메뉴 건너뛰기




Volumn 46, Issue 2, 2011, Pages 43-63

Ghrelin and lipid metabolism: Key partners in energy balance

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; GHRELIN; GHRELIN RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NEUROPEPTIDE; TRANSCRIPTION FACTOR BSX; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

EID: 79953714548     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-10-0068     Document Type: Review
Times cited : (72)

References (224)
  • 1
    • 0033657074 scopus 로고    scopus 로고
    • Leptin and the neuroendocrinology offasting
    • (doi:10.1159/000061014)
    • Ahima RS 2000 Leptin and the neuroendocrinology offasting. Frontiers of Hormone Research 26 42-56. (doi:10.1159/000061014)
    • (2000) Frontiers of Hormone Research , vol.26 , pp. 42-56
    • Ahima, R.S.1
  • 2
    • 0033852765 scopus 로고    scopus 로고
    • Leptin
    • (doi:10.1146/annurev.physiol.62.1.413)
    • Ahima RS & Flier JS 2000 Leptin. Annual Review of Physiology 62 413-437. (doi:10.1146/annurev.physiol.62.1.413)
    • (2000) Annual Review of Physiology , vol.62 , pp. 413-437
    • Ahima, R.S.1    Flier, J.S.2
  • 4
    • 33847022735 scopus 로고    scopus 로고
    • Role of hypothalamic adenosine 5′-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neu-roglucopenia
    • (doi:10.1210/en. 2006-1039)
    • Alquier T, Kawashima J, Tsuji Y & Kahn BB 2007 Role of hypothalamic adenosine 5′-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neu-roglucopenia. Endocrinology 148 1367-1375. (doi:10.1210/en. 2006-1039)
    • (2007) Endocrinology , vol.148 , pp. 1367-1375
    • Alquier, T.1    Kawashima, J.2    Tsuji, Y.3    Kahn, B.B.4
  • 5
    • 52449093433 scopus 로고    scopus 로고
    • Gene expression in arcuate nucleus-median eminence of rats treated with leptin or ciliary neurotrophic factor
    • (doi:10.1002/biof.5520310204)
    • Ambati S, Duan J, Duff E, Choi YH, Hartzell DL, Della-Fera MA & Baile CA 2007 Gene expression in arcuate nucleus-median eminence of rats treated with leptin or ciliary neurotrophic factor. Biofactors 31 133-144. (doi:10.1002/biof.5520310204)
    • (2007) Biofactors , vol.31 , pp. 133-144
    • Ambati, S.1    Duan, J.2    Duff, E.3    Choi, Y.H.4    Hartzell, D.L.5    Della-Fera, M.A.6    Baile, C.A.7
  • 9
    • 77953142015 scopus 로고    scopus 로고
    • Uncoupling protein-2 decreases the lipogenic actions of ghrelin
    • (doi:10.1210/en.2009-0850)
    • Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI & Horvath TL 2010 Uncoupling protein-2 decreases the lipogenic actions of ghrelin. Endocrinology 151 2078-2086. (doi:10.1210/en.2009-0850)
    • (2010) Endocrinology , vol.151 , pp. 2078-2086
    • Andrews, Z.B.1    Erion, D.M.2    Beiler, R.3    Choi, C.S.4    Shulman, G.I.5    Horvath, T.L.6
  • 10
    • 0035014773 scopus 로고    scopus 로고
    • Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse
    • (doi:10. 1159/000054639)
    • Arvaniti K, Huang Q & Richard D 2001 Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse. Neuroendocrinology 73 227-236. (doi:10. 1159/000054639)
    • (2001) Neuroendocrinology , vol.73 , pp. 227-236
    • Arvaniti, K.1    Huang, Q.2    Richard, D.3
  • 11
    • 41549108590 scopus 로고    scopus 로고
    • PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and-independent pathways in control of energy homeostasis and stress response
    • (doi:10.1016/j.cmet. 2008.01.006)
    • Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klockener T, Alessi D, Kloppenburg P & Bruning JC 2008 PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and-independent pathways in control of energy homeostasis and stress response. Cell Metabolism 7 291-301. (doi:10.1016/j.cmet. 2008.01.006)
    • (2008) Cell Metabolism , vol.7 , pp. 291-301
    • Belgardt, B.F.1    Husch, A.2    Rother, E.3    Ernst, M.B.4    Wunderlich, F.T.5    Hampel, B.6    Klockener, T.7    Alessi, D.8    Kloppenburg, P.9    Bruning, J.C.10
  • 12
    • 0030732108 scopus 로고    scopus 로고
    • Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat
    • (doi:10.1210/en. 138.11.4552)
    • Bennett PA, Thomas GB, Howard AD, Feighner SD, Van Der Ploeg LH, Smith RG & Robinson IC 1997 Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology 138 4552-4557. (doi:10.1210/en. 138.11.4552)
    • (1997) Endocrinology , vol.138 , pp. 4552-4557
    • Bennett, P.A.1    Thomas, G.B.2    Howard, A.D.3    Feighner, S.D.4    Ploeg, L.H.V.D.5    Smith, R.G.6    Robinson, I.C.7
  • 15
    • 56349110999 scopus 로고    scopus 로고
    • Effects of orchidectomy on adaptation of arcuate neuropeptide Y, proopiomelanocortin, and cocaine-and amphetamine-related transcript gene profiles to recurring insulin-induced hypoglycemia in the male rat
    • (doi:10.1016/j.npep.2008.09.001)
    • Briski KP & Parihar M 2008 Effects of orchidectomy on adaptation of arcuate neuropeptide Y, proopiomelanocortin, and cocaine-and amphetamine-related transcript gene profiles to recurring insulin-induced hypoglycemia in the male rat. Neuropeptides 42 585-591. (doi:10.1016/j.npep.2008.09.001)
    • (2008) Neuropeptides , vol.42 , pp. 585-591
    • Briski, K.P.1    Parihar, M.2
  • 16
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/ orexin-and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
    • doi:10.1002/ (SICI)1096-9861(19981228)402:4<460::AID-CNE3>3.0.CO;2-S)
    • Broberger C, de Lecea L, Sutcliffe JG & Hokfelt T 1998 Hypocretin/ orexin-and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. Journal of Comparative Neurology 402 460-474. (doi:10.1002/ (SICI)1096-9861(19981228)402:4<460::AID-CNE3>3.0.CO;2-S)
    • (1998) Journal of Comparative Neurology , vol.402 , pp. 460-474
    • Broberger, C.1    de Lecea, L.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 19
    • 50049105823 scopus 로고    scopus 로고
    • The regulation of AMP-activated protein kinase by upstream kinases
    • (doi:10.1038/ijo. 2008.124)
    • Carling D, Sanders MJ & Woods A 2008 The regulation of AMP-activated protein kinase by upstream kinases. International Journal of Obesity 32 (Supplement 4) S55-S59. (doi:10.1038/ijo. 2008.124)
    • (2008) International Journal of Obesity , vol.32 , Issue.SUPPLEMENT 4
    • Carling, D.1    Sanders, M.J.2    Woods, A.3
  • 20
    • 44649085556 scopus 로고    scopus 로고
    • Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats
    • (doi:10. 1016/j.lfs.2008.04.015)
    • Cesquini M, Stoppa GR, Prada PO, Torsoni AS, Romanatto T, Souza A, Saad MJ, Velloso LA & Torsoni MA 2008 Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats. Life Sciences 82 1262-1271. (doi:10. 1016/j.lfs.2008.04.015)
    • (2008) Life Sciences , vol.82 , pp. 1262-1271
    • Cesquini, M.1    Stoppa, G.R.2    Prada, P.O.3    Torsoni, A.S.4    Romanatto, T.5    Souza, A.6    Saad, M.J.7    Velloso, L.A.8    Torsoni, M.A.9
  • 21
    • 67649229596 scopus 로고    scopus 로고
    • Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway
    • (doi:10.1016/j.bbrc.2009.06.017)
    • Cha SH & Lane MD 2009 Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. Biochemical and Biophysical Research Communications 386 212-216. (doi:10.1016/j.bbrc.2009.06.017)
    • (2009) Biochemical and Biophysical Research Communications , vol.386 , pp. 212-216
    • Cha, S.H.1    Lane, M.D.2
  • 22
    • 55949086381 scopus 로고    scopus 로고
    • Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake
    • (doi:10. 1073/pnas.0809255105)
    • Cha SH, Wolfgang M, Tokutake Y, Chohnan S & Lane MD 2008 Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. PNAS 105 16871-16875. (doi:10. 1073/pnas.0809255105)
    • (2008) PNAS , vol.105 , pp. 16871-16875
    • Cha, S.H.1    Wolfgang, M.2    Tokutake, Y.3    Chohnan, S.4    Lane, M.D.5
  • 24
    • 18044389338 scopus 로고    scopus 로고
    • Glucose injection reduces neuropeptide Y and agouti-related protein expression in the arcuate nucleus: A possible physiological role in eating behavior. Brain Research
    • (doi:10.1016/j.molbrainres.2004.12.017)
    • Chang GQ, Karatayev O, Davydova Z, Wortley K & Leibowitz SF 2005 Glucose injection reduces neuropeptide Y and agouti-related protein expression in the arcuate nucleus: a possible physiological role in eating behavior. Brain Research. Molecular Brain Research 135 69-80. (doi:10.1016/j.molbrainres.2004.12.017)
    • (2005) Molecular Brain Research , vol.135 , pp. 69-80
    • Chang, G.Q.1    Karatayev, O.2    Davydova, Z.3    Wortley, K.4    Leibowitz, S.F.5
