Impacts of transcriptional regulation on aging and senescence

Ageing Research Reviews

Volumn 1, Issue 3, 2002, Pages 367-380

  Roy, Arun K ^a   Oh, Thomas ^a   Rivera, Omar ^a   Mubiru, James ^a   Song, Chung S ^a   Chatterjee, Bandana ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Aging; Gene regulation; Reactive oxygen species; Senescence phenotype; Transcription factors

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDOX EFFECTOR FACTOR 1; SILENT INFORMATION REGULATOR PROTEIN 2; THIOREDOXIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; ZINC FINGER PROTEIN;

AGING; CHROMATIN; COPING BEHAVIOR; CYCLIC AMP RESPONSIVE ELEMENT; DETERIORATION; ENZYME PHOSPHORYLATION; EPIGENETICS; GENE CONTROL; GENE SEQUENCE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; INFLAMMATION; LIFESPAN; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PHENOTYPE; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; SENESCENCE; SPECIES DIFFERENCE; STIMULUS; TRANSCRIPTION REGULATION; ANIMAL; ARTICLE; CELL AGING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; PHYSIOLOGY;

AGING; ANIMALS; CELL AGING; GENE EXPRESSION REGULATION; HUMANS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0036596779     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-1637(02)00006-5     Document Type: Review

References (80)

