메뉴 건너뛰기




Volumn 161, Issue 2, 2010, Pages 208-222

Nucleic acid sensing receptors in systemic lupus erythematosus: Development of novel DNA- and/or RNA-like analogues for treating lupus

Author keywords

HIN 200; HMGB1; systemic lupus erythematosus; Toll like receptors 7 and 9

Indexed keywords

CASPASE INHIBITOR; CPG OLIGODEOXYNUCLEOTIDE; CYTOSINE; DNA; DNA BINDING PROTEIN; DNA DIRECTED RNA POLYMERASE III; DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; NUCLEIC ACID; NUCLEOPROTEIN; OLIGONUCLEOTIDE; PROTEIN AIM2; PROTEIN MDA5; PROTEIN P202; RETINOIC ACID INDUCIBLE PROTEIN I; RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; Z DNA BINDING PROTEIN 1;

EID: 77954647644     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04176.x     Document Type: Review
Times cited : (28)

References (180)
  • 2
    • 0344492212 scopus 로고    scopus 로고
    • Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    • Baechler EC, Batliwalla FM, Karypis G et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003 100 : 2610 15.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2610-15
    • Baechler, E.C.1    Batliwalla, F.M.2    Karypis, G.3
  • 3
    • 17244373451 scopus 로고    scopus 로고
    • Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort
    • Alarcón-Segovia D, Alarcón-Riquelme ME, Cardiel MH et al. Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort. Arthritis Rheum 2005 52 : 1138 47.
    • (2005) Arthritis Rheum , vol.52 , pp. 1138-47
    • Alarcón-Segovia, D.1    Alarcón-Riquelme, M.E.2    Cardiel, M.H.3
  • 4
    • 34249860408 scopus 로고    scopus 로고
    • Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus
    • Graham RR, Kyogoku C, Sigurdsson S et al. Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proc Natl Acad Sci USA 2007 104 : 6758 63.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6758-63
    • Graham, R.R.1    Kyogoku, C.2    Sigurdsson, S.3
  • 5
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)
    • International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley JB, Alarcón-Riquelme ME et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008 40 : 204 10.
    • (2008) Nat Genet , vol.40 , pp. 204-10
    • Harley, J.B.1    Alarcón-Riquelme, M.E.2
  • 6
    • 67849099131 scopus 로고    scopus 로고
    • Recent insights into the genetic basis of systemic lupus erythematosus
    • Moser KL, Kelly JA, Lessard CJ, Harley JB. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 2009 10 : 373 9.
    • (2009) Genes Immun , vol.10 , pp. 373-9
    • Moser, K.L.1    Kelly, J.A.2    Lessard, C.J.3    Harley, J.B.4
  • 7
    • 75649151209 scopus 로고    scopus 로고
    • Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    • Javierre BM, Fernandez AF, Richter J et al. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res 2010 20 : 170 9.
    • (2010) Genome Res , vol.20 , pp. 170-9
    • Javierre, B.M.1    Fernandez, A.F.2    Richter, J.3
  • 8
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990 33 : 1665 73.
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-73
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 9
    • 0025736912 scopus 로고
    • 5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases
    • Corvetta A, Della Bitta R, Luchetti MM, Pomponio G. 5-Methylcytosine content of DNA in blood, synovial mononuclear cells and synovial tissue from patients affected by autoimmune rheumatic diseases. J Chromatogr 1991 566 : 481 91.
    • (1991) J Chromatogr , vol.566 , pp. 481-91
    • Corvetta, A.1    Della Bitta, R.2    Luchetti, M.M.3    Pomponio, G.4
  • 10
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol 1988 140 : 2197 200.
    • (1988) J Immunol , vol.140 , pp. 2197-200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 11
    • 0031664697 scopus 로고    scopus 로고
    • Molecular mimicry and immune-mediated diseases
    • Oldstone MB. Molecular mimicry and immune-mediated diseases. FASEB J 1998 12 : 1255 65.
    • (1998) FASEB J , vol.12 , pp. 1255-65
