Retraction: Central exercise action increases the ampk and mtor response to leptin (PLoS ONE (2017 )3: 12 (e3856) DOI: 10.1371/journal.pone.0003856);Central exercise action increases the AMPK and mTOR response to leptin

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Ropelle, Eduardo R ^a   Fernandes, Maria Fernanda A ^a   Flores, Marcelo B S ^a   Ueno, Mirian ^a   Rocco, Silvana ^a   Marin, Rodrigo ^a   Cintra, Dennys E ^a   Velloso, Lício A ^a   Franchini, Kleber G ^a   Saad, Mario J A ^a   Carvalheira, José B C ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 6; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CONTROLLED STUDY; DECREASED APPETITE; EXERCISE; FOOD INTAKE; HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WISTAR RAT; ANIMAL; EATING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALIA; RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; EATING; HYPOTHALAMUS; INTERLEUKIN-6; LEPTIN; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; PROTEIN KINASES; RATS; SIGNAL TRANSDUCTION;

EID: 57349093501     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0190765     Document Type: Erratum

References (68)

1. Richard D, Lachance P, Deshaies Y (1989) Effects of exercise-rest cycles on energy balance in rats. Am J Physiol 256: R886-891.
2. Richard D, Rivest S (1989) The role of exercise in thermogunesis and energy balance. Can J Physiol Pharmacol 67: 402-409.
3. Rivest S, Richard D (1990) Involvement of corticotropin-releasing factor in the anorexia induced by exercise. Brain Res Bull 25: 169-172.
4. Wing RR, Hill JO (2001) Successful weight loss maintenance. Annu Rev Nutr 21: 323-341.
5. Flores MB, Fernandes MF, Ropelle ER, Faria MC, Ueno M, et al. (2006) Exercise improves insulin and leptin sensitivity in hypothalamus of Wistar rats. Diabetes 55: 2554-2561.
6. Shapiro A, Matherry M, Mang Y, Tumer N, Cheng KY, et al. (2008) Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats. Diabetes 57: 614-622.
7. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, et al. (1999) Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. Jama 282: 1568-1575.
8. Van Heek M, Compton DS, France CF, Tedesco RP, Fawzi AB, et al. (1997) Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 99: 385-390.
9. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DC (2000) Central nervous system control of food intake. Nature 404: 661-671.
10. Gao S, Kinzig KP, Aja S, Scott KA, Keung W, et al. (2007) Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A 104: 17358-17363.
11. Kahn BB, Alquier T, Carling D, Hardie DG (2005) AMP-activated protein kinase: ancient energy gauge provides dues to modern understanding of metabolism. Cell Metab 1: 15-25.
12. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, et al. (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428: 569-574.
13. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, et al. (2006) Hypothalamic mTOR signaling regulates food intake. Science 312: 927-930.
14. Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, et al. (1997) Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277: 99-101.
15. Ropelle ER, Pauli JR, Fernandes MF, Rocco SA, Marin RM, et al. (2008) A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57: 594-605.
16. Shamji AF, Nghiem P, Schreiber SL (2003) Integration of growth factor and nutrient signaling: implications for cancer biology. Mol Cell 12: 271-280.
17. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, et al. (2001) Mammalian TOR: a homeostatic ATP sensor. Science 294: 1102-1105.
18. Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4: 648-657.
19. Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, et al. (2003) A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 8: 65-79.
20. Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ (2007) The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. J Biol Chem 282: 10341-10351.
21. Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, et al. (2003) Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil 24: 113-119.
22. Penkowa M, Keller C, Keller P, Jauffred S, Pedersen BK (2003) Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise. Faseb J 17: 2166-2168.
23. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, et al. (2000) Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529 Pt 1: 237-242.
24. Keller C, Keller P, Marshal S, Pedersen BK (2003) IL-6 gene expression in human adipose tissue in response to exercise-effect of carbohydrate ingestion. J Physiol 550: 927-931.
25. Lyngso D, Simonsen L, Bulow J (2002) Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J PhyBiol 543: 379-386.
26. Ruderman NB, Keller C, Richard AM, Saba AK, Luo Z, et al. (2006) Interleukin-6 Regulation of AMP-Activated Protein Kinase: Potential Role in the Systemic Response to Exercise and Prevention of the Metabolic Syndrome. Diabetes 55 Suppl 2: S48-54.
27. Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, et al. (2004) AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commum 320: 449-454.
28. Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, et al. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8: 75-79.
29. Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, et al. (1994) Association of transcription factor APRF and protein kinase Jakl with the interleukin-6 signal transducer gp130. Science 263: 89-92.
30. Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, et al. (1993) IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science 260: 1808-1810.
