Atypical pathways of NF-κB activation and aging

Experimental Gerontology

Volumn 44, Issue 4, 2009, Pages 250-255

  Kriete, Andres ^a   Mayo, Kelli L ^b  

^a DREXEL UNIVERSITY   (United States)

^b UMDNJ School of Osteopathic Medicine   (United States)

Author keywords

Aging; Calcium; Endoplasmic reticulum; Inflammation; Mitochondria; NF B; ROS; Stress signaling

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

AGING; CALCIUM HOMEOSTASIS; CELL AGING; CELL FUSION; DNA DAMAGE; ENDOPLASMIC RETICULUM; INNATE IMMUNITY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

AGING; CALCIUM CHANNELS; DNA DAMAGE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; NF-KAPPA B; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 62349092245     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2008.12.005     Document Type: Review

References (82)

1. Adler A.S., Sinha S., Kawahara T.L., Zhang J.Y., Segal E., and Chang H.Y. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 21 (2007) 3244-3257
2. Aoshiba K., and Nagai A. Chronic lung inflammation in aging mice. FEBS Lett. 581 (2007) 3512-3516
3. Banno T., Gazel A., and Blumenberg M. Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes. J. Biol. Chem. 280 (2005) 18973-18980
4. Bernard D., Gosselin K., Monte D., Vercamer C., Bouali F., et al. Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence. Cancer Res. 64 (2004) 472-481
5. 2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO J. 18 (1999) 522-533
6. Biswas G., Anandatheerthavarada H.K., Zaidi M., and Avadhani N.G. Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB/Rel activation through calcineurin-mediated inactivation of IkappaBbeta. J. Cell Biol. 161 (2003) 507-519
7. Bordone L., and Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell Biol. 6 (2005) 298-305
8. Brookes P.S., Yoon Y., Robotham J.L., Anders M.W., and Sheu S.S. Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am. J. Physiol. Cell Physiol. 287 (2004) C817-C833
9. Brough D., Schell M.J., and Irvine R.F. Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility. Biochem. J. 392 (2005) 291-297
10. 2+ homeostasis in peripheral neurones: implications for changes in function. Aging Cell 6 (2007) 285-296
11. Cai D., Frantz J.D., Tawa Jr. N.E., Melendez P.A., Oh B.C., et al. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 119 (2004) 285-298
12. Camandola S., Cutler R.G., Gary D.S., Milhavet O., and Mattson M.P. Suppression of calcium release from inositol 1, 4, 5-trisphosphate-sensitive stores mediates the anti-apoptotic function of nuclear factor-kappaB. J. Biol. Chem. 280 (2005) 22287-22296
13. Chapman R., Sidrauski C., and Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus. Annu. Rev. Cell. Dev. Biol. 14 (1998) 459-485
14. Choi B.H., and Kim J.S. Age-related decline in expression of calnexin. Exp. Mol. Med. 36 (2004) 499-503
15. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., et al. Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor. PLoS Biol. 6 (2008) e301
16. Csiszar A., Ungvari Z., Koller A., Edwards J.G., and Kaley G. Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J. 17 (2003) 1183-1185
17. de Magalhaes J.P., and Church G.M. Cells discover fire: employing reactive oxygen species in development and consequences for aging. Exp. Gerontol. 41 (2006) 1-10
18. Devin A., and Rigoulet M. Mechanisms of mitochondrial response to variations in energy demand in eukaryotic cells. Am. J. Physiol. Cell Physiol. 292 (2007) C52-C58
19. Fedoroff N. Redox regulatory mechanisms in cellular stress responses. Ann. Bot. (Lond) 98 (2006) 289-300
20. Finch C.E. A perspective on sporadic inclusion-body myositis: the role of aging and inflammatory processes. Neurology 66 (2006) S1-S6
21. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. NY Acad. Sci. 908 (2000) 244-254
22. Glazner G.W., Camandola S., Geiger J.D., and Mattson M.P. Endoplasmic reticulum D-myo-inositol 1, 4, 5-trisphosphate-sensitive stores regulate nuclear factor-kappaB binding activity in a calcium-independent manner. J. Biol. Chem. 276 (2001) 22461-22467
