-
1
-
-
13944269223
-
The plasticity of aging: Insights from long-lived mutants
-
Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 2005; 120:449-60.
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
2
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 2003; 421:182-7.
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
3
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 299:572-4.
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
4
-
-
33746228121
-
-
Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006; 126:257-68.
-
Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006; 126:257-68.
-
-
-
-
5
-
-
33751113602
-
Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction
-
Haigis MC, Guarente LP. Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006; 20:2913-21.
-
(2006)
Genes Dev
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
6
-
-
13944253348
-
Calorie restriction - the SIR2 connection
-
Guarente L, Picard F. Calorie restriction - the SIR2 connection. Cell 2005; 120:473-82.
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
7
-
-
0141766912
-
Demography of dietary restriction and death in Drosophila
-
Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science 2003; 301:1731-3.
-
(2003)
Science
, vol.301
, pp. 1731-1733
-
-
Mair, W.1
Goymer, P.2
Pletcher, S.D.3
Partridge, L.4
-
8
-
-
0020044308
-
Dietary restriction in mice beginning at 1 year of age: Effect on life-span and spontaneous cancer incidence
-
Weindruch R, Walford RL. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982; 215:1415-8.
-
(1982)
Science
, vol.215
, pp. 1415-1418
-
-
Weindruch, R.1
Walford, R.L.2
-
9
-
-
1842732174
-
Temporal linkage between the phenotypic and genomic responses to caloric restriction
-
Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci USA 2004; 101:5524-9.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 5524-5529
-
-
Dhahbi, J.M.1
Kim, H.J.2
Mote, P.L.3
Beaver, R.J.4
Spindler, S.R.5
-
10
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433:760-4.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
Rando, T.A.6
-
11
-
-
0141447476
-
Age of ovary determines remaining life expectancy in old ovariectomized mice
-
Cargill SL, Carey JR, Muller HG, Anderson G. Age of ovary determines remaining life expectancy in old ovariectomized mice. Aging Cell 2003; 2:185-90.
-
(2003)
Aging Cell
, vol.2
, pp. 185-190
-
-
Cargill, S.L.1
Carey, J.R.2
Muller, H.G.3
Anderson, G.4
-
12
-
-
35348971990
-
Resistance exercise reverses aging in human skeletal muscle
-
Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS ONE 2007; 2:465.
-
(2007)
PLoS ONE
, vol.2
, pp. 465
-
-
Melov, S.1
Tarnopolsky, M.A.2
Beckman, K.3
Felkey, K.4
Hubbard, A.5
-
13
-
-
21644487750
-
Microarrays as a tool to investigate the biology of aging: A retrospective and a look to the future
-
Melov S, Hubbard A. Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future. Sci Aging Knowledge Environ 2004; 2004:7.
-
(2004)
Sci Aging Knowledge Environ 2004
, pp. 7
-
-
Melov, S.1
Hubbard, A.2
-
14
-
-
24944457649
-
Aging and gene expression in the primate brain
-
Fraser HB, Khaitovich P, Plotkin JB, Paabo S, Eisen MB. Aging and gene expression in the primate brain. PLoS Biol 2005; 3:274.
-
(2005)
PLoS Biol
, vol.3
, pp. 274
-
-
Fraser, H.B.1
Khaitovich, P.2
Plotkin, J.B.3
Paabo, S.4
Eisen, M.B.5
-
15
-
-
3042631024
-
Gene regulation and DNA damage in the ageing human brain
-
Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature 2004; 429:883-91.
-
(2004)
Nature
, vol.429
, pp. 883-891
-
-
Lu, T.1
Pan, Y.2
Kao, S.Y.3
Li, C.4
Kohane, I.5
Chan, J.6
Yankner, B.A.7
-
16
-
-
0842267618
-
Comparing genomic expression patterns across species identifies shared transcriptional profile in aging
-
McCarroll SA, Murphy CT, Zou S, Pletcher SD, Chin CS, Jan YN, Kenyon C, Bargmann CI, Li H. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat Genet 2004; 36:197-204.
