메뉴 건너뛰기




Volumn 51, Issue 11, 2002, Pages 3211-3219

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; FAT; GLUCOSE; INSULIN; PALMITIC ACID; PROTON; UNCOUPLING PROTEIN 2;

EID: 0036829870     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.11.3211     Document Type: Article
Times cited : (193)

References (47)
  • 2
    • 0025300438 scopus 로고
    • Properties and functions of ATP-sensitive K-channels
    • Ashcroft SJ, Ashcroft FM: Properties and functions of ATP-sensitive K-channels. Cell Signal 2:197-214, 1990
    • (1990) Cell Signal , vol.2 , pp. 197-214
    • Ashcroft, S.J.1    Ashcroft, F.M.2
  • 3
    • 0032901360 scopus 로고    scopus 로고
    • Structure and function of the uncoupling protein from brown adipose tissue
    • Klingenberg M, Huang SG: Structure and function of the uncoupling protein from brown adipose tissue. Biochim Biophys Acta 1415:271-296, 1999
    • (1999) Biochim Biophys Acta , vol.1415 , pp. 271-296
    • Klingenberg, M.1    Huang, S.G.2
  • 4
    • 0035852755 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)
    • Echtay KS, Winkler E, Frischmuth K, Klingenberg M: Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci U S A 98:1416-1421, 2001
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1416-1421
    • Echtay, K.S.1    Winkler, E.2    Frischmuth, K.3    Klingenberg, M.4
  • 5
    • 0032991716 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
    • Chan CB, MacDonald PE, Saleh MC, Johns DC, Marban E, Wheeler MB: Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48:1482-1486, 1999
    • (1999) Diabetes , vol.48 , pp. 1482-1486
    • Chan, C.B.1    MacDonald, P.E.2    Saleh, M.C.3    Johns, D.C.4    Marban, E.5    Wheeler, M.B.6
  • 6
    • 0034735799 scopus 로고    scopus 로고
    • Coenzyme Q is an obligatory cofactor for uncoupling protein function
    • Echtay KS, Winkler E, Klingenberg M: Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408:609-613, 2000
    • (2000) Nature , vol.408 , pp. 609-613
    • Echtay, K.S.1    Winkler, E.2    Klingenberg, M.3
  • 10
    • 0035078830 scopus 로고    scopus 로고
    • Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
    • Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F: Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50:803-809, 2001
    • (2001) Diabetes , vol.50 , pp. 803-809
    • Lameloise, N.1    Muzzin, P.2    Prentki, M.3    Assimacopoulos-Jeannet, F.4
  • 11
    • 0032929816 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function
    • Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH: Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function. Diabetes 48:1020-1025, 1999
    • (1999) Diabetes , vol.48 , pp. 1020-1025
    • Wang, M.Y.1    Shimabukuro, M.2    Lee, Y.3    Trinh, K.Y.4    Chen, J.L.5    Newgard, C.B.6    Unger, R.H.7
  • 13
    • 0026775070 scopus 로고
    • Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene
    • Brubaker PL, Lee YC, Drucker DJ: Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene. J Biol Chem 267: 20728-20733, 1992
    • (1992) J Biol Chem , vol.267 , pp. 20728-20733
    • Brubaker, P.L.1    Lee, Y.C.2    Drucker, D.J.3
  • 14
    • 0024393902 scopus 로고
    • Tissue-specific differences in the levels of proglucagon-derived peptides in streptozotocin-induced diabetes
    • Brubaker PL, So DCY, Drucker DJ: Tissue-specific differences in the levels of proglucagon-derived peptides in streptozotocin-induced diabetes. Endocrinology 124:3003-3009, 1989
    • (1989) Endocrinology , vol.124 , pp. 3003-3009
    • Brubaker, P.L.1    So, D.C.Y.2    Drucker, D.J.3
  • 15
  • 16
  • 18
    • 0026093003 scopus 로고
    • The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells
    • Drucker DJ, Campos R, Reynolds R, Stobie K, Brubaker PL: The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells. Endocrinology 128:394-400, 1991
    • (1991) Endocrinology , vol.128 , pp. 394-400
    • Drucker, D.J.1    Campos, R.2    Reynolds, R.3    Stobie, K.4    Brubaker, P.L.5
  • 19
    • 0037059772 scopus 로고    scopus 로고
    • Control of insulin mRNA stability in rat pancreatic islets: Regulatory role of a 3′-untranslated region pyrimidine-rich sequence
    • Tillmar L, Carlsson C, Welsh N: Control of insulin mRNA stability in rat pancreatic islets: Regulatory role of a 3′-untranslated region pyrimidine-rich sequence. J Biol Chem 277:1099-1106, 2002
    • (2002) J Biol Chem , vol.277 , pp. 1099-1106
    • Tillmar, L.1    Carlsson, C.2    Welsh, N.3
  • 20
    • 0033305516 scopus 로고    scopus 로고
    • Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
    • Carlsson C, Borg LA, Welsh N: Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140:3422-3428, 1999
    • (1999) Endocrinology , vol.140 , pp. 3422-3428
    • Carlsson, C.1    Borg, L.A.2    Welsh, N.3
  • 22
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel AR: New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104:517-529, 2001
    • (2001) Cell , vol.104 , pp. 517-529
    • Saltiel, A.R.1
  • 23
    • 0027953703 scopus 로고
    • Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn CR: Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084, 1994
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 24
    • 0031016595 scopus 로고    scopus 로고
    • Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice
    • Ahren B, Simonsson E, Scheurink AJ, Mulder H, Myrsen U, Sundler F: Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice. Metabolism 46:97-106, 1997
    • (1997) Metabolism , vol.46 , pp. 97-106
    • Ahren, B.1    Simonsson, E.2    Scheurink, A.J.3    Mulder, H.4    Myrsen, U.5    Sundler, F.6
  • 25
    • 0029665527 scopus 로고    scopus 로고
    • High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat
    • Akiyama T, Tachibana I, Shirohara H, Watanabe N, Otsuki M: High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diabetes Res Clin Pract 31:27-35, 1996
    • (1996) Diabetes Res Clin Pract , vol.31 , pp. 27-35
    • Akiyama, T.1    Tachibana, I.2    Shirohara, H.3    Watanabe, N.4    Otsuki, M.5
  • 26
    • 0031786715 scopus 로고    scopus 로고
    • Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice
    • Ahren B, Scheurink AJ: Marked hyperleptinemia after high-fat diet associated with severe glucose intolerance in mice. Eur J Endocrinol 139:461-467, 1998
    • (1998) Eur J Endocrinol , vol.139 , pp. 461-467
    • Ahren, B.1    Scheurink, A.J.2
  • 28
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou YP, Grill V: Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584-1590, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 29
    • 0032030866 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
    • Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ: Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101:1094-1101, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1094-1101
    • Bollheimer, L.C.1    Skelly, R.H.2    Chester, M.W.3    McGarry, J.D.4    Rhodes, C.J.5
  • 30
    • 0032522368 scopus 로고    scopus 로고
    • A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties
    • Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ: A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 331:553-561, 1998
    • (1998) Biochem J , vol.331 , pp. 553-561
    • Skelly, R.H.1    Bollheimer, L.C.2    Wicksteed, B.L.3    Corkey, B.E.4    Rhodes, C.J.5
  • 32
    • 0024508097 scopus 로고
    • Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion
    • Bonner-Weir S, Deery D, Leahy JL, Weir GC: Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion. Diabetes 38:49-53, 1989
    • (1989) Diabetes , vol.38 , pp. 49-53
    • Bonner-Weir, S.1    Deery, D.2    Leahy, J.L.3    Weir, G.C.4
  • 34
    • 0021225459 scopus 로고
    • Effect of genetic background on the capacity for islet cell replication in mice
    • Swenne I, Andersson A: Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27:464-467, 1984
    • (1984) Diabetologia , vol.27 , pp. 464-467
    • Swenne, I.1    Andersson, A.2
  • 36
    • 0034042959 scopus 로고    scopus 로고
    • Islet growth and development in the adult
    • Bonner-Weir S: Islet growth and development in the adult. J Mol Endocrinol 24:297-302, 2000
    • (2000) J Mol Endocrinol , vol.24 , pp. 297-302
    • Bonner-Weir, S.1
  • 37
    • 0015846079 scopus 로고
    • Beta cell replication in rat pancreatic monolayer cultures: Effects of glucose, tolbutamide, glucocorticoid, growth hormone and glucagon
    • Chick WL: Beta cell replication in rat pancreatic monolayer cultures: Effects of glucose, tolbutamide, glucocorticoid, growth hormone and glucagon. Diabetes 22:687-693, 1973
    • (1973) Diabetes , vol.22 , pp. 687-693
    • Chick, W.L.1
  • 39
    • 0031019883 scopus 로고    scopus 로고
    • Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1
    • Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M: Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1. J Biol Chem 272:1659-1664, 1997
    • (1997) J Biol Chem , vol.272 , pp. 1659-1664
    • Assimacopoulos-Jeannet, F.1    Thumelin, S.2    Roche, E.3    Esser, V.4    McGarry, J.D.5    Prentki, M.6
  • 40
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications
    • Unger RH: Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications. Diabetes 44: 863-870, 1995
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 41
    • 0034680797 scopus 로고    scopus 로고
    • Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta-cell
    • Roduit R, Morin J, Masse F, Segall L, Roche E, Newgard CB, Assimacopoulos-Jeannet F, Prentki M: Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta-cell. J Biol Chem 275:35799-35806, 2000
    • (2000) J Biol Chem , vol.275 , pp. 35799-35806
    • Roduit, R.1    Morin, J.2    Masse, F.3    Segall, L.4    Roche, E.5    Newgard, C.B.6    Assimacopoulos-Jeannet, F.7    Prentki, M.8
  • 42
    • 0030029605 scopus 로고    scopus 로고
    • Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
    • Prentki M, Corkey BE: Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45:273-283, 1996
    • (1996) Diabetes , vol.45 , pp. 273-283
    • Prentki, M.1    Corkey, B.E.2
  • 43
    • 0036318123 scopus 로고    scopus 로고
    • Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats
    • Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V: Differential effects of hyperlipidemia on insulin secretion in islets of Langerhans from hyperglycemic versus normoglycemic rats. Diabetes 51:662-668, 2002
    • (2002) Diabetes , vol.51 , pp. 662-668
    • Briaud, I.1    Kelpe, C.L.2    Johnson, L.M.3    Tran, P.O.4    Poitout, V.5
  • 44
    • 0033969421 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3. Potential regulators of mitochondrial energy metabolism
    • Boss O, Hagen T, Lowell BB: Uncoupling proteins 2 and 3. Potential regulators of mitochondrial energy metabolism. Diabetes 49:143-156, 2000
    • (2000) Diabetes , vol.49 , pp. 143-156
    • Boss, O.1    Hagen, T.2    Lowell, B.B.3
  • 46
    • 0035125917 scopus 로고    scopus 로고
    • Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover
    • Unger RH, Zhou YT: Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover. Diabetes 50 (Suppl. 1): S118-S121, 2001
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Unger, R.H.1    Zhou, Y.T.2
  • 47
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M, Zhou YT, Levi M, Unger RH: Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes. Proc Natl Acad Sci U S A 95:2498-2502, 1998
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.