Relative contributions of the AcrAB, MdfA and NorE efflux pumps to quinolone resistance in Escherichia coli

Journal of Antimicrobial Chemotherapy

Volumn 51, Issue 3, 2003, Pages 545-556

  Yang, Shirley ^a   Clayton, Sonia Rahmati ^a   Zechiedrich, E Lynn ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; ANTIINFECTIVE AGENT; CARBENICILLIN; CEFOTAXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLINAFLOXACIN; DODECYL SULFATE SODIUM; ERYTHROMYCIN; ETHIDIUM BROMIDE; GEMIFLOXACIN; KANAMYCIN; LEVOFLOXACIN; LIPOPROTEIN; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; NALIDIXIC ACID; NEOMYCIN; NORFLOXACIN; OFLOXACIN; PROTEIN ACRAB; PROTEIN MDFA; PROTEIN NORE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; RIFAMPICIN; SPARFLOXACIN; TETRACYCLINE; TETRAPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ESCHERICHIA COLI; GENE OVEREXPRESSION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY;

4-QUINOLONES; ANTI-INFECTIVE AGENTS; ANTIPORTERS; BACTERIAL PROTEINS; CARRIER PROTEINS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; LIPOPROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDOREDUCTASES; PROTON-MOTIVE FORCE;

EID: 0037342874     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg126     Document Type: Article

References (48)

