Mitochondrial membrane potential and aging

Aging Cell

Volumn 3, Issue 1, 2004, Pages 35-40

  Nicholls, David G ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Membrane potential; Mitochondrion; Oxidative stress; Protonmotive force; Superoxide; Uncoupling

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTON; REACTIVE OXYGEN METABOLITE; PROTON PUMP;

AGING; BIOENERGY; CELL RESPIRATION; ELECTRON TRANSPORT; ENZYME SYNTHESIS; MEMBRANE POTENTIAL; METABOLIC REGULATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON MOTIVE FORCE; RESPIRATION CONTROL; RESPIRATORY CHAIN; REVIEW; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE POTENTIAL; MITOCHONDRION; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTON PUMPS; PROTON-MOTIVE FORCE;

EID: 4544264062     PISSN: 14749718     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-9728.2003.00079.x     Document Type: Review

References (32)

1. Brand MD, Brindle KM, Buckingham JA, Harper JA, Rolfe DFS, Stuart JA (1999) The significance and mechanism of mitochondrial proton conductance. Int. J. Obes. 23, S4-S11.
2. Brand MD, Chien LF, Ainscow EK, Rolfe DF, Porter RK (1994) The causes and functions of mitochondrial proton leak. Biochim. Biophys. Acta 1187, 132-139.
3. Cavazzoni M, Barogi S, Baracca A, Castelli GP, Lenaz G (1999) The effect of aging and an oxidative stress on peroxide levels and the mitochondrial membrane potential in isolated rat hepatocytes. FEBS Lett. 449, 53-56.
4. Ferlini C, Scambia G, Fattorossi A (1998) Is chloromethyl-X-rosamine useful in measuring mitochondrial transmembrane potential? Cytometry 31, 74-75.
5. Gilmore K, Wilson M (1999) The use of chloromethyl-X-rosamine (Mitotracker red) to measure loss of mitochondrial membrane potential in apoptotic cells is incompatible with cell fixation. Cytometry 36 355-358.
6. Hafner RP, Brown GC, Brand MD (1990) Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and proton-motive force in isolated mitochondria using the 'top-down' approach of metabolic control theory. Eur. J. Biochem. 188, 313-319.
7. Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu JK, Wehr CM, Vinarsky V, Bartholomew JC, Ames BN (1999) (R.)-α-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 13, 411-418.
8. Hagen TM, Ingersoll RT, Wehr CM, Lykkesfeldt J, Vinarsky V, Bartholomew JC, Song MH, Ames BN (1998a) Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc. Natl Acad. Sci. USA 95, 9562-9566.
9. Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN (2002) Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc. Natl Acad. Sci. USA 99, 1870-1875.
10. Hagen TM, Wehr CM, Ames BN (1998b) Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tertbutyl-alpha-phenyl-nitrone. Ann. NY Acad. Sci. 854, 214-223.
11. Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, Ames BN (1997) Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc. Natl Acad. Sci. USA 94, 3064-3069.
12. 2 formation by rat heart mitochondria on substrate availability and donor age. J. Bioenerg. Biomembr. 29, 89-95.
13. Kamo N, Muratsugu M, Hongoh R, Kobatake Y (1979) Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J. Membr. Biol. 49, 105-121.
14. Kokoszka JE, Coskun P, Esposito LA, Wallace DC (2001) Increased mitochondrial oxidative stress in the Soc2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc. Natl Acad. Sci. USA 98, 2278-2283.
15. Korshunov SS, Skulachev VP, Starkov AA (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416, 15-18.
16. Merry BJ (2003) Oxidative stress and mitochondrial function with aging - the effects of calorie restriction. Aging Cell 3 DOI: 10.1046/j.1474-9728.2003.0074.x.
17. Nicholls DG (1974a) Hamster brown adipose tissue mitochondria: the control of respiration and the proton electrochemical potential by possible physiological effectors of the proton conductance of the inner membrane. Eur. J. Biochem. 49, 573-583.
18. Nicholls DG (1974b) The influence of respiration and ATP hydrolysis on the proton electrochemical potential gradient across the inner membrane of rat liver mitochondria as determined by ion distribution. Eur. J. Biochem. 50, 305-315.
19. Nicholls DG (1977) The effective proton conductances of the inner membrane of mitochondria from brown adipose tissue: dependency on proton electrochemical gradient. Eur. J. Biochem. 77, 349-356.
20. Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. London: Academic Press.
21. Nicholls DG, Ward MW (2000) Mitochondrial membrane potential and cell death: mortality and millivolts. Trends Neurosci. 23 166-174.
22. Pfaff E, Heldt HW, Klingenberg M (1969) Adenine nucleotide translocation of mitochondria. Kinetics of the adenine nucleotide exchange. Eur. J. Biochem. 10, 484-493.
23. Rottenberg H, Wu S (1997) Mitochondrial dysfunction in lymphocytes from old mice: enhanced activation of the permeability transition. Biochem. Biophys. Res. Commun. 240, 68-74.
24. Rottenberg H, Wu SL (1998) Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim. Biophys. Acta 1404, 393-404.
25. Scorrano L, Petronilli V, Colonna R, Di Lisa F, Bernardi P (1999) Chloromethyl-tetramethylrosamine (Mitotracker Orange™) induces the mitochondrial permeability transition and inhibits respiratory complex I. Implications for the mechanism of cytochrome c release. J. Biol. Chem. 274, 24 657-24 663.
26. Skulachev VP (1996) Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q. Rev. Biophys. 29, 169-202.
27. Stock D, Gibbons C, Arechaga I, Leslie AG, Walker JE (2000) The rotary mechanism of ATP synthase. Curr. Opin. Struct. Biol. 10, 672-679.
28. Stock D, Leslie AG, Walker JE (1999) Molecular architecture of the rotary motor in ATP synthase. Science 286, 1700-1705.
29. Stuart JA, Cadenas S, Jekabsons MB, Roussel D, Brand MID (2001) Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim. Biophys. Acta Bio-Energetics 1504, 144-158.
30. Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM, Tatton WG (1999) Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence. Biochem. Biophys. Res. Commun. 261, 123-130.
31. Ward MW, Rego AC, Frenguelli BG, Nicholls DG (2000) Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J Neurosci. 20, 7208-7219.
32. 2+ homeostasis in aged cerebellar granule neurons in brain slices. J. Neurosci. 22, 10 761-10 771.