-
1
-
-
0037423247
-
A war on obesity, not the obese
-
Friedman JM (2003) A war on obesity, not the obese. Science 299: 856-858.
-
(2003)
Science
, vol.299
, pp. 856-858
-
-
Friedman, J.M.1
-
2
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier JS (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337-350.
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
4
-
-
20944432208
-
Gateway to the metabolic syndrome
-
Medina-Gomez G, Vidal-Puig A (2005) Gateway to the metabolic syndrome. Nat Med 11: 602-603.
-
(2005)
Nat Med
, vol.11
, pp. 602-603
-
-
Medina-Gomez, G.1
Vidal-Puig, A.2
-
5
-
-
76049101204
-
Obesity as a clinical and public health problem: Is there a need for a new definition based on lipotoxicity effects?
-
Sorensen TI, Virtue S, Vidal-Puig A (2010) Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? Biochim Biophys Acta 1801: 400-404.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 400-404
-
-
Sorensen, T.I.1
Virtue, S.2
Vidal-Puig, A.3
-
6
-
-
0036182137
-
Lipotoxic diseases
-
Unger RH (2002) Lipotoxic diseases. Annu Rev Med 53: 319-336.
-
(2002)
Annu Rev Med
, vol.53
, pp. 319-336
-
-
Unger, R.H.1
-
7
-
-
12444334643
-
Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
-
Lelliott C, Vidal-Puig AJ (2004) Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 28 Suppl 4: S22-S28.
-
(2004)
Int J Obes Relat Metab Disord
, vol.28
, Issue.SUPPL 4
-
-
Lelliott, C.1
Vidal-Puig, A.J.2
-
8
-
-
54749114466
-
It's not how fat you are, it's what you do with it that counts
-
Virtue S, Vidal-Puig A (2008) It's not how fat you are, it's what you do with it that counts. PLoS Biol 6: e237.
-
(2008)
PLoS Biol
, vol.6
-
-
Virtue, S.1
Vidal-Puig, A.2
-
9
-
-
76049102302
-
Hypothalamic lipotoxicity and the metabolic syndrome
-
Marti;́nez de Morentin PB, Varela L, Ferno J, Nogueiras R, Diéguez C, et al. (2010) Hypothalamic lipotoxicity and the metabolic syndrome. Biochim Biophys Acta 1801: 350-361.
-
(2010)
Biochim Biophys Acta
, vol.1801
, pp. 350-361
-
-
de Morentin, P.B.M.1
Varela, L.2
Ferno, J.3
Nogueiras, R.4
Diéguez, C.5
-
10
-
-
27744436291
-
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
-
Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB (2005) Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 493: 63-71.
-
(2005)
J Comp Neurol
, vol.493
, pp. 63-71
-
-
Elmquist, J.K.1
Coppari, R.2
Balthasar, N.3
Ichinose, M.4
Lowell, B.B.5
-
11
-
-
34547701951
-
Neurobiology of feeding and energy expenditure
-
Gao Q, Horvath TL (2007) Neurobiology of feeding and energy expenditure. Annu Rev Neurosci 30: 367-398.
-
(2007)
Annu Rev Neurosci
, vol.30
, pp. 367-398
-
-
Gao, Q.1
Horvath, T.L.2
-
12
-
-
3142782772
-
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
-
Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, et al. (2004) Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10: 734-738.
-
(2004)
Nat Med
, vol.10
, pp. 734-738
-
-
Howard, J.K.1
Cave, B.J.2
Oksanen, L.J.3
Tzameli, I.4
Bjorbaek, C.5
-
13
-
-
33645982255
-
From mice to men: Insights into the insulin resistance syndromes
-
Biddinger SB, Kahn CR (2006) From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 68: 123-158.
-
(2006)
Annu Rev Physiol
, vol.68
, pp. 123-158
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
14
-
-
33745838578
-
Central insulin action in energy and glucose homeostasis
-
Plum L, Belgardt BF, Bruning JC (2006) Central insulin action in energy and glucose homeostasis. J Clin Invest 116: 1761-1766.
-
(2006)
J Clin Invest
, vol.116
, pp. 1761-1766
-
-
Plum, L.1
Belgardt, B.F.2
Bruning, J.C.3
-
15
-
-
33746810001
-
Neuronal PTP1B regulates body weight, adiposity and leptin action
-
Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, et al. (2006) Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12: 917-924.
-
(2006)
Nat Med
, vol.12
, pp. 917-924
-
-
Bence, K.K.1
Delibegovic, M.2
Xue, B.3
Gorgun, C.Z.4
Hotamisligil, G.S.5
-
16
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder M, Kaufman RJ (2005) The mammalian unfolded protein response. Annu Rev Biochem 74: 739-789.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
17
-
-
33749492425
-
Endoplasmic reticulum stress signaling in disease
-
Marciniak SJ, Ron D (2006) Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149.