-
(2004)
Nat Genet
, vol.36
, pp. 197-204
-
-
McCarroll, S.A.1
Murphy, C.T.2
Zou, S.3
Pletcher, S.D.4
Chin, C.S.5
Jan, Y.N.6
Kenyon, C.7
Bargmann, C.I.8
Li, H.9
-
17
-
-
37249049422
-
-
Zahn JM, Poosala S, Owen AB, Ingram DK, Lustig A, Carter A, Weeraratna AT, Taub DD, Gorospe M, Mazan-Mamczarz K, Lakatta EG, Boheler KR, Xu X, Mattson MP, Falco G, Ko MS, Schlessinger D, Firman J, Kummerfeld SK, Wood WH, Zonderman AB, Kim SK, Becker KG. AGEMAP: A Gene Expression Database for Aging in Mice. PLoS Genet 2007; 3:201.
-
Zahn JM, Poosala S, Owen AB, Ingram DK, Lustig A, Carter A, Weeraratna AT, Taub DD, Gorospe M, Mazan-Mamczarz K, Lakatta EG, Boheler KR, Xu X, Mattson MP, Falco G, Ko MS, Schlessinger D, Firman J, Kummerfeld SK, Wood WH, Zonderman AB, Kim SK, Becker KG. AGEMAP: A Gene Expression Database for Aging in Mice. PLoS Genet 2007; 3:201.
-
-
-
-
18
-
-
37249009271
-
Motif module map reveals enforcement of aging by continual NF?B activity
-
Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF?B activity. Genes Dev 2007; 21:3244-57.
-
(2007)
Genes Dev
, vol.21
, pp. 3244-3257
-
-
Adler, A.S.1
Sinha, S.2
Kawahara, T.L.3
Zhang, J.Y.4
Segal, E.5
Chang, H.Y.6
-
19
-
-
4444376712
-
Signaling to NFkappaB
-
Hayden MS, Ghosh S. Signaling to NFkappaB. Genes Dev 2004; 18:2195-224.
-
(2004)
Genes Dev
, vol.18
, pp. 2195-2224
-
-
Hayden, M.S.1
Ghosh, S.2
-
20
-
-
3242719545
-
Modulation of NFkappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NFkappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo J 2004; 23:2369-80.
-
(2004)
Embo J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
-
21
-
-
4143129696
-
Regulation of NFkappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
-
Lin L, Hron JD, Peng SL. Regulation of NFkappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 2004; 21:203-13.
-
(2004)
Immunity
, vol.21
, pp. 203-213
-
-
Lin, L.1
Hron, J.D.2
Peng, S.L.3
-
22
-
-
33645312379
-
Circuitry of nuclear factor kappaB signaling
-
Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev 2006; 210:171-86.
-
(2006)
Immunol Rev
, vol.210
, pp. 171-186
-
-
Hoffmann, A.1
Baltimore, D.2
-
23
-
-
34547838179
-
Genomewide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NFkappaB upon TLR4 activation
-
Lim CA, Yao F, Wong JJ, George J, Xu H, Chiu KP, Sung WK, Lipovich L, Vega VB, Chen J, Shahab A, Zhao XD, Hibberd M, Wei CL, Lim B, Ng HH, Ruan Y, Chin KC. Genomewide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NFkappaB upon TLR4 activation. Mol Cell 2007; 27:622-35.
-
(2007)
Mol Cell
, vol.27
, pp. 622-635
-
-
Lim, C.A.1
Yao, F.2
Wong, J.J.3
George, J.4
Xu, H.5
Chiu, K.P.6
Sung, W.K.7
Lipovich, L.8
Vega, V.B.9
Chen, J.10
Shahab, A.11
Zhao, X.D.12
Hibberd, M.13
Wei, C.L.14
Lim, B.15
Ng, H.H.16
Ruan, Y.17
Chin, K.C.18
-
24
-
-
0029834145
-
Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B
-
Helenius M, Hanninen M, Lehtinen SK, Salminen A. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J 1996; 318:603-8.
-
(1996)
Biochem J
, vol.318
, pp. 603-608
-
-
Helenius, M.1
Hanninen, M.2
Lehtinen, S.K.3
Salminen, A.4
-
25
-
-
0030960606
-
Age-related changes in the regulation of transcription factor NFkappa B in rat brain
-
Korhonen P, Helenius M, Salminen A. Age-related changes in the regulation of transcription factor NFkappa B in rat brain. Neurosci Lett 1997; 225:61-4.
-
(1997)
Neurosci Lett
, vol.225
, pp. 61-64
-
-
Korhonen, P.1
Helenius, M.2
Salminen, A.3
-
26
-
-
34548208677
-
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
-
Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007; 5:201.
