Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels

Journal of General Physiology

Volumn 115, Issue 5, 2000, Pages 583-598

  Suchyna, Thomas M ^a   Johnson, Janice H ^b   Hamer, Katherine ^b   Leykam, Joseph F ^d   Gage, Douglas A ^d   Clemo, Henry F ^c   Baumgarten, Clive M ^c   Sachs, Frederick ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b NPS Pharmaceutical Inc   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Michigan State University   (United States)

Author keywords

Astrocyte; Mechanogated; Myocytes; Swell; Ventricular

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; AMILORIDE; CALCIUM CHANNEL BLOCKING AGENT; CATION CHANNEL; DILTIAZEM; DIZOCILPINE; GADOLINIUM; GLUTAMIC ACID; ION CHANNEL; NIFEDIPINE; SPIDER VENOM;

ANIMAL CELL; ARTICLE; ASTROCYTE; CARDIOMYOPATHY; DRUG EFFECT; HEART MUSCLE CELL; HEART VENTRICLE; MASS SPECTROMETRY; NERVE CELL CULTURE; NONHUMAN; PATCH CLAMP; RABBIT; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TOXIN ANALYSIS;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; ASTROCYTES; CATIONS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEART VENTRICLES; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUSCLE FIBERS; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; RABBITS; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SPIDER VENOMS; SPIDERS; STRESS, MECHANICAL;

EID: 0034103610     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.115.5.583     Document Type: Article

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