Resistance mechanisms in clinical isolates of Candida albicans

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 6, 2002, Pages 1704-1713

  White, Theodore C ^a   Holleman, Scott ^a   Dy, Francis ^a   Mirels, Laurence F ^a   Stevens, David A ^a  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOTRIMAZOLE; FLUCONAZOLE; GENE PRODUCT; ITRACONAZOLE; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN CDR1; PROTEIN CDR2; PROTEIN ERG11; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS RESISTANCE; FUNGUS ISOLATION; GENE CONTROL; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CODE; MOLECULAR DYNAMICS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CANDIDA ALBICANS; CANDIDIASIS; DNA PROBES; DNA, FUNGAL; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, MDR; MICROBIAL SENSITIVITY TESTS; PHENOTYPE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, FUNGAL;

EID: 0036093372     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.6.1704-1713.2002     Document Type: Article

References (42)

1. The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter
2. Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene
3. A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole
4. Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: Possible role for drug efflux in drug resistance
5. Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate
6. A fourth gene from the Candida albicans CDR family of ABC transporters
7. r gene
8. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli
9. Resistance to antifungal drugs: Current status and clinical implications
10. Nucleotide sequence of cytochrome P450 LIA1 (lanosterol 14 alpha-demethylase) from Candida albicans
11. The R467K amino acid substitution in Candida albicans sterol 14α-demethylase causes drug resistance through reduced affinity
12. High prevalence of antifungal resistance in Candida spp. from patients with AIDS
13. Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains
14. Distinct patterns of gene expression associated with development of fluconazole resistance in serial Candida albicans isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis
15. Sequence of the Candida albicans gene encoding actin
16. Transcriptional analyses of antifungal drug resistance in Candida albicans
17. Contribution of mutations in the cytochrome P450 14 alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
18. Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR
19. Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation
20. Molecular and phenotypic characterization of genotypic Candida albicans subgroups and comparison with Candida dubliniensis and Candida stellatoidea
21. Myelofibrosis complicated by infection due to Candida albicans: Emergence of resistance to antifungal agents during therapy
22. Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia
23. Emergence of resistance of Candida albicans to clotrimazole in human immunodeficiency virus-infected children: In vitro and clinical correlations
24. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
25. Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans
26. Variations in fluconazole susceptibility and electrophoretic karyotype among oral isolates of Candida albicans from patients with AIDS and oral candidiasis
27. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
28. The yeast Candida albicans has a clonal mode of reproduction in a population of infected human immunodeficiency virus-positive patients
29. Resistance of Candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with AIDS: Documentation by in vitro susceptibility testing and DNA subtype analysis
30. Development of interpretive breakpoints for antifungal susceptibility testing: Conceptual framework and analysis of in vitro/in vivo correlation data for fluconazole, itraconazole, and Candida infections
31. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
32. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
33. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
34. Mitotic recombination in Candida albicans: Recessive lethal alleles linked to a gene required for methionine biosynthesis
35. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
36. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α-demethylase in Candida albicans
37. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
38. Stable azole drug resistance associated with a substrain of Candida albicans from an HIV-infected patient