Hypothalamic AMP-activated protein kinase mediates counter-regulatory responses to hypoglycaemia in rats

Diabetologia

Volumn 48, Issue 10, 2005, Pages 2170-2178

  Han, S M ^a   Namkoong, C ^a   Jang, P G ^a   Park, I S ^b   Hong, S W ^b   Katakami, H ^c   Chun, S ^a   Kim, S W ^a   Park, J Y ^a   Lee, K U ^a   Kim, M S ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Inha University School of Medicine   (South Korea)

^c UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

AMP activated protein kinase; Catecholamines; Corticosterone; Counter regulatory response; Glucagon; Hypoglycaemia; Hypothalamus; Neuroendocrine; Paraventricular nucleus; Ventromedial hypothalamus

Indexed keywords

CATECHOLAMINE; CORTICOSTERONE; GLUCAGON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; GENE OVEREXPRESSION; GLUCAGON BLOOD LEVEL; HORMONE RESPONSE; HYPOGLYCEMIA; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; ZONA INCERTA;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; ENZYME INHIBITORS; GENETIC VECTORS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; INSULIN; MALE; MULTIENZYME COMPLEXES; NEUROSECRETORY SYSTEMS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 26244461692     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1913-1     Document Type: Article

References (33)

1. Cryer PE (1981) Glucose counterregulation in man. Diabetes 30:261-264
2. Biggers DW, Myers SR, Neal D et al (1989) Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 3:7-16
3. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI (1995) Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184
4. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI (1997) Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-365
5. Hardie DG, Carling D, Carlson M (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855
6. Rutter GA, da Silva Xavier G, Leclerc I (2003) Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homeostasis. Biochem J 375:1-16
7. Mu J, Brozinick JT Jr, Valladares O, Bucan M, Birnbaum MJ (2001) A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 7:1085-1094
8. Henin N, Vincent MF, Gruber HE, Van den Berghe G (1995) Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J 9:541-546
9. da Silva Xavier G, Leclerc I, Salt IP et al (2000) Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci U S A 97:4023-4028
10. Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE, Bartlett PF (1999) Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem 72:1707-1716
11. Kim MS, Park JY, Namkoong C et al (2004) Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10:727-733
12. Minokoshi Y, Alquier T, Furukawa N et al (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-574
13. Kim MS, Small CJ, Stanley SA et al (2000) The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 105:1005-1011
14. Stein SC, Woods A, Jones NA, Davison MD, Carling D (2000) The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 345:437-443
15. Mu J, Barton ER, Birnbaum MJ (2003) Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'. Biochem Soc Trans 31:236-241
16. Mercer EH, Hoyle GW, Kapur RP, Brinster RL, Palmiter RD (1991) The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron 7:703-716
17. Obici S, Feng Z, Arduini A, Conti R, Rossetti L (2003) Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 9:756-761
18. Paxinos G, Watson C (1997) The rat brain in stereotaxic coordinates, 2nd edn. Academic, San Diego, CA, p. 25-31 plates
19. Davies SP, Carling D, Hardie DG (1989) Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur J Biochem 186:123-128
20. Kim MS, Yoon CY, Jang PG et al (2004) The mitogenic and anti-apoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 18:2291-2301
21. Silver IA, Erecinska M (1994) Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 14:5068-5076
22. Perrin C, Knauf C, Burcelin R (2004) Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis. Endocrinology 145:4025-4033
23. Namkoong C, Kim MS, Jang PG et al (2005) Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes 54:63-68
24. McCrimmon RJ, Fan X, Ding Y, Zhu W, Jacob RJ, Sherwin RS (2004) Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus. Diabetes 53:1953-1958
25. Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI (1994) Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 93:1677-1682
26. Niimi M, Sato M, Tamaki M, Wada Y, Takahara J, Kawanishi K (1995) Induction of Fos protein in the rat hypothalamus elicited by insulin-induced hypoglycemia. Neurosci Res 23:361-364
27. Herman JP, Cullinan WE (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 20:78-84
28. Hosoya Y, Sugiura Y, Okado N, Loewy AD, Kohno K (1991) Descending input from the hypothalamic paraventricular nucleus to sympathetic preganglionic neurons in the rat. Exp Brain Res 85:10-20
29. Cryer PE (2001) Hypoglycemia-associated autonomic failure in diabetes. Am J Physiol Endocrinol Metab 281:E1115-E1121
30. Evans SB, Wilkinson CW, Bentson K, Gronbeck P, Zavosh A, Figlewicz DP (2001) PVN activation is suppressed by repeated hypoglycemia but not antecedent corticosterone in the rat. Am J Physiol Regul Integr Comp Physiol 281:R1426-R1436
31. Ritter S, Dinh TT, Zhang Y (2000) Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856:37-47
32. + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes 53:2542-2551
33. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 4:507-512