-
1
-
-
3142668982
-
Apoptosis and systemic lupus erythematosus
-
Sheriff A, Gaipl US, Voll RE, Kalden JR, Herrmann M. Apoptosis and systemic lupus erythematosus. Rheum Dis Clin North Am 2004 30 : 505 27.
-
(2004)
Rheum Dis Clin North Am
, vol.30
, pp. 505-27
-
-
Sheriff, A.1
Gaipl, U.S.2
Voll, R.E.3
Kalden, J.R.4
Herrmann, M.5
-
2
-
-
0344492212
-
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
-
Baechler EC, Batliwalla FM, Karypis G et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003 100 : 2610 15.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2610-15
-
-
Baechler, E.C.1
Batliwalla, F.M.2
Karypis, G.3
-
3
-
-
17244373451
-
Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort
-
Alarcón-Segovia D, Alarcón-Riquelme ME, Cardiel MH et al. Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort. Arthritis Rheum 2005 52 : 1138 47.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1138-47
-
-
Alarcón-Segovia, D.1
Alarcón-Riquelme, M.E.2
Cardiel, M.H.3
-
4
-
-
34249860408
-
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
-
Graham RR, Kyogoku C, Sigurdsson S et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci USA 2007 104 : 6758 63.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6758-63
-
-
Graham, R.R.1
Kyogoku, C.2
Sigurdsson, S.3
-
5
-
-
38649125210
-
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
-
International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)
-
International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley JB, Alarcón-Riquelme ME et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008 40 : 204 10.
-
(2008)
Nat Genet
, vol.40
, pp. 204-10
-
-
Harley, J.B.1
Alarcón-Riquelme, M.E.2
-
6
-
-
67849099131
-
Recent insights into the genetic basis of systemic lupus erythematosus
-
Moser KL, Kelly JA, Lessard CJ, Harley JB. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 2009 10 : 373 9.
-
(2009)
Genes Immun
, vol.10
, pp. 373-9
-
-
Moser, K.L.1
Kelly, J.A.2
Lessard, C.J.3
Harley, J.B.4
-
7
-
-
75649151209
-
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
-
Javierre BM, Fernandez AF, Richter J et al. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res 2010 20 : 170 9.
-
(2010)
Genome Res
, vol.20
, pp. 170-9
-
-
Javierre, B.M.1
Fernandez, A.F.2
Richter, J.3
-
8
-
-
0025666735
-
Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
-
Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990 33 : 1665 73.
-
(1990)
Arthritis Rheum
, vol.33
, pp. 1665-73
-
-
Richardson, B.1
Scheinbart, L.2
Strahler, J.3
Gross, L.4
Hanash, S.5
Johnson, M.6
-
9
-
-
0025736912
-
5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases
-
Corvetta A, Della Bitta R, Luchetti MM, Pomponio G. 5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases. J Chromatogr 1991 566 : 481 91.
-
(1991)
J Chromatogr
, vol.566
, pp. 481-91
-
-
Corvetta, A.1
Della Bitta, R.2
Luchetti, M.M.3
Pomponio, G.4
-
10
-
-
0023936754
-
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
-
Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988 140 : 2197 200.
-
(1988)
J Immunol
, vol.140
, pp. 2197-200
-
-
Cornacchia, E.1
Golbus, J.2
Maybaum, J.3
Strahler, J.4
Hanash, S.5
Richardson, B.6
-
11
-
-
0031664697
-
Molecular mimicry and immune-mediated diseases
-
Oldstone MB. Molecular mimicry and immune-mediated diseases. FASEB J 1998 12 : 1255 65.
-
(1998)
FASEB J
, vol.12
, pp. 1255-65
-
-
Oldstone, M.B.1
-
12
-
-
13444287958
-
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
-
McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 2005 11 : 85 9.
-
(2005)
Nat Med
, vol.11
, pp. 85-9
-
-
McClain, M.T.1
Heinlen, L.D.2
Dennis, G.J.3
Roebuck, J.4
Harley, J.B.5
James, J.A.6
-
13
-
-
0014910678
-
The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid
-
Carpenter DF, Steinberg AD, Schur PH, Talal N. The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid. Lab Invest 1970 23 : 628 34.
-
(1970)
Lab Invest
, vol.23
, pp. 628-34
-
-
Carpenter, D.F.1
Steinberg, A.D.2
Schur, P.H.3
Talal, N.4
-
14
-
-
33644515263
-
Toll-like receptor-7 modulates immune complex glomerulonephritis
-
Pawar RD, Patole PS, Zecher D et al. Toll-like receptor-7 modulates immune complex glomerulonephritis. J Am Soc Nephrol 2006 17 : 141 9.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 141-9
-
-
Pawar, R.D.1
Patole, P.S.2
Zecher, D.3
-
15
-
-
0345306152
-
Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF1 mice
-
Hasegawa K, Hayashi T. Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF1 mice. Lupus 2003 12 : 838 45.
-
(2003)
Lupus
, vol.12
, pp. 838-45
-
-
Hasegawa, K.1
Hayashi, T.2
-
16
-
-
1642396952
-
Activation of Toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
-
Anders HJ, Vielhauer V, Eis V et al. Activation of Toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J 2004 18 : 534 6.
-
(2004)
FASEB J
, vol.18
, pp. 534-6
-
-
Anders, H.J.1
Vielhauer, V.2
Eis, V.3
-
17
-
-
6344227970
-
Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: High level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow
-
Lian ZX, Kikuchi K, Yang GX, Ansari AA, Ikehara S, Gerswin ME. Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow. J Immunol 2004 173 : 5283 9.
-
(2004)
J Immunol
, vol.173
, pp. 5283-9
-
-
Lian, Z.X.1
Kikuchi, K.2
Yang, G.X.3
Ansari, A.A.4
Ikehara, S.5
Gerswin, M.E.6
-
18
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi H, Takeuchi O, Kawai T et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000 408 : 740 5.
-
(2000)
Nature
, vol.408
, pp. 740-5
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
-
19
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004 303 : 1529 31.
-
(2004)
Science
, vol.303
, pp. 1529-31
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis Sousa, E.C.5
-
20
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
-
Heil F, Hemmi H, Hochrein H et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 2004 303 : 1526 9.
-
(2004)
Science
, vol.303
, pp. 1526-9
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
-
21
-
-
1842631428
-
Recognition of single-stranded RNA viruses by Toll-like receptor 7
-
Lund JM, Alexopoulou L, Sato A et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 2004 101 : 5598 603.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 5598-603
-
-
Lund, J.M.1
Alexopoulou, L.2
Sato, A.3
-
22
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001 413 : 732 8.
-
(2001)
Nature
, vol.413
, pp. 732-8
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
23
-
-
22944490869
-
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
-
Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 2005 202 : 321 31.
-
(2005)
J Exp Med
, vol.202
, pp. 321-31
-
-
Christensen, S.R.1
Kashgarian, M.2
Alexopoulou, L.3
Flavell, R.A.4
Akira, S.5
Shlomchik, M.J.6
-
24
-
-
0029854905
-
A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: Implications for the origins of autoantibodies in autoimmune disease
-
Hannum LG, Ni D, Haberman AM, Weigert MG, Shlomchik MJ. A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J Exp Med 1996 184 : 1269 78.
-
(1996)
J Exp Med
, vol.184
, pp. 1269-78
-
-
Hannum, L.G.1
Ni, D.2
Haberman, A.M.3
Weigert, M.G.4
Shlomchik, M.J.5
-
25
-
-
0026566292
-
Antibodies to histones in systemic lupus erythematosus and drug-induced lupus
-
Monestier M, Kotzin BL. Antibodies to histones in systemic lupus erythematosus and drug-induced lupus. Rheum Dis Clin North Am 1992 18 : 415 36.