  • 26
    • 23644453797 scopus 로고    scopus 로고
    • Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids
    • (doi:10.2337/diabetes.54.8.2269)
    • Coll AP, Challis BG, López M, Piper S, Yeo GS & O'Rahilly S 2005 Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54 2269-2276. (doi:10.2337/diabetes.54.8.2269)
    • (2005) Diabetes , vol.54 , pp. 2269-2276
    • Coll, A.P.1    Challis, B.G.2    López, M.3    Piper, S.4    Yeo, G.S.5    O'Rahilly, S.6
  • 29
    • 66149083518 scopus 로고    scopus 로고
    • Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. American
    • (doi:10.1152/ ajpendo.90932.2008)
    • Cotero VE & Routh VH 2009 Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose. American Journal of Physiology. Endocrinology and Metabolism 296 E1101-E1109. (doi:10.1152/ ajpendo.90932.2008)
    • (2009) Journal of Physiology. Endocrinology and Metabolism , vol.296
    • Cotero, V.E.1    Routh, V.H.2
  • 30
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • (doi:10.1016/S0896-6273(03)00063-1)
    • Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML et al. 2003 The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37 649-661. (doi:10.1016/S0896-6273(03)00063-1)
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6    Strasburger, C.J.7    Bidlingmaier, M.8    Esterman, M.9    Heiman, M.L.10
  • 31
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • (doi:10.2337/ diabetes.50.8.1714)
    • Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE & Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 1714-1719. (doi:10.2337/ diabetes.50.8.1714)
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 33
    • 34250208472 scopus 로고    scopus 로고
    • Localization and effect of ectopic expression of CPT1c in CNS feeding centers
    • (doi:10.1016/ j.bbrc.2007.05.161)
    • Dai Y, Wolfgang MJ, Cha SH & Lane MD 2007 Localization and effect of ectopic expression of CPT1c in CNS feeding centers. Biochemical and Biophysical Research Communications 359 469-474. (doi:10.1016/ j.bbrc.2007.05.161)
    • (2007) Biochemical and Biophysical Research Communications , vol.359 , pp. 469-474
    • Dai, Y.1    Wolfgang, M.J.2    Cha, S.H.3    Lane, M.D.4
  • 34
    • 22244459572 scopus 로고    scopus 로고
    • Monitoring energy balance: Metabolites of fatty acid synthesis as hypothalamic sensors
    • (doi:10.1146/annurev.biochem. 73.011303.074027)
    • Dowell P, Hu Z & Lane MD 2005 Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. Annual Review of Biochemistry 74 515-534. (doi:10.1146/annurev.biochem. 73.011303.074027)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 515-534
    • Dowell, P.1    Hu, Z.2    Lane, M.D.3
  • 35
    • 29344464362 scopus 로고    scopus 로고
    • Effects of a fixed meal pattern on ghrelin secretion: Evidence for a learned response independent of nutrient status
    • (doi:10.1210/en.2005-0973)
    • Drazen DL, Vahl TP, D'Alessio DA, Seeley RJ & Woods SC 2006 Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status. Endocrinology 147 23-30. (doi:10.1210/en.2005-0973)
    • (2006) Endocrinology , vol.147 , pp. 23-30
    • Drazen, D.L.1    Vahl, T.P.2    D'alessio, D.A.3    Seeley, R.J.4    Woods, S.C.5
  • 36
    • 0032414516 scopus 로고    scopus 로고
    • Hyperphagia induced by hypoglycemia in rats is independent of leptin and hypothalamic neuropeptide Y (NPY)
    • (doi:10.1016/S0196-9781(98)00106-5)
    • Dryden S, Pickavance L, Henderson L & Williams G 1998 Hyperphagia induced by hypoglycemia in rats is independent of leptin and hypothalamic neuropeptide Y (NPY). Peptides 19 1549-1555. (doi:10.1016/S0196-9781(98)00106-5)
    • (1998) Peptides , vol.19 , pp. 1549-1555
    • Dryden, S.1    Pickavance, L.2    Henderson, L.3    Williams, G.4
  • 37
    • 10044263250 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein immunoreactivity in food-restricted, obese, and insulin-treated animals: Evidence for glia cell localization
    • (doi:10.1016/j.expneurol.2004. 09.002)
    • Dunbar J, Lapanowski K, Barnes M & Rafols J 2005 Hypothalamic agouti-related protein immunoreactivity in food-restricted, obese, and insulin-treated animals: evidence for glia cell localization. Experimental Neurology 191 184-192. (doi:10.1016/j.expneurol.2004. 09.002)
    • (2005) Experimental Neurology , vol.191 , pp. 184-192
    • Dunbar, J.1    Lapanowski, K.2    Barnes, M.3    Rafols, J.4
  • 40
    • 0033180532 scopus 로고    scopus 로고
    • Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
    • (doi:10.1016/S0896-6273(01)80035-0)
    • Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB & Elmquist JK 1999 Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23 775-786. (doi:10.1016/S0896-6273(01)80035-0)
    • (1999) Neuron , vol.23 , pp. 775-786
    • Elias, C.F.1    Aschkenasi, C.2    Lee, C.3    Kelly, J.4    Ahima, R.S.5    Bjorbaek, C.6    Flier, J.S.7    Saper, C.B.8    Elmquist, J.K.9
  • 42
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • (doi:10.1038/385165a0)
    • Fan W, Boston BA, Kesterson RA, Hruby VJ & Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385 165-168. (doi:10.1038/385165a0)
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 44
    • 29344444782 scopus 로고    scopus 로고
    • Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus
    • (doi:10.1210/en.2005-0956)
    • Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC & Lechan RM 2006 Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology 147 520-529. (doi:10.1210/en.2005-0956)
    • (2006) Endocrinology , vol.147 , pp. 520-529
    • Fekete, C.1    Singru, P.S.2    Sanchez, E.3    Sarkar, S.4    Christoffolete, M.A.5    Riberio, R.S.6    Rand, W.M.7    Emerson, C.H.8    Bianco, A.C.9    Lechan, R.M.10
  • 45
    • 33845588762 scopus 로고    scopus 로고
    • Emerging therapeutic strategies for obesity
    • doi:10.1210/er. 2006-0041)
    • Foster-Schubert KE & Cummings DE 2006 Emerging therapeutic strategies for obesity. Endocrine Reviews 27 779-793. (doi:10.1210/er. 2006-0041)
    • (2006) Endocrine Reviews , vol.27 , pp. 779-793
    • Foster-Schubert, K.E.1    Cummings, D.E.2
  • 46
    • 23944487985 scopus 로고    scopus 로고
    • Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus
    • (doi:10.1016/j.neuropharm.2005. 04.017)
    • Gamber KM, Macarthur H & Westfall TC 2005 Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. Neuropharmacology 49 646-652. (doi:10.1016/j.neuropharm.2005. 04.017)
    • (2005) Neuropharmacology , vol.49 , pp. 646-652
    • Gamber, K.M.1    Macarthur, H.2    Westfall, T.C.3
  • 48
    • 0034824420 scopus 로고    scopus 로고
    • Regulation of pit-1 expression by ghrelin and ghrp-6 through the GH secretagogue receptor
    • (doi:10.1210/me. 15.9.1484)
    • Garcia A, Alvarez CV, Smith RG & Dieguez C 2001 Regulation of pit-1 expression by ghrelin and ghrp-6 through the GH secretagogue receptor. Molecular Endocrinology 15 1484-1495. (doi:10.1210/me. 15.9.1484)
    • (2001) Molecular Endocrinology , vol.15 , pp. 1484-1495
    • Garcia, A.1    Alvarez, C.V.2    Smith, R.G.3    Dieguez, C.4
  • 49
    • 34547954723 scopus 로고    scopus 로고
    • Time course effects of adrenalectomy and food intake on cocaine-and amphetamine-regulated transcript expression in the hypothalamus
    • (doi:10. 1016/j.brainres.2007.05.077)
    • Germano CM, de Castro M, Rorato R, Laguna MT, Antunes-Rodrigues J, Elias CF & Elias LL 2007 Time course effects of adrenalectomy and food intake on cocaine-and amphetamine-regulated transcript expression in the hypothalamus. Brain Research 1166 55-64. (doi:10. 1016/j.brainres.2007.05.077)
    • (2007) Brain Research , vol.1166 , pp. 55-64
    • Germano, C.M.1    de Castro, M.2    Rorato, R.3    Laguna, M.T.4    Antunes-Rodrigues, J.5    Elias, C.F.6    Elias, L.L.7
  • 50
    • 57749084282 scopus 로고    scopus 로고
    • Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa
    • (doi:10.1677/JME-08-0102)
    • Gonzalez CR, Vazquez MJ, Lopez M & Dieguez C 2008 Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa. Journal of Molecular Endocrinology 41 415-421. (doi:10.1677/JME-08-0102)
    • (2008) Journal of Molecular Endocrinology , vol.41 , pp. 415-421
    • Gonzalez, C.R.1    Vazquez, M.J.2    Lopez, M.3    Dieguez, C.4
  • 52
    • 59649088264 scopus 로고    scopus 로고
    • Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons
    • (doi:10.1677/JOE-08-0348)
