Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions

Nucleic Acids Research

Volumn 27, Issue 11, 1999, Pages 2434-2441

  Khrapko, Konstantin ^a,b,e   Bodyak, Natalya ^a,b   Thilly, William G ^b   Van Orsouw, Nathalie J ^c   Zhang, Xiaomin ^a   Coller, Hilary A ^d   Peris, Thomas T ^a   Upton, Melissa ^a   Vijg, Jan ^c   Wei, Jeanne Y ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; CELL AGING; CONTROLLED STUDY; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; GENOME; HEART MUSCLE CELL; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0033151863     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/27.11.2434     Document Type: Article

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