1. Ammendola R., Mesuraca M., Russo T., Cimino F. Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues. J. Biol. Chem. 267:1992;17944-17948.
2. Ammendola R., Mesuraca M., Russo T., Cimino F. The DNA binding efficiency of Sp1 is affected by redox changes. Eur. J. Biochem. 225:1994;483-489.
3. An M.R., Hsieh C.C., Reisner P.D., Rabek J.P., Scott S.G., Kuninger D.T., Papaconstantinou J. Evidence for post-transcriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response. Mol. Cell Biol. 16:1996;2295-2306.
4. Archer T.K., Lefebvre P., Wolford R.G., Hager G.L. Transcription factor loading on the MMTV promoter: a bimodal mechanism for promoter activation. Science. 255:1992;1573-1576.
5. Baeuerle P.A., Baltimore D. NF-kappa B: ten years after. Cell. 87:1996;13-20.
6. Baler R., Dahl G., Voellmy R. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF-1. Mol. Cell Biol. 13:1993;2486-2496.
7. Bannister A.J., Kouzarides T. The CBP co-activator is a histone acetyltransferase. Nature. 384:1996;641-643.
8. Barlev N.A., Liu L., Chehab N.H., Mansfield K., Harris K.G., Halazonetis T.D., Berger S.L. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell. 8:2001;1243-1254.
9. Belikov S., Gelius B., Almouzni G., Wrange O. Hormone activation induces nucleosome positioning in vivo. EMBO J. 19:2000;1023-1033.
10. Bennett R.A., Wilson D.M., Wong D. III, Demple B. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc. Natl. Acad. Sci. U.S.A. 94:1997;7166-7169.
11. Berger S.L., Felsenfeld G. Chromatin goes global. Mol. Cell. 8:2001;263-268.
12. Blake M.J., Fargnoli J., Gershon D., Holbrook N.J. Concomitant decline in heat-induced hyperthermia and HSP-70 mRNA expression in aged rats. Am. J. Physiol. 260:1991;R663-R667.
13. Braunstein M., Rose A.B., Holmes S.G., Allis C.D., Broach J.R. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7:1993;592-604.
14. Cao Z., Umek R.M., McKnight S.L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1991;1538-1552.
15. Chen S., Supakar P.C., Vellanoweth R.L., Song C.S., Chatterjee B., Roy A.K. Functional role of a conformationally flexible homopurine/homopyrimidine domain of the androgen receptor gene promoter interacting with Sp1 and a pyrimidine single strand DNA binding protein. Mol. Endocrinol. 11:1997;3-15.
16. Christy R.J., Yang V.W., Ntambi J.M., Geiman D.E., Landschulz W.H., Friedman A.D., Nakabeppu Y., Kelly T.J., Lane M.D. Differentiation-induced gene expression in 3T3-L1 pre-adipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev. 3:1989;1323-1335.
17. Commoner B., Townsend J., Pake G.E. Free radicals in biological materials. Nature. 174:1954;689-691.
18. Deguchi Y., Negoro S., Kishimoto S. Age-related changes of heat shock protein gene transcription in human peripheral blood mononuclear cells. Biochem. Biophys. Res. Commun. 157:1988;580-584.
19. Dutnall R.N., Pillus L. Deciphering NAD-dependent deacetylases. Cell. 105:2001;161-164.
20. El Jack A.K., Hamm J.K., Pilch P.F., Farmer S.R. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. J. Biol. Chem. 274:1999;7946-7951.
21. Ferbeyre G., Lowe S.W. The price of tumour suppression? Nature. 415:2002;26-27.
22. Finch, C.E., 1990. Longevity Senescence and the Genome. University of Chicago Press, Chicago.
23. Gasser S.M., Cockell M.M. The molecular biology of the SIR proteins. Gene. 279:2001;1-16.
24. Ghosh A.K., Lacson R., Liu P., Cichy S.B., Danilkovich A., Guo S., Unterman T.G. A nucleoprotein complex containing CCAAT/enhancer-binding protein beta interacts with an insulin response sequence in the insulin-like growth factor-binding protein-1 gene and contributes to insulin-regulated gene expression. J. Biol. Chem. 276:2001;8507-8515.
25. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 2:1956;298-300.
26. Hayashi S., Hajiro-Nakanishi K., Makino Y., Eguchi H., Yodoi J., Tanaka H. Functional modulation of estrogen receptor by redox state with reference to thioredoxin as a mediator. Nucleic Acids Res. 25:1997;4035-4040.
27. Helenius M., Hanninen M., Lehtinen S.K., Salminen A. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J. Mol. Cell Cardiol. 28:1996;487-498.
28. Heydari A.R., You S., Takahashi R., Gutsmann-Conrad A., Sarge K.D., Richardson A. Age-related alterations in the activation of heat-shock transcription factor 1 in rat hepatocytes. Exp. Cell Res. 256:2000;83-93.
29. Hirota K., Matsui M., Iwata S., Nishiyama A., Mori K., Yodoi J. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl. Acad. Sci. USA. 94:1997;3633-3638.
30. Hsieh C.C., Xiong W., Xie Q., Rabek J.P., Scott S.G., An M.R., Reisner P.D., Kuninger D.T., Papaconstantinou J. Effects of age on the post-transcriptional regulation of CCAAT/enhancer binding protein alpha and CCAAT/enhancer binding protein beta isoform synthesis in control and LPS-treateds livers. Mol. Biol. Cell. 9:1998;1479-1494.
31. Hsieh M.M., Hegde V., Kelley M.R., Deutsch W.A. Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation. Nucleic Acids Res. 29:2001;3116-3122.
32. Kagi J.H. Overview of metallothionein. Methods Enzymol. 205:1991;613-626.
33. Karagiannides I., Tchkonia T., Dobson D.E., Steppan C.M., Cummins P., Chan G., Salvatori K., Hadzopoulou-Cladaras M., Kirkland J.L. Altered expression of C/EBP family members results in decreased adipogenesis with aging. Am. J. Physiol Regul. Integr. Comp Physiol. 280:2001;R1772-R1780.
34. Kirkwood T.L., Kapahi P., Shanley D.P. Evolution, stress and longevity. J. Anat. 197(Suppl. 4):2000;587-590.
35. Klar A.J., Strathern J.N., Broach J.R., Hicks J.B. Regulation of transcription in expressed and unexpressed mating type cassettes of yeast. Nature. 289:1981;239-244.
36. Komarov P.G., Komarova E.A., Kondratov R.V., Christov-Tselkov K., Coon J.S., Chernov M.V., Gudkov A.V. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science. 285:1999;1733-1737.
37. Laity J.H., Lee B.M., Wright P.E. Zinc-finger proteins: new insights into structural and functional diversity. Curr. Opin. Struct. Biol. 11:2001;39-46.
38. Lavrovsky Y., Chatterjee B., Clark R.A., Roy A.K. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp. Gerontol. 35:2000;521-532.