31. Narazaki M, Witthuhn BA, Yoshida K , Sivennoinen O, Yasukawa K, et al. (1994) Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci U S A 91: 2285-2289.
32. Sadowski HB, Shuai K, Darnell JE Jr, Gilman MZ (1993) A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 261: 1739-1744.
33. Chen RH, Chang MC, Su YH, Tsai YT, Kuo ML (1999) Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 274: 23013-23019.
34. Kim EK, Miller I, Aja S, Landree LE, Pinn M, et al. (2004) C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 279: 19970-19976.
35. Bi S, Scott KA, Hyun J, Ladenheim EE, Moran TH (2005) Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling. Endocrinology 146: 1676-1685.
36. Bruce CR, Lee JS, Kiens B, Hawley JA (2004) Postexercise muscle triacylglycerol and glycogen metabolism in obese insulin-resistant zucker rats. Obes Res 12: 1158-1165.
37. Martins C, Robertson MD, Morgan LM (2008) Effects of exercise and restrained eating behaviour on appetite control. Proc Nutr Soc 67: 28-41.
38. Martins C, Truby H, Morgan LM (2007) Short-term appetite control in response to a 6-week exercise programme in sedentary volunteers. Br J Nutr 98: 834-842.
39. Santti E, Huupponen R, Rouru J, Hanninen V, Pesonen U, et al. (1994) Potentiatin of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise. Br J Pharmacol 113: 1231-1236.
40. Daval M, Foufelle F, Ferre P (2006) Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574: 55-62.
41. Long YC, Zierath JR (2006) AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116: 1776-1783.
42. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, et al. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339-343.
43. Andersson U, Treebak JT, Nielsen JN, Smith KL, Abbott CR, et al. (2005) Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity. Biochem Biophys Res Common 329: 719-725.
44. Carling D (2004) The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem Sci 29: 18-24.
45. Hardie DG, Scott JW, Pan DA, Hudson ER (2003) Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546: 113-120.
46. Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson JO (2002) Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem Biophys Res Common 293: 560-565.
47. Boulton TG, Stahl N, Yancopoulos GD (1994) Ciliary neurotrophic factor/ leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J Biol Chem 269: 11648-11655.
48. Al-Khalili L, Bouzakri K, Glund S, Lonnqvist F, Koistinen HA, et al. (2006) Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol Endocrinol 20: 3364-3375.
49. Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, et al. (2004) Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem 279: 23942-23952.
50. Weigert C, Hennige AM, Brodbeck K, Haring HU, Schleicher ED (2005) Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am J Physiol Endocrinol Metab 289: E251-257.
51. Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, et al. (2006) Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem 281: 7060-7067.
52. Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, et al. (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55: 2688-2697.
53. Reznick RM, Zong H, Li J, Morino K, Moore IK, et al. (2007) Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab 5: 151-156.
54. Stouthard JM, Romijn JA, Van der Poll T, Endert E, Klein S, et al. (1995) Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol 263: E813-819.
55. Rothwell NJ, Busbridge NJ, Lefeuvre RA, Hardwick AJ, Gauldie J, et al. (1991) Interleukin-6 is a centrally acting endogenous pyrogen in the rat. Can J Physiol Pharmacol 69: 1465-1469.
56. Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis CS, Kyrou I, et al. (1997) Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure. Neuroendocrinology 66: 54-62.
57. Li G, Klein RL, Matheny M, King MA, Meyer EM, et al. (2002) Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience 115: 879-889.
58. Nybo L, Nielsen B, Pedersen BY, Moller K, Secher NH (2002) Interleukin-6 release from the human brain during prolonged exercise. J Physiol 542: 991-995.
59. Febbraio MA, Pedersen BK (2002) Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. Faseb J 16: 1335-1347.
60. Pedersen BK, Hoffman-Goetz L (2000) Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80: 1055-1081.
61. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, et al. (2006) Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 281: 18933-18941.
62. Scott AM, Atwater I, Rojas E (1981) A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 21: 470-475.
63. Pauli JR, Ropelle ER, Cintra DE, Carvalho-Filho MA, Moraes JC, et al. (2008) Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats. J Physiol 586: 659-671.
64. Carvalheira JB, Siloto RM, Ignacchitti I, Brenelli SL, Carvalho CR, et al. (2001) Insulin modulates leptin-incluced STAT3 activation in rat hypothalamus. FEBS Lett 500: 119-124.
65. Ropelle ER, Pauli JR, Prada PO, de Souza CT, Picardi PK, et al. (2006) Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTPIB and IRS-1 serine phosphorylation. J Physiol 577: 997-1007.
66. Carvalheira JB, Ribeiro EB, Araujo EP, Guimaraes, RB, Telles MM, et al. (2003) Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats. Diabetologia 46: 1629-1640.
67. Araujo EP, Amaral ME, Souza CT, Bordin S, Ferreira F, et al. (2002) Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. FEBS Lett 531: 437-442.
68. Mai JK, Assheuer J, Paxinos G (1997) Atlas of the human brain. San Diego; London: Academic. pp viii, 336.