistance
    • Poole, K. (2002). Mechanisms of bacterial biocide and antibiotic resistance. Journal of Applied Microbiology 92, Suppl., 55S-64S.
    • (2002) Journal of Applied Microbiology , vol.92 , Issue.SUPPL.
    • Poole, K.1
  • 13
    • 0036267595 scopus 로고    scopus 로고
    • Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA
    • Rahmati, S., Yang, S., Davidson, A. L. & Zechiedrich, E. L. (2002). Control of the AcrAB multidrug efflux pump by quorum-sensing regulator SdiA. Molecular Microbiology 43, 677-85.
    • (2002) Molecular Microbiology , vol.43 , pp. 677-685
    • Rahmati, S.1    Yang, S.2    Davidson, A.L.3    Zechiedrich, E.L.4
  • 15
    • 0034871821 scopus 로고    scopus 로고
    • Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa
    • Kohler, T., van Delden, C., Curty, L. K., Hamzehpour, M. M. & Pechere, J. C. (2001). Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa. Journal of Bacteriology 183, 5213-22.
    • (2001) Journal of Bacteriology , vol.183 , pp. 5213-5222
    • Kohler, T.1    van Delden, C.2    Curty, L.K.3    Hamzehpour, M.M.4    Pechere, J.C.5
  • 16
    • 0034792632 scopus 로고    scopus 로고
    • The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis
    • Sharff, A., Fanutti, C., Shi, J., Calladine, C. & Luisi, B. (2001). The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis. European Journal of Biochemistry 268, 5011-26.
    • (2001) European Journal of Biochemistry , vol.268 , pp. 5011-5026
    • Sharff, A.1    Fanutti, C.2    Shi, J.3    Calladine, C.4    Luisi, B.5
  • 17
    • 0027026475 scopus 로고
    • Self-protection mechanisms in antibiotic producers
    • Cundliffe, E. (1992). Self-protection mechanisms in antibiotic producers. Ciba Foundation Symposium 171, 199-208.
    • (1992) Ciba Foundation Symposium , vol.171 , pp. 199-208
    • Cundliffe, E.1
  • 18
    • 0035984816 scopus 로고    scopus 로고
    • Novel ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus
    • Piddock, L. J., Jin, Y. F., Webber, M. A. & Everett, M. J. (2002). Novel ciprofloxacin-resistant, nalidixic acid-susceptible mutant of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 46, 2276-8.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 2276-2278
    • Piddock, L.J.1    Jin, Y.F.2    Webber, M.A.3    Everett, M.J.4
  • 19
    • 0033031244 scopus 로고    scopus 로고
    • Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa
    • Lomovskaya, O., Lee, A., Hoshino, K., Ishida, H., Mistry, A., Warren, M. S. et al. (1999). Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 43, 1340-6.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 1340-1346
    • Lomovskaya, O.1    Lee, A.2    Hoshino, K.3    Ishida, H.4    Mistry, A.5    Warren, M.S.6
  • 20
    • 0034050047 scopus 로고    scopus 로고
    • Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams
    • Mazzariol, A., Cornaglia, G. & Nikaido, H. (2000). Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams. Antimicrobial Agents and Chemotherapy 44, 1387-90.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 1387-1390
    • Mazzariol, A.1    Cornaglia, G.2    Nikaido, H.3
  • 21
    • 0036499021 scopus 로고    scopus 로고
    • Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community-acquired pneumonia
    • Lynch, J. P., III & Martinez, F. J. (2002). Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community-acquired pneumonia. Clinical Infectious Diseases 34, Suppl. 1, S27-46.
    • (2002) Clinical Infectious Diseases , vol.34 , Issue.SUPPL. 1
    • Lynch J.P. III1    Martinez, F.J.2
  • 22
    • 0029129966 scopus 로고
    • Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa
    • Li, X. Z., Nikaido, H. & Poole, K. (1995). Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 39, 1948-53.
    • (1995) Antimicrobial Agents and Chemotherapy , vol.39 , pp. 1948-1953
    • Li, X.Z.1    Nikaido, H.2    Poole, K.3
  • 23
  • 24
    • 0037649345 scopus 로고    scopus 로고
    • Macrolide hyper-susceptibility is associated with the absence of efflux mechanism in clinical isolates of H. influenzae
    • Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-1612, American Society for Microbiology, Washington, DC, USA
    • Bozdogan, B., Peric, M., Jacobs, M. R. & Appelbaum, P. C. (2002). Macrolide hyper-susceptibility is associated with the absence of efflux mechanism in clinical isolates of H. influenzae. In Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-1612, p. 76. American Society for Microbiology, Washington, DC, USA.
    • (2002) , pp. 76
    • Bozdogan, B.1    Peric, M.2    Jacobs, M.R.3    Appelbaum, P.C.4
  • 25
    • 0037649343 scopus 로고    scopus 로고
    • Interactions among multiple efflux pumps: Additive and synergistic effects on antimicrobial resistance
    • Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract 1188, American Society for Microbiology, Washington, DC, USA
    • Lomovskaya, O. (2002). Interactions among multiple efflux pumps: additive and synergistic effects on antimicrobial resistance. In Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract 1188, p. 466. American Society for Microbiology, Washington, DC, USA.
    • (2002) , pp. 466
    • Lomovskaya, O.1
  • 26
    • 0034962534 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: Penem resistance mechanisms and their interplay
    • Okamoto, K., Gotoh, N. & Nishino, T. (2001). Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay. Antimicrobial Agents and Chemotherapy 45, 1964-71.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 1964-1971
    • Okamoto, K.1    Gotoh, N.2    Nishino, T.3
  • 28
    • 0028303739 scopus 로고
    • Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa
    • Yoshida, T., Muratani, T., Iyobe, S. & Mitsuhashi, S. (1994). Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 38, 1466-9.
