Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats

Journal of Neurochemistry

Volumn 77, Issue 4, 2001, Pages 993-1000

  Hidaka, Shuji ^a   Yoshimatsu, Hironobu ^a   Kondou, Seiya ^a   Oka, Kyoko ^a,b   Tsuruta, Yoshio ^a   Sakino, Hiroshi ^a   Itateyama, Emi ^a   Noguchi, Hitoshi ^a   Himeno, Katsurou ^a   Okamoto, Kenjirou ^a   Teshima, Yasushi ^a   Okeda, Toshimitsu ^a,c   Sakata, Toshiie ^a  

^a OITA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c OITA UNIVERSITY   (Japan)

Author keywords

Agouti gene related protein; Diabetic hyperphagia; Insulin; Leptin; Melanocortin system

Indexed keywords

AGOUTI RELATED PROTEIN; INSULIN; LEPTIN; MELANOCORTIN RECEPTOR; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARCUATE NUCLEUS; ARTICLE; BLOOD SAMPLING; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; FOOD DEPRIVATION; GENE EXPRESSION; HYPERGLYCEMIA; HYPERPHAGIA; HYPOINSULINEMIA; HYPOTHALAMUS; INSULIN INFUSION; LIPID STORAGE; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RAT STRAIN; STREPTOZOCIN DIABETES; WEIGHT REDUCTION;

ANIMALS; BLOOD GLUCOSE; CEREBRAL VENTRICLES; DIABETES MELLITUS, EXPERIMENTAL; FEEDING BEHAVIOR; FOOD DEPRIVATION; GENE EXPRESSION REGULATION; HYPERPHAGIA; HYPOTHALAMUS; INFUSIONS, PARENTERAL; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; NEUROPEPTIDE Y; PROTEIN PRECURSORS; PROTEINS; RATS; RATS, WISTAR; RATS, ZUCKER; RNA, MESSENGER; TRANSCRIPTION, GENETIC; WEIGHT LOSS;

AGOUTI; ANIMALIA; RODENTIA;

EID: 0035015268     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00317.x     Document Type: Article

References (33)

