High occurrence of simultaneous mutations in target enzymes and MtrRCDE efflux system in quinolone-resistant Neisseria gonorrhoeae

Sexually Transmitted Diseases

Volumn 31, Issue 6, 2004, Pages 353-359

  Dewi, Beti Ernawati ^a,d   Akira, Sasaki ^b   Hayashi, Hideo ^c   Ba Thein, William ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b Department of Urology   (Japan)

^c Chugoku Gakuen University   (Japan)

^d UNIVERSITY OF INDONESIA   (Indonesia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE IV; GENOMIC DNA; OFLOXACIN; PENICILLIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REPRESSOR PROTEIN; TETRACYCLINE DERIVATIVE;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE; GENE LOCUS; GENE MUTATION; GONORRHEA; GYRA GENE; MINIMUM INHIBITORY CONCENTRATION; MTRR GENE; NEISSERIA GONORRHOEAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARC GENE; PROMOTER REGION;

ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; CIPROFLOXACIN; DNA GYRASE; DNA TOPOISOMERASE IV; DRUG RESISTANCE, BACTERIAL; FERREDOXIN-NADP REDUCTASE; FLUOROQUINOLONES; GONORRHEA; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MUTATION; NEISSERIA GONORRHOEAE; OFLOXACIN; PENICILLINS; REPRESSOR PROTEINS; TETRACYCLINE;

EID: 2542482572     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007435-200406000-00007     Document Type: Article

References (29)

1. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines 2002. MMWR Morb Mortal Wkly Rep 2002; 51(RR-6):1-78.
2. Mavroidi A, Tzouvelekis LS, Kyriakis KP, Avgerinou H, Daniilidou M, Tzelepi E. Multidrug-resistant strains of Neisseria gonorrhoeae in Greece. Antimicrob Agents Chemother 2001; 45:2651-2654.
3. Shultz TR, Tapsall JW, White PA. Correlation of in vitro susceptibilities to newer quinolones of naturally occurring quinolone-resistant Neisseria gonorrhoeae strains with changes in GyrA and ParC. Antimicrob Agents Chemother 2001; 45:734-738.
4. Lkhamsuren E, Shultz TR, Limnios EA, Tapsall JW. The antibiotic susceptibility of Neisseria gonorrhoeae isolated in Ulaanbaatar, Mongolia. Sex Transm Infect 2001; 77:218-219.
5. Rahman M, Sultan Z, Monira S, et al. Antimicrobial susceptibility of Neisseria gonorrhoeae isolated in Bangladesh (1997 to 1999): Rapid shift to fluoroquinolone resistance. J Clin Microbiol 2002; 40:2037-2040.
6. Tanaka M, Nakayama H, Haraoka M, Saika T. Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998. J Clin Microbiol 2000; 38:521-525.
7. Tanaka M, Takahashi K, Saika T, Kobayashi I, Ueno T, Kumazawa J. Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan. J Urol 1998; 159:2215-2219.
8. Deguchi T, Yasuda M, Maeda SI, Saito I, Kawada Y. Serotyping of quinolone-resistant Neisseria gonorrhoeae isolates with alterations in GyrA and ParC [Letter]. J Antimicrob Chemother 1998; 41:418-420.
9. Yasuda M, Fukuda H, Yokoi S, Ishihara S, Kawada Y, Deguchi T. In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV. J Urol 2000; 164:847-851.
10. Trees DL, Sandul AL, Peto-Mesola V, et al. Alterations within the quinolone resistance-determining regions of GyrA and ParC of Neisseria gonorrhoeae isolated in the Far East and the United States. Int J Antimicrob Agents 1999; 12:325-332.
11. Deguchi T, Yasuda M, Nakano M, et al. Uncommon occurrence of mutations in the gyrB gene associated with quinolone resistance in clinical isolates of Neisseria gonorrhoeae [Letter]. Antimicrob Agents Chemother 1996; 40:2437-2438.
12. Chaudhry U, Ray K, Bala M, Saluja D. Mutation patterns in gyrA and parC genes of ciprofloxacin resistant isolates of Neisseria gonorrhoeae from India. Sex Transm Infect 2002; 78:440-444.
13. Su X, Lind I. Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains isolated in Denmark from 1995 to 1998. Antimicrob Agents Chemother 2001; 45:117-123.
14. Hooper DC. Emerging mechanisms of fluoroquinolone resistance. Emerg Infect Dis 2001; 7:337-341.
15. Poole K. Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrob Agents Chemother 2000; 44:2233-2241.
16. Zarantonelli L, Borthagaray G, Lee EH, Veal W, Shafer WM. Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae. J Antimicrob Chemother 2001; 47:651-654.
17. Hagman KE, Pan W, Spratt BG, Balthazar JT, Judd RC, Shafer WM. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system. Microbiology 1995; 141:611-622.
18. Veal WL, Nicholas RA, Shafer WM. Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. J Bacteriol 2002; 184:5619-5624.
19. Shafer WM, Balthazar JT, Hagman KE, Morse SA. Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids. Microbiology 1995; 141:907-911.
20. Pan W, Spratt BG. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Mol Microbiol 1994; 11:769-775.
21. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 4th ed. Wayne, PA: National Committee for Clinical Laboratory Standards, 1997.
22. Performance Standards for Antimicrobial Susceptibility Testing, Ninth Informational Supplement, vol 19. Wayne, PA: National Committee for Clinical Laboratory Standards, 1999.
23. Ison CA, Woodford PJ, Madders H, Claydon E. Drift in susceptibility of Neisseria gonorrhoeae to ciprofloxacin and emergence of therapeutic failure. Antimicrob Agents Chemother 1998; 42:2919-2922.
24. Skaletsky SRaHJ. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S MSe, ed. Bioinformatics Methods and Protocols: Methods in Molecular Biology. Totowa, NJ: Humana Press, 2000:365-386.
25. Deguchi T, Yasuda M, Nakano M, et al. Quinolone-resistant Neisseria gonorrhoeae: Correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother 1996; 40:1020-1023.
26. Sparling PF, Sarubbi FA Jr, Blackman E. Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae. J Bacteriol 1975; 124:740-749.
27. Kohler T, Michea-Hamzehpour M, Plesiat P, Kahr AL, Pechere JC. Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. Antimicrob Agents Chemother 1997; 41: 2540-2543.
28. Tsunoe H, Tanaka M, Mochida O, et al. Association between proline-requiring auxotype and fluoroquinolone resistance in Neisseria gonorrhoeae isolated in Japan. J Infect Chemother 2001; 7:218-223.
29. Muratani T, Akasaka S, Kobayashi T, et al. Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan. Antimicrob Agents Chemother 2001; 45:3603-3606.