메뉴 건너뛰기




Volumn 977, Issue 2, 2003, Pages 221-230

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats

Author keywords

Autoradiography; Brain to plasma ratio; Food intake; Iodo MT II

Indexed keywords

ANOREXIGENIC AGENT; HEPTAPEPTIDE; IODINE 125; IODO MELANOTAN 2; MELANOTAN 2; PROTEIN C FOS; UNCLASSIFIED DRUG;

EID: 0038169077     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02683-0     Document Type: Article
Times cited : (54)

References (35)
  • 1
    • 0031471301 scopus 로고    scopus 로고
    • Brain melanocortin receptors: From cloning to function
    • Adan R.A.H., Gispen W.H. Brain melanocortin receptors: from cloning to function. Peptides. 18:1997;1279-1287.
    • (1997) Peptides , vol.18 , pp. 1279-1287
    • Adan, R.A.H.1    Gispen, W.H.2
  • 2
    • 0032446713 scopus 로고    scopus 로고
    • The area postrema modulates hypothalamic fos responses to intragastric hypertonic saline in conscious rats
    • Carlson S.H., Collister J.P., Osborn J.W. The area postrema modulates hypothalamic fos responses to intragastric hypertonic saline in conscious rats. Am. J. Physiol. 275:1998;R1921-1927.
    • (1998) Am. J. Physiol. , vol.275 , pp. 1921-1927
    • Carlson, S.H.1    Collister, J.P.2    Osborn, J.W.3
  • 6
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 7
    • 0025393578 scopus 로고
    • Circumventricular structures: CNS sensors of circulating peptides and autonomic control
    • Ferguson A.V., Donevan S.D., Papas S., Smith P.M. Circumventricular structures: CNS sensors of circulating peptides and autonomic control. Endocrinol. Exp. 24:1990;19-27.
    • (1990) Endocrinol. Exp. , vol.24 , pp. 19-27
    • Ferguson, A.V.1    Donevan, S.D.2    Papas, S.3    Smith, P.M.4
  • 9
    • 0032400808 scopus 로고    scopus 로고
    • Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight
    • Grill H.J., Ginsberg A.B., Seeley R.J., Kaplan J.M. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J. Neurosci. 18:1998;10128-10135.
    • (1998) J. Neurosci. , vol.18 , pp. 10128-10135
    • Grill, H.J.1    Ginsberg, A.B.2    Seeley, R.J.3    Kaplan, J.M.4
  • 11
    • 0036515969 scopus 로고    scopus 로고
    • Chronic application of MT-II in a rat model of obesity results in sustained weight loss
    • Hamilton B.S., Doods H.N. Chronic application of MT-II in a rat model of obesity results in sustained weight loss. Obes. Res. 10:2002;182-186.
    • (2002) Obes. Res. , vol.10 , pp. 182-186
    • Hamilton, B.S.1    Doods, H.N.2
  • 12
    • 0029154516 scopus 로고
    • Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors
    • Hruby V.J., Lu D., Sharma S.D., Castrucci A.L., Kesterson R.A., al-Obeidi F.A., Hadley M.E., Cone R.D. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38:1995;3454-3461.
    • (1995) J. Med. Chem. , vol.38 , pp. 3454-3461
    • Hruby, V.J.1    Lu, D.2    Sharma, S.D.3    Castrucci, A.L.4    Kesterson, R.A.5    Al-Obeidi, F.A.6    Hadley, M.E.7    Cone, R.D.8
  • 13
    • 0343450068 scopus 로고    scopus 로고
    • Circumventricular organs
    • G. Adelman, & B.H. Smith. New York: Elsevier
    • Johnson A.K. Circumventricular organs. Adelman G., Smith B.H. Encyclopedia of Neuroscience. 1999;404-407 Elsevier, New York.
    • (1999) Encyclopedia of Neuroscience , pp. 404-407
    • Johnson, A.K.1
  • 15
    • 0345148807 scopus 로고    scopus 로고
    • Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain
    • Lindblom J., Schioth H.B., Larsson A., Wikberg J.E.S., Bergstrom L. Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810:1998;161-171.
    • (1998) Brain Res. , vol.810 , pp. 161-171
    • Lindblom, J.1    Schioth, H.B.2    Larsson, A.3    Wikberg, J.E.S.4    Bergstrom, L.5
  • 18
    • 0036424065 scopus 로고    scopus 로고
    • Determination of melanotan-II in rat plasma by liquid chromatography/tandem mass spectrometry: Determination of pharmacokinetic parameters in rat following intravenous administration
    • Mock S., Shen X., Tamvakopoulos C. Determination of melanotan-II in rat plasma by liquid chromatography/tandem mass spectrometry: determination of pharmacokinetic parameters in rat following intravenous administration. Rapid Commun. Mass Spectrom. 16:2002;2142-2147.
    • (2002) Rapid Commun. Mass Spectrom. , vol.16 , pp. 2142-2147
    • Mock, S.1    Shen, X.2    Tamvakopoulos, C.3
  • 19
    • 0028134706 scopus 로고
    • Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
    • Mountjoy K.G., Mortrud M.T., Low M.J., Simerly R.B., Cone R.D. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8:1994;1298-1308.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1298-1308