1. Binder, S., Levitt, A. M., Sacks, J. J. & Hughes, J. M. (1999). Emerging infectious diseases: public health issues for the 21st century. Science 284, 1311-3.
2. Cunha, B. A. (1998). Quinolones: clinical use and formulary considerations. Advances in Therapy 15, 277-87.
3. Hooper, D. C. (1998). Clinical applications of quinolones. Biochimica et Biophysica Acta 1400, 45-61.
4. Levine, C., Hiasa, H. & Marians, K. J. (1998). DNA gyrase and topoisomerase IV: biochemical activities, physiological roles during chromosome replication, and drug sensitivities. Biochimica et Biophysica Acta 1400, 29-43.
5. Kreuzer, K. N. & Cozzarelli, N. R. (1979). Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth. Journal of Bacteriology 140, 424-35.
6. Osheroff, N., Corbett, A. H. & Robinson, M. J. (1994). Mechanism of action of topoisomerase II-targeted antineoplastic drugs. Advances in Pharmacology 29B, 105-26.
7. Froelich-Ammon, S. J. & Osheroff, N. (1995). Topoisomerase poisons: harnessing the dark side of enzyme mechanism. Journal of Biological Chemistry 270, 21429-32.
8. Acar, J. F. & Goldstein, F. W. (1997). Trends in bacterial resistance to fluoroquinolones. Clinical Infectious Diseases 24, Suppl. 1, S67-73.
9. Chen, D. K., McGeer, A., de Azavedo, J. C. & Low, D. E. (1999). Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. New England Journal of Medicine 341, 233-9.
10. Hooper, D. C. (2001). Emerging mechanisms of fluoroquinolone resistance. Emerging Infectious Diseases 7, 337-41.
11. Piddock, L. J. (1999). Mechanisms of fluoroquinolone resistance: an update 1994-1998. Drugs 58, 11-8.
12. Giraud, E., Cloeckaert, A., Kerboeuf, D. & Chaslus-Dancla, E. (2000). Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar Typhimurium. Antimicrobial Agents and Chemotherapy 44, 1223-8.
13. Paulsen, I. T., Nguyen, L., Sliwinski, M. K., Rabus, R. & Saier, M. H. J. (2000). Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. Journal of Molecular Biology 301, 75-100.
14. Okusu, H., Ma, D. & Nikaido, H. (1996). AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. Journal of Bacteriology 178, 306-8.
15. Edgar, R. & Bibi, E. (1997). MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. Journal of Bacteriology 179, 2274-80.
16. Morita, Y., Kodama, K., Shiota, S., Mine, T., Kataoka, A., Mizushima, T. et al. (1998). NorM, a putative multidrug efflux protein, of Vibrio, parahaemolyticus and its homolog in Escherichia coli. Antimicrobial Agents and Chemotherapy 42, 1778-82.
17. Zgurskaya, H. I. & Nikaido, H. (1999). Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proceedings of the National Academy of Sciences, USA 96, 7190-5.
18. Brown, M. H., Paulsen, I. T. & Skurray, R. A. (1999). The multidrug efflux protein NorM is a prototype of a new family of transporters. Molecular Microbiology 31, 394-5.
19. Khodursky, A. B., Zechiedrich, E. L. & Cozzarelli, N. R. (1995). Topoisomerase IV is a target of quinolones in Escherichia coli. Proceedings of the National Academy of Sciences, USA 92, 11801-5.
20. Guzman, L. M., Belin, D., Carson, M. J. & Beckwith, J. (1995). Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. Journal of Bacteriology 177, 4121-30.
21. Zgurskaya, H. I. & Nikaido, H. (2000). Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. Journal of Bacteriology 182, 4264-7.
22. Blattner, F. R., Plunkett, G. R., Bloch, C. A., Perna, N. T., Burland, V., Riley, M. et al. (1997). The complete genome sequence of Escherichia coli K-12. Science 277, 1453-74.
23. Eisenstadt, E., Carlton, B. C. & Brown, B. J. (1994). Gene mutation. In Methods for General and Molecular Bacteriology (Gerhardt, P., Murray, R. G. E., Wood, W. A. & Krieg, N. R., Eds), p. 304. American Society for Microbiology, Washington, DC, USA.
24. McMurry, L., Petrucci, R. E. J. & Levy, S. B. (1980). Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli. Proceedings of the National Academy of Sciences, USA 77, 3974-7.
25. Kaback, H. R., Reeves, J. P., Short, S. A. & Lombardi, F. J. (1974). Mechanisms of active transport in isolated bacterial membrane vesicles. Archives of Biochemistry and Biophysics 160, 215-22.
26. Miller, J. H. (1972). Experiments in Genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
27. Zechiedrich, E. L., Khodursky, A. B. & Cozzarelli, N. R. (1997). Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. Genes and Development 11, 2580-92.
28. Khodursky, A. B. & Cozzarelli, N. R. (1998). The mechanism of inbibition of topoisomerase IV by quinolone antibacterials. Journal of Biological Chemistry 273, 27668-77.
29. Heisig, P. (1996). Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrobial Agents and Chemotherapy 40, 879-85.
30. Yoshida, H., Kojima, T., Yamagishi, J.-I. & Nakamura, S. (1988). Quinolone-resistant mutations of the gyrA gene of Escherichia coli. Molecular and General Genetics 211, 1-7.
31. Clark, L. & Carbon, J. (1976). A colony bank containing synthetic ColE1 hybrid plasmids representative of the entire Escherichia coli genome. Cell 9, 91-9.
32. Liu, J., Takiff, H. E. & Nikaido, H. (1996). Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump. Journal of Bacteriology 178, 3791-5.
33. Nikaido, H. (1996). Multidrug efflux pumps of gram-negative bacteria. Journal of Bacteriology 178, 5853-9.
34. Nishino, K. & Yamaguchi, A. (2001). Analysis of a complete library of putative drug transporter genes in Escherichia coli. Journal of Bacteriology 183, 5803-12.
35. Lynch, A. S. & Wang, J. C. (1993). Anchoring of DNA to the bacterial cytoplasmic membrane through cotranscriptional synthesis of polypeptides encoding membrane proteins or proteins for export: a mechanism of plasmid hypernegative supercoiling in mutants deficient in DNA topoisomerase I. Journal of Bacteriology 175, 1645-55.
36. Paulsen, I. T., Brown, M. H. & Skurray, R. A. (1996). Proton-dependent multidrug efflux systems. Microbiology Reviews 60, 575-608.
37. +-driven multidrug efflux pump. Journal of Bacteriology 182, 6694-7.
38. Edgar, R. & Bibi, E. (1999). A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA. EMBO Journal 18, 822-32.
39. Thanassi, D. G., Cheng, L. W. & Nikaido, H. (1997). Active efflux of bile salts by Escherichia coli. Journal of Bacteriology 179, 2512-8.
40. Rahmati, S., Yang, S., Davidson, A. L. & Zechiedrich, E. L. (2002). Control of the AcrAB multidrug efflux pump by quorum sensing regulator SdiA. Molecular Microbiology 43, 677-85.
41. Saier, M. H. J., Paulsen, I. T., Sliwinski, M. K., Pao, S. S., Skurray, R. A. & Nikaido, H. (1998). Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB Journal 12, 265-74.
42. Lee, A., Mao, W., Warren, M. S., Mistry, A., Hoshino, K., Okumura, R. et al. (2000). Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance. Journal of Bacteriology 182, 3142-50.
43. Sulavik, M. C., Houseweart, C., Cramer, C., Jiwani, N., Murgolo, N., Greene, J. et al. (2001). Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrobial Agents and Chemotherapy 45, 1126-36.
44. Hooper, D. C. (2000). New uses for new and old quinolones and the challenge of resistance. Clinical Infectious Diseases 30, 243-54.
45. Oethinger, M., Kern, W. V., Jellen-Ritter, A. S., McMurry, L. M. & Levy, S. B. (2000). Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB eff lux pump. Antimicrobial Agents and Chemotherapy 44, 10-3.
46. Kato, J.-I., Nishimura, Y., Yamada, M., Suzuki, H. & Hirota, Y. (1988). Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli. Journal of Bacteriology 170, 3967-77.
47. Chang, A. C. Y. & Cohen, S. N. (1978). Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the p15A cryptic miniplasmid. Journal of Bacteriology 134, 1141-56.
48. Bolivar, F., Betlach, M. C., Heyneker, H. L., Shine, J., Rodriguez, R. L. & Boyer, H. W. (1977). Origin of replication of pBR345 plasmid DNA. Proceedings of the National Academy of Sciences, USA 74, 5265-9.