    • (1994) Antimicrobial Agents and Chemotherapy , vol.38 , pp. 1466-1469
    • Yoshida, T.1    Muratani, T.2    Iyobe, S.3    Mitsuhashi, S.4
  • 29
    • 0032414382 scopus 로고    scopus 로고
    • Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa
    • Jalal, S. & Wretlind, B. (1998). Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa. Microbial Drug Resistance 4, 257-61.
    • (1998) Microbial Drug Resistance , vol.4 , pp. 257-261
    • Jalal, S.1    Wretlind, B.2
  • 30
    • 0034535460 scopus 로고    scopus 로고
    • Influence of the MexA-MexB-OprM multidrug efflux system on expression of the MexC-MexD-OprJ and MexE-MexF-OprN multidrug efflux systems in Pseudomonas aeruginosa
    • Li, X. Z., Barre, N. & Poole, K. (2000). Influence of the MexA-MexB-OprM multidrug efflux system on expression of the MexC-MexD-OprJ and MexE-MexF-OprN multidrug efflux systems in Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 46, 885-93.
    • (2000) Journal of Antimicrobial Chemotherapy , vol.46 , pp. 885-893
    • Li, X.Z.1    Barre, N.2    Poole, K.3
  • 31
    • 0030273002 scopus 로고    scopus 로고
    • Tetracycline resistance determinants: Mechanisms of action, regulation of expression, genetic mobility, and distribution
    • Roberts, M. C. (1996). Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution. FEMS Microbiology Reviews 19, 1-24.
    • (1996) FEMS Microbiology Reviews , vol.19 , pp. 1-24
    • Roberts, M.C.1
  • 32
    • 0033999155 scopus 로고    scopus 로고
    • Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
    • Jalal, S., Ciofu, O., Hoiby, N., Gotoh, N. & Wretlind, B. (2000). Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrobial Agents and Chemotherapy 44, 710-2.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 710-712
    • Jalal, S.1    Ciofu, O.2    Hoiby, N.3    Gotoh, N.4    Wretlind, B.5
  • 33
    • 0033802637 scopus 로고    scopus 로고
    • Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa
    • Pumbwe, L. & Piddock, L. J. (2000). Two efflux systems expressed simultaneously in multidrug-resistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 44, 2861-4.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 2861-2864
    • Pumbwe, L.1    Piddock, L.J.2
  • 34
    • 0029971845 scopus 로고    scopus 로고
    • Multidrug resistance in enteric and other Gram-negative bacteria
    • George, A. M. (1996). Multidrug resistance in enteric and other Gram-negative bacteria. FEMS Microbiology Letters 139, 1-10.
    • (1996) FEMS Microbiology Letters , vol.139 , pp. 1-10
    • George, A.M.1
  • 35
    • 0034119459 scopus 로고    scopus 로고
    • Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA
    • Barbosa, T. M. & Levy, S. B. (2000). Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. Journal of Bacteriology 182, 3467-74.
    • (2000) Journal of Bacteriology , vol.182 , pp. 3467-3474
    • Barbosa, T.M.1    Levy, S.B.2
  • 37
    • 0033845018 scopus 로고    scopus 로고
    • Identification of the conjugative mef gene in clinical Acinetobacter junii and Neisseria gonorrhoeae isolates
    • Luna, V. A., Cousin, S., Jr, Whittington, W. L. & Roberts, M. C. (2000). Identification of the conjugative mef gene in clinical Acinetobacter junii and Neisseria gonorrhoeae isolates. Antimicrobial Agents and Chemotherapy 44, 2503-6.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 2503-2506
    • Luna, V.A.1    Cousin S., Jr.2    Whittington, W.L.3    Roberts, M.C.4
  • 38
    • 0036732832 scopus 로고    scopus 로고
    • Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 study
    • Farrell, D. J., Morrissey, I., Bakker, S. & Felmingham, D. (2002). Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 study. Journal of Antimicrobial Chemotherapy 50, Suppl. S1, 39-47.
    • (2002) Journal of Antimicrobial Chemotherapy , vol.50 , Issue.SUPPL. S1 , pp. 39-47
    • Farrell, D.J.1    Morrissey, I.2    Bakker, S.3    Felmingham, D.4
  • 39
    • 0033039934 scopus 로고    scopus 로고
    • In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM
    • Ziha-Zarifi, I., Llanes, C., Kohler, T., Pechere, J. C. & Plesiat, P. (1999). In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM. Antimicrobial Agents and Chemotherapy 43, 287-91.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 287-291
    • Ziha-Zarifi, I.1    Llanes, C.2    Kohler, T.3    Pechere, J.C.4    Plesiat, P.5
  • 42
    • 0343067131 scopus 로고    scopus 로고
    • Rapid detection of efflux pumps and their relation with drug resistance in yeast cells
    • Prudencio, C., Sansonetty, F., Sousa, M. J., Corte-Real, M. & Leao, C. (2000). Rapid detection of efflux pumps and their relation with drug resistance in yeast cells. Cytometry 39, 26-35.
    • (2000) Cytometry , vol.39 , pp. 26-35
    • Prudencio, C.1    Sansonetty, F.2    Sousa, M.J.3    Corte-Real, M.4    Leao, C.5
  • 44
    • 0030770318 scopus 로고    scopus 로고
    • The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin
    • Brenwald, N. P., Gill, M. J. & Wise, R. (1997). The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin. Journal of Antimicrobial Chemotherapy 40, 458-60.