-
(1992)
Rheum Dis Clin North Am
, vol.18
, pp. 415-36
-
-
Monestier, M.1
Kotzin, B.L.2
-
26
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Schlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002 416 : 603 7.
-
(2002)
Nature
, vol.416
, pp. 603-7
-
-
Leadbetter, E.A.1
Rifkin, I.R.2
Hohlbaum, A.M.3
Beaudette, B.C.4
Schlomchik, M.J.5
Marshak-Rothstein, A.6
-
27
-
-
0347480224
-
Activation of autoreactive B cells by CpG dsDNA
-
Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A. Activation of autoreactive B cells by CpG dsDNA. Immunity 2003 19 : 837 47.
-
(2003)
Immunity
, vol.19
, pp. 837-47
-
-
Viglianti, G.A.1
Lau, C.M.2
Hanley, T.M.3
Miko, B.A.4
Shlomchik, M.J.5
Marshak-Rothstein, A.6
-
28
-
-
58749093255
-
Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha
-
Uccellini MB, Busconi L, Green NM et al. Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. J Immunol 2008 181 : 5875 84.
-
(2008)
J Immunol
, vol.181
, pp. 5875-84
-
-
Uccellini, M.B.1
Busconi, L.2
Green, N.M.3
-
29
-
-
27744444832
-
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
-
Lau CM, Broughton C, Tabor AS et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005 202 : 1171 7.
-
(2005)
J Exp Med
, vol.202
, pp. 1171-7
-
-
Lau, C.M.1
Broughton, C.2
Tabor, A.S.3
-
30
-
-
44649161194
-
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses toDNA-containing antigens
-
Chaturvedi A, Dorward D, Pierce SK. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses toDNA-containing antigens. Immunity 2008 28 : 799 809.
-
(2008)
Immunity
, vol.28
, pp. 799-809
-
-
Chaturvedi, A.1
Dorward, D.2
Pierce, S.K.3
-
31
-
-
65549136622
-
Endocytic sequestration of the B cell antigen receptor and Toll-like receptor 9 in anergic cells
-
O'Neill SK, Veselits ML, Zhang M et al. Endocytic sequestration of the B cell antigen receptor and Toll-like receptor 9 in anergic cells. Proc Natl Acad Sci USA 2009 106 : 6262 7.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6262-7
-
-
O'Neill, S.K.1
Veselits, M.L.2
Zhang, M.3
-
32
-
-
3042548183
-
Toll-like receptor 9-dependent and -independent dendritic cell activation bychromatin-immunoglobulin G complexes
-
Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation bychromatin-immunoglobulin G complexes. J Exp Med 2004 199 : 1631 40.
-
(2004)
J Exp Med
, vol.199
, pp. 1631-40
-
-
Boulé, M.W.1
Broughton, C.2
MacKay, F.3
Akira, S.4
Marshak-Rothstein, A.5
Rifkin, I.R.6
-
33
-
-
85047693371
-
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
-
Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005 115 : 407 17.
-
(2005)
J Clin Invest
, vol.115
, pp. 407-17
-
-
Means, T.K.1
Latz, E.2
Hayashi, F.3
Murali, M.R.4
Golenbock, D.T.5
Luster, A.D.6
-
34
-
-
33748472865
-
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
-
Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006 25 : 417 28.
-
(2006)
Immunity
, vol.25
, pp. 417-28
-
-
Christensen, S.R.1
Shupe, J.2
Nickerson, K.3
Kashgarian, M.4
Flavell, R.A.5
Shlomchik, M.J.6
-
35
-
-
59649107055
-
TLR7-dependent and FcgammaR-independent production of type i interferon in experimental mouse lupus
-
Lee PY, Kumagai Y, Li Y, Takeuchi O et al. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J Exp Med 2008 205 : 2995 3006.
-
(2008)
J Exp Med
, vol.205
, pp. 2995-3006
-
-
Lee, P.Y.1
Kumagai, Y.2
Li, Y.3
Takeuchi, O.4
-
36
-
-
42449117483
-
Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
-
Savarese E, Steinberg C, Pawar RD et al. Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum 2008 58 : 1107 15.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1107-15
-
-
Savarese, E.1
Steinberg, C.2
Pawar, R.D.3
-
37
-
-
77953691247
-
TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells
-
doi:10.1136/ard.2009.108282
-
Pan ZJ, Maier S, Schwarz K et al. TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells. Ann Rheum Dis 2009 doi:10.1136/ard.2009.108282.
-
(2009)
Ann Rheum Dis
-
-
Pan, Z.J.1
Maier, S.2
Schwarz, K.3
-
38
-
-
36048962438
-
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
-
Deane JA, Pisitkun P, Barrett RS et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007 27 : 801 10.
-
(2007)
Immunity
, vol.27
, pp. 801-10
-
-
Deane, J.A.1
Pisitkun, P.2
Barrett, R.S.3
-
39
-
-
33745168605
-
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
-
Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB, Bolland S. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006 312 : 1669 72.
-
(2006)
Science
, vol.312
, pp. 1669-72
-
-
Pisitkun, P.1
Deane, J.A.2
Difilippantonio, M.J.3
Tarasenko, T.4
Satterthwaite, A.B.5
Bolland, S.6
-
40
-
-
33745617886
-
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
-
Subramanian S, Tus K, Li QZ et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA 2006 103 : 9970 5.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 9970-5
-
-
Subramanian, S.1
Tus, K.2
Li, Q.Z.3
-
41
-
-
50549086761
-
Yaa autoimmune phenotypes are conferred by overexpression of TLR7
-
Fairhurst AM, Hwang SH, Wang A et al. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 2008 38 : 1971 8.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1971-8
-
-
Fairhurst, A.M.1
Hwang, S.H.2
Wang, A.3
-
42
-
-
33645076274
-
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
-
Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006 203 : 553 61.
-
(2006)
J Exp Med
, vol.203
, pp. 553-61
-
-
Ehlers, M.1
Fukuyama, H.2
McGaha, T.L.3
Aderem, A.4
Ravetch, J.V.5
-
43
-
-
76249125968
-
IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus
-
Richez C, Yasuda K, Bonegio RG et al. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol 2010 184 : 796 806.
-
(2010)
J Immunol
, vol.184
, pp. 796-806
-
-
Richez, C.1
Yasuda, K.2
Bonegio, R.G.3
-
44
-
-
0037029604
-
Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice
-
Bolland S, Yim YS, Tus K, Wakeland EK, Ravetch JV. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 2002 195 : 1167 74.
-
(2002)
J Exp Med
, vol.195
, pp. 1167-74
-
-
Bolland, S.1
Yim, Y.S.2
Tus, K.3
Wakeland, E.K.4
Ravetch, J.V.5
-
45
-
-
31044440025
-
Toll-like receptor 9 signaling protects against murine lupus
-
Wu X, Peng SL. Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 2006 54 : 336 42.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 336-42
-
-
Wu, X.1
Peng, S.L.2
-
46
-
-
33748465308
-
Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE
-
Yu P, Wellmann U, Kunder S et al. Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE. Int Immunol 2006 18 : 1211 19.
-
(2006)
Int Immunol
, vol.18
, pp. 1211-19
-
-
Yu, P.1
Wellmann, U.2
Kunder, S.3
-
47
-
-
13544254614
-
Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides
-
Brummel R, Lenert P. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J Immunol 2005 174 : 2429 34.