-
(2006)
Physiol Rev
, vol.86
, pp. 1133-1149
-
-
Marciniak, S.J.1
Ron, D.2
-
18
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
19
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
-
20
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, et al. (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313: 1137-1140.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
-
21
-
-
33747849846
-
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulumresident protein kinase IRE1
-
Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, et al. (2006) Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulumresident protein kinase IRE1. Cell Metab 4: 245-254.
-
(2006)
Cell Metab
, vol.4
, pp. 245-254
-
-
Lipson, K.L.1
Fonseca, S.G.2
Ishigaki, S.3
Nguyen, L.X.4
Foss, E.5
-
22
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK, Cnop M (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29: 42-61.
-
(2008)
Endocr Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
23
-
-
52949096557
-
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
-
Zhang X, Zhang G, Zhang H, Karin M, Bai H, et al. (2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135: 61-73.
-
(2008)
Cell
, vol.135
, pp. 61-73
-
-
Zhang, X.1
Zhang, G.2
Zhang, H.3
Karin, M.4
Bai, H.5
-
24
-
-
56749112559
-
Endoplasmic reticulum stress induces leptin resistance
-
Hosoi T, Sasaki M, Miyahara T, Hashimoto C, Matsuo S, et al. (2008) Endoplasmic reticulum stress induces leptin resistance. Mol Pharmacol 74: 1610-1619.
-
(2008)
Mol Pharmacol
, vol.74
, pp. 1610-1619
-
-
Hosoi, T.1
Sasaki, M.2
Miyahara, T.3
Hashimoto, C.4
Matsuo, S.5
-
25
-
-
57849115277
-
Endoplasmic reticulum stress plays a central role in development of leptin resistance
-
Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, et al. (2009) Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9: 35-51.
-
(2009)
Cell Metab
, vol.9
, pp. 35-51
-
-
Ozcan, L.1
Ergin, A.S.2
Lu, A.3
Chung, J.4
Sarkar, S.5
-
26
-
-
70349507353
-
Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin
-
(Silver Spring)
-
Won JC, Jang PG, Namkoong C, Koh EH, Kim SK, et al. (2009) Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin. Obesity (Silver Spring) 17: 1861-1865.
-
(2009)
Obesity
, vol.17
, pp. 1861-1865
-
-
Won, J.C.1
Jang, P.G.2
Namkoong, C.3
Koh, E.H.4
Kim, S.K.5
-
27
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350.
-
(2001)
N Engl J Med
, vol.344
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindstrom, J.2
Eriksson, J.G.3
Valle, T.T.4
Hamalainen, H.5
-
28
-
-
49649101838
-
Effect of supervised progressive resistance-exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes
-
Misra A, Alappan NK, Vikram NK, Goel K, Gupta N, et al. (2008) Effect of supervised progressive resistance-exercise training protocol on insulin sensitivity, glycemia, lipids, and body composition in Asian Indians with type 2 diabetes. Diabetes Care 31: 1282-1287.
-
(2008)
Diabetes Care
, vol.31
, pp. 1282-1287
-
-
Misra, A.1
Alappan, N.K.2
Vikram, N.K.3
Goel, K.4
Gupta, N.5
-
29
-
-
33750591273
-
Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats
-
Flores MB, Fernandes MF, Ropelle ER, Faria MC, Ueno M, et al. (2006) Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes 55: 2554-2561.
-
(2006)
Diabetes
, vol.55
, pp. 2554-2561
-
-
Flores, M.B.1
Fernandes, M.F.2
Ropelle, E.R.3
Faria, M.C.4
Ueno, M.5
-
31
-
-
77956827261
-
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition
-
doi:10.1371/journal.pbio.1000465
-
Ropelle ER, Flores MB, Cintra DE, Rocha GZ, Pauli JR, et al. (2010) IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKb and ER stress inhibition. PLoS Biol 8: doi:10.1371/journal.pbio.1000465.
-
(2010)
PLoS Biol
, vol.8
-
-
Ropelle, E.R.1
Flores, M.B.2
Cintra, D.E.3
Rocha, G.Z.4
Pauli, J.R.5
-
32
-
-
33750859187
-
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
-
Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, et al. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55: 2688-2697.
-
(2006)
Diabetes
, vol.55
, pp. 2688-2697
-
-
Carey, A.L.1
Steinberg, G.R.2
Macaulay, S.L.3
Thomas, W.G.4
Holmes, A.G.5
-
33
-
-
0036686906
-
Interleukin-6 release from the human brain during prolonged exercise
-
Nybo L, Nielsen B, Pedersen BK, Moller K, Secher NH (2002) Interleukin-6 release from the human brain during prolonged exercise. J Physiol 542: 991-995.
-
(2002)
J Physiol
, vol.542
, pp. 991-995
-
-
Nybo, L.1
Nielsen, B.2
Pedersen, B.K.3
Moller, K.4
Secher, N.H.5
-
34
-
-
42949146633
-
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
-
López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, et al. (2008) Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab 7: 389-399.
-
(2008)
Cell Metab
, vol.7
, pp. 389-399
-
-
López, M.1
Lage, R.2
Saha, A.K.3
Pérez-Tilve, D.4
Vázquez, M.J.5
|