    • Guillod-Maximin E, Roy AF, Vacher CM, Aubourg A, Bailleux V, Lorsignol A, Penicaud L, Parquet M & Taouis M 2009 Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons,. Journal of Endocrinology 200 93-105. (doi:10.1677/JOE-08-0348)
    • (2009) Journal of Endocrinology , vol.200 , pp. 93-105
    • Guillod-Maximin, E.1    Roy, A.F.2    Vacher, C.M.3    Aubourg, A.4    Bailleux, V.5    Lorsignol, A.6    Penicaud, L.7    Parquet, M.8    Taouis, M.9
  • 55
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • (doi:10.1038/1082)
    • Hahn TM, Breininger JF, Baskin DG & Schwartz MW 1998 Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neuroscience 1 271-272. (doi:10.1038/1082)
    • (1998) Nature Neuroscience , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 57
    • 26244461692 scopus 로고    scopus 로고
    • Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypogly-caemia in rats
    • (doi:10.1007/s00125-005-1913-1)
    • Han SM, Namkoong C, Jang PG, Park IS, Hong SW, Katakami H, Chun S, Kim SW, Park JY, Lee KU et al. 2005 Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypogly-caemia in rats. Diabetologia 48 2170-2178. (doi:10.1007/s00125-005-1913-1)
    • (2005) Diabetologia , vol.48 , pp. 2170-2178
    • Han, S.M.1    Namkoong, C.2    Jang, P.G.3    Park, I.S.4    Hong, S.W.5    Katakami, H.6    Chun, S.7    Kim, S.W.8    Park, J.Y.9    Lee, K.U.10
  • 58
    • 0035810771 scopus 로고    scopus 로고
    • Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor
    • (doi:10.1016/S0167-0115(01) 00234-8)
    • Haskell-Luevano C & Monck EK 2001 Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regulatory Peptides 99 1-7. (doi:10.1016/S0167-0115(01) 00234-8)
    • (2001) Regulatory Peptides , vol.99 , pp. 1-7
    • Haskell-Luevano, C.1    Monck, E.K.2
  • 59
    • 0035918601 scopus 로고    scopus 로고
    • Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: Identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants
    • (doi:10.1021/bi010025q)
    • Haskell-Luevano C, Cone RD, Monck EK & Wan YP 2001 Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants. Biochemistry 40 6164-6179. (doi:10.1021/bi010025q)
    • (2001) Biochemistry , vol.40 , pp. 6164-6179
    • Haskell-Luevano, C.1    Cone, R.D.2    Monck, E.K.3    Wan, Y.P.4
  • 60
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
    • (doi:10.1016/j. cmet.2005.05.009)
    • Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG & Hardie DG 2005 Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism 2 9-19. (doi:10.1016/j. cmet.2005.05.009)
    • (2005) Cell Metabolism , vol.2 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 61
    • 31544465941 scopus 로고    scopus 로고
    • Molecular disruption of hypothalamic nutrient sensing induces obesity
    • (doi:10.1038/nn1626)
    • He W, Lam TK, Obici S & Rossetti L 2006 Molecular disruption of hypothalamic nutrient sensing induces obesity. Nature Neuroscience 9 227-233. (doi:10.1038/nn1626)
    • (2006) Nature Neuroscience , vol.9 , pp. 227-233
    • He, W.1    Lam, T.K.2    Obici, S.3    Rossetti, L.4
  • 62
    • 27144550404 scopus 로고    scopus 로고
    • Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids
    • (doi:10.1523/JNEUROSCI.2769-05.2005)
    • Hentges ST, Low MJ & Williams JT 2005 Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids. Journal of Neuroscience 25 9746-9751. (doi:10.1523/JNEUROSCI.2769-05.2005)
    • (2005) Journal of Neuroscience , vol.25 , pp. 9746-9751
    • Hentges, S.T.1    Low, M.J.2    Williams, J.T.3
  • 64
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist
    • (doi:10.1210/me.2003-0069)
    • Holst B, Cygankiewicz A, Halkjar JT, Ankersen M & Schwartz TW 2003 High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Molecular Endocrinology 17 2201-2210. (doi:10.1210/me.2003-0069)
    • (2003) Molecular Endocrinology , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Halkjar, J.T.3    Ankersen, M.4    Schwartz, T.W.5
  • 65
    • 0033081871 scopus 로고    scopus 로고
    • Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
    • Horvath TL, Diano S & van den Pol AN 1999 Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. Journal of Neuroscience 19 1072-1087.
    • (1999) Journal of Neuroscience , vol.19 , pp. 1072-1087
    • Horvath, T.L.1    Diano, S.2    Pol, A.N.V.D.3
  • 67
    • 0242300121 scopus 로고    scopus 로고
    • Hypothalamic malonyl-CoA as a mediator of feeding behavior
    • (doi:10.1073/pnas.1834402100)
    • Hu Z, Cha SH, Chohnan S & Lane MD 2003 Hypothalamic malonyl-CoA as a mediator of feeding behavior. PNAS 100 12624-12629. (doi:10.1073/pnas.1834402100)
    • (2003) PNAS , vol.100 , pp. 12624-12629
    • Hu, Z.1    Cha, S.H.2    Chohnan, S.3    Lane, M.D.4
  • 68
    • 15244363998 scopus 로고    scopus 로고
    • Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects
    • (doi:10.1073/pnas.0500619102)
    • Hu Z, Cha SH, van Haasteren G, Wang J & Lane MD 2005 Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. PNAS 102 3972-3977. (doi:10.1073/pnas.0500619102)
    • (2005) PNAS , vol.102 , pp. 3972-3977
    • Hu, Z.1    Cha, S.H.2    van Haasteren, G.3    Wang, J.4    Lane, M.D.5
  • 70
    • 0036829870 scopus 로고    scopus 로고
    • Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet
    • Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB & Wheeler MB 2002 Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes 51 3211-3219.
    • (2002) Diabetes , vol.51 , pp. 3211-3219
    • Joseph, J.W.1    Koshkin, V.2    Zhang, C.Y.3    Wang, J.4    Lowell, B.B.5    Chan, C.B.6    Wheeler, M.B.7
  • 71
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • (doi:10. 1016/j.cmet.2004.12.003)
    • Kahn BB, Alquier T, Carling D & Hardie DG 2005 AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism 1 15-25. (doi:10. 1016/j.cmet.2004.12.003)
    • (2005) Cell Metabolism , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 72
    • 0025721025 scopus 로고
    • Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food
    • (doi:10. 1073/pnas.88.23.10931)
    • Kalra SP, Dube MG, Sahu A, Phelps CP & Kalra PS 1991 Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. PNAS 88 10931-10935. (doi:10. 1073/pnas.88.23.10931)
    • (1991) PNAS , vol.88 , pp. 10931-10935
    • Kalra, S.P.1    Dube, M.G.2    Sahu, A.3    Phelps, C.P.4    Kalra, P.S.5
  • 73
    • 0034522843 scopus 로고    scopus 로고
    • Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression
    • (doi:10.1210/en.141.12.4797)
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H & Wakabayashi I 2000 Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. Endocrinology 141 4797-4800. (doi:10.1210/en.141.12.4797)
    • (2000) Endocrinology , vol.141 , pp. 4797-4800
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 74
    • 0035513696 scopus 로고    scopus 로고
    • Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats
    • (doi:10.2337/diabetes.50.11. 2438)
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H & Wakabayashi I 2001 Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 50 2438-2443. (doi:10.2337/diabetes.50.11. 2438)
    • (2001) Diabetes , vol.50 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 82
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • (doi:10.1038/45230)
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 656-660. (doi:10.1038/45230)
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 85
  • 86
    • 0346121596 scopus 로고    scopus 로고
    • Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression
    • (doi:10.1111/j.1365-2826.2003.01113.x)
    • Korner J, Wissig S, Kim A, Conwell IM & Wardlaw SL 2003 Effects of agouti-related protein on metabolism and hypothalamic neuropeptide gene expression. Journal of Neuroendocrinology 15 1116-1121. (doi:10.1111/j.1365-2826.2003.01113.x)
    • (2003) Journal of Neuroendocrinology , vol.15 , pp. 1116-1121
    • Korner, J.1    Wissig, S.2    Kim, A.3    Conwell, I.M.4    Wardlaw, S.L.5
  • 89
    • 56449117024 scopus 로고    scopus 로고
    • AMPK: A metabolic gauge regulating whole-body energy homeostasis
    • (doi:10.1016/j.molmed. 2008.09.007)
    • Lage R, Diéguez C, Vidal-Puig A & López M 2008 AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends in Molecular Medicine 14 539-549. (doi:10.1016/j.molmed. 2008.09.007)
    • (2008) Trends In Molecular Medicine , vol.14 , pp. 539-549
    • Lage, R.1    Diéguez, C.2    Vidal-Puig, A.3    López, M.4
  • 90
    • 77955797107 scopus 로고    scopus 로고
    • Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender
    • (doi:10.1096/fj.09-150672)
    • Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C & López M 2010 Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender. FASEB Journal 24 2670-2679. (doi:10.1096/fj.09-150672)
    • (2010) FASEB Journal , vol.24 , pp. 2670-2679
    • Lage, R.1    Vázquez, M.J.2    Varela, L.3    Saha, A.K.4    Vidal-Puig, A.5    Nogueiras, R.6    Diéguez, C.7    López, M.8
  • 91
    • 63149108459 scopus 로고    scopus 로고
    • Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain
    • (doi:10.1016/j.bbrc. 2009.02.145)
    • Lane MD & Cha SH 2009 Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. Biochemical and Biophysical Research Communications 382 1-5. (doi:10.1016/j.bbrc. 2009.02.145)
    • (2009) Biochemical and Biophysical Research Communications , vol.382 , pp. 1-5
    • Lane, M.D.1    Cha, S.H.2
  • 93
    • 11144242445 scopus 로고    scopus 로고
    • Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior
    • (doi:10.1210/en.2004-0968)
    • Lee K, Li B, Xi X, Suh Y & Martin RJ 2005 Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 146 3-10. (doi:10.1210/en.2004-0968)
    • (2005) Endocrinology , vol.146 , pp. 3-10
    • Lee, K.1    Li, B.2    Xi, X.3    Suh, Y.4    Martin, R.J.5
  • 94
    • 34547607269 scopus 로고    scopus 로고
    • Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression
    • (doi:10.1074/jbc.M700053200)
    • Lee GH, Kim HK, Chae SW, Kim DS, Ha KC, Cuddy M, Kress C, Reed JC, Kim HR & Chae HJ 2007 Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression. Journal of Biological Chemistry 282 21618-21628. (doi:10.1074/jbc.M700053200)
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 21618-21628
    • Lee, G.H.1    Kim, H.K.2    Chae, S.W.3    Kim, D.S.4    Ha, K.C.5    Cuddy, M.6    Kress, C.7    Reed, J.C.8    Kim, H.R.9    Chae, H.J.10
  • 95
    • 58549091080 scopus 로고    scopus 로고
    • Ghrelin and new metabolic frontiers
    • (doi:10.1159/000178055)
    • van der Lely AJ 2009 Ghrelin and new metabolic frontiers. Hormone Research 71 (Supplement 1) 129-133. (doi:10.1159/000178055)
    • (2009) Hormone Research , vol.71 , Issue.SUPPL 1 , pp. 129-133
    • Lely, A.J.V.D.1
  • 96
    • 2942528459 scopus 로고    scopus 로고
    • Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin
    • (doi:10.1210/er.2002-0029)
    • van der Lely AJ, Tschop M, Heiman ML & Ghigo E 2004 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Reviews 25 426-457. (doi:10.1210/er.2002-0029)
    • (2004) Endocrine Reviews , vol.25 , pp. 426-457
    • Lely, A.J.V.D.1    Tschop, M.2    Heiman, M.L.3    Ghigo, E.4
  • 97
    • 0037012795 scopus 로고    scopus 로고
    • Functional characterizations of cocaine-and amphetamine-regulated transcript mRNA expression in rat hypothalamus
    • (doi:10.1016/ S0304-3940(02)00151-9)
    • Li HY, Hwang HW & Hu YH 2002 Functional characterizations of cocaine-and amphetamine-regulated transcript mRNA expression in rat hypothalamus. Neuroscience Letters 323 203-206. (doi:10.1016/ S0304-3940(02)00151-9)
    • (2002) Neuroscience Letters , vol.323 , pp. 203-206
    • Li, H.Y.1    Hwang, H.W.2    Hu, Y.H.3
  • 98
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • (doi:10.1126/science.288.5475.2379)
    • Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD & Kuhajda FP 2000 Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 2379-2381. (doi:10.1126/science.288.5475.2379)
    • (2000) Science , vol.288 , pp. 2379-2381
    • Loftus, T.M.1    Jaworsky, D.E.2    Frehywot, G.L.3    Townsend, C.A.4    Ronnett, G.V.5    Lane, M.D.6    Kuhajda, F.P.7
  • 99
    • 33745294817 scopus 로고    scopus 로고
    • Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA
    • (doi:10.2337/db05-1356)
    • López M, Lelliott CJ, Tovar S, Kimber W, Gallego R, Virtue S, Blount M, Vázquez MJ, Finer N, Powles T et al. 2006 Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. Diabetes 55 1327-1336. (doi:10.2337/db05-1356)
    • (2006) Diabetes , vol.55 , pp. 1327-1336
    • López, M.1    Lelliott, C.J.2    Tovar, S.3    Kimber, W.4    Gallego, R.5    Virtue, S.6    Blount, M.7    Vázquez, M.J.8    Finer, N.9    Powles, T.10
  • 100
    • 33847720313 scopus 로고    scopus 로고
    • Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake
    • (doi:10.1002/bies.20539)
    • López M, Lelliott CJ & Vidal-Puig A 2007 Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. BioEssays 29 248-261. (doi:10.1002/bies.20539)
    • (2007) BioEssays , vol.29 , pp. 248-261
    • López, M.1    Lelliott, C.J.2    Vidal-Puig, A.3
  • 102
    • 50249115571 scopus 로고    scopus 로고
    • The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function-reply
    • (doi:10.1016/ j.cmet.2008.08.003)
    • López M, Saha AK, Diéguez C & Vidal-Puig A 2008b The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function-reply. Cell Metabolism 8 176. (doi:10.1016/ j.cmet.2008.08.003)
    • (2008) Cell Metabolism , vol.8 , pp. 176
    • López, M.1    Saha, A.K.2    Diéguez, C.3    Vidal-Puig, A.4
  • 106
    • 78349278772 scopus 로고    scopus 로고
    • AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicity
    • (doi:10.1002/path.2778)
    • Martínez de Morentin PB, González CR & López M 2010a AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicity. Journal of Pathology 222 329-334. (doi:10.1002/path.2778)
    • (2010) Journal of Pathology , vol.222 , pp. 329-334
    • de Morentin, P.B.M.1    González, C.R.2    López, M.3
  • 109
    • 3242811250 scopus 로고    scopus 로고
    • Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus
    • (doi:10.2337/diabetes.53.8.1953)
    • McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ & Sherwin RS 2004 Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. Diabetes 53 1953-1958. (doi:10.2337/diabetes.53.8.1953)
    • (2004) Diabetes , vol.53 , pp. 1953-1958
    • McCrimmon, R.J.1    Fan, X.2    Ding, Y.3    Zhu, W.4    Jacob, R.J.5    Sherwin, R.S.6
  • 110
    • 33748296106 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counter-regulatory hormone responses in rats with defective counter-regulation
    • (doi:10.2337/db05-1359)
    • McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W & Sherwin RS 2006 Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counter-regulatory hormone responses in rats with defective counter-regulation. Diabetes 55 1755-1760. (doi:10.2337/db05-1359)
    • (2006) Diabetes , vol.55 , pp. 1755-1760
    • McCrimmon, R.J.1    Fan, X.2    Cheng, H.3    McNay, E.4    Chan, O.5    Shaw, M.6    Ding, Y.7    Zhu, W.8    Sherwin, R.S.9
  • 112
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • (doi:10.1038/ nature02440)
    • Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ et al. 2004 AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428 569-574. (doi:10.1038/ nature02440)
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.B.4    Lee, A.5    Xue, B.6    Mu, J.7    Foufelle, F.8    Ferre, P.9    Birnbaum, M.J.10
  • 113
    • 0035863948 scopus 로고    scopus 로고
    • Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary
    • (doi:10.1002/ 1096-9861(20010115)429:3 < 469::AID-CNE8 > 3.0.CO;2-#)
    • Mitchell V, Bouret S, Beauvillain JC, Schilling A, Perret M, Kordon C & Epelbaum J 2001 Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary. Journal of Comparative Neurology 429 469-489. (doi:10.1002/ 1096-9861(20010115)429:3 < 469::AID-CNE8 > 3.0.CO;2-#)
    • (2001) Journal of Comparative Neurology , vol.429 , pp. 469-489
    • Mitchell, V.1    Bouret, S.2    Beauvillain, J.C.3    Schilling, A.4    Perret, M.5    Kordon, C.6    Epelbaum, J.7
  • 114
    • 77956834575 scopus 로고    scopus 로고
    • Mens sana in corpore sano Exercise and hypothalamic ER stress
    • (doi:10.1371/journal.pbio.1000464)
    • de Morentin PB & López M 2010 "Mens sana in corpore sano": exercise and hypothalamic ER stress. PLoS Biology 8 e1000464. (doi:10.1371/journal.pbio.1000464)
    • (2010) PLoS Biology , vol.8
    • de Morentin, P.B.1    López, M.2
  • 117
    • 70349244719 scopus 로고    scopus 로고
    • AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. American
    • (doi:10.1152/ajpcell.00127.2009)
    • Murphy BA, Fakira KA, Song Z, Beuve A & Routh VH 2009 AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. American Journal of Physiology. Cell Physiology 297 C750-C758. (doi:10.1152/ajpcell.00127.2009)
    • (2009) Journal of Physiology. Cell Physiology , vol.297