    • (1997) Journal of Antimicrobial Chemotherapy , vol.40 , pp. 458-460
    • Brenwald, N.P.1    Gill, M.J.2    Wise, R.3
  • 45
    • 0033040998 scopus 로고    scopus 로고
    • Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus
    • Aeschlimann, J. R., Dresser, L. D., Kaatz, G. W. & Rybak, M. J. (1999). Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 43, 335-40.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 335-340
    • Aeschlimann, J.R.1    Dresser, L.D.2    Kaatz, G.W.3    Rybak, M.J.4
  • 46
    • 0031057694 scopus 로고    scopus 로고
    • Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells
    • Molnar, J., Hever, A., Fakla, I., Fischer, J., Ocsovski, I. & Aszalos, A. (1997). Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells. Anticancer Research 17, 481-6.
    • (1997) Anticancer Research , vol.17 , pp. 481-486
    • Molnar, J.1    Hever, A.2    Fakla, I.3    Fischer, J.4    Ocsovski, I.5    Aszalos, A.6
  • 48
    • 0029052668 scopus 로고
    • Verapamiltobramycin synergy in Pseudomonas cepacia but not Pseudomonas aeruginosa in vitro
    • Cohn, R. C., Rudzienski, L. & Putnam, R. W. (1995). Verapamiltobramycin synergy in Pseudomonas cepacia but not Pseudomonas aeruginosa in vitro. Chemotherapy 41, 330-3.
    • (1995) Chemotherapy , vol.41 , pp. 330-333
    • Cohn, R.C.1    Rudzienski, L.2    Putnam, R.W.3
  • 50
    • 0035186868 scopus 로고    scopus 로고
    • Efflux pumps: Their role in antibacterial drug discovery
    • Lomovskaya, O. & Watkins, W. J. (2001). Efflux pumps: their role in antibacterial drug discovery. Current Medicinal Chemistry 8, 1699-711.
    • (2001) Current Medicinal Chemistry , vol.8 , pp. 1699-1711
    • Lomovskaya, O.1    Watkins, W.J.2
  • 51
    • 0032779638 scopus 로고    scopus 로고
    • Reversal of tetracycline resistance mediated by different bacterial tetracycline resistance determinants by an inhibitor of the Tet(B) antiport protein
    • Nelson, M. L. & Levy, S. B. (1999). Reversal of tetracycline resistance mediated by different bacterial tetracycline resistance determinants by an inhibitor of the Tet(B) antiport protein. Antimicrobial Agents and Chemotherapy 43, 1719-24.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 1719-1724
    • Nelson, M.L.1    Levy, S.B.2
  • 52
    • 0031876772 scopus 로고    scopus 로고
    • Screening of an inhibitor of the tetracycline efflux pump in a tetracycline-resistant clinical isolate of Staphylococcus aureus 743
    • Hirata, T., Wakatabe, R., Nielsen, J., Satoh, T., Nihira, S. & Yamaguchi, A. (1998). Screening of an inhibitor of the tetracycline efflux pump in a tetracycline-resistant clinical isolate of Staphylococcus aureus 743. Biological and Pharmaceutical Bulletin 21, 678-81.
    • (1998) Biological and Pharmaceutical Bulletin , vol.21 , pp. 678-681
    • Hirata, T.1    Wakatabe, R.2    Nielsen, J.3    Satoh, T.4    Nihira, S.5    Yamaguchi, A.6
  • 53
    • 0035905848 scopus 로고    scopus 로고
    • Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: Structure-activity relationships
    • Guz, N. R., Stermitz, F. R., Johnson, J. B., Beeson, T. D., Willen, S., Hsiang, J. et al. (2001). Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. Journal of Medicinal Chemistry 44, 261-8.
    • (2001) Journal of Medicinal Chemistry , vol.44 , pp. 261-268
    • Guz, N.R.1    Stermitz, F.R.2    Johnson, J.B.3    Beeson, T.D.4    Willen, S.5    Hsiang, J.6
  • 54
    • 0344717988 scopus 로고    scopus 로고
    • Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin
    • Renau, T. E., Leger, R., Flamme, E. M., Sangalang, J., She, M. W., Yen, R. et al. (1999). Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. Journal of Medicinal Chemistry 42, 4928-31.
    • (1999) Journal of Medicinal Chemistry , vol.42 , pp. 4928-4931
    • Renau, T.E.1    Leger, R.2    Flamme, E.M.3    Sangalang, J.4    She, M.W.5    Yen, R.6
  • 55
    • 0035162640 scopus 로고    scopus 로고
    • Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: Novel agents for combination therapy
    • Lomovskaya, O., Warren, M. S., Lee, A., Galazzo, J., Fronko, R., Lee M. et al. (2001). Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrobial Agents and Chemotherapy 45, 105-16.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 105-116
    • Lomovskaya, O.1    Warren, M.S.2    Lee, A.3    Galazzo, J.4    Fronko, R.5    Lee, M.6
  • 56
    • 0035110460 scopus 로고    scopus 로고
    • MC-207110 Daiichi Seiyaku/Microcide Pharmaceuticals
    • Barrett, J. F. (2001). MC-207110 Daiichi Seiyaku/Microcide Pharmaceuticals. Current Opinion on Investigational Drugs 2, 212-5.
