The renaissance of natural products as drug candidates

Science

Volumn 310, Issue 5747, 2005, Pages 451-453

  Paterson, Ian ^a   Anderson, Edward A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN; HALICHONDRIN B; NATURAL PRODUCT; 2 (3 AMINO 2 HYDROXYPROPYL)HEXACOSAHYDRO 3 METHOXY 26 METHYL 20,27 BIS(METHYLENE)11,15 18,21 24,28 TRIEPOXY 7,9 ETHANO 12,15 METHANO 9H,15H FURO(3,2 I)FURO(2',3' 5,6)PYRANO(4,3 B)(1,4)DIOXACYCLOPENTACOSIN 5 (4H) ONE; 2-(3-AMINO-2-HYDROXYPROPYL)HEXACOSAHYDRO-3-METHOXY-26-METHYL-20,27-BIS(METHYLENE)11,15-18,21-24,28-TRIEPOXY-7,9-ETHANO-12,15-METHANO-9H,15H-FURO(3,2-I)FURO(2',3'-5,6)PYRANO(4,3-B)(1,4)DIOXACYCLOPENTACOSIN-5-(4H)-ONE; ALKANE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BIOLOGICAL PRODUCT; BRYOSTATIN 1; CARBAMIC ACID DERIVATIVE; DISCODERMOLIDE; FURAN DERIVATIVE; KETONE; LACTONE; MACROLIDE; PYRONE DERIVATIVE;

DRUG DEVELOPMENT;

BIOTECHNOLOGY; CANCER CHEMOTHERAPY; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG MANUFACTURE; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; REVIEW; SCALE UP; ARTICLE; CHEMICAL STRUCTURE; CLINICAL TRIAL; DRUG DESIGN; DRUG SCREENING; GENETIC ENGINEERING; MOLECULAR EVOLUTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKANES; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; CARBAMATES; CLINICAL TRIALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; EVOLUTION, MOLECULAR; FURANS; GENETIC ENGINEERING; KETONES; LACTONES; MACROLIDES; MOLECULAR STRUCTURE; PYRONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27144547510     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1116364     Document Type: Review

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