    • Murphy, B.A.1    Fakira, K.A.2    Song, Z.3    Beuve, A.4    Routh, V.H.5
  • 118
    • 0024418313 scopus 로고
    • The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus
    • (doi:10. 1210/endo-125-4-2056)
    • Nahon JL, Presse F, Bittencourt JC, Sawchenko PE & Vale W 1989 The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinology 125 2056-2065. (doi:10. 1210/endo-125-4-2056)
    • (1989) Endocrinology , vol.125 , pp. 2056-2065
    • Nahon, J.L.1    Presse, F.2    Bittencourt, J.C.3    Sawchenko, P.E.4    Vale, W.5
  • 120
    • 19944426367 scopus 로고    scopus 로고
    • Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats
    • (doi:10.2337/diabetes.54.1.63)
    • Namkoong C, Kim MS, Jang PG, Han SM, Park HS, Koh EH, Lee WJ, Kim JY, Park IS, Park JY et al. 2005 Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes 54 63-68. (doi:10.2337/diabetes.54.1.63)
    • (2005) Diabetes , vol.54 , pp. 63-68
    • Namkoong, C.1    Kim, M.S.2    Jang, P.G.3    Han, S.M.4    Park, H.S.5    Koh, E.H.6    Lee, W.J.7    Kim, J.Y.8    Park, I.S.9    Park, J.Y.10
  • 121
    • 36248937133 scopus 로고    scopus 로고
    • Effects of estradiol on acute and recurrent insulin-induced hypoglycemia-associated patterns of arcuate neuropeptide Y, proopiomelanocortin, and cocaine-and amphetamine-related transcript gene expression in the ovari-ectomized rat
    • (doi:10.1159/ 000109678)
    • Nedungadi TP & Briski KP 2007 Effects of estradiol on acute and recurrent insulin-induced hypoglycemia-associated patterns of arcuate neuropeptide Y, proopiomelanocortin, and cocaine-and amphetamine-related transcript gene expression in the ovari-ectomized rat. Neuroendocrinology 86 270-276. (doi:10.1159/ 000109678)
    • (2007) Neuroendocrinology , vol.86 , pp. 270-276
    • Nedungadi, T.P.1    Briski, K.P.2
  • 122
    • 33846417285 scopus 로고    scopus 로고
    • Estrogen differentially modulates the cannabinoid-induced presynaptic inhibition of amino acid neurotransmission in proopiomelanocortin neurons of the arcuate nucleus
    • (doi:10.1159/000096996)
    • Nguyen QH & Wagner EJ 2006 Estrogen differentially modulates the cannabinoid-induced presynaptic inhibition of amino acid neurotransmission in proopiomelanocortin neurons of the arcuate nucleus. Neuroendocrinology 84 123-137. (doi:10.1159/000096996)
    • (2006) Neuroendocrinology , vol.84 , pp. 123-137
    • Nguyen, Q.H.1    Wagner, E.J.2
  • 123
    • 4644249772 scopus 로고    scopus 로고
    • Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin
    • (doi:10.2337/diabetes.53.10. 2552)
    • Nogueiras R, Tovar S, Mitchell SE, Rayner DV, Archer ZA, Dieguez C & Williams LM 2004 Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin. Diabetes 53 2552-2558. (doi:10.2337/diabetes.53.10. 2552)
    • (2004) Diabetes , vol.53 , pp. 2552-2558
    • Nogueiras, R.1    Tovar, S.2    Mitchell, S.E.3    Rayner, D.V.4    Archer, Z.A.5    Dieguez, C.6    Williams, L.M.7
  • 127
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet induced obesity
    • (doi:10.1523/JNEUROSCI.5977-08.2009)
    • Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson TJ, Disse E, Pfluger P, López M et al. 2009 Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet induced obesity. Journal of Neuroscience 29 5916-5925. (doi:10.1523/JNEUROSCI.5977-08.2009)
    • (2009) Journal of Neuroscience , vol.29 , pp. 5916-5925
    • Nogueiras, R.1    Pérez-Tilve, D.2    Veyrat-Durebex, C.3    Morgan, D.A.4    Varela, L.5    Haynes, W.G.6    Patterson, T.J.7    Disse, E.8    Pfluger, P.9    López, M.10
  • 128
    • 77649092148 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by energy availability: A role for the central nervous system
    • . (doi:10.1111/j.1467-789X.2009. 00669.x)
    • Nogueiras R, López M & Diéguez C 2010 Regulation of lipid metabolism by energy availability: a role for the central nervous system. Obesity Reviews 11 185-201. (doi:10.1111/j.1467-789X.2009. 00669.x)
    • (2010) Obesity Reviews , vol.11 , pp. 185-201
    • Nogueiras, R.1    López, M.2    Diéguez, C.3
  • 129
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • (doi:10. 1038/nn0602-861)
    • Obici S, Feng Z, Karkanias G, Baskin DG & Rossetti L 2002a Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature Neuroscience 5 566-572. (doi:10. 1038/nn0602-861)
    • (2002) Nature Neuroscience , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 130
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • (doi:10.1038/nm798)
    • Obici S, Zhang BB, Karkanias G & Rossetti L 2002b Hypothalamic insulin signaling is required for inhibition of glucose production. Nature Medicine 8 1376-1382. (doi:10.1038/nm798)
    • (2002) Nature Medicine , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 131
    • 0038037734 scopus 로고    scopus 로고
    • Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
    • (doi:10. 1038/nm873)
    • Obici S, Feng Z, Arduini A, Conti R & Rossetti L 2003 Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nature Medicine 9 756-761. (doi:10. 1038/nm873)
    • (2003) Nature Medicine , vol.9 , pp. 756-761
    • Obici, S.1    Feng, Z.2    Arduini, A.3    Conti, R.4    Rossetti, L.5
  • 132
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • (doi:10.1126/science.278.5335.135)
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I & Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278 135-138. (doi:10.1126/science.278.5335.135)
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 134
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • (doi:10.1038/sj.cdd.4401373)
    • Oyadomari S & Mori M 2004 Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death and Differentiation 11 381-389. (doi:10.1038/sj.cdd.4401373)
    • (2004) Cell Death and Differentiation , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 135
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • (doi:10. 1016/j.cmet.2008.12.004)
    • Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr & Ozcan U 2009 Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metabolism 9 35-51. (doi:10. 1016/j.cmet.2008.12.004)
    • (2009) Cell Metabolism , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3    Chung, J.4    Sarkar, S.5    Nie, D.6    Myers, J.M.G.7    Ozcan, U.8
  • 136
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • (doi:10.1210/er.2005-0009)
    • Pagotto U, Marsicano G, Cota D, Lutz B & Pasquali R 2006 The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocrine Reviews 27 73-100. (doi:10.1210/er.2005-0009)
    • (2006) Endocrine Reviews , vol.27 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3    Lutz, B.4    Pasquali, R.5
  • 137
    • 38049120264 scopus 로고    scopus 로고
    • Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
    • (doi:10.1096/fj.07-8945com)
    • Pecqueur C, Bui T, Gelly C, Hauchard J, Barbot C, Bouillaud F, Ricquier D, Miroux B & Thompson CB 2008 Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB Journal 22 9-18. (doi:10.1096/fj.07-8945com)
    • (2008) FASEB Journal , vol.22 , pp. 9-18
    • Pecqueur, C.1    Bui, T.2    Gelly, C.3    Hauchard, J.4    Barbot, C.5    Bouillaud, F.6    Ricquier, D.7    Miroux, B.8    Thompson, C.B.9
  • 140
    • 33745838578 scopus 로고    scopus 로고
    • Central insulin action in energy and glucose homeostasis
    • (doi:10.1172/JCI29063)
    • Plum L, Belgardt BF & Bruning JC 2006 Central insulin action in energy and glucose homeostasis. Journal of Clinical Investigation 116 1761-1766. (doi:10.1172/JCI29063)
    • (2006) Journal of Clinical Investigation , vol.116 , pp. 1761-1766
    • Plum, L.1    Belgardt, B.F.2    Bruning, J.C.3
  • 141
    • 70350369729 scopus 로고    scopus 로고
    • The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelano-cortin neurons with regulation of food intake
    • (doi:10.1038/nm.2026)
    • Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP et al. 2009 The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelano-cortin neurons with regulation of food intake. Nature Medicine 15 1195-1201. (doi:10.1038/nm.2026)
    • (2009) Nature Medicine , vol.15 , pp. 1195-1201
    • Plum, L.1    Lin, H.V.2    Dutia, R.3    Tanaka, J.4    Aizawa, K.S.5    Matsumoto, M.6    Kim, A.J.7    Cawley, N.X.8    Paik, J.H.9    Loh, Y.P.10
  • 145
    • 44649099112 scopus 로고    scopus 로고
    • Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue
    • (doi:10.1038/emboj.2008.92)
    • Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM & Li P 2008 Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO Journal 27 1537-1548. (doi:10.1038/emboj.2008.92)
    • (2008) EMBO Journal , vol.27 , pp. 1537-1548
    • Qi, J.1    Gong, J.2    Zhao, T.3    Zhao, J.4    Lam, P.5    Ye, J.6    Li, J.Z.7    Wu, J.8    Zhou, H.M.9    Li, P.10
  • 147
    • 0037320466 scopus 로고    scopus 로고
    • The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat
    • (doi:10.1046/ j.1365-2826.2003.00962.x)
    • Raposinho PD, White RB & Aubert ML 2003 The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Journal of Neuroendocrinology 15 173-181. (doi:10.1046/ j.1365-2826.2003.00962.x)
    • (2003) Journal of Neuroendocrinology , vol.15 , pp. 173-181
    • Raposinho, P.D.1    White, R.B.2    Aubert, M.L.3
  • 150
    • 40949150324 scopus 로고    scopus 로고
    • A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in highprotein diet-induced weight loss
    • (doi:10. 2337/db07-0573)
    • Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JA et al. 2008b A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in highprotein diet-induced weight loss. Diabetes 57 594-605. (doi:10. 2337/db07-0573)
    • (2008) Diabetes , vol.57 , pp. 594-605
    • Ropelle, E.R.1    Pauli, J.R.2    Fernandes, M.F.3    Rocco, S.A.4    Marin, R.M.5    Morari, J.6    Souza, K.K.7    Dias, M.M.8    Gomes-Marcondes, M.C.9    Gontijo, J.A.10
  • 151
    • 77956827261 scopus 로고    scopus 로고
    • IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition
    • (doi:10.1371/journal.pbio.1000465)
    • Ropelle ER, Flores MB, Cintra DE, Rocha GZ, Pauli JR, Morari J, de Zouza CT, Moraes JC, Prada PO, Guadagnini D et al. 2010 IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition. PLoS Biology 8 e1000465. (doi:10.1371/journal.pbio.1000465)
    • (2010) PLoS Biology , vol.8
    • Ropelle, E.R.1    Flores, M.B.2    Cintra, D.E.3    Rocha, G.Z.4    Pauli, J.R.5    Morari, J.6    de Zouza, C.T.7    Moraes, J.C.8    Prada, P.O.9    Guadagnini, D.10
  • 152
    • 0345374578 scopus 로고    scopus 로고
    • Minireview: Malonyl CoA, AMP-activated protein kinase, and adiposity
    • (doi:10.1210/en.2003-0849)
    • Ruderman NB, Saha AK & Kraegen EW 2003 Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology 144 5166-5171. (doi:10.1210/en.2003-0849)
    • (2003) Endocrinology , vol.144 , pp. 5166-5171
    • Ruderman, N.B.1    Saha, A.K.2    Kraegen, E.W.3
  • 153
    • 34249707945 scopus 로고    scopus 로고
    • A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior
    • (doi:10.1016/j.cmet.2007.05.007)
    • Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, Tschop MH & Treier M 2007 A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior. Cell Metabolism 5 450-463. (doi:10.1016/j.cmet.2007.05.007)
    • (2007) Cell Metabolism , vol.5 , pp. 450-463
    • Sakkou, M.1    Wiedmer, P.2    Anlag, K.3    Hamm, A.4    Seuntjens, E.5    Ettwiller, L.6    Tschop, M.H.7    Treier, M.8
  • 154
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuro-peptides and G protein-coupled receptors that regulate feeding behavior
    • (doi:10.1016/S0092-8674(00)80949-6)
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S et al. 1998 Orexins and orexin receptors: a family of hypothalamic neuro-peptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 573-585. (doi:10.1016/S0092-8674(00)80949-6)
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6    Williams, S.C.7    Richardson, J.A.8    Kozlowski, G.P.9    Wilson, S.10
  • 155
    • 0025072899 scopus 로고
    • Increased hypothalamic content of preproneuropeptide Y messenger ribo-nucleic acid in genetically obese Zucker rats and its regulation by food deprivation
    • (doi:10.1210/endo-127-2-730)
    • Sanacora G, Kershaw M, Finkelstein JA & White JD 1990 Increased hypothalamic content of preproneuropeptide Y messenger ribo-nucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127 730-737. (doi:10.1210/endo-127-2-730)
    • (1990) Endocrinology , vol.127 , pp. 730-737
    • Sanacora, G.1    Kershaw, M.2    Finkelstein, J.A.3    White, J.D.4
  • 158
    • 70349352744 scopus 로고    scopus 로고
    • Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase
    • (doi:10. 1089/ars.2009.2625)
    • Santos CX, Tanaka LY, Wosniak J & Laurindo FR 2009 Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase. Antioxidants & Redox Signaling 11 2409-2427. (doi:10. 1089/ars.2009.2625)
    • (2009) Antioxidants & Redox Signaling , vol.11 , pp. 2409-2427
    • Santos, C.X.1    Tanaka, L.Y.2    Wosniak, J.3    Laurindo, F.R.4
  • 159
    • 0037146943 scopus 로고    scopus 로고
    • Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats
    • (doi:10.1016/S0006-8993(02)03674-0)
    • Savontaus E, Conwell IM & Wardlaw SL 2002 Effects of adrenalectomy on AGRP, POMC, NPY and CART gene expression in the basal hypothalamus of fed and fasted rats. Brain Research 958 130-138. (doi:10.1016/S0006-8993(02)03674-0)
    • (2002) Brain Research , vol.958 , pp. 130-138
    • Savontaus, E.1    Conwell, I.M.2    Wardlaw, S.L.3
  • 160
    • 0025804616 scopus 로고
    • Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus offood-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats
    • (doi:10.1210/endo-128-5-2645)
    • Schwartz MW, Marks JL, Sipols AJ, Baskin DG, Woods SC, Kahn SE & Porte D Jr 1991 Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus offood-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128 2645-2647. (doi:10.1210/endo-128-5-2645)
    • (1991) Endocrinology , vol.128 , pp. 2645-2647
    • Schwartz, M.W.1    Marks, J.L.2    Sipols, A.J.3    Baskin, D.G.4    Woods, S.C.5    Kahn, S.E.6    Porte, J.D.7
  • 162
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomela-nocortin mRNA expression in the rostral arcuate nucleus
    • (doi:10.2337/diabetes.46.12.2119)
    • Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P & Baskin DG 1997 Leptin increases hypothalamic pro-opiomela-nocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 2119-2123. (doi:10.2337/diabetes.46.12.2119)
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6    Baskin, D.G.7
  • 163
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • (doi:10.1038/nm1196-1254)
    • Scrocchi LA, Brown TJ, MaClusky N, Brubaker PL, Auerbach AB, Joyner AL & Drucker DJ 1996 Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nature Medicine 2 1254-1258. (doi:10.1038/nm1196-1254)
    • (1996) Nature Medicine , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    Maclusky, N.3    Brubaker, P.L.4    Auerbach, A.B.5    Joyner, A.L.6    Drucker, D.J.7
  • 164
    • 55049140818 scopus 로고    scopus 로고
    • Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats
    • (doi:10.1507/endocrj.K08E-091)
    • Seo S, Ju S, Chung H, Lee D & Park S 2008 Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats. Endocrine Journal 55 867-874. (doi:10.1507/endocrj.K08E-091)
    • (2008) Endocrine Journal , vol.55 , pp. 867-874
    • Seo, S.1    Ju, S.2    Chung, H.3    Lee, D.4    Park, S.5
  • 165
    • 0037320674 scopus 로고    scopus 로고
    • Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
    • (doi:10.1210/en.2002-220795)
    • Seoane LM, López M, Tovar S, Casanueva F, Señarís R & Diéguez C 2003 Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 144 544-551. (doi:10.1210/en.2002-220795)
    • (2003) Endocrinology , vol.144 , pp. 544-551
    • Seoane, L.M.1    López, M.2    Tovar, S.3    Casanueva, F.4    Señarís, R.5    Diéguez, C.6
  • 167
    • 50449092987 scopus 로고    scopus 로고
    • Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via AMP-activated protein kinase signaling in the arcuate nucleus of rats
    • (doi:10.1210/en.2008-0229)
    • Shimizu H, Arima H, Watanabe M, Goto M, Banno R, Sato I, Ozaki N, Nagasaki H & Oiso Y 2008 Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via AMP-activated protein kinase signaling in the arcuate nucleus of rats. Endocrinology 149 4544-4553. (doi:10.1210/en.2008-0229)
    • (2008) Endocrinology , vol.149 , pp. 4544-4553
    • Shimizu, H.1    Arima, H.2    Watanabe, M.3    Goto, M.4    Banno, R.5    Sato, I.6    Ozaki, N.7    Nagasaki, H.8    Oiso, Y.9
  • 168
    • 0035866077 scopus 로고    scopus 로고
    • Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus
    • Shimizu-Albergine M, Ippolito DL & Beavo JA 2001 Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. Journal of Neuroscience 21 1238-1246.