-
(2007)
PLoS Biol
, vol.5
, pp. 201
-
-
Chambers, S.M.1
Shaw, C.A.2
Gatza, C.3
Fisk, C.J.4
Donehower, L.A.5
Goodell, M.A.6
-
27
-
-
12844285560
-
Transcriptional networks and cellular senescence in human mammary fibroblasts
-
Hardy K, Mansfield L, Mackay A, Benvenuti S, Ismail S, Arora P, O'Hare MJ, Jat PS. Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell 2005; 16:943-53.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 943-953
-
-
Hardy, K.1
Mansfield, L.2
Mackay, A.3
Benvenuti, S.4
Ismail, S.5
Arora, P.6
O'Hare, M.J.7
Jat, P.S.8
-
28
-
-
1642515805
-
Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence
-
Bernard D, Gosselin K, Monte D, Vercamer C, Bouali F, Pourtier A, Vandenbunder B, Abbadie C. Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence. Cancer Res 2004; 64:472-81.
-
(2004)
Cancer Res
, vol.64
, pp. 472-481
-
-
Bernard, D.1
Gosselin, K.2
Monte, D.3
Vercamer, C.4
Bouali, F.5
Pourtier, A.6
Vandenbunder, B.7
Abbadie, C.8
-
29
-
-
0029059060
-
Embryonic lethality and liver degeneration in mice lacking the RelA component of NFkappa B
-
Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NFkappa B. Nature 1995; 376:167-70.
-
(1995)
Nature
, vol.376
, pp. 167-170
-
-
Beg, A.A.1
Sha, W.C.2
Bronson, R.T.3
Ghosh, S.4
Baltimore, D.5
-
30
-
-
13944253943
-
CDK4 regulation by TNFR1 and JNK is required for NFkappaB-mediated epidermal growth control
-
Zhang JY, Tao S, Kimmel R, Khavari PA. CDK4 regulation by TNFR1 and JNK is required for NFkappaB-mediated epidermal growth control. J Cell Biol 2005; 168:561-6.
-
(2005)
J Cell Biol
, vol.168
, pp. 561-566
-
-
Zhang, J.Y.1
Tao, S.2
Kimmel, R.3
Khavari, P.A.4
-
31
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
-
Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, Sakano Y, Paupard MC, Hall DH, Driscoll M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 2002; 419:808-14.
-
(2002)
Nature
, vol.419
, pp. 808-814
-
-
Herndon, L.A.1
Schmeissner, P.J.2
Dudaronek, J.M.3
Brown, P.A.4
Listner, K.M.5
Sakano, Y.6
Paupard, M.C.7
Hall, D.H.8
Driscoll, M.9
-
32
-
-
33745532801
-
Increased cell-to-cell variation in gene expression in ageing mouse heart
-
Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dolle ME, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 2006; 441:1011-4.
-
(2006)
Nature
, vol.441
, pp. 1011-1014
-
-
Bahar, R.1
Hartmann, C.H.2
Rodriguez, K.A.3
Denny, A.D.4
Busuttil, R.A.5
Dolle, M.E.6
Calder, R.B.7
Chisholm, G.B.8
Pollock, B.H.9
Klein, C.A.10
Vijg, J.11
-
33
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005; 120:513-22.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
34
-
-
33645295820
-
Modelling cancer in human skin tissue
-
Khavari PA. Modelling cancer in human skin tissue. Nat Rev Cancer 2006; 6:270-80.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 270-280
-
-
Khavari, P.A.1
-
35
-
-
5444262078
-
IKKbeta/NFkappaB activation causes severe muscle wasting in mice
-
Cai D, Frantz JD, Tawa NE, Jr., Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NFkappaB activation causes severe muscle wasting in mice. Cell 2004; 119:285-98.
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa Jr., N.E.3
Melendez, P.A.4
Oh, B.C.5
Lidov, H.G.6
Hasselgren, P.O.7
Frontera, W.R.8
Lee, J.9
Glass, D.J.10
Shoelson, S.E.11
-
36
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11:191-8.
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
37
-
-
28844474597
-
SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NFκB Signaling
-
Chen J, Zhou Y, Mueller Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NFκB Signaling. J Biol Chem 2005; 280:40364-74.
-
(2005)
J Biol Chem
, vol.280
, pp. 40364-40374
-
-
Chen, J.1
Zhou, Y.2
Mueller Steiner, S.3
Chen, L.F.4
Kwon, H.5
Yi, S.6
Mucke, L.7
Gan, L.8
|