메뉴 건너뛰기




Volumn 187, Issue 6, 2005, Pages 1923-1929

Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; GENTAMICIN; GLYCOPROTEIN P;

EID: 14644397893     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.187.6.1923-1929.2005     Document Type: Article
Times cited : (143)

References (32)
  • 1
    • 2942731519 scopus 로고    scopus 로고
    • Crystal structure of the membrane fusion protein, MexA of the multidrug transporter in Pseudomonas aeruginosa
    • Akama, H., T. Matsuura, S. Kashiwagi, H. Yoneyama, T. Tsukihara, A. Nakagawa, and T. Nakae. 2004. Crystal structure of the membrane fusion protein, MexA of the multidrug transporter in Pseudomonas aeruginosa. J. Biol. Chem. 279:25939-25942.
    • (2004) J. Biol. Chem. , vol.279 , pp. 25939-25942
    • Akama, H.1    Matsuura, T.2    Kashiwagi, S.3    Yoneyama, H.4    Tsukihara, T.5    Nakagawa, A.6    Nakae, T.7
  • 2
    • 0035782880 scopus 로고    scopus 로고
    • Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump
    • Avila-Sakar, A. J., S. Misaghi, E. M. Wilson-Kubalek, K. H. Downing, H. Zgurskaya, H. Nikaido, and E. Nogales. 2001. Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump. J. Struct. Biol. 136:81-88.
    • (2001) J. Struct. Biol. , vol.136 , pp. 81-88
    • Avila-Sakar, A.J.1    Misaghi, S.2    Wilson-Kubalek, E.M.3    Downing, K.H.4    Zgurskaya, H.5    Nikaido, H.6    Nogales, E.7
  • 3
    • 0019883199 scopus 로고
    • Pyranine (8-hydroxy-1,3,6-pyrenetrisulfonate) as a probe of internal aqueous hydrogen ion concentration in phospholipid vesicles
    • Clement, N. R., and J. M. Gould. 1981. Pyranine (8-hydroxy-1,3,6- pyrenetrisulfonate) as a probe of internal aqueous hydrogen ion concentration in phospholipid vesicles. Biochemistry 20:1534-1544.
    • (1981) Biochemistry , vol.20 , pp. 1534-1544
    • Clement, N.R.1    Gould, J.M.2
  • 4
    • 0025738363 scopus 로고
    • Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli
    • Davidson, A. L., and H. Nikaido. 1991. Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli J. Biol. Chem. 266:8946-8951.
    • (1991) J. Biol. Chem. , vol.266 , pp. 8946-8951
    • Davidson, A.L.1    Nikaido, H.2
  • 5
    • 0028318241 scopus 로고
    • A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria
    • Dinh, T., I. T. Paulsen, and M. H. Saier, Jr. 1994. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J. Bacteriol. 176:3825-3831.
    • (1994) J. Bacteriol. , vol.176 , pp. 3825-3831
    • Dinh, T.1    Paulsen, I.T.2    Saier Jr., M.H.3
  • 6
    • 0036889033 scopus 로고    scopus 로고
    • Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops
    • Elkins, C. A., and H. Nikaido. 2002. Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. J. Bacteriol. 184:6490-6498.
    • (2002) J. Bacteriol. , vol.184 , pp. 6490-6498
    • Elkins, C.A.1    Nikaido, H.2
  • 7
    • 0042838181 scopus 로고    scopus 로고
    • Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump
    • Elkins, C. A., and H. Nikaido. 2003. Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. J. Bacteriol. 185:5349-5356.
    • (2003) J. Bacteriol. , vol.185 , pp. 5349-5356
    • Elkins, C.A.1    Nikaido, H.2
  • 8
    • 0029796966 scopus 로고    scopus 로고
    • Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
    • Fralick, J. A. 1996. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J. Bacteriol. 178:5803-5805.
