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Volumn 51, Issue 5, 2007, Pages 1855-1858

A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; VORICONAZOLE;

EID: 34248398758     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00182-07     Document Type: Article
Times cited : (47)

References (42)
  • 5
    • 0033677649 scopus 로고    scopus 로고
    • A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole
    • Calabrese, D., J. Bille, and D. Sanglard. 2000. A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole. Microbiology 146:2743-2754.
    • (2000) Microbiology , vol.146 , pp. 2743-2754
    • Calabrese, D.1    Bille, J.2    Sanglard, D.3
  • 6
    • 2542494102 scopus 로고    scopus 로고
    • Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles
    • Chau, A. S., C. A. Mendrick, F. J. Sabatelli, D. Loebenberg, and P. M. McNicholas. 2004. Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles. Antimicrob. Agents Chemother. 48:2124-2131.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 2124-2131
    • Chau, A.S.1    Mendrick, C.A.2    Sabatelli, F.J.3    Loebenberg, D.4    McNicholas, P.M.5
  • 7
    • 33846194584 scopus 로고    scopus 로고
    • Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue
    • Cheng, S., C. J. Clancy, Z. Zhang, B. Hao, W. Wang, K. A. Iczkowski, M. A. Pfaller, and M. H. Nguyen. 2007. Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue. Cell. Microbiol. 9:492-501.
    • (2007) Cell. Microbiol , vol.9 , pp. 492-501
    • Cheng, S.1    Clancy, C.J.2    Zhang, Z.3    Hao, B.4    Wang, W.5    Iczkowski, K.A.6    Pfaller, M.A.7    Nguyen, M.H.8
  • 8
    • 33745597941 scopus 로고    scopus 로고
    • Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments
    • Clancy, C. J., H. Huang, S. Cheng, H. Derendorf, and M. H. Nguyen. 2006. Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments. Antimicrob. Agents Chemother. 50:2569-2572.
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 2569-2572
    • Clancy, C.J.1    Huang, H.2    Cheng, S.3    Derendorf, H.4    Nguyen, M.H.5
  • 10
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents characterization of CDR2, a new multidrug ABC transporter gene
    • Dominique, I. F. M., and M. B. Jacques. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 134:405-416.
    • (1997) Microbiology , vol.134 , pp. 405-416
    • Dominique, I.F.M.1    Jacques, M.B.2
  • 11
    • 13744251715 scopus 로고    scopus 로고
    • Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection
    • Forche, A., G. May, and P. T. Magee. 2005. Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection. Eukaryot. Cell 4:156-165.
    • (2005) Eukaryot. Cell , vol.4 , pp. 156-165
    • Forche, A.1    May, G.2    Magee, P.T.3
  • 12
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a step-wise development of fluconazole resistance in clinical Candida albicans strains
    • Franz, R., S. L. Kelly, D. C. Lamb, D. E. Kelly, M. Ruhnke, and J. Morshhauser. 1998. Multiple molecular mechanisms contribute to a step-wise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob. Agents Chemother. 42:3065-3072.
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 3065-3072
    • Franz, R.1    Kelly, S.L.2    Lamb, D.C.3    Kelly, D.E.4    Ruhnke, M.5    Morshhauser, J.6
  • 13
    • 0037331161 scopus 로고    scopus 로고
    • Geraghty, P., and K. Kavanagh. 2003. Erythromycin, an inhibitor of mitoribosomal protein biosynthesis, alters the amphotericin B susceptibility of Candida albicans. J. Pharm. Pharmocol. 55:179-184.
    • Geraghty, P., and K. Kavanagh. 2003. Erythromycin, an inhibitor of mitoribosomal protein biosynthesis, alters the amphotericin B susceptibility of Candida albicans. J. Pharm. Pharmocol. 55:179-184.
  • 14
    • 0037398882 scopus 로고    scopus 로고
    • Disruption of mitochondrial function in Candida albicans leads to reduced cellular ergosterol levels and elevated growth in the presence of amphotericin B
    • Geraghty, P., and K. Kavanagh. 2003. Disruption of mitochondrial function in Candida albicans leads to reduced cellular ergosterol levels and elevated growth in the presence of amphotericin B. Arch. Microbiol. 179:295-300.