-
(2005)
J Immunol
, vol.174
, pp. 2429-34
-
-
Brummel, R.1
Lenert, P.2
-
48
-
-
15244349648
-
TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production
-
Lenert P, Brummel R, Field EH, Ashman RF. TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production. J Clin Immunol 2005 25 : 29 40.
-
(2005)
J Clin Immunol
, vol.25
, pp. 29-40
-
-
Lenert, P.1
Brummel, R.2
Field, E.H.3
Ashman, R.F.4
-
49
-
-
77952242576
-
Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice
-
doi:10.1016/j.jaut.2009.11.001
-
Santiago-Raber ML, Dunand-Sauthier I, Wu T et al. Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice. J Autoimmun 2009 doi:10.1016/j.jaut.2009.11.001.
-
(2009)
J Autoimmun
-
-
Santiago-Raber, M.L.1
Dunand-Sauthier, I.2
Wu, T.3
-
50
-
-
23944497673
-
Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
-
Patole PS, Gröne HJ, Segerer S et al. Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 2005 16 : 1326 38.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 1326-38
-
-
Patole, P.S.1
Gröne, H.J.2
Segerer, S.3
-
51
-
-
67749135880
-
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
-
Kono DH, Haraldsson MK, Lawson BR et al. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 2009 106 : 12061 6.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12061-6
-
-
Kono, D.H.1
Haraldsson, M.K.2
Lawson, B.R.3
-
52
-
-
40749098665
-
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
-
Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 2008 452 : 234 8.
-
(2008)
Nature
, vol.452
, pp. 234-8
-
-
Kim, Y.M.1
Brinkmann, M.M.2
Paquet, M.E.3
Ploegh, H.L.4
-
53
-
-
31344466165
-
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
-
Tabeta K, Hoebe K, Janssen EM et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 2006 7 : 156 64.
-
(2006)
Nat Immunol
, vol.7
, pp. 156-64
-
-
Tabeta, K.1
Hoebe, K.2
Janssen, E.M.3
-
54
-
-
67449136127
-
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
-
Fukui R, Saitoh S, Matsumoto F et al. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med 2009 206 : 1339 50.
-
(2009)
J Exp Med
, vol.206
, pp. 1339-50
-
-
Fukui, R.1
Saitoh, S.2
Matsumoto, F.3
-
55
-
-
67650600639
-
Glomerular expression of Toll-like receptor-9 in lupus nephritis but not in normal kidneys: Implications for the amplification of the inflammatory response
-
Papadimitraki ED, Tzardi M, Bertsias G, Sotsiou E, Boumpas DT. Glomerular expression of Toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response. Lupus 2009 18 : 831 5.
-
(2009)
Lupus
, vol.18
, pp. 831-5
-
-
Papadimitraki, E.D.1
Tzardi, M.2
Bertsias, G.3
Sotsiou, E.4
Boumpas, D.T.5
-
56
-
-
67049143142
-
Response to ODN-CpG by B Cells from patients with systemic lupus erythematosus correlates with disease activity
-
Zorro S, Arias M, Riaño F et al. Response to ODN-CpG by B Cells from patients with systemic lupus erythematosus correlates with disease activity. Lupus 2009 18 : 718 26.
-
(2009)
Lupus
, vol.18
, pp. 718-26
-
-
Zorro, S.1
Arias, M.2
Riaño, F.3
-
57
-
-
64049093899
-
The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population
-
Wu O, Chen GP, Chen H et al. The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population. Immunobiology 2009 214 : 392 402.
-
(2009)
Immunobiology
, vol.214
, pp. 392-402
-
-
Wu, O.1
Chen, G.P.2
Chen, H.3
-
58
-
-
43349094856
-
Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
-
Komatsuda A, Wakui H, Iwamoto K et al. Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 2008 152 : 482 7.
-
(2008)
Clin Exp Immunol
, vol.152
, pp. 482-7
-
-
Komatsuda, A.1
Wakui, H.2
Iwamoto, K.3
-
59
-
-
69449088671
-
Regression of systemic lupus erythematosus after development of an acquired Toll-like receptor signaling defect and antibody deficiency
-
Visentini M, Conti V, Cagliuso M et al. Regression of systemic lupus erythematosus after development of an acquired Toll-like receptor signaling defect and antibody deficiency. Arthritis Rheum 2009 60 : 2767 71.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2767-71
-
-
Visentini, M.1
Conti, V.2
Cagliuso, M.3
-
60
-
-
70350323680
-
Association study of a single nucleotide polymorphism in the exon 2 region of Toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese
-
Xu CJ, Zhang WH, Pan HF, Li XP, Xu JH, Ye DQ. Association study of a single nucleotide polymorphism in the exon 2 region of Toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. Mol Biol Rep 2009 36 : 2245 8.
-
(2009)
Mol Biol Rep
, vol.36
, pp. 2245-8
-
-
Xu, C.J.1
Zhang, W.H.2
Pan, H.F.3
Li, X.P.4
Xu, J.H.5
Ye, D.Q.6
-
61
-
-
67249107279
-
Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus
-
Sánchez E, Callejas-Rubio JL, Sabio JM et al. Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. Clin Exp Rheumatol 2009 27 : 267 71.
-
(2009)
Clin Exp Rheumatol
, vol.27
, pp. 267-71
-
-
Sánchez, E.1
Callejas-Rubio, J.L.2
Sabio, J.M.3
-
62
-
-
0345447639
-
Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
-
Spies B, Hochrein H, Vabulas M et al. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol 2003 171 : 5908 12.
-
(2003)
J Immunol
, vol.171
, pp. 5908-12
-
-
Spies, B.1
Hochrein, H.2
Vabulas, M.3
-
63
-
-
4444325043
-
TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine
-
Babiuk S, Mookherjee N, Pontarollo R et al. TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine. Immunology 2004 113 : 114 20.
-
(2004)
Immunology
, vol.113
, pp. 114-20
-
-
Babiuk, S.1
Mookherjee, N.2
Pontarollo, R.3
-
64
-
-
33744804308
-
TLR9-independent activation of B lymphocytes by bacterial DNA
-
Cortez-Gonzalez X, Pellicciotta I, Gerloni M et al. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol 2006 25 : 253 61.
-
(2006)
DNA Cell Biol
, vol.25
, pp. 253-61
-
-
Cortez-Gonzalez, X.1
Pellicciotta, I.2
Gerloni, M.3
-
65
-
-
38949093002
-
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
-
Ishii KJ, Kawagoe T, Koyama S et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008 451 : 725 9.
-
(2008)
Nature
, vol.451
, pp. 725-9
-
-
Ishii, K.J.1
Kawagoe, T.2
Koyama, S.3
-
66
-
-
27944453599
-
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
-
Okabe Y, Kawane K, Akira S, Taniguchi T, Nagata S. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med 2005 202 : 1333 9.
-
(2005)
J Exp Med
, vol.202
, pp. 1333-9
-
-
Okabe, Y.1
Kawane, K.2
Akira, S.3
Taniguchi, T.4
Nagata, S.5
-
67
-
-
12344290452
-
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
-
Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 2005 6 : 49 56.
-
(2005)
Nat Immunol
, vol.6
, pp. 49-56
-
-
Yoshida, H.1
Okabe, Y.2
Kawane, K.3
Fukuyama, H.4
Nagata, S.5
-
68
-
-
47149108866
-
Interferon-inducible Ifi200-family genes in systemic lupus erythematosus
-
Choubey D, Panchanathan R. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol Lett 2008 119 : 32 41.
