Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress

Experimental Gerontology

Volumn 36, Issue 3, 2001, Pages 475-486

  Sitte, N ^a   Merker, K ^a   Grune, T ^a   Von Zglinicki, T ^b,c  

^a HUMBOLDT UNIVERSITY   (Germany)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

Ageing; Fibroblasts; Lipofuscin; Oxidative stress; Proteolysis; Senescence; Telomeres

Indexed keywords

LIPOFUSCIN;

AGING; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; LIFESPAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENESCENCE; TELOMERE;

BIOLOGICAL MARKERS; CELL CYCLE; CELL DIVISION; CELL LINE; FIBROBLASTS; HUMANS; LIPID PEROXIDES; LIPOFUSCIN; OXIDATIVE STRESS; TELOMERE; TIME FACTORS;

EID: 0035092972     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00253-9     Document Type: Article

References (37)

1. Oxidants, antioxidants, and the degenerative diseases of ageing
2. The potential intermediate role of lysosomes in oxygen free radical pathology
3. A novel hypothesis of lipofuscinogenesis and cellular ageing based on interactions between oxidative stress and autophagocytosis
4. The MRC-5 human embryonal lung fibroblast two-dimensional gel cellular protein database: quantitative identification of polypeptides whose relative abundance differs between quiescent, proliferating and SV40 transformed cells
5. Retinal age pigments generated by self-assembling lysosomotropic detergents
6. Lipofuscin-induced autofluorescence of living neonatal rat cardiomyocytes
7. Degradation of oxidized proteins in mammalian cells
8. The waste-product theory of aging: waste dilution by cell division
9. The waste-product theory of aging: cell division rate as a function of waste volume
10. Inhibition of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain
11. Leupeptin causes an accumulation of lipofuscin-like substances in liver cells of young rats
12. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons
13. Mechanisms of lipofuscinogenesis: effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells
14. Age-related changes in the lipofuscin accumulation of brain and heart
15. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
16. Autofluorescence of human skin fibroblasts during growth inhibition and in vitro ageing
17. Autofluorescence as an index of ageing in human fibroblasts in culture
18. The ageing, growth and death of cells
19. Accelerated telomere shortening in fibroblasts after extended periods of confluency
20. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts
21. Microarray analysis of replicative senescence
22. Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
23. Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
24. Protein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part I - Effects of proliferative senescence
25. Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes - a novel in vitro model of lipofuscinogenesis
26. Oxidative stress, caloric restriction, and aging
27. On the histochemistry and ultrastructure of age pigment
28. Age-related macular degeneration: The lipofuscin component n-retinyl-n-retinylidene ethanolamide detaches pro-apoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells
29. Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
30. Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis
31. On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes
32. Intracellular interactions under oxidative stress and ageing
33. Lipofuscin accumulation and ageing of fibroblasts
34. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
35. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
36. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible prognostic factor?