    • (2001) Current Opinion on Investigational Drugs , vol.2 , pp. 212-215
    • Barrett, J.F.1
  • 57
    • 0027160409 scopus 로고
    • Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine
    • Ahmed, M., Borsch, C. M., Neyfakh, A. A. & Schuldiner, S. (1993). Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine. Journal of Biological Chemistry 268, 11086-9.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 11086-11089
    • Ahmed, M.1    Borsch, C.M.2    Neyfakh, A.A.3    Schuldiner, S.4
  • 58
    • 0027514765 scopus 로고
    • Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter
    • Neyfakh, A. A., Borsch, C. M. & Kaatz, G. W. (1993). Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrobial Agents and Chemotherapy 37, 128-9.
    • (1993) Antimicrobial Agents and Chemotherapy , vol.37 , pp. 128-129
    • Neyfakh, A.A.1    Borsch, C.M.2    Kaatz, G.W.3
  • 59
    • 0023008517 scopus 로고
    • Determination of the complete nucleotide sequence of pNS1, a staphylococcal tetracycline-resistance plasmid propagated in Bacillus subtilis
    • Noguchi, N., Aoki, T., Sasatsu, M., Kono, M., Shishido, K. & Ando, T. (1986). Determination of the complete nucleotide sequence of pNS1, a staphylococcal tetracycline-resistance plasmid propagated in Bacillus subtilis. FEMS Microbiology Letters 37, 283-8.
    • (1986) FEMS Microbiology Letters , vol.37 , pp. 283-288
    • Noguchi, N.1    Aoki, T.2    Sasatsu, M.3    Kono, M.4    Shishido, K.5    Ando, T.6
  • 60
    • 0038324876 scopus 로고    scopus 로고
    • Identification of a novel multidrug resistance efflux system (MdeA) from Staphylococcus aureus
    • Program and Abstracts of the Forty-second interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-427, American Society for Microbiology, Washington, DC, USA
    • Huang, J., O'Toole P. W., Shen, W., Jiang, X., Lobo, N., Palmer, L. M. et al. (2002). Identification of a novel multidrug resistance efflux system (MdeA) from Staphylococcus aureus. In Program and Abstracts of the Forty-second interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-427, p. 65. American Society for Microbiology, Washington, DC, USA.
    • (2002) , pp. 65
    • Huang, J.1    O'Toole, P.W.2    Shen, W.3    Jiang, X.4    Lobo, N.5    Palmer, L.M.6
  • 62
    • 0032907704 scopus 로고    scopus 로고
    • Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae
    • Gill, M. J., Brenwald, N. P. & Wise, R. (1999). Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 43, 187-9.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 187-189
    • Gill, M.J.1    Brenwald, N.P.2    Wise, R.3
  • 63
    • 0029823199 scopus 로고    scopus 로고
    • Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus-pyogenes
    • Clancy, J., Petitpas, J., Dib-Hajj, F., Yuan, W., Cronan, M., Kamath, A. V. et al. (1996). Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus-pyogenes. Molecular Microbiology 22, 867-79.
    • (1996) Molecular Microbiology , vol.22 , pp. 867-879
    • Clancy, J.1    Petitpas, J.2    Dib-Hajj, F.3    Yuan, W.4    Cronan, M.5    Kamath, A.V.6
  • 64
    • 0037649339 scopus 로고    scopus 로고
    • Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenes CLIP 21369
    • Program and Abstracts of the Forty-first Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA, 2001. Abstract UL-11. American Society for Microbiology, Washington, DC, USA
    • Godreuil, S., Galimand, M., Gerbaud, G. & Courvalin, P. (2001). Efflux pump Lde is associated with fluoroquinolone resistance in Listeria monocytogenes CLIP 21369. In Program and Abstracts of the Forty-first Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA, 2001. Abstract UL-11. American Society for Microbiology, Washington, DC, USA.
    • (2001)
    • Godreuil, S.1    Galimand, M.2    Gerbaud, G.3    Courvalin, P.4
  • 65
    • 0031733415 scopus 로고    scopus 로고
    • mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors
    • De Rossi, E., Branzoni, M., Cantoni, R., Milano, A., Riccardi, G. & Ciferri, O. (1998). mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors. Journal of Bacteriology 180, 6068-71.
    • (1998) Journal of Bacteriology , vol.180 , pp. 6068-6071
    • De Rossi, E.1    Branzoni, M.2    Cantoni, R.3    Milano, A.4    Riccardi, G.5    Ciferri, O.6
  • 66
    • 0036796243 scopus 로고    scopus 로고
    • Overexpression and functional characterization of an ABC transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis
    • Chaudhuri, B. S., Bhakta, S., Barik, R., Basu, J., Kundu, M. & Chakrabarti, P. (2002). Overexpression and functional characterization of an ABC transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis. Biochemical Journal 367, 279-85.
    • (2002) Biochemical Journal , vol.367 , pp. 279-285
    • Chaudhuri, B.S.1    Bhakta, S.2    Barik, R.3    Basu, J.4    Kundu, M.5    Chakrabarti, P.6
  • 68
    • 0035180195 scopus 로고    scopus 로고
    • Characterization of emeA, a norA homolog and multidrug resistance efflux pump, in Enterococcus faecalis
    • Jonas, B. M., Murray, B. E. & Weinstock, G. M. (2001). Characterization of emeA, a norA homolog and multidrug resistance efflux pump, in Enterococcus faecalis. Antimicrobial Agents and Chemotherapy 45, 3574-9.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 3574-3579
    • Jonas, B.M.1    Murray, B.E.2    Weinstock, G.M.3
  • 69
    • 0036098236 scopus 로고    scopus 로고
    • An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin
    • Singh, K. V., Weinstock, G. M. & Murray, B. E. (2002). An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin Antimicrobial Agents and Chemotherapy 46, 1845-50.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 1845-1850
    • Singh, K.V.1    Weinstock, G.M.2    Murray, B.E.3
  • 70
    • 0030663047 scopus 로고    scopus 로고
    • The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump
    • Sanchez, L., Pan, W., Vinas, M. & Nikaido, H. (1997). The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. Journal of Bacteriology 179, 6855-7.