-
(2008)
Immunol Lett
, vol.119
, pp. 32-41
-
-
Choubey, D.1
Panchanathan, R.2
-
69
-
-
35748950430
-
Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders
-
Mondini M, Vidali M, Airò P et al. Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann NY Acad Sci 2007 1110 : 47 56.
-
(2007)
Ann NY Acad Sci
, vol.1110
, pp. 47-56
-
-
Mondini, M.1
Vidali, M.2
Airò, P.3
-
70
-
-
77649105762
-
Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene
-
Song LL, Ponomareva L, Shen H, Duan X, Alimirah F, Choubey D. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. PLoS One 2010 5 : e8569.
-
(2010)
PLoS One
, vol.5
-
-
Song, L.L.1
Ponomareva, L.2
Shen, H.3
Duan, X.4
Alimirah, F.5
Choubey, D.6
-
71
-
-
0344234427
-
Links between type i interferons and the genetic basis of disease in mouse lupus
-
Jørgensen TN, Gubbels MR, Kotzin BL. Links between type I interferons and the genetic basis of disease in mouse lupus. Autoimmunity 2003 36 : 491 502.
-
(2003)
Autoimmunity
, vol.36
, pp. 491-502
-
-
Jørgensen, T.N.1
Gubbels, M.R.2
Kotzin, B.L.3
-
72
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Roberts TL, Idris A, Dunn JA et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009 323 : 1057 60.
-
(2009)
Science
, vol.323
, pp. 1057-60
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
-
73
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung V, Ablasser A, Charrel-Dennis M et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009 458 : 514 18.
-
(2009)
Nature
, vol.458
, pp. 514-18
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
-
74
-
-
0033568547
-
Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster
-
Wang H, Chatterjee G, Meyer JJ et al. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon- activatable gene 200 cluster. Genomics 1999 60 : 281 94.
-
(1999)
Genomics
, vol.60
, pp. 281-94
-
-
Wang, H.1
Chatterjee, G.2
Meyer, J.J.3
-
75
-
-
37349005293
-
The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function
-
Gubbels Bupp MR, Li M, Pashine A, Aud D, Peng SL. The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function. Rheumatology (Oxf) 2008 47 : 103 4.
-
(2008)
Rheumatology (Oxf)
, vol.47
, pp. 103-4
-
-
Gubbels Bupp, M.R.1
Li, M.2
Pashine, A.3
Aud, D.4
Peng, S.L.5
-
77
-
-
38549096975
-
Microarray analysis of glomerular gene expression in murine lupus nephritis
-
Teramoto K, Negoro N, Kitamoto K et al. Microarray analysis of glomerular gene expression in murine lupus nephritis. J Pharmacol Sci 2008 106 : 56 67.
-
(2008)
J Pharmacol Sci
, vol.106
, pp. 56-67
-
-
Teramoto, K.1
Negoro, N.2
Kitamoto, K.3
-
78
-
-
70349503643
-
Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR
-
Kimkong I, Avihingsanon Y, Hirankarn N. Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR. Lupus 2009 18 : 1066 72.
-
(2009)
Lupus
, vol.18
, pp. 1066-72
-
-
Kimkong, I.1
Avihingsanon, Y.2
Hirankarn, N.3
-
79
-
-
3042844142
-
Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli
-
Peterson KS, Huang JF, Zhu J et al. Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli. J Clin Invest 2004 113 : 1722 33.
-
(2004)
J Clin Invest
, vol.113
, pp. 1722-33
-
-
Peterson, K.S.1
Huang, J.F.2
Zhu, J.3
-
80
-
-
34548572051
-
Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells
-
Yamauchi M, Hashimoto M, Ichiyama K et al. Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Int Immunol 2007 19 : 935 42.
-
(2007)
Int Immunol
, vol.19
, pp. 935-42
-
-
Yamauchi, M.1
Hashimoto, M.2
Ichiyama, K.3
-
81
-
-
5644255667
-
Interferon-alpha-inducible proteins are novel autoantigens in murine lupus
-
Hueber W, Zeng D, Strober S, Utz PJ. Interferon-alpha-inducible proteins are novel autoantigens in murine lupus. Arthritis Rheum 2004 50 : 3239 49.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 3239-49
-
-
Hueber, W.1
Zeng, D.2
Strober, S.3
Utz, P.J.4
-
82
-
-
34547143110
-
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
-
Takaoka A, Wang Z, Choi MK et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007 448 : 501 5.
-
(2007)
Nature
, vol.448
, pp. 501-5
-
-
Takaoka, A.1
Wang, Z.2
Choi, M.K.3
-
83
-
-
44449157593
-
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
-
Wang Z, Choi MK, Ban T et al. Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci USA 2008 105 : 5477 82.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 5477-82
-
-
Wang, Z.1
Choi, M.K.2
Ban, T.3
-
84
-
-
0345827590
-
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
-
McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci USA 2004 101 : 233 8.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 233-8
-
-
McWhirter, S.M.1
Fitzgerald, K.A.2
Rosains, J.3
Rowe, D.C.4
Golenbock, D.T.5
Maniatis, T.6
-
85
-
-
68249113997
-
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
-
Rebsamen M, Heinz LX, Meylan E et al. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep 2009 10 : 916 22.
-
(2009)
EMBO Rep
, vol.10
, pp. 916-22
-
-
Rebsamen, M.1
Heinz, L.X.2
Meylan, E.3
-
86
-
-
58749100879
-
Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors
-
Kaiser WJ, Upton JW, Mocarski ES. Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J Immunol 2008 181 : 6427 34.
-
(2008)
J Immunol
, vol.181
, pp. 6427-34
-
-
Kaiser, W.J.1
Upton, J.W.2
Mocarski, E.S.3
-
87
-
-
55749088259
-
IFN beta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI)
-
Lippmann J, Rothenburg S, Deigendesch N et al. IFN beta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol 2008 10 : 2579 88.
-
(2008)
Cell Microbiol
, vol.10
, pp. 2579-88
-
-
Lippmann, J.1
Rothenburg, S.2
Deigendesch, N.3
-
88
-
-
35748967851
-
High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
-
Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2007 220 : 35 46.
-
(2007)
Immunol Rev
, vol.220
, pp. 35-46
-
-
Bianchi, M.E.1
Manfredi, A.A.2
-
89
-
-
55549128746
-
High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease
-
Pisetsky DS, Erlandsson-Harris H, Andersson U. High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 2008 10 : 209.
-
(2008)
Arthritis Res Ther
, vol.10
, pp. 209
-
-
Pisetsky, D.S.1
Erlandsson-Harris, H.2
Andersson, U.3
-
90
-
-
34250837518
-
A novel role for HMGB1 in TLR9 mediated inflammatory responses to CpG-DNA
-
Ivanov S, Dragoi AM, Wang X et al. A novel role for HMGB1 in TLR9 mediated inflammatory responses to CpG-DNA. Blood 2007 110 : 1970 81.
-
(2007)
Blood
, vol.110
, pp. 1970-81
-
-
Ivanov, S.1
Dragoi, A.M.2
Wang, X.3
-
91
-
-
0024584528
-
Specific recognition of cruciform DNA by nuclear protein HMG1
-
Bianchi ME, Beltrame M, Paonessa G. Specific recognition of cruciform DNA by nuclear protein HMG1. Science 1989 243 : 1056 9.
-
(1989)
Science
, vol.243
, pp. 1056-9
-
-
Bianchi, M.E.1
Beltrame, M.2
Paonessa, G.3
-
92
-
-
34247236200
-
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
-
Tian J, Avalos AM, Mao SY et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007 8 : 487 96.
