An intronic NF-κB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-α and interleukin-1β

DNA and Cell Biology

Volumn 18, Issue 9, 1999, Pages 709-722

  Xu, Yong ^a   Kiningham, Kelley K ^a   Devalaraja, Madhav N ^a,b   Yeh, Che Chung ^a,c   Majima, Hideyuki ^a,d   Kasarskis, Edward J ^a   St Clair, Daret K ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MANGANESE SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 1; PRIMER DNA; SUPEROXIDE DISMUTASE;

ARTICLE; BINDING SITE; CELL CULTURE; DNA FLANKING REGION; ENHANCER REGION; GENE EXPRESSION; GENE INDUCTION; GENE LOCATION; GENE MUTATION; HUMAN; HUMAN CELL; INTRON; MOLECULAR CLONING; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; BINDING SITES; DNA PRIMERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERLEUKIN-1; INTRONS; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032588841     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454999314999     Document Type: Article

References (50)

1. BAEUERLE, P. A., and BALTIMORE, D. (1989). A 65-kappaD sub-unit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev. 3, 1689-1698.
2. BAEUERLE, P. A., and BALTIMORE, D. (1996). NF-κB: Ten years after. Cell 87, 13-20.
3. BALDWIN, A. S. (1996). The NF-κB and IκB proteins: New discoveries and insights. Annu. Rev. Immunol. 14, 649-681.
4. BEG, A. A., FINCO, T. S., NANTERMET, P. V., and BALDWIN, A. S. (1993). Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: A mechanism for NF-κB activation. Mol. Cell. Biol. 13, 3301-3310.
5. BIRKENMEIER, E. H., GWYNN, B., HOWARD, S., JERRY, J., GORDON, J. I., LANDSCHULZ, W. H., and MCKNIGHT, S. L. (1989). Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev. 3, 1146-1156.
6. BORG, L. A. H., CAGLIERO, E., SANDLER, S., WELSH, N., and EIZIRIK, D. L. (1992). Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets. Endocrinology 130, 2851-2857.
7. CHEN-KIANG, S., HSU, W., NATKUNAM, Y., and ZHANG, X. (1993). Nuclear signaling by interleukin-6. Curr. Opin. Immunol. 5, 124-128.
8. CHURCH, S. L., GRANT, J. M., RIDNOUR, L. A., OBERLEY, L. W., SWANSON, P. E., MELTZER, P. S., and TRENT, J. M. (1993). Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc. Natl. Acad. Sci. USA 90, 3113-3117.
9. CRAPO, J. D., and TIERNEY, D. F. (1974). Superoxide dismutase and pulmonary oxygen toxicity. Am. J. Physiol. 226, 1401-1407.
10. DAS, K. C., LEWIS-MOLOCK, Y., and WHITE, C. W. (1995a). Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B. Mol. Cell. Biochem. 148, 45-57.
11. DAS, K. C., LEWIS-MOLOCK, Y., and WHITE, C. W. (1995b). Activation of NF-κB and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma. Am. J. Physiol. 269, L588-L602.
12. DIEHL, J. A., and HANNINK, M. (1994). Identification of a C/EBP-Rel complex in avian cells. Mol. Cell. Biol. 14, 6635-6646.
13. DUCKETT, C. S., PERKINS, N. D., KOWALIK, T. F., SCHMID, R. M., HUANG, E-S, BALDWIN, A., and NABEL, G. J. (1993). Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol. Cell. Biol. 13, 1315-1322.
14. FURLONG, E. E. M., KEON, N. K., THORNTON, F. D., REIN, T., and MARTIN, F. (1996). Expression of a 74-kDa nuclear factor 1 (NFl) protein is induced in mouse mammary gland involution. J. Biol. Chem. 271, 29688-29697.
15. GRAHAM, F. L., and VAN DER EB, A. J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
16. HALLIWELL, B., and GUTTERIDGE, J. M. C. (1989). Free Radicals in Biology and Medicine, ed 2. (Clarendon Press, Oxford) pp. 86-123.
17. JOHNSON, P. F., LANDSCHULZ, W. H., GRAVES, B. J., and MCKNIGHT, S. L. (1987). Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev. 1, 133-146.
18. JONES, P. L., PING, D., and BOSS, J. M. (1997). Tumor necrosis factor alpha and interleukin-1/3 regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-β and NF-κB. Mol. Cell. Biol. 17, 6970-6981.
19. KELLER, J. N., KINDY, M. S., HOLTSBERG, F. W., ST. CLAIR, D. K., YEN, H-C, GERMEYER, A., STEINER, S. M., BRUCE-KELLER, A. J., HUTCHINS, J. B., and MATTSON, M. P. (1998). Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18, 687-697.
20. KININGHAM, K. K., and ST. CLAIR, D. K. (1997). Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. Cancer Res. 57, 5265-5271.
21. KRALL, J., BABLEY, A. C., MULLENBACH, G. L., HALLEWELL, R. A., and LYNCH, R. E. (1988). Superoxide mediates the toxicity of paraquat for cultured mammalian cells. J. Biol. Chem. 263, 1910-1914.
22. LECLAIR, K. P., BLANAR, M. A., and SHARP, P. A. (1992). The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89, 8145-8149.
23. LEE, Y.-M., MIAU, L.-H., CHANG, C.-J., and LEE, S.-C. (1996). Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBPβ) and NF-κB or Nopp140. Mol. Cell. Biol. 16, 4257-4263.