    • (1997) Journal of Bacteriology , vol.179 , pp. 6855-6857
    • Sanchez, L.1    Pan, W.2    Vinas, M.3    Nikaido, H.4
  • 71
    • 0030788726 scopus 로고    scopus 로고
    • The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system
    • Hagman, K. E., Lucas, C. E., Balthazar, J. T., Snyder, L., Nilles, M., Judd, R. C. et al. (1997). The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system. Microbiology 143, 2117-25.
    • (1997) Microbiology , vol.143 , pp. 2117-2125
    • Hagman, K.E.1    Lucas, C.E.2    Balthazar, J.T.3    Snyder, L.4    Nilles, M.5    Judd, R.C.6
  • 72
    • 0031948133 scopus 로고    scopus 로고
    • Antibiotic resistance caused by Gram-negative multidrug efflux pumps
    • Nikaido, H. (1998). Antibiotic resistance caused by Gram-negative multidrug efflux pumps. Clinical Infectious Diseases 27, Suppl. 1, S32-41.
    • (1998) Clinical Infectious Diseases , vol.27 , Issue.SUPPL. 1
    • Nikaido, H.1
  • 73
    • 0030045627 scopus 로고    scopus 로고
    • Salmonella typhimurium acrB-like gene: Identification and role in resistance to biliary salts and detergents and in murine infection
    • Lacroix, F. J., Cloeckaert, A., Grepinet, O., Pinault, C., Popoff, M. Y., Waxin, H. et al. (1996). Salmonella typhimurium acrB-like gene: identification and role in resistance to biliary salts and detergents and in murine infection. FEMS Microbiology Letters 135, 161-7.
    • (1996) FEMS Microbiology Letters , vol.135 , pp. 161-167
    • Lacroix, F.J.1    Cloeckaert, A.2    Grepinet, O.3    Pinault, C.4    Popoff, M.Y.5    Waxin, H.6
  • 74
    • 0031720812 scopus 로고    scopus 로고
    • Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains
    • Nikaido, H., Basina, M., Nguyen, V. & Rosenberg, E. Y. (1998). Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains. Journal of Bacteriology 180, 4686-92.
    • (1998) Journal of Bacteriology , vol.180 , pp. 4686-4692
    • Nikaido, H.1    Basina, M.2    Nguyen, V.3    Rosenberg, E.Y.4
  • 75
    • 0344731446 scopus 로고    scopus 로고
    • A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104
    • Arcangioli, M. A., Leroy-Setrin, S., Martel, J. L. & Chaslus-Dancla, E. (1999). A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104. FEMS Microbiology Letters 174, 327-32.
    • (1999) FEMS Microbiology Letters , vol.174 , pp. 327-332
    • Arcangioli, M.A.1    Leroy-Setrin, S.2    Martel, J.L.3    Chaslus-Dancla, E.4
  • 76
    • 0026653589 scopus 로고
    • Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity
    • Morimyo, M., Hongo, E., Hama-Inaba, H. & Machida, I. (1992). Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity. Nucleic Acids Research 20, 3159-65.
    • (1992) Nucleic Acids Research , vol.20 , pp. 3159-3165
    • Morimyo, M.1    Hongo, E.2    Hama-Inaba, H.3    Machida, I.4
  • 77
    • 0028986717 scopus 로고
    • EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents
    • Yerushalmi, H., Lebendiker, M. & Schuldiner, S. (1995). EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents. Journal of Biological Chemistry 270, 6856-63.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 6856-6863
    • Yerushalmi, H.1    Lebendiker, M.2    Schuldiner, S.3
  • 78
    • 0031836031 scopus 로고    scopus 로고
    • NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli
    • Morita, Y., Kodama, K., Shiota, S., Mine, T., Kataoka, A., Mizushima, T. et al. (1998). NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrobial Agents and Chemotherapy 42, 1778-82.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 1778-1782
    • Morita, Y.1    Kodama, K.2    Shiota, S.3    Mine, T.4    Kataoka, A.5    Mizushima, T.6
  • 79
    • 0034817367 scopus 로고    scopus 로고
    • Analysis of a complete library of putative drug transporter genes in Escherichia coli
    • Nishino, K. & Yamaguchi, A. (2001). Analysis of a complete library of putative drug transporter genes in Escherichia coli. Journal of Bacteriology 183, 5803-12.
    • (2001) Journal of Bacteriology , vol.183 , pp. 5803-5812
    • Nishino, K.1    Yamaguchi, A.2
  • 80
    • 0021099993 scopus 로고
    • The tetracycline resistance determinants of RP1 and Tn1721: Nucleotide sequence analysis
    • Waters, S. H., Rogowsky, P., Grinsted, J., Altenbuchner, J. & Schmitt, R. (1983). The tetracycline resistance determinants of RP1 and Tn1721: nucleotide sequence analysis. Nucleic Acids Research 11, 6089-105.
    • (1983) Nucleic Acids Research , vol.11 , pp. 6089-6105
    • Waters, S.H.1    Rogowsky, P.2    Grinsted, J.3    Altenbuchner, J.4    Schmitt, R.5
  • 81
    • 0027324803 scopus 로고
    • Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance
    • Bentley, J., Hyatt, L. S., Ainley, K., Parish, J. H., Herbert, R. B. & White, G. R. (1993). Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance. Gene 127, 117-20.