1. Booth D. A. (1971) Some characteristics of feeding during streptozotocin-induced diabetes in the rat. J. Comp. Physiol. Psychol. 80, 238-249.
2. Broberger C., Johansen J., Johansson C., Schalling M. and Hokfelt T. (1998) The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl Acad. Sci. USA 95, 15043-15048.
3. Ebihara K., Ogawa Y., Katsuura G., Numata Y., Masuzaki H., Satoh N., Tamaki M., Yoshioka T., Hayase M., Matsuoka N., Aizawa-Abe M., Yoshimasa Y. and Nakao K. (1999) Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes 48, 2028-2033.
4. Fujimoto K., Sakata T., Shiraishi T., Kurata K., Terada K. and Etou H. (1986) Anorexia induced in rat by D-glucosamine deoxidized at C-1. Am. J. Physiol. 251, R481-R491.
5. Hahn T. M., Breininger J. F., Baskin D. G. and Schwartz M. W. (1998) Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neurosci. 1, 271-272.
6. Havel P. J., Hahn T. M., Sindelar D. K., Baskin D. G., Dallman M. F., Weigle D. S. and Schwartz M. W. (2000) Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 49, 244-252.
7. Hidaka S., Kakuma T., Yoshimatsu H., Sakino S., Fukuchi S. and Sakata T. (1999) Streptozotocin treatment upregulates uncoupling protein 3 expression in the rat heart. Diabetes 48, 430-435.
8. Hidaka S., Kakuma T., Yoshimatsu H., Yasunaga S., Kurokawa M. and Sakata T. (1998) Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats. Biochim. Biophys. Acta 1389, 178-181.
9. Kalra S. P., Dube M. G., Pu S., Xu B., Horvath T. L. and Kalra P. S. (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrinol. Rev. 20, 68-100.
10. Kim E. M., Grace M. K., Welch C. C., Billington C. J. and Levine A. S. (1999) STZ-induced diabetes decreases and insulin normalizes POMC mRNA in arcuate nucleus and pituitary in rats. Am. J. Physiol. 276, R1320-R1326.
11. Kristensen P., Judge M. E., Thim L., Ribel U., Christjansen K. N., Wulff B. S., Clausen J. T., Jensen P. B., Madsen O. D., Vrang N., Larsen P. J. and Hastrup S. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393, 72-76.
12. Leibel R. L., Chung W. K. and Chua S. C. Jr (1997) The molecular genetics of rodent single gene obesities. J. Biol. Chem. 272, 31937-31940.
13. Lu D., Willard D., Patel I. R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R. P., Wilkiso W. O. and Cone R. D. (1994) Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371, 799-802.
14. Miller M. W., Duhl D. M., Vrieling H., Cordes S. P., Ollmann M. M., Winkes B. M. and Brash G. S. (1994) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the Lethal-Yellow mutation. Genes Dev. 7, 454-467.
15. Mizuno T. M., Kleopoulos S. P., Bergen H. T., Roberts J. L., Priest C. A. and Mobbs C. V. (1998) Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47, 294-297.
16. Ollmann M. M., Wilson B. D., Yang Y. K., Kerns J. A., Chen Y., Gantz I. and Barsh G. S. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138.
17. Porte D. Jr, Seeley R. J., Woods S. C., Baskin D. G., Figlewicz D. P. and Schwartz M. W. (1998) Obesity, diabetes and the central nervous system. Diabetalogia 41, 863-881.
18. Qu D., Ludwig D. S., Gammeltoft S., Piper M., Pelleymounter M. A., Cullen M. J., Mathes W. F., Przypek R., Kanarek R. and Maratos-Flier E. (1996) A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243-247.
19. Rossi M., Kim M. S., Morgan D. G. A., Small C. J., Edwards C. M. B., Sunter D., Abusnana S., Goldstone A. P., Russell S. H., Stanley S. A., Smith D. M., Yagaloff K., Ghatei M. A. and Bloom S. R. (1998) A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139, 4428-4431.
20. Sanacora G., Kershaw M., Finkelstein J. A. and White J. D. (1990) Increased hypothalamic content of preproneuropeptide Y mRNA in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127, 730-737.
21. Schwartz M. W., Baskin D. G., Bukowski T. R., Kuijper J. L., Foster D., Lasser G., Prunkard D. E., Porte D. Jr, Woods S. C., Seeley R. J. and Weigle D. S. (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531-535.
22. Schwartz M. W., Figlewicz D. P., Baskin D. G., Woods S. C. and Porte D. Jr (1992) Insulin in the brain: a hormonal regulator of energy balance. Endocrinol. Rev. 13, 387-414.
23. Schwartz M. W., Seeley R. J., Woods S. C., Weigle D. S., Campfield L. A., Burn P. and Baskin D. G. (1997) Leptin increase hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119-2123.
24. Sergeyev V., Broberger C., Gorbatyuk O. and Hokfelt T. (2000) Effect of 2-mercaptoacetate and 2-deoxy-D-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in the rat hypothalamus. Neuroreport 11, 117-121.
25. Shutter J. R., Graham M., Kinsey A. C., Scully S., Luthy R. and Stark K. L. (1997) Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11, 593-602.
26. Sipols A. J., Baskin D. G. and Schwartz M. W. (1995) Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44, 147-151.
27. Siracusa L. D. (1994) The agouti gene: turned on to yellow. Trends Genet. 10, 423-428.
28. Stephens T. W., Basinski M., Bristow P. K., Bue-Valleskey J. M., Burgett S. G., Craft L., Hale J., Hoffmann J., Hsiung H. M., Kriauciunas A., Mackellar W., Rosteck P. R. Jr, Schnener B., Smith D., Tinsley F. C., Zhang X.-Y. and Heiman M. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532.
29. White J. D., Olchovsky D., Kershaw M. and Berelowitz M. (1990) Increased hypothalamic content of preproneuropeptide-Y messenger ribonucleic acid in streptozotocin-diabetic rats. Endocrinology 126, 765-772.
30. Williams G., Gill J. S., Lee Y. C., Cardoso H. M., Ghatei M. A., Okpere B. E. and Bloom S. R. (1988) Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats. Diabetes 38, 321-327.
31. Wilson B. D., Bagnol D., Kaelin C. B., Ollmann M. M., Gantz I., Watson S. J. and Barsh G. S. (1999) Physiological and anatomical circuitry between agouti-related protein and leptin signaling. Endocrinology 140, 2387-2397.
32. Woods S. C., Lotter E. C., McKay L. D. and Porte D. Jr (1979) Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282, 503-505.
33. vy/-mice: ectopic expression of agouti gene. FASEB J. 8, 479-488.