    • Mountjoy, K.G.1    Mortrud, M.T.2    Low, M.J.3    Simerly, R.B.4    Cone, R.D.5
  • 20
    • 0033926927 scopus 로고    scopus 로고
    • Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat
    • Murphy B., Nunes C.N., Ronan J.J., Hanaway M., Fairhurst A.M., Mellin T.N. Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat. J. Appl. Physiol. 89:2000;273-282.
    • (2000) J. Appl. Physiol. , vol.89 , pp. 273-282
    • Murphy, B.1    Nunes, C.N.2    Ronan, J.J.3    Hanaway, M.4    Fairhurst, A.M.5    Mellin, T.N.6
  • 22
    • 0036312394 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity
    • Pierroz D.D., Ziotopoulou M., Ungsunan L., Moschos S., Flier J.S., Mantzoros C.S. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes. 51:2002;1337-1345.
    • (2002) Diabetes , vol.51 , pp. 1337-1345
    • Pierroz, D.D.1    Ziotopoulou, M.2    Ungsunan, L.3    Moschos, S.4    Flier, J.S.5    Mantzoros, C.S.6
  • 23
    • 0006419450 scopus 로고    scopus 로고
    • Circumventricular organs of the brain
    • W.M. Pardridge. New York: Cambridge University Press
    • Prescott L., Brightman M.W. Circumventricular organs of the brain. Pardridge W.M. Introduction to the Blood-Brain Barrier. 1998;270-276 Cambridge University Press, New York.
    • (1998) Introduction to the Blood-Brain Barrier , pp. 270-276
    • Prescott, L.1    Brightman, M.W.2
  • 25
    • 0020634846 scopus 로고
    • Widespread presence of large molecular weight adrenocorticotropin-like substances in normal rat extrapituitary tissues
    • Saito E., Iwasa S., Odell W.D. Widespread presence of large molecular weight adrenocorticotropin-like substances in normal rat extrapituitary tissues. Endocrinology. 113:1983;1010-1018.
    • (1983) Endocrinology , vol.113 , pp. 1010-1018
    • Saito, E.1    Iwasa, S.2    Odell, W.D.3
  • 26
    • 0021921907 scopus 로고
    • The central neural connections of the area postrema of the rat
    • Shapiro R.E., Miselis R.R. The central neural connections of the area postrema of the rat. J. Comp. Neurol. 234:1985;344-364.
    • (1985) J. Comp. Neurol. , vol.234 , pp. 344-364
    • Shapiro, R.E.1    Miselis, R.R.2
  • 27
    • 0025602491 scopus 로고
    • Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and α-melanocyte stimulating hormone
    • Tatro J.B. Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and α-melanocyte stimulating hormone. Brain Res. 536:1990;124-132.
    • (1990) Brain Res. , vol.536 , pp. 124-132
    • Tatro, J.B.1
  • 28
    • 0023606861 scopus 로고
    • Specific receptors for alpha-melanocyte-stimulating hormone are widely distributed in tissues of rodents
    • Tatro J.B., Reichlin S. Specific receptors for alpha-melanocyte-stimulating hormone are widely distributed in tissues of rodents. Endocrinology. 121:1987;1900-1907.
    • (1987) Endocrinology , vol.121 , pp. 1900-1907
    • Tatro, J.B.1    Reichlin, S.2
  • 31
    • 0034730442 scopus 로고    scopus 로고
    • Role of melanocortins in the central control of feeding
    • Vegoni A.V., Bertolini A. Role of melanocortins in the central control of feeding. Eur. J. Pharmacol. 405:2000;25-32.
    • (2000) Eur. J. Pharmacol. , vol.405 , pp. 25-32
    • Vegoni, A.V.1    Bertolini, A.2
  • 32
    • 0029078140 scopus 로고
    • Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats
    • Wen Y.-D., Remmel R.P., Pham P.T., Vince R., Zimmerman C.L. Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats. Pharm. Res. 12:1995;911-915.
    • (1995) Pharm. Res. , vol.12 , pp. 911-915
    • Wen, Y.-D.1    Remmel, R.P.2    Pham, P.T.3    Vince, R.4    Zimmerman, C.L.5
  • 33
    • 0035130527 scopus 로고    scopus 로고
    • Paraventricular hypothalamic a-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects
    • Wirth M.M., Olszewski P.K., Yu C., Levine A.S., Giraudo S.Q. Paraventricular hypothalamic a-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects. Peptides. 22:2001;129-134.
    • (2001) Peptides , vol.22 , pp. 129-134
    • Wirth, M.M.1    Olszewski, P.K.2    Yu, C.3    Levine, A.S.4    Giraudo, S.Q.5
  • 35
    • 0025732250 scopus 로고
    • Blood content in guinea-pig tissues: Correlation for the study of drug tissue distribution
    • Yu H.-T., Chiu Y.-W., Liu H.-H., Chang T.-C., Shen Y.-Z. Blood content in guinea-pig tissues: correlation for the study of drug tissue distribution. Pharmacol. Res. 23:1991;337-347.
    • (1991) Pharmacol. Res. , vol.23 , pp. 337-347
    • Yu, H.-T.1    Chiu, Y.-W.2    Liu, H.-H.3    Chang, T.-C.4    Shen, Y.-Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.