    • (1993) Gene , vol.127 , pp. 117-120
    • Bentley, J.1    Hyatt, L.S.2    Ainley, K.3    Parish, J.H.4    Herbert, R.B.5    White, G.R.6
  • 83
    • 0030956372 scopus 로고    scopus 로고
    • MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition
    • Edgar, R. & Bibi, E. (1997). MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. Journal of Bacteriology 179, 2274-80.
    • (1997) Journal of Bacteriology , vol.179 , pp. 2274-2280
    • Edgar, R.1    Bibi, E.2
  • 86
    • 0026770691 scopus 로고
    • Systematic sequencing of the Escherichia coli genome: Analysis of the 0-2.4 min region
    • Yura, T., Mori, H., Nagai, H., Nagata, T., Ishihama, A., Fujita, N. et al. (1992). Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region. Nucleic Acids Research 20, 3305-8.
    • (1992) Nucleic Acids Research , vol.20 , pp. 3305-3308
    • Yura, T.1    Mori, H.2    Nagai, H.3    Nagata, T.4    Ishihama, A.5    Fujita, N.6
  • 87
    • 0033977101 scopus 로고    scopus 로고
    • Families of transmembrane sugar transport proteins
    • Saier, M. H., Jr (2000). Families of transmembrane sugar transport proteins. Molecular Microbiology 35, 699-710.
    • (2000) Molecular Microbiology , vol.35 , pp. 699-710
    • Saier M.H., Jr.1
  • 88
    • 0030579174 scopus 로고    scopus 로고
    • Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification
    • Fujisaki, S., Ohnuma, S., Horiuchi, T., Takahashi, I., Tsukui, S., Nishimura, Y. et al. (1996). Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification. Gene 175, 83-7.
    • (1996) Gene , vol.175 , pp. 83-87
    • Fujisaki, S.1    Ohnuma, S.2    Horiuchi, T.3    Takahashi, I.4    Tsukui, S.5    Nishimura, Y.6
  • 89
    • 0027508337 scopus 로고
    • Molecular cloning and characterization of acrA and acrE genes of Escherichia coli
    • Ma, D., Cook, D. N., Alberti, M., Pon, N. G., Nikaido, H. & Hearst, J. E. (1993). Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. Journal of Bacteriology 175, 6299-313.
    • (1993) Journal of Bacteriology , vol.175 , pp. 6299-6313
    • Ma, D.1    Cook, D.N.2    Alberti, M.3    Pon, N.G.4    Nikaido, H.5    Hearst, J.E.6
  • 90
    • 0030029513 scopus 로고    scopus 로고
    • AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
    • Okusu, H., Ma, D. & Nikaido, H. (1996). AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. Journal of Bacteriology 178, 306-8.
    • (1996) Journal of Bacteriology , vol.178 , pp. 306-308
    • Okusu, H.1    Ma, D.2    Nikaido, H.3
  • 91
    • 0013215795 scopus 로고    scopus 로고
    • Mutation of the AcrAB antibiotic efflux pump in Escherichia coli confers susceptibility to oxazolidinone antibiotics
    • Program and Abstracts of the Thirly-sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, LA, USA, 1996. Abstract C-42. American Society for Microbiology, Washington, DC, USA
    • Buysse, J. M., Demyan, W. F., Dunyak, D. S., Stapert, D., Hamel, J. C. & Ford, C. W. (1996). Mutation of the AcrAB antibiotic efflux pump in Escherichia coli confers susceptibility to oxazolidinone antibiotics. In Program and Abstracts of the Thirly-sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, LA, USA, 1996. Abstract C-42. American Society for Microbiology, Washington, DC, USA.
    • (1996)
    • Buysse, J.M.1    Demyan, W.F.2    Dunyak, D.S.3    Stapert, D.4    Hamel, J.C.5    Ford, C.W.6
  • 92
    • 0034090541 scopus 로고    scopus 로고
    • AcrD of Escherichia coli is an aminoglycoside efflux pump
    • Rosenberg, E. Y., Ma, D. & Nikaido, H. (2000). AcrD of Escherichia coli is an aminoglycoside efflux pump. Journal of Bacteriology 182, 1754-6.
    • (2000) Journal of Bacteriology , vol.182 , pp. 1754-1756
    • Rosenberg, E.Y.1    Ma, D.2    Nikaido, H.3
  • 93
    • 0034806355 scopus 로고    scopus 로고
    • Novel macrolide-specific ABC-type efflux transporter in Escherichia coli
    • Kobayashi, N., Nishino, K. & Yamaguchi, A. (2001). Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. Journal of Bacteriology 183, 5639-44.
    • (2001) Journal of Bacteriology , vol.183 , pp. 5639-5644
    • Kobayashi, N.1    Nishino, K.2    Yamaguchi, A.3
  • 94
    • 0033734699 scopus 로고    scopus 로고
    • Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia
    • Alonso, A. & Martinez, J. L. (2000). Cloning and characterization of SmeDEF, a novel multidrug efflux pump from Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 44, 3079-86.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 3079-3086
    • Alonso, A.1    Martinez, J.L.2
  • 95
    • 0035183854 scopus 로고    scopus 로고
    • SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia
    • Zhang, L., Li, X. Z. & Poole, K. (2001). SmeDEF multidrug efflux pump contributes to intrinsic multidrug resistance in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 45, 3497-503.