    • (2003) Arch. Microbiol , vol.179 , pp. 295-300
    • Geraghty, P.1    Kavanagh, K.2
  • 15
    • 0031692037 scopus 로고    scopus 로고
    • Gupta, V., K., K. Avmeet, P. Shankarling, A. Neeti, S. Panwar, and R. Prasad. 1998. Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation. Curr. Genet. 34:192-199.
    • Gupta, V., K., K. Avmeet, P. Shankarling, A. Neeti, S. Panwar, and R. Prasad. 1998. Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation. Curr. Genet. 34:192-199.
  • 16
    • 0033807662 scopus 로고    scopus 로고
    • Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors
    • Henry, K. W., J. T. Nickels, and T. D. Edlind. 2000. Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitors. Antimicrob. Agents Chemother. 44:2693-2700.
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 2693-2700
    • Henry, K.W.1    Nickels, J.T.2    Edlind, T.D.3
  • 17
    • 33645791257 scopus 로고    scopus 로고
    • Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida alibicans
    • Hiller, D., D. Sanglard, and J. Morschhauser. 2006. Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida alibicans. Antimicrob. Agents Chemother. 50:1365-1371.
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1365-1371
    • Hiller, D.1    Sanglard, D.2    Morschhauser, J.3
  • 19
    • 0029818929 scopus 로고    scopus 로고
    • Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients
    • Kelly, S. L., D. C. Lamb, D. E. Kelly, J. Loeffler, and H. Einsele. 1996. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. Lancet 348:1523-1524.
    • (1996) Lancet , vol.348 , pp. 1523-1524
    • Kelly, S.L.1    Lamb, D.C.2    Kelly, D.E.3    Loeffler, J.4    Einsele, H.5
  • 20
    • 0031024163 scopus 로고    scopus 로고
    • Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6-desaturation
    • Kelly, S. L., D. C. Lamb, D. E. Kelly, N. J. Manning, J. Loeffler, and H. Hebart. 1997. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6-desaturation. FEBS Lett. 400:80-82.
    • (1997) FEBS Lett , vol.400 , pp. 80-82
    • Kelly, S.L.1    Lamb, D.C.2    Kelly, D.E.3    Manning, N.J.4    Loeffler, J.5    Hebart, H.6
  • 23
    • 0037130284 scopus 로고    scopus 로고
    • The genetic basis of fluconazole resistance development in Candida albicans
    • Morschhauser, J. 2002. The genetic basis of fluconazole resistance development in Candida albicans. Biochim. Biophys. Acta 1587:240-248.
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 240-248
    • Morschhauser, J.1
  • 24
    • 78649636937 scopus 로고    scopus 로고
    • Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard
    • National Committee for Clinical Laboratory Standards, National Committee for Clinical Laboratory Standards, Wayne, PA
    • National Committee for Clinical Laboratory Standards. 1997. Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard. NCCLS document M27-A. National Committee for Clinical Laboratory Standards, Wayne, PA.
    • (1997) NCCLS document M27-A
  • 25
    • 0038779227 scopus 로고    scopus 로고
    • Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors
    • Niewerth, M., D. Kunze, M. Seibold, M. Schaller, H. C. Korting, and B. Hube. 2003. Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob. Agents Chemother. 47:1805-1817.
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 1805-1817
    • Niewerth, M.1    Kunze, D.2    Seibold, M.3    Schaller, M.4    Korting, H.C.5    Hube, B.6
  • 26
    • 33645785596 scopus 로고    scopus 로고
    • Overexpression of Candida alibicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibilty
    • Niimi, K., K. Maki, F. Ikeda, A. R. Holmes, E. Lamping, M. Niimi, B. C. Monk, and R. D. Cannon. 2006. Overexpression of Candida alibicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibilty. Antimicrob. Agents Chemother. 50:1148-1155.
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1148-1155
    • Niimi, K.1    Maki, K.2    Ikeda, F.3    Holmes, A.R.4    Lamping, E.5    Niimi, M.6    Monk, B.C.7    Cannon, R.D.8
  • 27
  • 28
    • 33646231985 scopus 로고    scopus 로고
    • Interpretive breakpoints for fluconazole and Candida revisited: A blueprint for the future of antifungal susceptibility testing
    • Pfaller, M. A., D. J. Diekema, and D. J. Sheehan. 2006. Interpretive breakpoints for fluconazole and Candida revisited: a blueprint for the future of antifungal susceptibility testing. Clin. Microbiol. Rev. 19:435-447.