39. Lee C.K., Klopp R.G., Weindruch R., Prolla T.A. Gene expression profile of aging and its retardation by caloric restriction. Science. 285:1999;1390-1393.
40. Lemon B., Inouye C., King D.S., Tjian R. Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. Nature. 414:2001;924-928.
41. Lin C.S., Kuo H.H., Chen J.Y., Yang C.S., Wang W.B. Epstein-barr virus nuclear antigen 2 retards cell growth, induces p21 (WAF1) expression, and modulates p53 activity post-translationally. J. Mol. Biol. 303:2000;7-23.
42. Lindquist S., Craig E.A. The heat-shock proteins. Annu. Rev. Genet. 22:1988;631-677.
43. Loeb L.A., Preston B.D. Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet. 20:1986;201-230.
44. Mangelsdorf D.J., Evans R.M. The RXR heterodimers and orphan receptors. Cell. 83:1995;841-850.
45. Matthews J.R., Wakasugi N., Virelizier J.L., Yodoi J., Hay R.T. Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 20:1992;3821-3830.
46. McCord J.M., Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein hemocuprein. J. Biol. Chem. 244:1969;6049-6055.
47. McKay L.I., Cidlowski J.A. Cross-talk between nuclear factor-kappa B and the steroid hormone receptors: mechanisms of mutual antagonism. Mol. Endocrinol. 12:1998;45-56.
48. McKenna N.J., Lanz R.B., O'Malley B.W. Nuclear receptor coregulators: cellular and molecular biology. Endocr. Rev. 20:1999;321-344.
49. Naar A.M., Lemon B.D., Tjian R. Transcriptional co-activator complexes. Annu. Rev. Biochem. 70:2001;475-501.
50. Niedzwiecki A., Kongpachith A.M., Fleming J.E. Aging affects expression of 70-kDa heat shock proteins in Drosophila. J. Biol. Chem. 266:1991;9332-9338.
51. Okamoto K., Tanaka H., Ogawa H., Makino Y., Eguchi H., Hayashi S., Yoshikawa N., Poellinger L., Umesono K., Makino I. Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J. Biol. Chem. 274:1999;10363-10371.
52. Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130.
53. Pei D.Q., Shih C.H. Transcriptional activation and repression by cellular DNA binding protein C/EBP. J. Virol. 64:1990;1517-1522.
54. Qin J., Clore G.M., Kennedy W.M., Huth J.R., Gronenborn A.M. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF kappa B. Structure. 3:1995;289-297.
55. Ray A., Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U.S.A. 91:1994;752-756.
56. Rorth P., Montell D.J. Drosophila C/EBP: a tissue-specific DNA binding protein required for embryonic development. Genes Dev. 6:1992;2299-2311.
57. Roy A.K., Vellanoweth R.L., Chen S., Supakar P.C., Jung M.H., Song C.S., Chatterjee B. The evolutionary tangle of aging, sex, and reproduction and an experimental approach to its molecular dissection. Exp. Gerontol. 31:1996;83-94.
58. Roy A.K. Transcription factors and aging. Mol. Med. 3:1997;496-504.
59. Sano M., Fukuda K., Sato T., Kawaguchi H., Suematsu M., Matsuda S., Koyasu S., Matsui H., Yamauchi-Takihara K., Harada M., Saito Y., Ogawa S. ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Circ. Res. 89:2001;661-669.
60. Spencer N.F., Poynter M.E., Im S.Y., Daynes R.A. Constitutive activation of NF-kappa B in an animal model of aging. Int. Immunol. 9:1997;1581-1588.
61. Stadtman E.R. Protein oxidation and aging. Science. 257:1992;1220-1224.
62. Supakar P.C., Song C.S., Jung M.H., Slomczynska M.A., Kim J.M., Vellanoweth R.L., Chatterjee B., Roy A.K. A novel regulatory element associated with age-dependent expression of the rat androgen receptor gene. J. Biol. Chem. 268:1993;26400-26408.
63. Supakar P.C., Jung M.H., Song C.S., Chatterjee B., Roy A.K. Nuclear factor kappa B functions as a negative regulator for the rat androgen receptor gene and NF-kappa B activity increases during the age-dependent desensitization of the liver. J. Biol. Chem. 270:1995;837-842.
64. Supakar P.C., Roy A.K. Role of transcription factors in the age-dependent regulation of the androgen receptor gene in rat liver. Biol. Signals Recept. 5:1996;170-179.
65. Suske G. The Sp-family of transcription factors. Gene. 238:1999;291-300.
66. Tanabe O., Akira S., Kamiya T., Wong G.G., Hirano T., Kishimoto T. Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human. J. Immunol. 141:1988;3875-3881.
67. Tanaka T., Nakamura H., Nishiyama A., Hosoi F., Masutani H., Wada H., Yodoi J. Redox regulation by thioredoxin superfamily: protection against oxidative stress and aging. Free Radic. Res. 33:2001;851-855.
68. Timchenko N.A., Wilde M., Nakanishi M., Smith J.R., Darlington G.J. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10:1996;804-815.
69. Tissenbaum H.A., Guarente L. Increased dosage of a SIR-2 gene extends life-span in Caenorhabditis elegans. Nature. 410:2001;227-230.
70. Toliver-Kinsky T., Papaconstantinou J., Perez-Polo J.R. Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity. J. Neurosci. Res. 48:1997;580-587.
71. Truss M., Bartsch J., Schelbert A., Hache R.J., Beato M. Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo. EMBO J. 14:1995;1737-1751.
72. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Igelmann H., Lu X., Soron G., Cooper B., Brayton C., Hee P.S., Thompson T., Karsenty G., Bradley A., Donehower L.A. p53 Mutant mice that display early ageing-associated phenotypes. Nature. 415:2002;45-53.
73. Vaziri H., Dessain S.K., Ng E.E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:2001;149-159.
74. Vellanoweth R.L., Suprakar P.C., Roy A.K. Transcription factors in development, growth, and aging. Lab. Invest. 70:1994;784-799.
75. Verma I.M., Stevenson J. IkappaB kinase: beginning, not the end. Proc. Natl. Acad. Sci. U.S.A. 94:1997;11758-11760.
76. Vignali M., Hassan A.H., Neely K.E., Workman J.L. ATP-dependent chromatin-remodeling complexes. Mol. Cell Biol. 20:2000;1899-1910.
77. Wolffe, A.P., 1992. Chromatin: Structure and Function. Academic Press, London.
78. Wu X., Bishopric N.H., Discher D.J., Murphy B.J., Webster K.A. Physical and functional sensitivity of zinc-finger transcription factors to redox change. Mol. Cell Biol. 16:1996;1035-1046.
79. Xanthoudakis S., Miao G., Wang F., Pan Y.C., Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11:1992;3323-3335.
80. Xanthoudakis S., Miao G.G., Curran T. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc. Natl. Acad. Sci. U.S.A. 91:1994;23-27.