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 3497-3503
    • Zhang, L.1    Li, X.Z.2    Poole, K.3
  • 96
    • 0025893384 scopus 로고
    • Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: Similarity of the product to transmembrane transport proteins
    • Bissonnette, L., Champetier, S., Buisson, J. P. & Roy, P. H. (1991). Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins. Journal of Bacteriology 173, 4493-502.
    • (1991) Journal of Bacteriology , vol.173 , pp. 4493-4502
    • Bissonnette, L.1    Champetier, S.2    Buisson, J.P.3    Roy, P.H.4
  • 97
    • 0027367171 scopus 로고
    • Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: Regulation by iron and possible involvement in the secretion of the siderophore pyoverdine
    • Poole, K., Heinrichs, D. E. & Neshat, S. (1993). Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine. Molecular Microbiology 10, 529-44.
    • (1993) Molecular Microbiology , vol.10 , pp. 529-544
    • Poole, K.1    Heinrichs, D.E.2    Neshat, S.3
  • 98
    • 0344572646 scopus 로고    scopus 로고
    • Carbapenem activities against Pseudomonas aeruginosa: Respective contributions of OprD and efflux systems
    • Kohler, T., Michea-Hamzehpour, M., Epp, S. F. & Pechere, J. C. (1999). Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems. Antimicrobial Agents and Chemotherapy 43, 424-7.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 424-427
    • Kohler, T.1    Michea-Hamzehpour, M.2    Epp, S.F.3    Pechere, J.C.4
  • 99
    • 0033060792 scopus 로고    scopus 로고
    • Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa
    • Masuda, N., Gotoh, N., Ishii, C., Sakagawa, E., Ohya, S. & Nishino, T. (1999). Interplay between chromosomal beta-lactamase and the MexAB-OprM efflux system in intrinsic resistance to beta-lactams in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 43, 400-2.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 400-402
    • Masuda, N.1    Gotoh, N.2    Ishii, C.3    Sakagawa, E.4    Ohya, S.5    Nishino, T.6
  • 100
    • 0031952858 scopus 로고    scopus 로고
    • Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa
    • Li, X. Z., Zhang, L., Srikumar, R. & Poole, K. (1998). Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 42, 399-403.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 399-403
    • Li, X.Z.1    Zhang, L.2    Srikumar, R.3    Poole, K.4
  • 102
    • 0242648332 scopus 로고    scopus 로고
    • Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa
    • Poole, K., Gotoh, N., Tsujimoto, H., Zhao, Q., Wada, A., Yamasaki, T. et al. (1996). Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. Molecular Microbiology 21, 713-24.
    • (1996) Molecular Microbiology , vol.21 , pp. 713-724
    • Poole, K.1    Gotoh, N.2    Tsujimoto, H.3    Zhao, Q.4    Wada, A.5    Yamasaki, T.6
  • 103
    • 0031016991 scopus 로고    scopus 로고
    • Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa
    • Kohler, T., Michea-Hamzehpour, M., Henze, U., Gotoh, N., Curty, L. K. & Pechere, J. C. (1997). Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Molecular Microbiology 23, 345-54.
    • (1997) Molecular Microbiology , vol.23 , pp. 345-354
    • Kohler, T.1    Michea-Hamzehpour, M.2    Henze, U.3    Gotoh, N.4    Curty, L.K.5    Pechere, J.C.6
  • 104
    • 0033994786 scopus 로고    scopus 로고
    • Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa
    • Maseda, H., Yoneyama, H. & Nakae, T. (2000). Assignment of the substrate-selective subunits of the MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 44, 658-64.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 658-664
    • Maseda, H.1    Yoneyama, H.2    Nakae, T.3
  • 105
    • 0036723860 scopus 로고    scopus 로고
    • The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan
    • Chuanchuen, R., Narasaki, C. T. & Schweizer, H. P. (2002). The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan. Journal of Bacteriology 184, 5036-44.
    • (2002) Journal of Bacteriology , vol.184 , pp. 5036-5044
    • Chuanchuen, R.1    Narasaki, C.T.2    Schweizer, H.P.3
  • 106
  • 107
    • 0030834464 scopus 로고    scopus 로고
    • Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae
    • Clancy, J., Dib-Hajj, F., Petitpas, J. W. & Yuan, W. (1997). Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae. Antimicrobial Agents and Chemotherapy 41, 2719-23.
    • (1997) Antimicrobial Agents and Chemotherapy , vol.41 , pp. 2719-2723
    • Clancy, J.1    Dib-Hajj, F.2    Petitpas, J.W.3    Yuan, W.4
  • 108
    • 0034075717 scopus 로고    scopus 로고
    • Studies of the novel ketolide ABT-773: Transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae
    • Capobianco, J. O., Cao, Z., Shortridge, V. D., Ma, Z., Flamm, R. K. & Zhong, P. (2000). Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 44, 1562-7.
    • (2000) Antimicrobial Agents and Chemotherapy , vol.44 , pp. 1562-1567
    • Capobianco, J.O.1    Cao, Z.2    Shortridge, V.D.3    Ma, Z.4    Flamm, R.K.5    Zhong, P.6
  • 109
    • 0034531990 scopus 로고    scopus 로고
    • In vitro activity of ketolides telithromycin and HMR 3004 against Italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility
    • Giovanetti, E., Montanari, M. P., Marchetti, F. & Varaldo, P. E. (2000). In vitro activity of ketolides telithromycin and HMR 3004 against Italian isolates of Streptococcus pyogenes and Streptococcus pneumoniae with different erythromycin susceptibility. Journal of Antimicrobial Chemotherapy 46, 905-8.
