Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses

PLoS Computational Biology

Volumn 6, Issue 6, 2010, Pages 1-12

  Kriete, Andres ^a   Bosl, William J ^b   Booker, Glenn ^a,c  

^a DREXEL UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Drexel University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; FEEDBACK; METABOLISM; SENSITIVITY ANALYSIS;

ADAPTIVE RESPONSE; CELL SYSTEM; FEEDBACK LOOPS; LOOP MOTIFS; NEGATIVE FEEDBACK LOOP; POSITIVE FEEDBACK LOOP; RESPONSE MODEL; RULE BASED; STRESSES RESPONSE; SYSTEM MODELS;

FUZZY LOGIC;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; ADENOSINE TRIPHOSPHATE; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE;

AGING; ARTICLE; AUTOPHAGY; CELL METABOLISM; CELL SURVIVAL; CONCEPTUAL FRAMEWORK; ENERGY METABOLISM; FEEDBACK SYSTEM; LIFESPAN; MITOCHONDRIAL RESPIRATION; NEGATIVE FEEDBACK; POSITIVE FEEDBACK; SIMULATION; STRESS; ANIMAL; BIOLOGICAL MODEL; CELL AGING; COMPUTER SIMULATION; FUZZY LOGIC; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SYSTEMS BIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL AGING; COMPUTER SIMULATION; ENERGY METABOLISM; FEEDBACK, PHYSIOLOGICAL; FUZZY LOGIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; STRESS, PHYSIOLOGICAL; SYSTEMS BIOLOGY;

EID: 77955476576     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000820     Document Type: Article

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