The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

EMBO Journal

Volumn 19, Issue 11, 2000, Pages 2503-2514

  Van Veen, Hendrik W ^a   Margolles, Abelardo ^a   Müller, Michael ^b   Higgins, Christopher F ^c   Konings, Wil N ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Drug efflux; LmrA; Membrane protein; Multidrug resistance; Transport mechanism

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEIN;

ARTICLE; DRUG BINDING SITE; DRUG TRANSPORT; HYDROLYSIS; MULTIDRUG RESISTANCE; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

EID: 0034212332     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.11.2503     Document Type: Article

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