-
(2007)
Nat Immunol
, vol.8
, pp. 487-96
-
-
Tian, J.1
Avalos, A.M.2
Mao, S.Y.3
-
93
-
-
33747751590
-
Alarmin(g) news about danger: Workshop on innate danger signals and HMGB1
-
Harris HE, Raucci A. Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep 2006 7 : 774 8.
-
(2006)
EMBO Rep
, vol.7
, pp. 774-8
-
-
Harris, H.E.1
Raucci, A.2
-
94
-
-
75749158495
-
RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes
-
Avalos AM, Kiefer K, Tian J et al. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity 2010 43 : 103 10.
-
(2010)
Autoimmunity
, vol.43
, pp. 103-10
-
-
Avalos, A.M.1
Kiefer, K.2
Tian, J.3
-
96
-
-
70749133481
-
The translocation of HMGB1 during cell activation and cell death
-
Gauley J, Pisetsky DS. The translocation of HMGB1 during cell activation and cell death. Autoimmunity 2009 42 : 299 301.
-
(2009)
Autoimmunity
, vol.42
, pp. 299-301
-
-
Gauley, J.1
Pisetsky, D.S.2
-
97
-
-
59649126956
-
Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: Implications for the pathogenesis of SLE
-
Urbonaviciute V, Fürnrohr BG, Meister S et al. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med 2008 205 : 3007 18.
-
(2008)
J Exp Med
, vol.205
, pp. 3007-18
-
-
Urbonaviciute, V.1
Fürnrohr, B.G.2
Meister, S.3
-
98
-
-
27744461020
-
Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
-
Popovic K, Ek M, Espinosa A et al. Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus. Arthritis Rheum 2005 52 : 3639 45.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 3639-45
-
-
Popovic, K.1
Ek, M.2
Espinosa, A.3
-
99
-
-
0027958019
-
Antibodies to HMG proteins in patients with drug-induced autoimmunity
-
Ayer LM, Rubin RL, Dixon GH, Fritzler MJ. Antibodies to HMG proteins in patients with drug-induced autoimmunity. Arthritis Rheum 1994 37 : 98 103.
-
(1994)
Arthritis Rheum
, vol.37
, pp. 98-103
-
-
Ayer, L.M.1
Rubin, R.L.2
Dixon, G.H.3
Fritzler, M.J.4
-
100
-
-
42449084910
-
Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus
-
Jiang W, Pisetsky DS. Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus. Ann Rheum Dis 2008 67 : 727 8.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 727-8
-
-
Jiang, W.1
Pisetsky, D.S.2
-
101
-
-
70349459734
-
RIG-I-dependent sensing of poly(dA : dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
-
Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-I-dependent sensing of poly(dA : dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009 10 : 1065 72.
-
(2009)
Nat Immunol
, vol.10
, pp. 1065-72
-
-
Ablasser, A.1
Bauernfeind, F.2
Hartmann, G.3
Latz, E.4
Fitzgerald, K.A.5
Hornung, V.6
-
102
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type i interferons through the RIG-I pathway
-
Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009 138 : 576 91.
-
(2009)
Cell
, vol.138
, pp. 576-91
-
-
Chiu, Y.H.1
MacMillan, J.B.2
Chen, Z.J.3
-
103
-
-
29244471275
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
-
Ishii KJ, Coban C, Kato H et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006 7 : 40 8.
-
(2006)
Nat Immunol
, vol.7
, pp. 40-8
-
-
Ishii, K.J.1
Coban, C.2
Kato, H.3
-
104
-
-
3242813113
-
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
-
Yoneyama M, Kikuchi M, Natsukawa T et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004 5 : 730 7.
-
(2004)
Nat Immunol
, vol.5
, pp. 730-7
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
-
105
-
-
0037154176
-
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
-
Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM, Fisher PB. mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc Natl Acad Sci USA 2002 99 : 637 42.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 637-42
-
-
Kang, D.C.1
Gopalkrishnan, R.V.2
Wu, Q.3
Jankowsky, E.4
Pyle, A.M.5
Fisher, P.B.6
-
106
-
-
33646342149
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
-
Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 441 : 101 5.
-
(2006)
Nature
, vol.441
, pp. 101-5
-
-
Kato, H.1
Takeuchi, O.2
Sato, S.3
-
107
-
-
46949097299
-
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
-
Kato H, Takeuchi O, Mikamo-Satoh E et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008 205 : 1601 10.
-
(2008)
J Exp Med
, vol.205
, pp. 1601-10
-
-
Kato, H.1
Takeuchi, O.2
Mikamo-Satoh, E.3
-
108
-
-
59749101255
-
Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses
-
Allam R, Pawar RD, Kulkarni OP et al. Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol 2008 38 : 3487 98.
-
(2008)
Eur J Immunol
, vol.38
, pp. 3487-98
-
-
Allam, R.1
Pawar, R.D.2
Kulkarni, O.P.3
-
109
-
-
0035423557
-
An etiopathogenic role for the type i IFN system in SLE
-
Ronnblom L, Alm GV. An etiopathogenic role for the type I IFN system in SLE. Trends Immunol 2001 22 : 427 31.
-
(2001)
Trends Immunol
, vol.22
, pp. 427-31
-
-
Ronnblom, L.1
Alm, G.V.2
-
110
-
-
4344617762
-
Interferon-alpha in systemic lupus erythematosus
-
Crow MK, Kirou KA. Interferon-alpha in systemic lupus erythematosus. Curr Opin Rheum 2004 16 : 541 7.
-
(2004)
Curr Opin Rheum
, vol.16
, pp. 541-7
-
-
Crow, M.K.1
Kirou, K.A.2
-
111
-
-
0345359586
-
Induction of clinical autoimmune disease by therapeutic interferon-alpha
-
Gota C, Calabrese L. Induction of clinical autoimmune disease by therapeutic interferon-alpha. Autoimmunity 2003 36 : 511 18.
-
(2003)
Autoimmunity
, vol.36
, pp. 511-18
-
-
Gota, C.1
Calabrese, L.2
-
112
-
-
0018775078
-
Immune interferon in the circulation of patients with autoimmune disease
-
Hooks JJ, Moutsopoulos HM, Geis SA, Stahl NI, Decker JL, Notkins AL. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med 1979 301 : 5 8.
-
(1979)
N Engl J Med
, vol.301
, pp. 5-8
-
-
Hooks, J.J.1
Moutsopoulos, H.M.2
Geis, S.A.3
Stahl, N.I.4
Decker, J.L.5
Notkins, A.L.6
-
113
-
-
0034533825
-
Activation of type i interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
-
Bengtsson AA, Sturfelt G, Truedsson L et al. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000 9 : 664 71.
-
(2000)
Lupus
, vol.9
, pp. 664-71
-
-
Bengtsson, A.A.1
Sturfelt, G.2
Truedsson, L.3
-
114
-
-
0242456113
-
Microarray analysis of gene expression in lupus
-
Crow MK, Wohlgemuth J. Microarray analysis of gene expression in lupus. Arthritis Res Ther 2003 5 : 279 87.
-
(2003)
Arthritis Res Ther
, vol.5
, pp. 279-87
-
-
Crow, M.K.1
Wohlgemuth, J.2
-
115
-
-
0037451167
-
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
-
Bennett L, Palucka AK, Arce E et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003 97 : 711 23.