23. Gomez C.R., Nomellini V., Faunce D.E., and Kovacs E.J. Innate immunity and aging. Exp. Gerontol. 43 (2008) 718-728
24. Hahn C.G., Gomez G., Restrepo D., Friedman E., Josiassen R., et al. Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am. J. Psychiatry 162 (2005) 616-618
25. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev. 18 (2004) 2195-2224
26. Helenius M., Hanninen M., Lehtinen S.K., and Salminen A. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J. Mol. Cell. Cardiol. 28 (1996) 487-498
27. Helenius M., Hanninen M., Lehtinen S.K., and Salminen A. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem. J. 318 Pt 2 (1996) 603-608
28. Hung J.H., Su I.J., Lei H.Y., Wang H.C., Lin W.C., et al. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J. Biol. Chem. 279 (2004) 46384-46392
29. Janssens S., Tinel A., Lippens S., and Tschopp J. PIDD mediates NF-kappaB activation in response to DNA damage. Cell 123 (2005) 1079-1092
30. Janssens S., and Tschopp J. Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ. 13 (2006) 773-784
31. Jiang H.Y., Wek S.A., McGrath B.C., Scheuner D., Kaufman R.J., et al. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol. Cell. Biol. 23 (2003) 5651-5663
32. Jouaville L.S., Pinton P., Bastianutto C., Rutter G.A., and Rizzuto R. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming. Proc. Natl. Acad. Sci. USA 96 (1999) 13807-13812
33. Kato H., Matsumine A., Wakabayashi T., Hasegawa M., Sudo A., et al. Large-scale gene expression profiles, differentially represented in osteoarthritic synovium of the knee joint using cDNA microarray technology. Biomarkers 12 (2007) 384-402
34. Kelder B., Boyce K., Kriete A., Clark R., Berryman D.E., et al. CIDE-A is expressed in liver of old mice and in type 2 diabetic mouse liver exhibiting steatosis. Comp. Hepatol. 6 (2007) 4
35. Kirischuk S., and Verkhratsky A. Calcium homeostasis in aged neurones. Life Sci. 59 (1996) 451-459
36. Korhonen P., Helenius M., and Salminen A. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci. Lett. 225 (1997) 61-64
37. Kriete A., Mayo K.L., Yalamanchili N., Beggs W., Bender P., et al. Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immunol. Ageing 5 (2008) 5
38. Krtolica A., and Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int. J. Biochem. Cell Biol. 34 (2002) 1401-1414
39. Kuilman T., Michaloglou C., Vredeveld L.C., Douma S., van Doorn R., et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell 133 (2008) 1019-1031
40. 2+ homeostasis in the agonist-sensitive internal store: functional interactions between mitochondria and the ER measured In situ in intact cells. J. Cell Biol. 142 (1998) 1235-1243
41. Lane N. A unifying view of ageing and disease: the double-agent theory. J. Theor. Biol. 225 (2003) 531-540
42. Lasorsa F.M., Pinton P., Palmieri L., Fiermonte G., Rizzuto R., and Palmieri F. Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells. J. Biol. Chem. 278 (2003) 38686-38692
43. Li N., and Karin M. Is NF-kappaB the sensor of oxidative stress?. FASEB J. 13 (1999) 1137-1143
44. Lu T., Pan Y., Kao S.Y., Li C., Kohane I., et al. Gene regulation and DNA damage in the ageing human brain. Nature 429 (2004) 883-891
45. Naidoo N., Ferber M., Master M., Zhu Y., and Pack A.I. Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling. J. Neurosci. 28 (2008) 6539-6548
46. Nicholls, D. 2002a. Mitochondrial bioenergetics, aging, and aging-related disease. Sci Aging Knowledge Environ 2002: pe12.
47. Nicholls D.G. Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease. Int. J. Biochem. Cell Biol. 34 (2002) 1372-1381
48. Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306 (2004) 457-461
49. 2+ uptake by mitochondria in pyruvate dehydrogenase-deficient human diploid fibroblasts. Am. J. Physiol. 274 (1998) C615-C622
50. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18 (1999) 6853-6866
51. Pahl H.L., and Baeuerle P.A. A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J. 14 (1995) 2580-2588
52. 2+ and reactive oxygen intermediates as messengers. FEBS Lett. 392 (1996) 129-136
53. Papazafiri P., and Kletsas D. Developmental and age-related alterations of calcium homeostasis in human fibroblasts. Exp. Gerontol. 38 (2003) 307-311
54. Peterson C., and Goldman J.E. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA 83 (1986) 2758-2762
55. Pizzo P., and Pozzan T. Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol. 17 (2007) 511-517
56. Pottorf W.J., Duckles S.P., and Buchholz J.N. Mechanisms of calcium buffering in adrenergic neurones and effects of ageing: testing the limits of homeostasis. J. Auton. Pharmacol. 20 (2000) 63-75
57. Rawson N.E., Gomez G., Cowart B., and Restrepo D. The use of olfactory receptor neurons (ORNs) from biopsies to study changes in aging and neurodegenerative diseases. Ann. NY Acad. Sci. 855 (1998) 701-707
58. 2+ mobilization. J. Biol. Chem. 268 (1993) 11528-11533
59. 2+ liaison. Sci STKE 2004: re1.
60. Robbesyn F., Salvayre R., and Negre-Salvayre A. Dual role of oxidized LDL on the NF-kappaB signaling pathway. Free Radic. Res. 38 (2004) 541-551
61. Salminen A., Huuskonen J., Ojala J., Kauppinen A., Kaarniranta K., and Suuronen T. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res. Rev. 7 (2008) 83-105
62. Salminen A., Suuronen T., Huuskonen J., and Kaarniranta K. NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?. Biochem. Biophys. Res. Commun. 367 (2008) 715-718
63. Sanders D., Brownlee C., and Harper J.F. Communicating with calcium. Plant Cell 11 (1999) 691-706
64. Sastre J., Pallardo F.V., and Vina J. The role of mitochondrial oxidative stress in aging. Free Radic. Biol. Med. 35 (2003) 1-8
65. Sen R., and Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46 (1986) 705-716
66. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3 (2003) 155-168
67. Singh H., Sen R., Baltimore D., and Sharp P.A. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature 319 (1986) 154-158
68. Sohal R.S., and Allen R.G. Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis. Exp. Gerontol. 25 (1990) 499-522
69. Sousa M.M., Yan S.D., Stern D., and Saraiva M.J. Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation. Lab. Invest. 80 (2000) 1101-1110
70. Spencer N.F., Poynter M.E., Im S.Y., and Daynes R.A. Constitutive activation of NF-kappa B in an animal model of aging. Int. Immunol. 9 (1997) 1581-1588
71. Squier T.C. Oxidative stress and protein aggregation during biological aging. Exp. Gerontol. 36 (2001) 1539-1550
72. Steinsaltz D., and Goldwasser L. Aging and total quality management extending the realibility metaphor for longevity. Evol. Ecol. Res. 8 (2006) 1445-1459
73. van der Vlies D., Pap E.H., Post J.A., Celis J.E., and Wirtz K.W. Endoplasmic reticulum resident proteins of normal human dermal fibroblasts are the major targets for oxidative stress induced by hydrogen peroxide. Biochem. J. 366 (2002) 825-830
74. Viswanathan M., Kim S.K., Berdichevsky A., and Guarente L. A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9 (2005) 605-615
75. Wang W., Fang H., Groom L., Cheng A., Zhang W., et al. Superoxide flashes in single mitochondria. Cell 134 (2008) 279-290
76. Xiao Z.Q., and Majumdar A.P. Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (2000) G855-G865
77. 2+]i signalling in rat cerebellar granule neurones aged in vitro. Neurobiol. Aging 25 (2004) 349-359
78. Yi M., Weaver D., and Hajnoczky G. Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J. Cell Biol. 167 (2004) 661-672
79. 2+ signals? Sci STKE 2005: pe18.
80. Yoshida H. ER stress and diseases. FEBS J. 274 (2007) 630-658
81. Zhang K., and Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 454 (2008) 455-462
82. Zhang K., Shen X., Wu J., Sakaki K., Saunders T., et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124 (2006) 587-599