Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity

Journal of Neuroscience Research

Volumn 48, Issue 6, 1997, Pages 580-587

  Toliver Kinsky, Tracy ^a   Papaconstantinou, John ^a   Perez Polo, J Regino ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Aging; Brain; Transcription factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR;

AGED; AGING; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; FOREBRAIN; GENETIC TRANSCRIPTION; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

AFFERENT PATHWAYS; AGING; ANIMALS; BASAL GANGLIA; CHOLINERGIC FIBERS; COGNITION DISORDERS; DNA; HIPPOCAMPUS; NERVE TISSUE PROTEINS; NF-KAPPA B; OXIDATIVE STRESS; RATS; RATS, INBRED BN; RATS, INBRED F344; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION, GENETIC;

EID: 0030991993     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19970615)48:6<580::AID-JNR11>3.0.CO;2-Z     Document Type: Article

References (30)

1. Ammendola R, Mesuraca M, Russo T, Cimino F (1992): Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues. J Biol Chem 267:17944-17948.
2. Baldwin AS Jr, Sharp PA (1988): Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter. Proc Natl Acad Sci USA 85:623-627.
3. Barger SW, Horster D, Furukawa K, Goodman Y, Krieglstein J, Mattson MP (1995): Tumornecrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc Natl Acad Sci USA 92:9328-9332.
4. Barger SW, Mattson MP (1996): Participation of gene expression in the protection against amyloid beta-peptide toxicity by the beta-amyloid precursor protein. Ann NY Acad Sci 777:303-309.
5. Bohnlein E, Lowenthal JW, Siekevitz M, Ballard DW, Franza BR, Greene WC (1988): The same inducible nuclear proteins regulate mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell 53:827-836.
6. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA (1996): Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor p75. Science 272:542-545.
7. Davies P, Maloney AJF (1976): Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403.
8. de Haan JB, Cristiano F, Iannello RC, Kola I (1995): Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem Mol Biol Int 35:1281-1297.
9. Fischer W, Wictorin K, Bjorklund A, Williams LR, Varon S, Gage FH (1987): Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329:65-68.
10. Ghosh S, Baltimore D (1990): Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature 344:678-682.
11. Ginnpease ME, Whisler RL (1996): Optimal NF-kappa-B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals. Biochem Biophys Res Commun 226:695-702.
12. Gnahn H, Hefti F, Heumann R, Schwab ME, Thoenen H (1983): NGF-mediated increase of choline acetyl-transferase (CHAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain. Dev Brain Res 9:45-52.
13. Grilli M, Goffi F, Memo M, Spano P (1996): Interleukin-1-beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. J Biol Chem 271:15002-15007.
14. Joseph SA, Tassorelli C, Prasad AV, Lyndbalta E (1996): NF-kappa-B transcription factor subunits in rat brain - colocalization of p65 and alpha-MSH. Peptides 17:655-664.
15. Kaltschmidt C, Kaltschmidt B, Baeuerle PA (1993): Brain synapses contain inducible forms of the transcription factor NF-κB. Mech Dev 43:135-147.
16. Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA (1994): Constitutive NF-κB activity in neurons. Mol Cell Biol 14:3981-3992.
17. Kaminska B, Kaczmarek L (1993): Robust induction of AP-1 transcription factor DNA binding activity in the hippocampus of aged rats. Neurosci Lett 153:189-191.
18. Koong AC, Chen EY, Giaccia AJ (1994): Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα on tyrosine residues. Cancer Res 54:1425-1430.
19. Lin YC, Brown K, Siebenlist U (1995): Activation of NF-kappa B requires proteolysis of theinhibitor I kappa B-α: Signal-induced phosphorylation of I kappa B-α alone does not release active NF-kappa B. Proc Natl Acad Sci USA 92:552-556.
20. Papaconstantinou J (1994): Unifying model of the programmed (intrinsic) and stochastic (extrinsic) theories of aging. The stress response genes, signal transduction-redox pathways and aging. Ann NY Acad Sci 719:195-211.
21. Prasad AV, Webster HP, Joseph SA (1994): Nuclear factor-kappa B in rat brain: Enhanced DNA-binding activity following convulsant-induced seizures. Neurosci Lett 170:145-148.
22. Schreck R, Albermann K, Baeuerle PA (1992): Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 17:221-237.
23. Sen R, Baltimore D (1986): Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism. Cell 47:921-928.
24. Shen J, Barnes CA (1996): Age-related decrease in cholinergic synaptic transmission in threehippocampal subfields. Neurobiol Aging 17:439-451.
25. Supakar PC, Jung MH, Song CS, Chatterjee B, Roy AK (1995): Nuclear factor kappa B functions as a negative regulator for the rat androgen receptor gene and NF-kappa B activity increases during the age-dependent desensitization of the liver. J Biol Chem 270:837-842.
26. Taglialatela G, Robinson R, Perez-Polo JR (1997): Inhibition of nuclear factor kappa B (NFκB) activity induces NGF-resistant apoptosis in PC12 cells. J Neurosci Res 47:155-162.
27. Terai K, Matsuo A, Mcgeer EG, Mcgeer PL (1996): Enhancement of immunoreactivity for NF-kappa-B in human cerebral infarctions. Brain Res 739:343-349.
28. Terai K, Matsuo A, Mcgeer PL (1996): Enhancement of immunoreactivity for NF kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease. Brain Res 735:159-168.
29. Trebilcock GU, Ponnappan U (1996): Induction and regulation of NFkappaB during aging: Role of protein kinases. Clin Immunol Immunopathol 79:87-91.
30. Yang K, Mu XS, Hayes RL (1995): Increased cortical nuclear factor-kappa B DNA binding activity after traumatic brain injury in rats. Neurosci Lett 197:101-104.