-
(2003)
J Exp Med
, vol.97
, pp. 711-23
-
-
Bennett, L.1
Palucka, A.K.2
Arce, E.3
-
116
-
-
33749331301
-
Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
-
Feng X, Wu H, Grossman JM et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 2006 54 : 2951 62.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2951-62
-
-
Feng, X.1
Wu, H.2
Grossman, J.M.3
-
117
-
-
70349505809
-
Longitudinal expression of type i interferon responsive genes in systemic lupus erythematosus
-
Petri M, Singh S, Tesfasyone H et al. Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus. Lupus 2009 18 : 980 9.
-
(2009)
Lupus
, vol.18
, pp. 980-9
-
-
Petri, M.1
Singh, S.2
Tesfasyone, H.3
-
118
-
-
70349254607
-
TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type i IFN
-
Di Domizio J, Blum A, Gallagher-Gambarelli M, Molens JP, Chaperot L, Plumas J. TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood 2009 114 : 1794 802.
-
(2009)
Blood
, vol.114
, pp. 1794-802
-
-
Di Domizio, J.1
Blum, A.2
Gallagher-Gambarelli, M.3
Molens, J.P.4
Chaperot, L.5
Plumas, J.6
-
119
-
-
0036855470
-
CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors
-
Takauji R, Iho S, Takatsuka H et al. CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors. J Leukoc Biol 2002 72 : 1011 19.
-
(2002)
J Leukoc Biol
, vol.72
, pp. 1011-19
-
-
Takauji, R.1
Iho, S.2
Takatsuka, H.3
-
120
-
-
70349260404
-
Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes
-
Yasuda K, Richez C, Uccellini MB et al. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol 2009 183 : 3109 17.
-
(2009)
J Immunol
, vol.183
, pp. 3109-17
-
-
Yasuda, K.1
Richez, C.2
Uccellini, M.B.3
-
121
-
-
14044278824
-
IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black × New Zealand White) F1 but not in BALB/c mice
-
Mathian A, Weinberg A, Gallegos M, Banchereau J, Koutouzov S. IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black × New Zealand White) F1 but not in BALB/c mice. J Immunol 2005 174 : 2499 506.
-
(2005)
J Immunol
, vol.174
, pp. 2499-506
-
-
Mathian, A.1
Weinberg, A.2
Gallegos, M.3
Banchereau, J.4
Koutouzov, S.5
-
122
-
-
0037451124
-
Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
-
Santiago-Raber ML, Baccala R, Haraldsson KM et al. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med 2003 197 : 777 88.
-
(2003)
J Exp Med
, vol.197
, pp. 777-88
-
-
Santiago-Raber, M.L.1
Baccala, R.2
Haraldsson, K.M.3
-
123
-
-
75749083254
-
Deficiency of type i IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease
-
Agrawal H, Jacob N, Carreras E et al. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol 2009 183 : 6021 9.
-
(2009)
J Immunol
, vol.183
, pp. 6021-9
-
-
Agrawal, H.1
Jacob, N.2
Carreras, E.3
-
124
-
-
68149126174
-
Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop
-
Green NM, Laws A, Kiefer K et al. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol 2009 183 : 1569 76.
-
(2009)
J Immunol
, vol.183
, pp. 1569-76
-
-
Green, N.M.1
Laws, A.2
Kiefer, K.3
-
125
-
-
33746238512
-
Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice
-
Brummel R, Roberts TL, Stacey KJ, Lenert P. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol 2006 36 : 1951 62.
-
(2006)
Eur J Immunol
, vol.36
, pp. 1951-62
-
-
Brummel, R.1
Roberts, T.L.2
Stacey, K.J.3
Lenert, P.4
-
126
-
-
0035900481
-
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
-
Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001 294 : 1540 3.
-
(2001)
Science
, vol.294
, pp. 1540-3
-
-
Blanco, P.1
Palucka, A.K.2
Gill, M.3
Pascual, V.4
Banchereau, J.5
-
127
-
-
66449097622
-
Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase i trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus
-
Yao Y, Richman L, Higgs BW et al. Neutralization of interferon-alpha/ beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 2009 60 : 1785 96.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1785-96
-
-
Yao, Y.1
Richman, L.2
Higgs, B.W.3
-
128
-
-
44849085476
-
The innate immune system in SLE: Type i interferons and dendritic cells
-
Rönnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 2008 17 : 394 9.
-
(2008)
Lupus
, vol.17
, pp. 394-9
-
-
Rönnblom, L.1
Pascual, V.2
-
129
-
-
6844255888
-
A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group
-
Tsakonas E, Joseph L, Esdaile JM et al. A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group. Lupus 1998 7 : 80 5.
-
(1998)
Lupus
, vol.7
, pp. 80-5
-
-
Tsakonas, E.1
Joseph, L.2
Esdaile, J.M.3
-
130
-
-
0028832030
-
In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers
-
Halpern MD, Pisetsky DS. In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers. Immunopharmacology 1995 29 : 47 52.
-
(1995)
Immunopharmacology
, vol.29
, pp. 47-52
-
-
Halpern, M.D.1
Pisetsky, D.S.2
-
131
-
-
0033843575
-
Inhibition of murine macrophage IL-12 production by natural and synthetic DNA
-
Pisetsky DS, Reich CF. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA. Clin Immunol 2000 96 : 198 204.
-
(2000)
Clin Immunol
, vol.96
, pp. 198-204
-
-
Pisetsky, D.S.1
Reich, C.F.2
-
132
-
-
0036913736
-
Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides
-
Zhu FG, Reich CF, Pisetsky DS. Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides. J Leukoc Biol 2002 72 : 1154 63.
-
(2002)
J Leukoc Biol
, vol.72
, pp. 1154-63
-
-
Zhu, F.G.1
Reich, C.F.2
Pisetsky, D.S.3
-
133
-
-
0032514616
-
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
-
Krieg AM, Wu T, Weeratna R et al. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci USA 1998 95 : 12631 6.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12631-6
-
-
Krieg, A.M.1
Wu, T.2
Weeratna, R.3
-
134
-
-
0034932263
-
Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs
-
Chen Y, Lenert P, Weeratna R et al. Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs. Gene Ther 2001 8 : 1024 32.
-
(2001)
Gene Ther
, vol.8
, pp. 1024-32
-
-
Chen, Y.1
Lenert, P.2
Weeratna, R.3
-
135
-
-
0034856551
-
CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kB activation
-
Lenert P, Stunz L, Yi AK, Krieg AM, Ashman RF. CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kB activation. Antisense Nucleic Acid Drug Dev 2001 11 : 247 56.
-
(2001)
Antisense Nucleic Acid Drug Dev
, vol.11
, pp. 247-56
-
-
Lenert, P.1
Stunz, L.2
Yi, A.K.3
Krieg, A.M.4
Ashman, R.F.5
-
136
-
-
24144476236
-
Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells
-
Lenert P, Yi AK, Krieg AM, Stunz LL, Ashman RF. Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells. Antisense Nucleic Acid Drug Dev 2003 13 : 143 50.
-
(2003)
Antisense Nucleic Acid Drug Dev
, vol.13
, pp. 143-50
-
-
Lenert, P.1
Yi, A.K.2
Krieg, A.M.3
Stunz, L.L.4
Ashman, R.F.5
-
137
-
-
0042346153
-
Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation
-
Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, Klinman DM. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 2003 171 : 1393 400.
