Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators - Identification of a novel pharmacophore

Molecular Pharmacology

Volumn 77, Issue 3, 2010, Pages 368-377

  Leuner, Kristina ^a   Heiser, J H ^a   Derksen, S ^b   Mladenov, M I ^c,d   Fehske, C J ^a   Schubert, R ^c   Gollasch, M ^e   Schneider, G ^b   Harteneck, C ^e,f   Chatterjee, S S ^g   Muller W E ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Institute of Organic Chemistry and Chemical Biology   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d SS CYRIL AND METHODIUS UNIVERSITY   (Macedonia)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f UNIVERSITY OF TÜBINGEN   (Germany)

^g DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIACYLPHLOROGLUCINOL DERIVATIVE; CALCIUM ION; DIACYLGLYCEROL; HYPERFORIN; PHLOROGLUCINOL; PHLOROGLUCINOL DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6 ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL STRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BICYCLO COMPOUNDS; BINDING SITES; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MICE; NEURITES; PC12 CELLS; PHLOROGLUCINOL; RATS; TERPENES; TRPV CATION CHANNELS;

EID: 77149175638     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.057513     Document Type: Article

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