Drug:H+ antiporters in chemical stress response in yeast

Trends in Microbiology

Volumn 17, Issue 1, 2009, Pages 22-31

  Sá Correia, Isabel ^a   dos Santos, Sandra C ^a   Teixeira, Miguel C ^a   Cabrito, Tânia R ^a   Mira, Nuno P ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ANTIPORTER; ARTESUNATE; BARBAN; BENOMYL; BENZOIC ACID; BLEOMYCIN; BUTYRIC ACID; CASPOFUNGIN; CERULENIN; CISPLATIN; CYCLOHEXIMIDE; DIAMIDE; DRUG H+ ANTIPORTER DERIVATIVE; FLUCONAZOLE; INDOMETACIN; KETOCONAZOLE; MALEIC ACID DIETHYL ESTER; MANCOZEB; MANGANESE; MENADIONE; METHOTREXATE; PARACETAMOL; PROPIONIC ACID; PUTRESCINE; QUINIDINE; QUININE; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CHEMICAL STRESS; DRUG TRANSPORT; EUKARYOTE; GENE EXPRESSION; GENE MUTATION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; TREATMENT RESPONSE; YEAST;

ANTIFUNGAL AGENTS; ANTIPORTERS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, MULTIPLE, FUNGAL; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK RESPONSE; MEMBRANE TRANSPORT PROTEINS; PROTON-MOTIVE FORCE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 58149316028     PISSN: 0966842X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tim.2008.09.007     Document Type: Review

References (74)