-
(2003)
J Immunol
, vol.171
, pp. 1393-400
-
-
Gursel, I.1
Gursel, M.2
Yamada, H.3
Ishii, K.J.4
Takeshita, F.5
Klinman, D.M.6
-
138
-
-
0242288068
-
Structural characterization of the inhibitory DNA motif for the type A[D]-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells
-
Lenert P, Rasmussen W, Ashman RF, Ballas ZK. Structural characterization of the inhibitory DNA motif for the type A[D]-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells. DNA Cell Biol 2003 22 : 621 31.
-
(2003)
DNA Cell Biol
, vol.22
, pp. 621-31
-
-
Lenert, P.1
Rasmussen, W.2
Ashman, R.F.3
Ballas, Z.K.4
-
139
-
-
17644405409
-
Sequence requirements for oligodeoxyribonucleotide inhibitory activity
-
Ashman RF, Goeken JA, Drahos J, Lenert P. Sequence requirements for oligodeoxyribonucleotide inhibitory activity. Int Immunol 2005 17 : 411 20.
-
(2005)
Int Immunol
, vol.17
, pp. 411-20
-
-
Ashman, R.F.1
Goeken, J.A.2
Drahos, J.3
Lenert, P.4
-
140
-
-
76049114916
-
A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways
-
Sun R, Sun L, Bao M et al. A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways. Clin Immunol 2010 134 : 262 76.
-
(2010)
Clin Immunol
, vol.134
, pp. 262-76
-
-
Sun, R.1
Sun, L.2
Bao, M.3
-
141
-
-
0036107449
-
Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells
-
Stunz LL, Lenert P, Peckham D et al. Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur J Immunol 2002 32 : 1212 22.
-
(2002)
Eur J Immunol
, vol.32
, pp. 1212-22
-
-
Stunz, L.L.1
Lenert, P.2
Peckham, D.3
-
142
-
-
16244423314
-
Inhibitory oligodeoxynucleotides - Therapeutic promise for systemic autoimmune diseases?
-
Lenert P. Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? Clin Exp Immunol 2005 140 : 1 10.
-
(2005)
Clin Exp Immunol
, vol.140
, pp. 1-10
-
-
Lenert, P.1
-
143
-
-
17844383756
-
Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
-
Duramad O, Fearon KL, Chang B et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol 2005 174 : 5193 200.
-
(2005)
J Immunol
, vol.174
, pp. 5193-200
-
-
Duramad, O.1
Fearon, K.L.2
Chang, B.3
-
144
-
-
35348918191
-
Structural requirements and applications of inhibitory oligodeoxyribonucleotides
-
Ashman RF, Lenert P. Structural requirements and applications of inhibitory oligodeoxyribonucleotides. Immunol Res 2007 39 : 4 14.
-
(2007)
Immunol Res
, vol.39
, pp. 4-14
-
-
Ashman, R.F.1
Lenert, P.2
-
145
-
-
40249088259
-
The DNA sugar backbone 2′ deoxyribose determines Toll-like receptor 9 activation
-
Haas T, Metzger J, Schmitz F et al. The DNA sugar backbone 2′ deoxyribose determines Toll-like receptor 9 activation. Immunity 2008 28 : 315 23.
-
(2008)
Immunity
, vol.28
, pp. 315-23
-
-
Haas, T.1
Metzger, J.2
Schmitz, F.3
-
146
-
-
33144458473
-
G-rich DNA suppresses systemic lupus
-
Patole PS, Zecher D, Pawar RD, Grone H-J, Schlondorff D, Anders H-J. G-rich DNA suppresses systemic lupus. J Am Soc Nephrol 2005 16 : 3273 80.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 3273-80
-
-
Patole, P.S.1
Zecher, D.2
Pawar, R.D.3
Grone, H.-J.4
Schlondorff, D.5
Anders, H.-J.6
-
147
-
-
26844467349
-
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
-
Barrat FJ, Meeker T, Gregorio J et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005 202 : 1131 9.
-
(2005)
J Exp Med
, vol.202
, pp. 1131-9
-
-
Barrat, F.J.1
Meeker, T.2
Gregorio, J.3
-
148
-
-
37149024435
-
Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity
-
Peter M, Bode K, Lipford GB, Eberle F, Heeg K, Dalpke AH. Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity. Immunology 2008 123 : 118 28.
-
(2008)
Immunology
, vol.123
, pp. 118-28
-
-
Peter, M.1
Bode, K.2
Lipford, G.B.3
Eberle, F.4
Heeg, K.5
Dalpke, A.H.6
-
149
-
-
0027468768
-
Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices
-
Pearson AM, Rich A, Krieger M. Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices. J Biol Chem 1993 268 : 3546 54.
-
(1993)
J Biol Chem
, vol.268
, pp. 3546-54
-
-
Pearson, A.M.1
Rich, A.2
Krieger, M.3
-
151
-
-
33144467291
-
Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
-
Lenert P. Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther 2006 8 : R203.
-
(2006)
Arthritis Res Ther
, vol.8
-
-
Lenert, P.1
-
152
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signaling for robust type-I interferon induction
-
Honda K, Ohba Y, Yannai H et al. Spatiotemporal regulation of MyD88-IRF-7 signaling for robust type-I interferon induction. Nature 2005 434 : 1035 40.
-
(2005)
Nature
, vol.434
, pp. 1035-40
-
-
Honda, K.1
Ohba, Y.2
Yannai, H.3
-
153
-
-
33746884630
-
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
-
Guiducci C, Ott G, Chan JH et al. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med 2006 203 : 1999 2008.
-
(2006)
J Exp Med
, vol.203
, pp. 1999-2008
-
-
Guiducci, C.1
Ott, G.2
Chan, J.H.3
-
154
-
-
77953275701
-
Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides
-
Avalos AM, Latz E, Mousseau B et al. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol 2009 183 : 6262 8.
-
(2009)
J Immunol
, vol.183
, pp. 6262-8
-
-
Avalos, A.M.1
Latz, E.2
Mousseau, B.3
-
155
-
-
77953481282
-
A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naïve B cells and constitutive expression in memory B cells
-
Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naïve B cells and constitutive expression in memory B cells. Blood 2003 102 : 956 63.
-
(2003)
Blood
, vol.102
, pp. 956-63
-
-
Bernasconi, N.L.1
Onai, N.2
Lanzavecchia, A.3
-
156
-
-
33645956556
-
Toll-like receptor stimulation as a third signal required for activation of human naive B cells
-
Ruprecht CR, Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 2006 36 : 810 16.
-
(2006)
Eur J Immunol
, vol.36
, pp. 810-16
-
-
Ruprecht, C.R.1
Lanzavecchia, A.2
-
157
-
-
11144353781
-
Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help
-
Poeck H, Wagner M, Battiany J et al. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2004 103 : 3058 64.
-
(2004)
Blood
, vol.103
, pp. 3058-64
-
-
Poeck, H.1
Wagner, M.2
Battiany, J.3
-
158
-
-
38849175552
-
Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9
-
Busconi L, Bauer JW, Tumang JR et al. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol 2007 179 : 7397 405.
-
(2007)
J Immunol
, vol.179
, pp. 7397-405
-
-
Busconi, L.1
Bauer, J.W.2
Tumang, J.R.3
-
159
-
-
70349453647
-
Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides
-
Klinman DM, Tross D, Klaschik S, Shirota H, Sato T. Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides. Ann NY Acad Sci 2009 1175 : 80 8.
-
(2009)
Ann NY Acad Sci
, vol.1175
, pp. 80-8
-
-
Klinman, D.M.1
Tross, D.2
Klaschik, S.3
Shirota, H.4
Sato, T.5
-
160
-
-
6344262317
-
Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma and IL-12-mediated signaling
-
Shirota H, Gursel M, Klinman DM. Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma and IL-12-mediated signaling. J Immunol 2004 173 : 5002 7.