    • (2001) Journal of Neuroscience , vol.21 , pp. 1238-1246
    • Shimizu-Albergine, M.1    Ippolito, D.L.2    Beavo, J.A.3
  • 169
    • 0036310223 scopus 로고    scopus 로고
    • Attenuation of diabetic hyperphagia in neuropeptide Y-deficient mice
    • (doi:10.2337/diabetes. 51.3.778)
    • Sindelar DK, Mystkowski P, Marsh DJ, Palmiter RD & Schwartz MW 2002 Attenuation of diabetic hyperphagia in neuropeptide Y-deficient mice. Diabetes 51 778-783. (doi:10.2337/diabetes. 51.3.778)
    • (2002) Diabetes , vol.51 , pp. 778-783
    • Sindelar, D.K.1    Mystkowski, P.2    Marsh, D.J.3    Palmiter, R.D.4    Schwartz, M.W.5
  • 171
    • 0028924906 scopus 로고
    • Effect of intracerebroven-tricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression
    • (doi:10.2337/ diabetes.44.2.147)
    • Sipols AJ, Baskin DG & Schwartz MW 1995 Effect of intracerebroven-tricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44 147-151. (doi:10.2337/ diabetes.44.2.147)
    • (1995) Diabetes , vol.44 , pp. 147-151
    • Sipols, A.J.1    Baskin, D.G.2    Schwartz, M.W.3
  • 172
    • 18844404431 scopus 로고    scopus 로고
    • Development of growth hormone secretagogues
    • (doi:10.1210/er.2004-0019)
    • Smith RG 2005 Development of growth hormone secretagogues. Endocrine Reviews 26 346-360. (doi:10.1210/er.2004-0019)
    • (2005) Endocrine Reviews , vol.26 , pp. 346-360
    • Smith, R.G.1
  • 173
    • 0038646086 scopus 로고    scopus 로고
    • Localization of messenger RNAs encoding enzymes associated with malonyl-CoA metabolism in mouse brain. Brain Research
    • (doi:10.1016/ S1567-133X(02)00013-3)
    • Sorensen A, Travers MT, Vernon RG, Price NT & Barber MC 2002 Localization of messenger RNAs encoding enzymes associated with malonyl-CoA metabolism in mouse brain. Brain Research. Gene Expression Patterns 1 167-173. (doi:10.1016/ S1567-133X(02)00013-3)
    • (2002) Gene Expression Patterns , vol.1 , pp. 167-173
    • Sorensen, A.1    Travers, M.T.2    Vernon, R.G.3    Price, N.T.4    Barber, M.C.5
  • 175
    • 33746037555 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice
    • (doi:10.1210/ en.2005-1587)
    • Steinberg GR, Watt MJ, Fam BC, Proietto J, Andrikopoulos S, Allen AM, Febbraio MA & Kemp BE 2006b Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice. Endocrinology 147 3906-3914. (doi:10.1210/ en.2005-1587)
    • (2006) Endocrinology , vol.147 , pp. 3906-3914
    • Steinberg, G.R.1    Watt, M.J.2    Fam, B.C.3    Proietto, J.4    Andrikopoulos, S.5    Allen, A.M.6    Febbraio, M.A.7    Kemp, B.E.8
  • 178
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • (doi:10.1073/pnas.0305930101)
    • Sun Y, Wang P, Zheng H & Smith RG 2004 Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. PNAS 101 4679-4684. (doi:10.1073/pnas.0305930101)
    • (2004) PNAS , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 179
    • 0036839379 scopus 로고    scopus 로고
    • Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice. American Journal of Physiology
    • (doi:10.1152/ajpregu. 00501.2001)
    • Swart I, Jahng JW, Overton JM & Houpt TA 2002 Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 283 R1020-R1026. (doi:10.1152/ajpregu. 00501.2001)
    • (2002) Regulatory, Integrative and Comparative Physiology , vol.283
    • Swart, I.1    Jahng, J.W.2    Overton, J.M.3    Houpt, T.A.4
  • 180
    • 45049083557 scopus 로고    scopus 로고
    • Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/ enhancer-binding protein-homologous protein (CHOP)
    • (doi:10.1016/j.free-radbiomed.2008.03.003)
    • Tagawa Y, Hiramatsu N, Kasai A, Hayakawa K, Okamura M, Yao J & Kitamura M 2008 Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/ enhancer-binding protein-homologous protein (CHOP). Free Radical Biology and Medicine 45 50-59. (doi:10.1016/j.free-radbiomed.2008.03.003)
    • (2008) Free Radical Biology and Medicine , vol.45 , pp. 50-59
    • Tagawa, Y.1    Hiramatsu, N.2    Kasai, A.3    Hayakawa, K.4    Okamura, M.5    Yao, J.6    Kitamura, M.7
  • 182
    • 0033749370 scopus 로고    scopus 로고
    • Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis
    • (doi:10.1073/pnas.220425597)
    • Tang QQ & Lane MD 2000 Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-β during adipogenesis. PNAS 97 12446-12450. (doi:10.1073/pnas.220425597)
    • (2000) PNAS , vol.97 , pp. 12446-12450
    • Tang, Q.Q.1    Lane, M.D.2
  • 183
    • 0031765095 scopus 로고    scopus 로고
    • Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus
    • (doi:10.1210/en.139.10. 4420)
    • Tannenbaum GS, Lapointe M, Beaudet A & Howard AD 1998 Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus. Endocrinology 139 4420-4423. (doi:10.1210/en.139.10. 4420)
    • (1998) Endocrinology , vol.139 , pp. 4420-4423
    • Tannenbaum, G.S.1    Lapointe, M.2    Beaudet, A.3    Howard, A.D.4
  • 185
    • 6344243041 scopus 로고    scopus 로고
    • Obesity-prone rats have preexisting defects in their counterregulatory response to insulin-induced hypoglyce-mia. American Journal of Physiology. Regulatory
    • Tkacs NC & Levin BE 2004 Obesity-prone rats have preexisting defects in their counterregulatory response to insulin-induced hypoglyce-mia. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 287 R1110-R1115.
    • (2004) Integrative and Comparative Physiology , vol.287
    • Tkacs, N.C.1    Levin, B.E.2
  • 186
    • 0034115121 scopus 로고    scopus 로고
    • Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomela-nocortin mRNA in non-coma hypoglycemia
    • (doi:10.2337/diabetes.49.5.820)
    • Tkacs NC, Dunn-Meynell AA & Levin BE 2000 Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomela-nocortin mRNA in non-coma hypoglycemia. Diabetes 49 820-826. (doi:10.2337/diabetes.49.5.820)
    • (2000) Diabetes , vol.49 , pp. 820-826
    • Tkacs, N.C.1    Dunn-Meynell, A.A.2    Levin, B.E.3
  • 187
    • 34247616021 scopus 로고    scopus 로고
    • Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    • (doi:10.1016/j.cmet.2007.04.001)
    • Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE et al. 2007 Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metabolism 5 383-393. (doi:10.1016/j.cmet.2007.04.001)
    • (2007) Cell Metabolism , vol.5 , pp. 383-393
    • Tong, Q.1    Ye, C.2    McCrimmon, R.J.3    Dhillon, H.4    Choi, B.5    Kramer, M.D.6    Yu, J.7    Yang, Z.8    Christiansen, L.M.9    Lee, C.E.10
  • 189
    • 0038169077 scopus 로고    scopus 로고
    • Exploring the site of anorectic action of peripherally administered synthetic melano-cortin peptide MT-II in rats
    • (doi:10. 1016/S0006-8993(03)02683-0)
    • Trivedi P, Jiang M, Tamvakopoulos CC, Shen X, Yu H, Mock S, Fenyk-Melody J, Van Der Ploeg LH & Guan XM 2003 Exploring the site of anorectic action of peripherally administered synthetic melano-cortin peptide MT-II in rats. Brain Research 977 221-230. (doi:10. 1016/S0006-8993(03)02683-0)
    • (2003) Brain Research , vol.977 , pp. 221-230
    • Trivedi, P.1    Jiang, M.2    Tamvakopoulos, C.C.3    Shen, X.4    Yu, H.5    Mock, S.6    Fenyk-Melody, J.7    Ploeg, L.H.V.D.8    Guan, X.M.9
  • 190
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • (doi:10.1038/35038090)
    • Tschop M, Smiley DL & Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407 908-913. (doi:10.1038/35038090)
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 192
  • 193
    • 22044441761 scopus 로고    scopus 로고
    • Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice
    • (doi:10.1016/j.regpep.2005.04.004)
    • Tsubone T, Masaki T, Katsuragi I, Tanaka K, Kakuma T & Yoshimatsu H 2005 Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice. Regulatory Peptides 130 97-103. (doi:10.1016/j.regpep.2005.04.004)
    • (2005) Regulatory Peptides , vol.130 , pp. 97-103
    • Tsubone, T.1    Masaki, T.2    Katsuragi, I.3    Tanaka, K.4    Kakuma, T.5    Yoshimatsu, H.6
  • 195
    • 3042640680 scopus 로고    scopus 로고
    • Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake
    • (doi:10.1210/en.2004-0059)
    • Verty AN, McFarlane JR, McGregor IS & Mallet PE 2004 Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Endocrinology 145 3224-3231. (doi:10.1210/en.2004-0059)
    • (2004) Endocrinology , vol.145 , pp. 3224-3231
    • Verty, A.N.1    McFarlane, J.R.2    McGregor, I.S.3    Mallet, P.E.4
  • 196
    • 0037424283 scopus 로고    scopus 로고
    • Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids
    • (doi:10.1016/S0006-8993(02)04064-7)
    • Vrang N, Larsen PJ, Tang-Christensen M, Larsen LK & Kristensen P 2003 Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids. Brain Research 965 45-50. (doi:10.1016/S0006-8993(02)04064-7)
    • (2003) Brain Research , vol.965 , pp. 45-50
    • Vrang, N.1    Larsen, P.J.2    Tang-Christensen, M.3    Larsen, L.K.4    Kristensen, P.5
  • 197
    • 73949113823 scopus 로고    scopus 로고
    • Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic β-cells
    • (doi:10.1016/j.peptides.2009.11.011)
    • Wang W, Liu Y, Chen Y, Cao C, Xiang Y, Zhang D, Han L, Zhao H & Liu G 2010a Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic β-cells. Peptides 31 307-314. (doi:10.1016/j.peptides.2009.11.011)
    • (2010) Peptides , vol.31 , pp. 307-314
    • Wang, W.1    Liu, Y.2    Chen, Y.3    Cao, C.4    Xiang, Y.5    Zhang, D.6    Han, L.7    Zhao, H.8    Liu, G.9
  • 198
    • 77950368247 scopus 로고    scopus 로고
    • Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line
    • (doi:10.1016/j.regpep. 2009.12.017)
    • Wang W, Zhang D, Zhao H, Chen Y, Liu Y, Cao C, Han L & Liu G 2010b Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line. Regulatory Peptides 161 43-50. (doi:10.1016/j.regpep. 2009.12.017)
    • (2010) Regulatory Peptides , vol.161 , pp. 43-50
    • Wang, W.1    Zhang, D.2    Zhao, H.3    Chen, Y.4    Liu, Y.5    Cao, C.6    Han, L.7    Liu, G.8
  • 199
    • 53949106299 scopus 로고    scopus 로고
    • Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus
    • (doi:10.1016/j.febslet.2008.09.045)
    • Watanabe M, Arima H, Fukushima K, Goto M, Shimizu H, Hayashi M, Banno R, Sato I, Ozaki N, Nagasaki H et al. 2008 Direct and indirect modulation of neuropeptide Y gene expression in response to hypoglycemia in rat arcuate nucleus. FEBS Letters 582 3632-3638. (doi:10.1016/j.febslet.2008.09.045)
    • (2008) FEBS Letters , vol.582 , pp. 3632-3638
    • Watanabe, M.1    Arima, H.2    Fukushima, K.3    Goto, M.4    Shimizu, H.5    Hayashi, M.6    Banno, R.7    Sato, I.8    Ozaki, N.9    Nagasaki, H.10
  • 200
    • 78449267024 scopus 로고    scopus 로고
    • Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus
    • (doi:10.1007/s11010-010-0534-2)
    • Wen JP, Liu CE, Hu YT, Chen G & Lin LX 2010 Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus. Molecular and Cellular Biochemistry 344 109-115. (doi:10.1007/s11010-010-0534-2)
    • (2010) Molecular and Cellular Biochemistry , vol.344 , pp. 109-115
    • Wen, J.P.1    Liu, C.E.2    Hu, Y.T.3    Chen, G.4    Lin, L.X.5
  • 201
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
    • (doi:10.1159/ 000054491)
    • Willesen MG, Kristensen P & Romer J 1999 Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70 306-316. (doi:10.1159/ 000054491)
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Romer, J.3
  • 202
    • 0033316562 scopus 로고    scopus 로고
    • Physiological and anatomical circuitry between agouti-related protein and leptin signaling
    • (doi:10.1210/en.140.5.2387)
    • Wilson BD, Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ & Barsh GS 1999 Physiological and anatomical circuitry between agouti-related protein and leptin signaling. Endocrinology 140 2387-2397. (doi:10.1210/en.140.5.2387)
    • (1999) Endocrinology , vol.140 , pp. 2387-2397
    • Wilson, B.D.1    Bagnol, D.2    Kaelin, C.B.3    Ollmann, M.M.4    Gantz, I.5    Watson, S.J.6    Barsh, G.S.7
  • 203
    • 50649094890 scopus 로고    scopus 로고
    • Hypothalamic malonyl-coenzymeAand the control of energy balance
    • (doi:10.1210/me.2007-0538)
    • Wolfgang MJ and Lane MD 2008 Hypothalamic malonyl-coenzymeAand the control of energy balance. Molecular Endocrinology 22 2012-2020. (doi:10.1210/me.2007-0538)
    • (2008) Molecular Endocrinology , vol.22 , pp. 2012-2020
    • Wolfgang, M.J.1    Lane, M.D.2
  • 204
    • 33646576512 scopus 로고    scopus 로고
    • The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
    • (doi:10.1073/pnas.0602205103)
    • Wolfgang MJ, Kurama T, Dai Y, Suwa A, Asaumi M, Matsumoto S, Cha SH, Shimokawa T & Lane MD 2006 The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. PNAS 103 7282-7287. (doi:10.1073/pnas.0602205103)
    • (2006) PNAS , vol.103 , pp. 7282-7287
    • Wolfgang, M.J.1    Kurama, T.2    Dai, Y.3    Suwa, A.4    Asaumi, M.5    Matsumoto, S.6    Cha, S.H.7    Shimokawa, T.8    Lane, M.D.9
  • 205
    • 37649003524 scopus 로고    scopus 로고
    • Regulation of hypothalamic malonyl-CoA by central glucose and leptin
    • (doi:10.1073/pnas. 0709778104)
    • Wolfgang MJ, Cha SH, Sidhaye A, Chohnan S, Cline G, Shulman GI & Lane MD 2007 Regulation of hypothalamic malonyl-CoA by central glucose and leptin. PNAS 104 19285-19290. (doi:10.1073/pnas. 0709778104)
    • (2007) PNAS , vol.104 , pp. 19285-19290
    • Wolfgang, M.J.1    Cha, S.H.2    Sidhaye, A.3    Chohnan, S.4    Cline, G.5    Shulman, G.I.6    Lane, M.D.7
  • 206
    • 70349507353 scopus 로고    scopus 로고
    • Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin
    • (doi:10.1038/oby.2009.194)
    • Won JC, Jang PG, Namkoong C, Koh EH, Kim SK, Park JY, Lee KU & Kim MS 2009 Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity 17 1861-1865. (doi:10.1038/oby.2009.194)
    • (2009) Obesity , vol.17 , pp. 1861-1865
    • Won, J.C.1    Jang, P.G.2    Namkoong, C.3    Koh, E.H.4    Kim, S.K.5    Park, J.Y.6    Lee, K.U.7    Kim, M.S.8
  • 207
    • 0018621289 scopus 로고
    • Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
    • (doi:10.1038/ 282503a0)
    • Woods SC, Lotter EC, McKay LD & Porte D Jr 1979 Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282 503-505. (doi:10.1038/ 282503a0)
    • (1979) Nature , vol.282 , pp. 503-505
    • Woods, S.C.1    Lotter, E.C.2    McKay, L.D.3    Porte, J.D.4
  • 208
    • 23044437445 scopus 로고    scopus 로고
    • Ca(2+)/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
    • (doi:10.1016/j. cmet.2005.06.005)
    • Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M & Carling D 2005 Ca(2+)/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metabolism 2 21-33. (doi:10.1016/j. cmet.2005.06.005)
    • (2005) Cell Metabolism , vol.2 , pp. 21-33
    • Woods, A.1    Dickerson, K.2    Heath, R.3    Hong, S.P.4    Momcilovic, M.5    Johnstone, S.R.6    Carlson, M.7    Carling, D.8
  • 213
    • 33751229931 scopus 로고    scopus 로고
    • A pivotal role for endogenous TGF-b-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    • (doi:10.1073/pnas.0604708103)
    • Xie M, Zhang D, Dyck JR, Li Y, Zhang H, Morishima M, Mann DL, Taffet GE, Baldini A, Khoury DS et al. 2006 A pivotal role for endogenous TGF-b-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. PNAS 103 17378-17383. (doi:10.1073/pnas.0604708103)
    • (2006) PNAS , vol.103 , pp. 17378-17383
    • Xie, M.1    Zhang, D.2    Dyck, J.R.3    Li, Y.4    Zhang, H.5    Morishima, M.6    Mann, D.L.7    Taffet, G.E.8    Baldini, A.9    Khoury, D.S.10
  • 214
    • 0031788012 scopus 로고    scopus 로고
    • Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: Comparison with leptin
    • (doi:10.1210/ en.139.2.466)
    • Xu B, Dube MG, Kalra PS, Farmerie WG, Kaibara A, Moldawer LL, Martin D & Kalra SP 1998 Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology 139 466-473. (doi:10.1210/ en.139.2.466)
    • (1998) Endocrinology , vol.139 , pp. 466-473
    • Xu, B.1    Dube, M.G.2    Kalra, P.S.3    Farmerie, W.G.4    Kaibara, A.5    Moldawer, L.L.6    Martin, D.7    Kalra, S.P.8
  • 215
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • (doi:10. 1016/j.cell.2008.01.017)
    • Yang J, Brown MS, Liang G, Grishin NV & Goldstein JL 2008 Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132 387-396. (doi:10. 1016/j.cell.2008.01.017)
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 217
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKb/NF-kB and ER stress link overnutrition to energy imbalance and obesity
    • (doi:10.1016/j.cell. 2008.07.043)
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H & Cai D 2008 Hypothalamic IKKb/NF-kB and ER stress link overnutrition to energy imbalance and obesity. Cell 135 61-73. (doi:10.1016/j.cell. 2008.07.043)
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 218
    • 65549106372 scopus 로고    scopus 로고
    • Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart
    • (doi:10.1016/j.peptides.2009.03.024)
    • Zhang GG, Teng X, Liu Y, Cai Y, Zhou YB, Duan XH, Song JQ, Shi Y, Tang CS, Yin XH et al. 2009 Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart. Peptides 30 1109-1116. (doi:10.1016/j.peptides.2009.03.024)
    • (2009) Peptides , vol.30 , pp. 1109-1116
    • Zhang, G.G.1    Teng, X.2    Liu, Y.3    Cai, Y.4    Zhou, Y.B.5    Duan, X.H.6    Song, J.Q.7    Shi, Y.8    Tang, C.S.9    Yin, X.H.10
  • 223
    • 0033760590 scopus 로고    scopus 로고
    • Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling
    • (doi:10.2337/diabetes.49.11.1890)
    • Ziotopoulou M, Erani DM, Hileman SM, Bjorbaek C & Mantzoros CS 2000 Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling. Diabetes 49 1890-1896. (doi:10.2337/diabetes.49.11.1890)
    • (2000) Diabetes , vol.49 , pp. 1890-1896
    • Ziotopoulou, M.1    Erani, D.M.2    Hileman, S.M.3    Bjorbaek, C.4    Mantzoros, C.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.