Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR

Science Signaling

Volumn 2, Issue 62, 2009, Pages

  Wang, Chao Yung ^a   Kim, Hyung Hwan ^a   Hiroi, Yukio ^a   Sawada, Naoki ^a   Salomone, Salvatore ^b   Benjamin, Laura E ^c   Walsh, Kenneth ^d   Moskowitz, Michael A ^b   Liao, James K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT 1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN SERINE THREONINE KINASE; RAPAMYCIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; FRAP1 PROTEIN, MOUSE; PHOSPHOTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIET; FOOD INTAKE; ISCHEMIA; MALE; MOUSE; NONHUMAN; OBESITY; PERIPHERAL ISCHEMIA; PRIORITY JOURNAL; VASCULARIZATION; ANIMAL; CELL AGING; COMPARATIVE STUDY; DISEASE PREDISPOSITION; DRUG EFFECT; EATING; ENZYME ACTIVATION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MAMMALIA; MUS; MUS MUSCULUS;

ANIMALS; CARDIOVASCULAR DISEASES; CARRIER PROTEINS; CELL AGING; DISEASE SUSCEPTIBILITY; EATING; ENZYME ACTIVATION; ISCHEMIA; MICE; MICE, TRANSGENIC; OBESITY; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 66149107054     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000143     Document Type: Article

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56. This work was support by grants from the NIH (HL052233, HL080187, and NS010828) and the Chang Gung Memorial Hospital (CMRPG370811). There are no disclosures or conflicts regarding this work for all of the authors.