24. LI, J. J., OBERLEY, L. W., ST. CLAIR, D. K., RIDNOUR, L. A., and OBERLEY, T.D. (1995). Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10, 1989-2000.
25. LI, Y., HUANG, T. T., CARLSON, E. J., MELAV, S., URSELL, P. C., OLSON, J. L., NOBLE, L. T., YOSHIMURA, M. P., BERG, C., CHAN, P. H., WALLACE, D. C., and EPSTEIN, C. T. (1995). Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genet. 11, 376-381.
26. MANNA, S. K., ZHONG, H. J., YAN, T. OBERLEY, L. W., and AGGARWAL, B. B. (1998). Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1. J. Biol. Chem. 273, 13245-13254.
27. MASUDA, A., LONGO, D. L., KOBAYASHI, Y., APPELLA, E., OPPENHEIM, J. J., and MATSUSHIMA, K. (1988). Induction of mitochondrial manganese superoxide dismutase by interleukin 1. FASEB J. 2, 3087-3091.
28. RADEKE, H. H., MEIER, B., TOPLEY, N., FLOGE, J., HABERMEHL, G. G., and RESCH, K. (1990). Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells. Kidney Int. 37, 767-775.
29. SAFFORD, S. E., OBERLEY, T. D., URANO, M., and ST. CLAIR, D. K. (1994). Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. Cancer Res. 54, 4261-4265.
30. SAMBROOK, J., FRITSCH, E. F., and MANIATIS, T. (1989). Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor Laboratory, Cold Spring Harbor, NY) pp. 16.54-16.59.
31. SCHIAVONE, J. R., and HASSAN, H. M. (1987). Biosynthesis of superoxide dismutase in eight prokaryotes: Effects of oxygen, paraquat and iron chelator. FEMS Microbiol. Lett. 42, 33-38.
32. SPITZ, D. R., and OBERLEY, L. W. (1989). An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal. Biochem. 179, 8-18.
33. STAUFFER, D. R., CHUKWUMEZIE, B. N., WILBERDING, J. A., ROSEN, E. D., and CASTELLINO, F. J. (1998). Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene. J. Biol. Chem. 273, 2277-2287.
34. STEIN, B., and BALDWIN, A. S. (1993). Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol. Cell. Biol. 13, 7191-7198.
35. STEIN, B., and YANG, M. X. (1995). Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPκ. Mol. Cell. Biol. 15, 4971-4979.
36. STEIN, B., COGSWELL, P. C., and BALDWIN, A. S. (1993). Functional and physical associations between NF-kappa B and C/EBP family members: A Rel domain-bZIP interaction. Mol. Cell. Biol. 13, 3964-3974.
37. STEVENS, J. B., and AUTOR, A. P. (1977). Induction of superoxide dismutase by oxygen in neonatal rat lung. J. Biol. Chem. 252, 3509-3514.
38. URANO, M., KURODA, M., REYNOLDS, R., OBERLEY, T. D., and ST. CLAIR, D. K. (1995). Expression of manganese superoxide dismutase reduces tumor control radiation dose: Gene radiotherapy. Cancer Res. 55, 2490-2493.
39. VINSON, C. R., SIGLER, P. B., and MCKNIGHT, S. L. (1989). Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246, 911-916.
40. VISNER, G. A., DOUGALL, W. C., WILSON, J. M., BURR, I. A., and NICK, H. S. (1990). Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor: Role in the acute inflammatory response. J. Biol. Chem. 265, 2856-2864.
41. WAN, X. S., DEVALARAJA, M. N., and ST. CLAIR, D. K. (1994). Molecular structure and organization of the human manganese superoxide dismutase gene. DNA Cell Biol. 13, 1127-1136.
42. WEISIGER, R. A., and FRIDOVICH, I. J. (1973). Superoxide dismutase: Organelle specificity. J. Biol. Chem. 248, 4793-4796.
43. WHITE, J. E., and TSAN, M.-F. (1994). Induction of pulmonary Mn superoxide dismutase mRNA by interleukin-1. Am. J. Physiol. 266, L664-L671.
44. WISPE, J. R., WARNER, B. B., CLARK, J. C., DEY, C. R., NEUMAN, J., CLASSER, S. W., CRAPO, J. D., CHANG, L.-Y., and WHITSETT, J. A. (1992). Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury. J. Biol. Chem. 267, 23937-23941.
45. WONG, G. H. W., and GOEDDEL, D. V. (1988). Induction of manganese superoxide dismutase by tumor necrosis factor: Possible protective mechanism. Science 242, 941-944.
46. XU, Y., KRISHNAN, A., WAN, X. S., MAJIMA, H., YEH, C.-C., LUDEWIG, G., KASARSKIS, E. J., and ST. CLAIR, D. K. (1999). Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells. Oncogene 18, 93-102.
47. YEH, C.-C., WAN, X. S., and ST. CLAIR, D. K. (1998). Transcriptional regulation of the 5′ proximal promoter of the human manganese superoxide dismutase gene. DNA Cell Biol. 17, 921-930.
48. YEN, H.-C., OBERLEY, T. D., VICHITBANDHA, S., HO, Y.-S., and ST. CLAIR, D. K. (1996). The protective role of manganese superoxide dismutase against Adriamycin-induced acute cardiac toxicity in transgenic mice. J. Clin. Invest. 98, 1253-1260.
49. YOSHIOKA, T., HOMMA, T., MEYRICK, B., TAKEDA, M., MOORE-JARRETT, T., KON, V., and ICHIKAWA, I. (1994). Oxidants induce transcriptional activation of manganese superoxide dismutase in glomerular cells. Kidney Int. 46, 405-413.
50. ZHONG, W., OBERLEY, L. W., OBERLEY, T. D., and ST. CLAIR, D. K. (1997). Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene 14, 481-490.