A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans

Genetics

Volumn 172, Issue 4, 2006, Pages 2139-2156

  Coste, Alix ^a   Turner, Vincent ^a   Ischer, Françoise ^a   Morschhäuser, Joachim ^b   Forche, Anja ^c   Selmecki, Anna ^c   Berman, Judith ^c   Bille, Jacques ^a   Sanglard, Dominique ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER CDR1; ABC TRANSPORTER CDR2; AMINO ACID; ANTIFUNGAL AGENT; FLUCONAZOLE; PYRROLE DERIVATIVE; TERBINAFINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TAC1P; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CANDIDA ALBICANS; CHROMOSOME; CHROMOSOME DUPLICATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE ACTIVITY; GENE LOCUS; GENE MUTATION; GENETIC RECOMBINATION; HETEROZYGOSITY LOSS; HOMOZYGOSITY; MATING TYPE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; WILD TYPE;

ALLELES; ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CANDIDA ALBICANS; CHROMOSOMES, FUNGAL; DRUG RESISTANCE, MICROBIAL; FLUPHENAZINE; FUNGAL PROTEINS; HETEROZYGOTE; HOMOZYGOTE; LOSS OF HETEROZYGOSITY; MEMBRANE TRANSPORT PROTEINS; NUCLEIC ACID HYBRIDIZATION; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTORS;

CANDIDA ALBICANS;

EID: 33646171879     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.105.054767     Document Type: Article

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