    • (1996) J. Bacteriol. , vol.178 , pp. 5803-5805
    • Fralick, J.A.1
  • 9
    • 0033543578 scopus 로고    scopus 로고
    • Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family
    • Goldberg, M., T. Pribyl, S. Juhnke, and D. H. Nies. 1999. Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family. J. Biol. Chem. 274:26065-26070.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26065-26070
    • Goldberg, M.1    Pribyl, T.2    Juhnke, S.3    Nies, D.H.4
  • 10
  • 11
    • 0346749468 scopus 로고    scopus 로고
    • H-induced changes in the conformation of AcrA, the membrane fusion protein of Escherichia coli multidrug efflux system
    • Ip, H., K. Stratton, H. Zgurskaya, and J. Liu. 2003. pH-induced changes in the conformation of AcrA, the membrane fusion protein of Escherichia coli multidrug efflux system. J. Biol. Chem. 278:50474-50482.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50474-50482
    • Ip, H.1    Stratton, K.2    Zgurskaya, H.3    Liu, J.4
  • 12
    • 0026437584 scopus 로고
    • pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids
    • Kamp, F., and J. A. Hamilton. 1992. pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids. Proc. Natl. Acad. Sci. USA 89:11367-11370.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11367-11370
    • Kamp, F.1    Hamilton, J.A.2
  • 13
    • 0028050605 scopus 로고
    • Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: Active efflux as a contributing factor to β-lactam resistance
    • Li, X.-Z., D. Ma, D. M. Livermore, and H. Nikaido. 1994. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to β-lactam resistance. Antimicrob. Agents Chemother. 38:1742-1752.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 1742-1752
    • Li, X.-Z.1    Ma, D.2    Livermore, D.M.3    Nikaido, H.4
  • 14
    • 0028926676 scopus 로고
    • Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli
    • Ma, D., D. N. Cook, M. Alberti, N. G. Pon, H. Nikaido, and J. E. Hearst. 1995. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microbiol. 16:45-55.
    • (1995) Mol. Microbiol. , vol.16 , pp. 45-55
    • Ma, D.1    Cook, D.N.2    Alberti, M.3    Pon, N.G.4    Nikaido, H.5    Hearst, J.E.6
  • 15
    • 0037057652 scopus 로고    scopus 로고
    • Crystal structure of bacterial multidrug efflux transporter AcrB
    • Murakami, S., R. Nakashima, E. Yamashita, and A. Yamaguchi. 2002. Crystal structure of bacterial multidrug efflux transporter AcrB. Nature 419:587-593.
    • (2002) Nature , vol.419 , pp. 587-593
    • Murakami, S.1    Nakashima, R.2    Yamashita, E.3    Yamaguchi, A.4
  • 16
    • 0029845913 scopus 로고    scopus 로고
    • Multidrug efflux pumps of gram-negative bacteria
    • Nikaido, H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
    • (1996) J. Bacteriol. , vol.178 , pp. 5853-5859
    • Nikaido, H.1
  • 17
    • 0031948133 scopus 로고    scopus 로고
    • Antibiotic resistance caused by Gram-negative multidrug efflux pumps
    • Nikaido, H. 1998. Antibiotic resistance caused by Gram-negative multidrug efflux pumps. Clin. Infect. Dis. 27(Suppl. 1):S32-S41.
    • (1998) Clin. Infect. Dis. , vol.27 , Issue.1 SUPPL.
    • Nikaido, H.1
  • 18
    • 0031720812 scopus 로고    scopus 로고
    • Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those β-lactam antibiotics containing lipophilic side chains
    • Nikaido, H., M. Basina, V. Nguyen, and E. Y. Rosenberg. 1998. Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those β-lactam antibiotics containing lipophilic side chains. J. Bacteriol. 180:4686-4692.
    • (1998) J. Bacteriol. , vol.180 , pp. 4686-4692
    • Nikaido, H.1    Basina, M.2    Nguyen, V.3    Rosenberg, E.Y.4
  • 19
    • 0032323640 scopus 로고    scopus 로고
    • Overview of bacterial ABC transporters
    • Nikaido, H., and J. A. Hall. 1998. Overview of bacterial ABC transporters. Methods Enzymol. 292:3-20.
    • (1998) Methods Enzymol. , vol.292 , pp. 3-20
    • Nikaido, H.1    Hall, J.A.2
  • 20
    • 0034817367 scopus 로고    scopus 로고
    • Analysis of a complete library of putative drug transporter genes in Escherichia coli
    • Nishino, K., and A. Yamaguchi. 2001. Analysis of a complete library of putative drug transporter genes in Escherichia coli. J. Bacteriol. 183:5803-5812.
    • (2001) J. Bacteriol. , vol.183 , pp. 5803-5812
    • Nishino, K.1    Yamaguchi, A.2
  • 21
    • 0030029513 scopus 로고    scopus 로고
    • AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
    • Okusu, H., D. Ma, and H. Nikaido. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178:306-308.
    • (1996) J. Bacteriol. , vol.178 , pp. 306-308
    • Okusu, H.1    Ma, D.2    Nikaido, H.3
  • 22
    • 0034090541 scopus 로고    scopus 로고
    • AcrD of Escherichia coli is an aminoglycoside efflux pump
    • Rosenberg, E. Y., D. Ma, and H. Nikaido. 2000. AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-1756.
