Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 1, 2003, Pages 432-435

  Kumano, Miyuki ^a   Fujita, Masaya ^c   Nakamura, Kouji ^a   Murata, Makiko ^b   Ohki, Reiko ^b   Yamane, Kunio ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b KYORIN UNIVERSITY   (Japan)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; LINCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; BACTERIUM ISOLATE; BACTERIUM MUTANT; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

BACILLUS SUBTILIS; DRUG RESISTANCE, BACTERIAL; LINCOMYCIN; MICROBIAL SENSITIVITY TESTS; MUTATION;

EID: 12244279068     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.1.432-435.2003     Document Type: Article

References (11)

1. Ahmed, M., C. M. Borsch, S. S. Taylor, N. Vazquez-Laslop, and A. A. Neyfakh. 1994. A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J. Biol. Chem. 269:28506-28513.
2. Aramaki, H., N. Yagi, and M. Suzuki. 1995. Residues important for the function of a multihelical DNA binding domain in the new transcription factor family of Cam and Tet repressors. Protein Eng. 8:1259-1266.
3. H holoenzymes. J. Biochem. (Tokyo) 124:89-97.
4. Griffith, J. K., M. E. Baker, D. A. Rouch, M. G. Page, R. A. Skurray, I. T. Paulsen, K. F. Chater, S. A. Baldwin, and P. J. Henderson. 1992. Membrane transport proteins: implications of sequence comparisons. Curr. Opin. Cell Biol. 4:684-695.
5. Kakeshita, H., A. Oguro, R. Amikura, K. Nakamura, and K. Yamane. 2000. Expression of the ftsY gene, encoding a homologue of the alpha subunit of mammalian signal recognition particle receptor, is controlled by different promoters in vegetative and sporulating cells of Bacillus subtilis. Microbiology 146:2595-2603.
6. Kumano, M., A. Tamakoshi, and K. Yamane. 1997. A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22°-25°) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation. Microbiology 143:2775-2782.
7. Lomovskaya, O., K. Lewis, and A. Matin. 1995. EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. J. Bacteriol. 177:2328-2334.
8. Marger, M., and M. H. Saier, Jr. 1993. A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem. Sci. 18:13-20.
9. Markham, P. N., and A. A. Neyfakh. 2001. Efflux-mediated drug resistance in Gram-positive bacteria. Curr. Opin. Microbiol. 4:509-514.
10. Saier, M. H., Jr., I. T. Paulsen, M. K. Sliwinski, S. S. Pao, R. A. Skurray, and H. Nikaido. 1998. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 12:265-274.
11. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.