Molecular basis of multidrug transport by ATP-binding cassette transporters: A proposed two-cylinder engine model

Journal of Molecular Microbiology and Biotechnology

Volumn 3, Issue 2, 2001, Pages 185-192

  Van Veen, Hendrik W ^a   Higgins, Christopher F ^b   Konings, Wil N ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ANTHRACYCLINE DERIVATIVE; AZIDOPINE; CALCIUM CHANNEL BLOCKING AGENT; COLCHICINE; CYCLOSPORIN; CYTOTOXIC AGENT; DACTINOMYCIN; DAUNORUBICIN DERIVATIVE; EPIPODOPHYLLOTOXIN DERIVATIVE; ESTRADIOL; GLUTATHIONE DERIVATIVE; GLYCOPROTEIN P; HOE 33342; IMMUNOSUPPRESSIVE AGENT; PACLITAXEL; RHODAMINE 123; STEROID HORMONE; VERAPAMIL; VINBLASTINE; VINCA ALKALOID;

BINDING AFFINITY; CANCER; CONFERENCE PAPER; DISEASE MODEL; DRUG BINDING SITE; DRUG HALF LIFE; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TRANSPORT; HUMAN; HYDROLYSIS; INFECTION CONTROL; MOLECULAR MODEL; MOLECULAR RECOGNITION; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BINDING SITES; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; MODELS, MOLECULAR; P-GLYCOPROTEINS; SUBSTRATE SPECIFICITY;

PROKARYOTA; VINCA;

EID: 0035088361     PISSN: 14641801     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (84)

1. Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein
2. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
3. Cooperative, competitive and non-competitive interactions between modulators of P-glycoprotein
4. Inventory and function of yeast ABC patients: About sex, stress, pleiotropic drug and heavy metal resistance
5. Multidrug resistance in Lactococcus lactis: Evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane
6. Energetics and mechanism of drug transport by the lactococcal multidrug transporter LmrP
7. Characterization of the azidopine and vinblastine binding site of P-glycoprotein of the azidopine and vinblastine binding site of P-glycoprotein
8. Equilibrium, kinetic and photoaffinity labeling studies of daunomycin binding to P-glycoprotein-containing membranes of multidrug-resistant Chinese hamster ovary cells
9. Structural requirements for activity of propafenon-type modulators in P-glycoprotein-mediated multidrug resistance
10. Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP
11. Localization of the iodomycin binding site in hamster P-glycoprotein
12. 3H]verapamil radioligand-binding assay
13. Cation-π interactions in chemistry and biology: A new view of benzene, Phe, Tyr, and Trp
14. Evidence for two non-identical drug-interaction sites in the human P-glycoprotein
15. The importance of a nitrogen atom in modulators of multidrug resistance
16. A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA
17. The ABC maltose transporter
18. Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
19. Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis
20. DNA-containing liposomes as a model for the study of cell membrane permeation by antracycline derivatives
21. Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis
22. Genetic analysis of the multidrug transporter
23. Major photoaffinity drug labeling sites for iodoarylazidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12
24. Osmoregulated ABC-transport system of Lactococcus lactis senses water stress via changes in the physical state of the membrane
25. ABC transporters: From microorganisms to man
26. Is the multidrug transporter a flippase?
27. Structure of the multidrug resistance P-glycoprotein
28. Structural, mechanistic and clinical aspects of MRP1
29. ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans
30. Fluorescent cellular indicators are extruded by the multidrug resistance protein
31. Transmembrane organisation of mouse P-glycoprotein determined by epitope insertion and immunofluorescence
32. Quantitative structure-activity relationship of multidrug resistance reversal agents
33. Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p
34. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
35. Functional analysis of a tryptophan-less P-glycoprotein: A tool for tryptophan insertion and fluorescence spectroscopy
36. Both lobes of the soluble receptor of the periplasmic histidine permease, an ABC transporter (Traffic ATPase), interact with the membrane-bound complex
37. Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1)
38. r 190,000 multidrug resistance protein (MRP): Evidence for contransport with reduced glutathione
39. Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques
40. Communication between multiple drug binding sites on P-glycoprotein
41. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein
42. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity
43. A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE
44. Efflux-mediated multidrug resistance in Bacillus subtilis: Similarities and dissimilarities with the mammlian system
45. Multiple recognition of various amphiphilic molecules by the multidrug resistance P-glycoprotein: Molecular mechanisms and pharmacological consequences coming from functional interactions between various drugs
46. A comparative molecular field analysis of propafenone-type modulators of cancer multidrug resistance
47. Molecular interactions in ribose transport: The binding protein module symmetrically associates with the homodimeric membrane transporter
48. Proton-dependent multidrug efflux systems
49. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
50. Antibiotic resistance: Era of the multidrug pump
51. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state
52. Photosensitized labeling of a functional multidrug transporter in living drug resistant tumor cells
53. Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis
54. A general pattern for substrate recognition by P-glycoprotein
55. Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: A comparison
56. P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites
57. ATP hydrolysis and mechanism in P-glycoprotein and CFTR
58. The catalytic cycle of P-glycoprotein
59. Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein
60. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
61. Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein
62. P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer
63. Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies
64. Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport
65. Secondary and tertiary structure changes of reconstituted P-glycoprotein
66. Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein
67. Transport of the anti-cancer drug doxorubicin across cytoplasmic membrane and membranes composed of phospholipids derived from Escherichia coli occurs via a similar mechanism
68. Localization of a substrate specificity domain in the multidrug resistance protein
69. Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease
70. Translocation pathway in the catalysis of active transport
71. Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) protein superfamily
72. Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins
73. How does P-glycoprotein recognize its substrate?
74. P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site
75. Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites
76. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene
77. The homodimeric ATP-binding transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism
78. Multidrug resistance mediated by a bacterial homolog of the human drug transporter MDR1
79. Mechanism of ligand recognition by BmrR, the multidrug-responding transcriptional regulator: Mutational analysis of the ligand-binding site
80. Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis
81. Dissection of drug-binding-induced conformational changes in P-glycoprotein
82. A common site for substrates and protons in EmrE, an ion-coupled multidrug transporter
83. Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter
84. Structure-based mechanism for drug binding by multidrug transporters