-
(2004)
J Immunol
, vol.173
, pp. 5002-7
-
-
Shirota, H.1
Gursel, M.2
Klinman, D.M.3
-
161
-
-
0037637548
-
Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis
-
Zeuner RA, Verthelyi D, Gursel M, Ishii KJ, Klinman DM. Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis Rheum 2003 48 : 1701 7.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 1701-7
-
-
Zeuner, R.A.1
Verthelyi, D.2
Gursel, M.3
Ishii, K.J.4
Klinman, D.M.5
-
162
-
-
13444302229
-
Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice
-
Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice. Arthritis Rheum 2005 52 : 651 8.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 651-8
-
-
Dong, L.1
Ito, S.2
Ishii, K.J.3
Klinman, D.M.4
-
163
-
-
47249095737
-
Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
-
Sato T, Shimosato T, Alvord WG, Klinman DM. Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. J Immunol 2008 180 : 7648 54.
-
(2008)
J Immunol
, vol.180
, pp. 7648-54
-
-
Sato, T.1
Shimosato, T.2
Alvord, W.G.3
Klinman, D.M.4
-
164
-
-
17044423406
-
Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock
-
Shirota H, Gursel I, Gursel M, Klinman DM. Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock. J Immunol 2005 174 : 4579 83.
-
(2005)
J Immunol
, vol.174
, pp. 4579-83
-
-
Shirota, H.1
Gursel, I.2
Gursel, M.3
Klinman, D.M.4
-
165
-
-
0344984245
-
Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells
-
Jing N, Li Y, Xu X et al. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 2003 22 : 685 96.
-
(2003)
DNA Cell Biol
, vol.22
, pp. 685-96
-
-
Jing, N.1
Li, Y.2
Xu, X.3
-
166
-
-
4644325545
-
G-quartet oligonucleotides: A new class of signal transducers and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
-
Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of signal transducers and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res 2004 64 : 6603 9.
-
(2004)
Cancer Res
, vol.64
, pp. 6603-9
-
-
Jing, N.1
Li, Y.2
Xiong, W.3
Sha, W.4
Jing, L.5
Tweardy, D.J.6
-
167
-
-
0033034413
-
High affinity interactions of nucleolin with G-G-aspired rDNA
-
Hanakahi LA, Sun H, Maizels N. High affinity interactions of nucleolin with G-G-aspired rDNA. J Biol Chem 1999 274 : 15908 12.
-
(1999)
J Biol Chem
, vol.274
, pp. 15908-12
-
-
Hanakahi, L.A.1
Sun, H.2
Maizels, N.3
-
168
-
-
0033597820
-
Ku binds telomeric DNA in vitro
-
Bianchi A, de Lange T. Ku binds telomeric DNA in vitro. J Biol Chem 1999 274 : 21223 7.
-
(1999)
J Biol Chem
, vol.274
, pp. 21223-7
-
-
Bianchi, A.1
De Lange, T.2
-
169
-
-
37549066665
-
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
-
Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 2007 37 : 3582 6.
-
(2007)
Eur J Immunol
, vol.37
, pp. 3582-6
-
-
Barrat, F.J.1
Meeker, T.2
Chan, J.H.3
Guiducci, C.4
Coffman, R.L.5
-
170
-
-
77649289335
-
Treatment with a Toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice
-
Graham KL, Lee LY, Higgins JP, Steinman L, Utz PJ, Ho PP. Treatment with a Toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice. Autoimmunity 2010 43 : 140 55.
-
(2010)
Autoimmunity
, vol.43
, pp. 140-55
-
-
Graham, K.L.1
Lee, L.Y.2
Higgins, J.P.3
Steinman, L.4
Utz, P.J.5
Ho, P.P.6
-
171
-
-
28544449709
-
Immune stimulation medicated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
Vollmer J, Tluk S, Schmitz C et al. Immune stimulation medicated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005 202 : 1575 85.
-
(2005)
J Exp Med
, vol.202
, pp. 1575-85
-
-
Vollmer, J.1
Tluk, S.2
Schmitz, C.3
-
172
-
-
33746266273
-
Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides
-
Jurk M, Kritzler A, Schulte B et al. Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides. Eur J Immunol 2006 36 : 1815 26.
-
(2006)
Eur J Immunol
, vol.36
, pp. 1815-26
-
-
Jurk, M.1
Kritzler, A.2
Schulte, B.3
-
173
-
-
33751565283
-
Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines
-
Gorden KK, Qiu X, Batiste JJ, Wightman PP, Vasilakos JP, Alkan SS. Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. J Immunol 2006 177 : 8164 70.
-
(2006)
J Immunol
, vol.177
, pp. 8164-70
-
-
Gorden, K.K.1
Qiu, X.2
Batiste, J.J.3
Wightman, P.P.4
Vasilakos, J.P.5
Alkan, S.S.6
-
174
-
-
60549110710
-
Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9
-
Wang D, Bhagat L, Yu D et al. Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9. J Med Chem 2009 52 : 551 8.
-
(2009)
J Med Chem
, vol.52
, pp. 551-8
-
-
Wang, D.1
Bhagat, L.2
Yu, D.3
-
175
-
-
33847049885
-
DNA motifs suppressing TLR9 responses
-
Trieu A, Roberts TL, Dunn JA, Sweet MJ, Stacey KJ. DNA motifs suppressing TLR9 responses. Crit Rev Immunol 2006 26 : 527 44.
-
(2006)
Crit Rev Immunol
, vol.26
, pp. 527-44
-
-
Trieu, A.1
Roberts, T.L.2
Dunn, J.A.3
Sweet, M.J.4
Stacey, K.J.5
-
176
-
-
57349191215
-
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
-
Ewald SE, Lee BL, Lau L et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 2008 456 : 658 62.
-
(2008)
Nature
, vol.456
, pp. 658-62
-
-
Ewald, S.E.1
Lee, B.L.2
Lau, L.3
-
177
-
-
70449477746
-
Critical role for asparagine endopeptidase in endocytic toll-like receptor signaling in dendritic cells
-
Sepulveda FE, Maschalidi S, Colisson R et al. Critical role for asparagine endopeptidase in endocytic toll-like receptor signaling in dendritic cells. Immunity 2009 31 : 737 48.
-
(2009)
Immunity
, vol.31
, pp. 737-48
-
-
Sepulveda, F.E.1
Maschalidi, S.2
Colisson, R.3
-
178
-
-
34250698370
-
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
-
Latz E, Verma A, Visintin A et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007 8 : 772 9.
-
(2007)
Nat Immunol
, vol.8
, pp. 772-9
-
-
Latz, E.1
Verma, A.2
Visintin, A.3
-
179
-
-
68149132205
-
Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type i IFN production in macrophages
-
Yao M, Liu X, Li D, Chen T, Cai Z, Cao X. Late endosome/lysosome- localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol 2009 183 : 1751 8.
-
(2009)
J Immunol
, vol.183
, pp. 1751-8
-
-
Yao, M.1
Liu, X.2
Li, D.3
Chen, T.4
Cai, Z.5
Cao, X.6
-
180
-
-
34249915031
-
Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
-
Pawar RD, Ramanjaneyulu A, Kulkarni OP, Lech M, Segerer S, Anders HJ. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 2007 18 : 1721 31.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1721-31
-
-
Pawar, R.D.1
Ramanjaneyulu, A.2
Kulkarni, O.P.3
Lech, M.4
Segerer, S.5
Anders, H.J.6
|