    • (2000) Journal of Antimicrobial Chemotherapy , vol.46 , pp. 905-908
    • Giovanetti, E.1    Montanari, M.P.2    Marchetti, F.3    Varaldo, P.E.4
  • 110
    • 0028860020 scopus 로고
    • A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter
    • Someya, Y., Yamaguchi, A. & Sawai, T. (1995). A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter. Antimicrobial Agents and Chemotherapy 39, 247-9.
    • (1995) Antimicrobial Agents and Chemotherapy , vol.39 , pp. 247-249
    • Someya, Y.1    Yamaguchi, A.2    Sawai, T.3
  • 111
    • 0019224466 scopus 로고
    • Heterogeneity of tetracycline resistance determinants
    • Mendez, B., Tachibana, C. & Levy, S. B. (1980). Heterogeneity of tetracycline resistance determinants. Plasmid 3, 99-108.
    • (1980) Plasmid , vol.3 , pp. 99-108
    • Mendez, B.1    Tachibana, C.2    Levy, S.B.3
  • 112
    • 0031755687 scopus 로고    scopus 로고
    • Activities of new fluoroquinolones against fluoroquinolone-resistant pathogens of the lower respiratory tract
    • Piddock, L. J., Johnson, M., Ricci, V. & Hill, S. L. (1998). Activities of new fluoroquinolones against fluoroquinolone-resistant pathogens of the lower respiratory tract. Antimicrobial Agents and Chemotherapy 42, 2956-60.
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , pp. 2956-2960
    • Piddock, L.J.1    Johnson, M.2    Ricci, V.3    Hill, S.L.4
  • 113
    • 0032778126 scopus 로고    scopus 로고
    • Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms
    • Heaton, V. J., Goldsmith, C. E., Ambler, J. E. & Fisher, L. M. (1999). Activity of gemifloxacin against penicillin- and ciprofloxacin-resistant Streptococcus pneumoniae displaying topoisomerase- and efflux-mediated resistance mechanisms. Antimicrobial Agents and Chemotherapy 43, 2998-3000.
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , pp. 2998-3000
    • Heaton, V.J.1    Goldsmith, C.E.2    Ambler, J.E.3    Fisher, L.M.4
  • 114
    • 0029849429 scopus 로고    scopus 로고
    • Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus
    • Takenouchi, T., Tabata, F., Iwata, Y., Hanzawa, H., Sugawara, M. & Ohya, S. (1996). Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 40, 1835-42.
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , pp. 1835-1842
    • Takenouchi, T.1    Tabata, F.2    Iwata, Y.3    Hanzawa, H.4    Sugawara, M.5    Ohya, S.6
  • 115
    • 0036168052 scopus 로고    scopus 로고
    • In vitro activities of novel des-fluoro(6) quinolone BMS-284756 against mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus selected with different quinolones
    • Schmitz, F. J., Boos, M., Mayer, S., Kohrer, K., Scheuring, S. & Fluit, A. C. (2002). In vitro activities of novel des-fluoro(6) quinolone BMS-284756 against mutants of Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus selected with different quinolones. Antimicrobial Agents and Chemotherapy 46, 934-5.
    • (2002) Antimicrobial Agents and Chemotherapy , vol.46 , pp. 934-935
    • Schmitz, F.J.1    Boos, M.2    Mayer, S.3    Kohrer, K.4    Scheuring, S.5    Fluit, A.C.6
  • 116
    • 0038324875 scopus 로고    scopus 로고
    • Efflux mediated resistance to tigecycline in Pseudomonas aeruginosa
    • Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-1601, American Society for Microbiology, Washington, DC, USA
    • Dean, C. R., Visalli, M. A., Projan, S. J., Sum, P. E. & Bradford, P. A. (2002). Efflux mediated resistance to tigecycline in Pseudomonas aeruginosa. In Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-1601, p. 73. American Society for Microbiology, Washington, DC, USA.
    • (2002) , pp. 73
    • Dean, C.R.1    Visalli, M.A.2    Projan, S.J.3    Sum, P.E.4    Bradford, P.A.5
  • 117
    • 0038324870 scopus 로고    scopus 로고
    • Characterization of a novel tetracycline derivative, tigecycline (GAR-936) as a substrate for efflux proteins: Potential for developing resistance in E. coli strains
    • Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-1602, American Society for Microbiology, Washington, DC, USA
    • Hirata, T., Nishino, K., Saito, A., Tamura, N. & Yamaguchi, A. (2002). Characterization of a novel tetracycline derivative, tigecycline (GAR-936) as a substrate for efflux proteins: potential for developing resistance in E. coli strains. In Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-1602, p. 74. American Society for Microbiology, Washington, DC, USA.
    • (2002) , pp. 74
    • Hirata, T.1    Nishino, K.2    Saito, A.3    Tamura, N.4    Yamaguchi, A.5
  • 118
    • 0038663502 scopus 로고    scopus 로고
    • Multidrug efflux phenotype in Straphylococcus aureus conferred by a pump recognizing organic cations and C8-methoxy fluoroquinolones
    • Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-425, American Society for Microbiology, Washington, DC, USA
    • Kaatz, G. W., Moudgal, V. V. & Seo, S. M. (2002). Multidrug efflux phenotype in Straphylococcus aureus conferred by a pump recognizing organic cations and C8-methoxy fluoroquinolones. In Program and Abstracts of the Forty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2002. Abstract C1-425, p. 64. American Society for Microbiology, Washington, DC, USA.
    • (2002) , pp. 64
    • Kaatz, G.W.1    Moudgal, V.V.2    Seo, S.M.3


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