메뉴 건너뛰기




Volumn 6, Issue 1, 2003, Pages 9-13

3D structure of AcrB: The archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm

Author keywords

AcrB; Multidrug efflux; RND family transporter; Substrate binding sites

Indexed keywords

AEROBIC RESPIRATION CONTROL PROTEIN A; MEMBRANE PROTEIN; PROTEIN; PROTEIN ACRB; TOLC PROTEIN; UNCLASSIFIED DRUG;

EID: 0037303355     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-7646(03)00004-9     Document Type: Review
Times cited : (41)

References (17)
  • 1
    • 0035782880 scopus 로고    scopus 로고
    • Lipid-layer crystallization and preliminary three-dimensional structure analysis of AcrA, the periplasmic component of a bacterial multidrug effiux efflux pump
    • Avila-Sakar, A., Misaghi, S., Wilson-Kubalek, E., Downing, K., Zgurskaya, H., Nikaido, H., Nogales, E., 2001. Lipid-layer crystallization and preliminary three-dimensional structure analysis of AcrA, the periplasmic component of a bacterial multidrug effiux efflux pump. J. Struct. Biol. 136, 81-88.
    • (2001) J. Struct. Biol. , vol.136 , pp. 81-88
    • Avila-Sakar, A.1    Misaghi, S.2    Wilson-Kubalek, E.3    Downing, K.4    Zgurskaya, H.5    Nikaido, H.6    Nogales, E.7
  • 2
    • 0036889033 scopus 로고    scopus 로고
    • Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops
    • Elkins, C., Nikaido, H., 2002. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops. J. Bacteriol. 184, 6490-6498.
    • (2002) J. Bacteriol. , vol.184 , pp. 6490-6498
    • Elkins, C.1    Nikaido, H.2
  • 3
    • 0033515434 scopus 로고    scopus 로고
    • Alignment and structure prediction of divergent protein families: Periplasmic and outer membrane proteins of bacterial efflux pumps
    • Johnson, J., Church, G., 1999. Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps. J. Mol. Biol. 287, 695-715.
    • (1999) J. Mol. Biol. , vol.287 , pp. 695-715
    • Johnson, J.1    Church, G.2
  • 4
    • 0034702177 scopus 로고    scopus 로고
    • Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
    • Koronakis, V., Sharff, A., Koronakis, E., Luisi, B., Hughes, C., 2000. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 405, 914-919.
    • (2000) Nature , vol.405 , pp. 914-919
    • Koronakis, V.1    Sharff, A.2    Koronakis, E.3    Luisi, B.4    Hughes, C.5
  • 5
    • 0027508337 scopus 로고
    • Molecular cloning and characterization of acrA and acrE genes of Escherichia coli
    • Ma, D., Cook, D., Alberti, M., Pon, N., Nikaido, H., Hearst, J., 1993. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175, 6299-6313.
    • (1993) J. Bacteriol. , vol.175 , pp. 6299-6313
    • Ma, D.1    Cook, D.2    Alberti, M.3    Pon, N.4    Nikaido, H.5    Hearst, J.6
  • 6
    • 0036437057 scopus 로고    scopus 로고
    • On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: The large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition
    • Mao, W., Warren, M., Black, D., Satou, T., Murata, T., Nishino, T., Gotoh, N., Lomovskaya, O., 2002. On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition. Mol. Microbiol. 46, 889-901.
    • (2002) Mol. Microbiol. , vol.46 , pp. 889-901
    • Mao, W.1    Warren, M.2    Black, D.3    Satou, T.4    Murata, T.5    Nishino, T.6    Gotoh, N.7    Lomovskaya, O.8
  • 7
    • 0037057652 scopus 로고    scopus 로고
    • Crystal structure of bacterial multidrug efflux transporter AcrB
    • Murakami, S., Nakashima, R., Yamashita, E., Yamaguchi, A., 2002. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419, 587-593.