    • (2006) Clin. Microbiol. Rev , vol.19 , pp. 435-447
    • Pfaller, M.A.1    Diekema, D.J.2    Sheehan, D.J.3
  • 29
    • 0031052377 scopus 로고    scopus 로고
    • Development of interpretive breakpoints for antifungal susceptibility testing: Conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infections
    • Rex, J. H., M. A. Pfaller, J. N. Galgiani, M. S. Bartlett, A. Espinel-Ingroff, M. A. Ghannoum, M. Lancaster, F. C. Odds, M. G. Rinaldi, T. J. Walsh, A. L. Barry, et al. 1997. Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infections. Clin. Infect. Dis. 24:235-247.
    • (1997) Clin. Infect. Dis , vol.24 , pp. 235-247
    • Rex, J.H.1    Pfaller, M.A.2    Galgiani, J.N.3    Bartlett, M.S.4    Espinel-Ingroff, A.5    Ghannoum, M.A.6    Lancaster, M.7    Odds, F.C.8    Rinaldi, M.G.9    Walsh, T.J.10    Barry, A.L.11
  • 30
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard, D., K. Kuchler, F. Ischer, J.-L. Pagani, M. Monod, and J. Bille. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.-L.4    Monod, M.5    Bille, J.6
  • 31
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilites of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1996. Susceptibilites of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40:2300-2305.
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 32
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
    • Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143: 405-416.
    • (1997) Microbiology , vol.143 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 33
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P-450 lanosterol 14 α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to antifungal agents
    • Sanglard, D., F. Ischer, L. Koymans, and J. Bille. 1997. Amino acid substitutions in the cytochrome P-450 lanosterol 14 α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to antifungal agents. Antimicrob. Agents Chemother. 42:241-253.
    • (1997) Antimicrob. Agents Chemother , vol.42 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Bille, J.4
  • 34
    • 0035080323 scopus 로고    scopus 로고
    • Role of ATP-binding cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata
    • Sanglard, D., F. Ischer, and J. Bille. 2001. Role of ATP-binding cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata. Antimicrob. Agents Chemother. 45:1174-1183.
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 1174-1183
    • Sanglard, D.1    Ischer, F.2    Bille, J.3
  • 35
    • 0031875677 scopus 로고    scopus 로고
    • Differential expression of secreted aspartyl proteinases in a model of human oral candidiasis and in patient samples from the oral cavity
    • Schaller, M., W. Schafer, H. C Korting, and B. Hube. 1998. Differential expression of secreted aspartyl proteinases in a model of human oral candidiasis and in patient samples from the oral cavity. Mol. Microbiol. 29:605-615.
    • (1998) Mol. Microbiol , vol.29 , pp. 605-615
    • Schaller, M.1    Schafer, W.2    Korting, H.C.3    Hube, B.4
  • 36
    • 33746506280 scopus 로고    scopus 로고
    • Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    • Selmecki, A., A. Forcher, and J. Berman. 2006. Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313:367-369.
    • (2006) Science , vol.313 , pp. 367-369
    • Selmecki, A.1    Forcher, A.2    Berman, J.3
  • 37
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White, T. C. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 41:1482-1487.
    • (1997) Antimicrob. Agents Chemother , vol.41 , pp. 1482-1487
    • White, T.C.1
  • 38
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White, T. C., K. A. Marr, and R. A. Bowden. 1998. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11:382-401
    • (1998) Clin. Microbiol. Rev , vol.11 , pp. 382-401
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 40
    • 0034081664 scopus 로고    scopus 로고
    • Targeted gene disruption in Candida albicans wild-type strains: The role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates
    • Wirsching, S., S. Michel, and J. Morschhauser. 2000. Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates. Mol. Microbiol. 36:856-865.
    • (2000) Mol. Microbiol , vol.36 , pp. 856-865
    • Wirsching, S.1    Michel, S.2    Morschhauser, J.3
  • 41
    • 0033989179 scopus 로고    scopus 로고
    • Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor
    • Wirsching, S., S. Michel, G. Kohler, and J. Morschhauser. 2000. Activation of the multiple drug resistance gene MDR1 in fluconazole-resistant, clinical Candida albicans strains is caused by mutations in a trans-regulatory factor. J. Bacteriol. 182:400-404.
    • (2000) J. Bacteriol , vol.182 , pp. 400-404
    • Wirsching, S.1    Michel, S.2    Kohler, G.3    Morschhauser, J.4
  • 42


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