New azoles with potent antifungal activity: Design, synthesis and molecular docking

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 4218-4226

  Che, Xiaoying ^a   Sheng, Chunquan ^a   Wang, Wenya ^a   Cao, Yongbing ^a   Xu, Yulan ^a   Ji, Haitao ^b   Dong, Guoqiang ^a   Miao, Zhenyuan ^a   Yao, Jianzhong ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antifungal activity; Azole; Molecular docking; Rational design

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 [4 [3 (3 NITROPHENOXY)PROPYL]PIPERAZIN 1 YL] 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [4 [3 (4 CHLOROPHENOXY)PROPYL]PIPERAZIN 1 YL] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; 3 [4 [3 (4 TERT BUTYLPHENOXY)PROPYL]PIPERAZIN 1 YL] 2 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)PROPAN 2 OL; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; PIPERAZINE DERIVATIVE; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG; VORICONAZOLE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA TROPICALIS; COMPUTER MODEL; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; FUNGAL STRAIN; IN VITRO STUDY; MICROSPORUM GYPSEUM; MOLECULAR DOCKING; NONHUMAN; TRICHOPHYTON RUBRUM;

ANTIFUNGAL AGENTS; AZOLES; CANDIDA ALBICANS; CATALYTIC DOMAIN; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; FUNGAL PROTEINS; FUNGI; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67749095652     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.05.018     Document Type: Article

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