Structure activity studies of the melanocortin-4 receptor by in vitro mutagenesis: Identification of agouti-related protein (AGRP), melanocortin agonist and synthetic peptide antagonist interaction determinants

Biochemistry

Volumn 40, Issue 20, 2001, Pages 6164-6179

  Haskell Luevano, Carrie ^a   Cone, Roger D ^b   Monck, Eileen K ^a   Wan, Y P ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c NEN Life Science Products   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; MUTAGENESIS; PROTEINS; STEREOCHEMISTRY;

PHARMACOLOGY;

BIOCHEMISTRY;

AGOUTI RELATED PROTEIN; AGOUTI RELATED PROTEIN[109-118]; AGOUTI RELATED PROTEIN[83-132]; ALPHA INTERMEDIN; ARGININE; ASPARTIC ACID; GLUTAMINE; INTERMEDIN DERIVATIVE; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN DERIVATIVE; METHIONINE; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANIN10 LYSINAMIDE]; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; PHENYLALANINE; RECEPTOR BLOCKING AGENT; SHU 9005; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALPHA-MSH; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LYSINE; MELANOCYTE-STIMULATING HORMONES; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PEPTIDES; PHENYLALANINE; PROTEIN BINDING; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; RECEPTORS, PEPTIDE; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035918601     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi010025q     Document Type: Article

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