    • (2002) Nature , vol.419 , pp. 587-593
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Yamaguchi, A.4
  • 8
    • 0002269404 scopus 로고
    • Gene-controlled resistance to acriflavin and other basic dyes in Escherichia coli
    • Nakamura, H., 1965. Gene-controlled resistance to acriflavin and other basic dyes in Escherichia coli. J. Bacteriol. 90, 8-14.
    • (1965) J. Bacteriol. , vol.90 , pp. 8-14
    • Nakamura, H.1
  • 9
    • 23444456920 scopus 로고
    • Prevention of drug access to bacterial targets: Role of permeability barriers and active efflux
    • Nikaido, H., 1994. Prevention of drug access to bacterial targets: role of permeability barriers and active efflux. Science 264, 382-388.
    • (1994) Science , vol.264 , pp. 382-388
    • Nikaido, H.1
  • 10
    • 0029845913 scopus 로고    scopus 로고
    • Multidrug efflux pumps of Gram-negative bacteria
    • Nikaido, H., 1996. Multidrug efflux pumps of Gram-negative bacteria. J. Bacteriol. 178, 5853-5859.
    • (1996) J. Bacteriol. , vol.178 , pp. 5853-5859
    • Nikaido, H.1
  • 11
    • 0031948133 scopus 로고    scopus 로고
    • Antibiotic resistance caused by Gram-negative multidrug efflux pumps
    • Nikaido, H., 1998. Antibiotic resistance caused by Gram-negative multidrug efflux pumps. Curr. Inf. Dis. 27, S32-S41.
    • (1998) Curr. Inf. Dis. , vol.27
    • Nikaido, H.1
  • 12
    • 0031720812 scopus 로고    scopus 로고
    • Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those β-lactam antibiotics containing lipophilic side chains
    • Nikaido, H., Basina, M., Nguyen, V., Rosenberg, E.Y., 1998. Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those β-lactam antibiotics containing lipophilic side chains. J. Bacteriol. 180, 4686-4692.
    • (1998) J. Bacteriol. , vol.180 , pp. 4686-4692
    • Nikaido, H.1    Basina, M.2    Nguyen, V.3    Rosenberg, E.Y.4
  • 14
    • 0036889445 scopus 로고    scopus 로고
    • Chimeric analysis of the multicomponent multidrug efflux transporters from Gram-negative bacteria
    • Tikhonova, E., Wang, Q., Zgurskaya, H., 2002. Chimeric analysis of the multicomponent multidrug efflux transporters from Gram-negative bacteria. J. Bacteriol. 184, 6499-6507.
    • (2002) J. Bacteriol. , vol.184 , pp. 6499-6507
    • Tikhonova, E.1    Wang, Q.2    Zgurskaya, H.3
  • 15
    • 0033534373 scopus 로고    scopus 로고
    • AcrA is a highly asymmetric protein capable of spanning the periplasm
    • Zgurskaya, H., Nikaido, H., 1998. AcrA is a highly asymmetric protein capable of spanning the periplasm. J. Mol. Biol. 285, 409-420.
    • (1998) J. Mol. Biol. , vol.285 , pp. 409-420
    • Zgurskaya, H.1    Nikaido, H.2
  • 16
    • 0033594886 scopus 로고    scopus 로고
    • Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
    • Zgurskaya, H., Nikaido, H., 1999. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc. Natl. Acad. Sci. USA 96, 7190-7195.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7190-7195
    • Zgurskaya, H.1    Nikaido, H.2
  • 17
    • 0033912430 scopus 로고    scopus 로고
    • Multidrug resistance mechanisms: Drug efflux across two membranes
    • Zgurskaya, H., Nikaido, H., 2000. Multidrug resistance mechanisms: drug efflux across two membranes. Mol. Microbiol. 37, 219-225.
    • (2000) Mol. Microbiol. , vol.37 , pp. 219-225
    • Zgurskaya, H.1    Nikaido, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.