1. Jungwirth H., and Kuchler K. Yeast ABC transporters-a tale of sex, stress, drugs and aging. FEBS Lett. 580 (2006) 1131-1138
2. Del Sorbo G., et al. Fungal transporters involved in efflux of natural toxic compounds and fungicides. Fungal Genet. Biol. 30 (2000) 1-15
3. Hayes J.D., and Wolf C.R. Molecular genetics of drug resistance. Modern Genetics Vol. 3 (1997), Harwood Academic
4. Kartner N., et al. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221 (1983) 1285-1288
5. Gulshan K., and Moye-Rowley W.S. Multidrug resistance in fungi. Eukaryot. Cell 6 (2007) 1933-1942
6. Hillenmeyer M.E., et al. The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science 320 (2008) 362-365
7. Higgins C.F. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446 (2007) 749-757
8. Paulsen I.T., et al. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. FEBS Lett. 430 (1998) 116-125
9. Sá-Correia I., and Tenreiro S. The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence. J. Biotechnol. 98 (2002) 215-226
10. Balzi E., and Goffeau A. Yeast multidrug resistance: the PDR network. J. Bioenerg. Biomembr. 27 (1995) 71-76
11. Roepe P.D. What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance?. Curr. Pharm. Des. 6 (2000) 241-260
12. Saidijam M., et al. Microbial drug efflux proteins of the major facilitator superfamily. Curr. Drug Targets 7 (2006) 793-811
13. Gbelska Y., et al. Evolution of gene families: the multidrug resistance transporter genes in five related yeast species. FEMS Yeast Res. 6 (2006) 345-355
14. Mima S., et al. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. FEBS Lett. 581 (2007) 1457-1463
15. Delling U., et al. Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs. Antimicrob. Agents Chemother. 42 (1998) 1034-1041
16. do Valle Matta M.A., et al. Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs. Gene 272 (2001) 111-119
17. Markovich S., et al. Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 48 (2004) 3871-3876
18. Teixeira M.C., et al. Environmental genomics: mechanistic insights into toxicity of and resistance to the herbicide 2,4-D. Trends Biotechnol. 25 (2007) 363-370
19. Hohmann S., and Mager W.H. Stress response mechanisms in the yeast Saccharomyces cerevisiae. In: Hohmann S., and Mager W.H. (Eds). Yeast Stress Responses (1997), Springer
20. Mager W.H., and Winderickx J. Yeast as a model for medical and medicinal research. Trends Pharmacol. Sci. 26 (2005) 265-273
21. Roohparvar R., et al. MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides. Fungal Genet. Biol. 44 (2007) 378-388
22. Nunes P.A., et al. Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance. Antimicrob. Agents Chemother. 45 (2001) 1528-1534
23. Vargas R.C., et al. Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant. Antimicrob. Agents Chemother. 48 (2004) 2531-2537
24. Tenreiro S., et al. The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Biochem. Biophys. Res. Commun. 327 (2005) 952-959
25. Tenreiro S., et al. AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 292 (2002) 741-748
26. Felder T., et al. Dtrlp, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae. Eukaryot. Cell 1 (2002) 799-810
27. Neyfakh A.A. Natural functions of bacterial multidrug transporters. Trends Microbiol. 5 (1997) 309-313
28. Vargas R.C., et al. Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells. Eukaryot. Cell 6 (2007) 134-142
29. + transporters in Saccharomyces cerevisiae. Mol. Cell. Biol. 11 (1991) 4266-4273
30. Velasco I., et al. Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Eukaryot. Cell 3 (2004) 1492-1503
31. Dikicioglu D., et al. Integration of metabolic modeling and phenotypic data in the evaluation and improvement of ethanol production using respiratory deficient mutants of Saccharomyces cerevisiae. Appl. Environ. Microbiol. 74 (2008) 5809-5816
32. Tomitori H., et al. Multiple polyamine transport systems on the vacuolar membrane in yeast. Biochem. J. 353 (2001) 681-688
33. Cohen S. A Guide to the Polyamines 1-543 (1998), Oxford University Press
34. Albertsen M., et al. Localization and function of the yeast multidrug transporter Tpo1p. J. Biol. Chem. 278 (2003) 12820-12825
35. Fernandes A.R., et al. Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes. Biochem. Biophys. Res. Commun. 337 (2005) 95-103
36. Teixeira M.C., et al. Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1. Biochem. Biophys. Res. Commun. 367 (2008) 249-255
37. Srikanth C.V., et al. Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology 151 (2005) 99-111
38. Kanazawa S., et al. ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol. Cell. Biol. 8 (1988) 664-673
39. Tenreiro S., et al. Expression of the AZR1 gene (ORF YGR224w), encoding a plasma membrane transporter of the major facilitator superfamily, is required for adaptation to acetic acid and resistance to azoles in Saccharomyces cerevisiae. Yeast 16 (2000) 1469-1481
40. Shimazu M., et al. A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae. J. Biol. Chem. 280 (2005) 4851-4857
41. Thakur J.K., et al. A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452 (2008) 604-609
42. Alenquer M., et al. Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5. FEMS Yeast Res. 6 (2006) 1130-1139
43. Teixeira M.C., and Sá-Correia I. Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes. Biochem. Biophys. Res. Commun. 292 (2002) 530-537
44. Natarajan K., et al. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell. Biol. 21 (2001) 4347-4368
45. Teixeira M.C., et al. The YEASTRACT database: a tool for the analysis of transcription regulatory associations in Saccharomyces cerevisiae. Nucleic Acids Res. 34 (2006) D446-D451
46. Le Crom S., et al. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol. Cell. Biol. 22 (2002) 2642-2649
47. Hikkel I., et al. A general strategy to uncover transcription factor properties identifies a new regulator of drug resistance in yeast. J. Biol. Chem. 278 (2003) 11427-11432
48. Lucau-Danila A., et al. Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. J. Biol. Chem. 278 (2003) 52641-52650
49. Akache B., et al. Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J. Biol. Chem. 279 (2004) 27855-27860
50. Brôco N., et al. FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on Pdr3 transcriptional regulator. Yeast 15 (1999) 1595-1608
51. Tenreiro S., et al. Transcriptional activation of FLR1 gene during Saccharomyces cerevisiae adaptation to growth with benomyl: role of Yap1p and Pdr3p. Biochem. Biophys. Res. Commun. 280 (2001) 216-222
52. Rodrigues-Pousada C.A., et al. Yeast activator proteins and stress response: an overview. FEBS Lett. 567 (2004) 80-85
53. Gasch A.P., et al. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell 11 (2000) 4241-4257
54. Uemura T., et al. Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. J. Biol. Chem. 280 (2005) 9646-9652
55. Decottignies A., et al. Identification and characterization of Snq2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J. Biol. Chem. 270 (1995) 18150-18157
56. Mamnun Y.M., et al. Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett. 559 (2004) 111-117
57. Kolaczkowska A., et al. Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae. FEBS Lett. 582 (2008) 977-983
58. Hoffman M.M., and Roepe P.D. Analysis of ion transport perturbations caused by huMdr1 protein overexpression. Biochemistry 36 (1997) 11153-11168
59. Prasad R., and Panwar S. Physiological functions of multidrug transporters in yeast. Curr. Sci. 86 (2004) 62-73
60. Alarco A.M., et al. AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J. Biol. Chem. 272 (1997) 19304-19313
61. Tomitori H., et al. Identification of a gene for a polyamine transport protein in yeast. J. Biol. Chem. 274 (1999) 3265-3267
62. Kennedy M.A., and Bard M. Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1517 (2001) 177-189
63. Tucker C.L., and Fields S. Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp. Funct. Genomics 5 (2004) 216-224
64. Barker K.S., et al. Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae. J. Antimicrob. Chemother. 51 (2003) 1131-1140
65. 2+ of the yeast Saccharomyces cerevisiae depends on general energy metabolism, metal transport, anti-oxidative defences, and DNA repair. Biometals 19 (2006) 705-714
66. Hahn J.S., et al. A stress regulatory network for co-ordinated activation of proteasome expression mediated by yeast heat shock transcription factor. Mol. Microbiol. 60 (2006) 240-251
67. Teixeira M.C., et al. Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid. FEMS Yeast Res. 6 (2006) 230-248
68. Nelissen B., et al. Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae. FEMS Microbiol. Rev. 21 (1997) 113-134
69. Saier M.H., and Paulsen I.T. Phylogeny of multidrug transporters. Semin. Cell Dev. Biol. 12 (2001) 205-213
70. Perea S., and Patterson T.F. Antifungal resistance in pathogenic fungi. Clin. Infect. Dis. 35 (2002) 1073-1080
71. Sanglard D., et al. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39 (1995) 2378-2386
72. Wirsching S., et al. MDR1-mediated drug resistance in Candida dubliniensis. Antimicrob. Agents Chemother. 45 (2001) 3416-3421
73. Hayashi K., et al. Bcmfs1, a novel major facilitator superfamily transporter from Botrytis cinerea, provides tolerance towards the natural toxic compounds camptothecin and cercosporin and towards fungicides. Appl. Environ. Microbiol. 68 (2002) 4996-5004
74. Haydon M.J., and Cobbett C.S. A novel major facilitator superfamily protein at the tonoplast influences zinc tolerance and accumulation in Arabidopsis. Plant Physiol. 143 (2007) 1705-1719