    • (2000) J. Bacteriol. , vol.182 , pp. 1754-1756
    • Rosenberg, E.Y.1    Ma, D.2    Nikaido, H.3
  • 23
    • 0023867105 scopus 로고
    • Porin channels in intact cells of Escherichia coli are not affected by Donnan potential across the outer membrane
    • Sen, K., J. Hellman, and H. Nikaido. 1988. Porin channels in intact cells of Escherichia coli are not affected by Donnan potential across the outer membrane. J. Biol. Chem. 263:1182-1187.
    • (1988) J. Biol. Chem. , vol.263 , pp. 1182-1187
    • Sen, K.1    Hellman, J.2    Nikaido, H.3
  • 24
    • 0028321391 scopus 로고
    • OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms
    • Sugawara, E., and H. Nikaido. 1994. OmpA protein of Escherichia coli outer membrane occurs in open and closed channel forms. J. Biol. Chem. 269:17981-17987.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17981-17987
    • Sugawara, E.1    Nikaido, H.2
  • 26
    • 0033170990 scopus 로고    scopus 로고
    • The RND permease superfamily: An ancient, ubiquitous and diverse family that includes human disease and development proteins
    • Tseng, T. T., K. S. Gratwick, J. Kollman, D. Park, D. H. Nies, A. Goffeau, and M. H. Saier, Jr. 1999. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J. Mol. Microbiol. Biotechnol. 1:107-125.
    • (1999) J. Mol. Microbiol. Biotechnol. , vol.1 , pp. 107-125
    • Tseng, T.T.1    Gratwick, K.S.2    Kollman, J.3    Park, D.4    Nies, D.H.5    Goffeau, A.6    Saier Jr., M.H.7
  • 27
    • 0141615783 scopus 로고    scopus 로고
    • AcrB multidrug efflux pump of Escherichia coli: Composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity
    • Yu, E. W., J. R. Aires, and H. Nikaido. 2003. AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity. J. Bacteriol. 185:5657-5664.
    • (2003) J. Bacteriol. , vol.185 , pp. 5657-5664
    • Yu, E.W.1    Aires, J.R.2    Nikaido, H.3
  • 28
    • 0038670226 scopus 로고    scopus 로고
    • Structural basis of multiple drug-binding capacity of AcrB multidrug efflux pump
    • Yu, E. W., G. McDermott, H. I. Zgurskaya, H. Nikaido, and D. E. Koshland, Jr. 2003. Structural basis of multiple drug-binding capacity of AcrB multidrug efflux pump. Science 300:976-980.
    • (2003) Science , vol.300 , pp. 976-980
    • Yu, E.W.1    McDermott, G.2    Zgurskaya, H.I.3    Nikaido, H.4    Koshland Jr., D.E.5
  • 29
    • 0033594886 scopus 로고    scopus 로고
    • Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
    • Zgurskaya, H. I., and H. Nikaido. 1999. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli. Proc. Natl. Acad. Sci. USA 96:7190-7195.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7190-7195
    • Zgurskaya, H.I.1    Nikaido, H.2
  • 30
    • 0033534373 scopus 로고    scopus 로고
    • AcrA is a highly asymmetric protein capable of spanning the periplasm
    • Zgurskaya, H. I., and H. Nikaido. 1999. AcrA is a highly asymmetric protein capable of spanning the periplasm. J. Mol. Biol. 285:409-420.
    • (1999) J. Mol. Biol. , vol.285 , pp. 409-420
    • Zgurskaya, H.I.1    Nikaido, H.2
  • 31
    • 0033912430 scopus 로고    scopus 로고
    • Multidrug resistance mechanisms: Drug efflux across two membranes
    • Zgurskaya, H. I., and H. Nikaido. 2000. Multidrug resistance mechanisms: drug efflux across two membranes. Mol. Microbiol. 37:219-235.
    • (2000) Mol. Microbiol. , vol.37 , pp. 219-235
    • Zgurskaya, H.I.1    Nikaido, H.2
  • 32
    • 0033940002 scopus 로고    scopus 로고
    • Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli
    • Zgurskaya, H. I., and H. Nikaido. 2000. Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli. J. Bacteriol. 182:4264-4267.
    • (2000) J. Bacteriol. , vol.182 , pp. 4264-4267
    • Zgurskaya, H.I.1    Nikaido, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.