    • Oldstone, M.B.1
  • 13
    • 0014910678 scopus 로고
    • The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid
    • Carpenter DF, Steinberg AD, Schur PH, Talal N. The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid. Lab Invest 1970 23 : 628 34.
    • (1970) Lab Invest , vol.23 , pp. 628-34
    • Carpenter, D.F.1    Steinberg, A.D.2    Schur, P.H.3    Talal, N.4
  • 14
    • 33644515263 scopus 로고    scopus 로고
    • Toll-like receptor-7 modulates immune complex glomerulonephritis
    • Pawar RD, Patole PS, Zecher D et al. Toll-like receptor-7 modulates immune complex glomerulonephritis. J Am Soc Nephrol 2006 17 : 141 9.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 141-9
    • Pawar, R.D.1    Patole, P.S.2    Zecher, D.3
  • 15
    • 0345306152 scopus 로고    scopus 로고
    • Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF1 mice
    • Hasegawa K, Hayashi T. Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB × NZWF1 mice. Lupus 2003 12 : 838 45.
    • (2003) Lupus , vol.12 , pp. 838-45
    • Hasegawa, K.1    Hayashi, T.2
  • 16
    • 1642396952 scopus 로고    scopus 로고
    • Activation of Toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
    • Anders HJ, Vielhauer V, Eis V et al. Activation of Toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J 2004 18 : 534 6.
    • (2004) FASEB J , vol.18 , pp. 534-6
    • Anders, H.J.1    Vielhauer, V.2    Eis, V.3
  • 17
    • 6344227970 scopus 로고    scopus 로고
    • Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: High level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow
    • Lian ZX, Kikuchi K, Yang GX, Ansari AA, Ikehara S, Gerswin ME. Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black (NZB) mice: high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow. J Immunol 2004 173 : 5283 9.
    • (2004) J Immunol , vol.173 , pp. 5283-9
    • Lian, Z.X.1    Kikuchi, K.2    Yang, G.X.3    Ansari, A.A.4    Ikehara, S.5    Gerswin, M.E.6
  • 18
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000 408 : 740 5.
    • (2000) Nature , vol.408 , pp. 740-5
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 19
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004 303 : 1529 31.
    • (2004) Science , vol.303 , pp. 1529-31
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis Sousa, E.C.5
  • 20
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
    • Heil F, Hemmi H, Hochrein H et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 2004 303 : 1526 9.
    • (2004) Science , vol.303 , pp. 1526-9
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3
  • 21
    • 1842631428 scopus 로고    scopus 로고
    • Recognition of single-stranded RNA viruses by Toll-like receptor 7
    • Lund JM, Alexopoulou L, Sato A et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 2004 101 : 5598 603.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5598-603
    • Lund, J.M.1    Alexopoulou, L.2    Sato, A.3
  • 22
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001 413 : 732 8.
    • (2001) Nature , vol.413 , pp. 732-8
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 24
    • 0029854905 scopus 로고    scopus 로고
    • A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: Implications for the origins of autoantibodies in autoimmune disease
    • Hannum LG, Ni D, Haberman AM, Weigert MG, Shlomchik MJ. A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J Exp Med 1996 184 : 1269 78.
    • (1996) J Exp Med , vol.184 , pp. 1269-78
    • Hannum, L.G.1    Ni, D.2    Haberman, A.M.3    Weigert, M.G.4    Shlomchik, M.J.5
  • 25
    • 0026566292 scopus 로고
    • Antibodies to histones in systemic lupus erythematosus and drug-induced lupus
    • Monestier M, Kotzin BL. Antibodies to histones in systemic lupus erythematosus and drug-induced lupus. Rheum Dis Clin North Am 1992 18 : 415 36.
    • (1992) Rheum Dis Clin North Am , vol.18 , pp. 415-36
    • Monestier, M.1    Kotzin, B.L.2
  • 28
    • 58749093255 scopus 로고    scopus 로고
    • Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha
    • Uccellini MB, Busconi L, Green NM et al. Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. J Immunol 2008 181 : 5875 84.
    • (2008) J Immunol , vol.181 , pp. 5875-84
    • Uccellini, M.B.1    Busconi, L.2    Green, N.M.3
  • 29
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau CM, Broughton C, Tabor AS et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005 202 : 1171 7.
    • (2005) J Exp Med , vol.202 , pp. 1171-7
    • Lau, C.M.1    Broughton, C.2    Tabor, A.S.3
  • 30
    • 44649161194 scopus 로고    scopus 로고
    • The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses toDNA-containing antigens
    • Chaturvedi A, Dorward D, Pierce SK. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses toDNA-containing antigens. Immunity 2008 28 : 799 809.
    • (2008) Immunity , vol.28 , pp. 799-809
    • Chaturvedi, A.1    Dorward, D.2    Pierce, S.K.3
  • 31
    • 65549136622 scopus 로고    scopus 로고
    • Endocytic sequestration of the B cell antigen receptor and Toll-like receptor 9 in anergic cells
    • O'Neill SK, Veselits ML, Zhang M et al. Endocytic sequestration of the B cell antigen receptor and Toll-like receptor 9 in anergic cells. Proc Natl Acad Sci USA 2009 106 : 6262 7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6262-7
    • O'Neill, S.K.1    Veselits, M.L.2    Zhang, M.3
  • 32
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation bychromatin-immunoglobulin G complexes
    • Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation bychromatin-immunoglobulin G complexes. J Exp Med 2004 199 : 1631 40.
    • (2004) J Exp Med , vol.199 , pp. 1631-40
    • Boulé, M.W.1    Broughton, C.2    MacKay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 34
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006 25 : 417 28.
    • (2006) Immunity , vol.25 , pp. 417-28
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 35
    • 59649107055 scopus 로고    scopus 로고
    • TLR7-dependent and FcgammaR-independent production of type i interferon in experimental mouse lupus
    • Lee PY, Kumagai Y, Li Y, Takeuchi O et al. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J Exp Med 2008 205 : 2995 3006.
    • (2008) J Exp Med , vol.205 , pp. 2995-3006
    • Lee, P.Y.1    Kumagai, Y.2    Li, Y.3    Takeuchi, O.4
  • 36
    • 42449117483 scopus 로고    scopus 로고
    • Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
    • Savarese E, Steinberg C, Pawar RD et al. Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum 2008 58 : 1107 15.
    • (2008) Arthritis Rheum , vol.58 , pp. 1107-15
    • Savarese, E.1    Steinberg, C.2    Pawar, R.D.3
  • 37
    • 77953691247 scopus 로고    scopus 로고
    • TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells
    • doi:10.1136/ard.2009.108282
    • Pan ZJ, Maier S, Schwarz K et al. TLR7 modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells. Ann Rheum Dis 2009 doi:10.1136/ard.2009.108282.
    • (2009) Ann Rheum Dis
    • Pan, Z.J.1    Maier, S.2    Schwarz, K.3
  • 38
    • 36048962438 scopus 로고    scopus 로고
    • Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    • Deane JA, Pisitkun P, Barrett RS et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007 27 : 801 10.
    • (2007) Immunity , vol.27 , pp. 801-10
    • Deane, J.A.1    Pisitkun, P.2    Barrett, R.S.3
  • 40
    • 33745617886 scopus 로고    scopus 로고
    • A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    • Subramanian S, Tus K, Li QZ et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA 2006 103 : 9970 5.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9970-5
    • Subramanian, S.1    Tus, K.2    Li, Q.Z.3
  • 41
    • 50549086761 scopus 로고    scopus 로고
    • Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    • Fairhurst AM, Hwang SH, Wang A et al. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 2008 38 : 1971 8.
    • (2008) Eur J Immunol , vol.38 , pp. 1971-8
    • Fairhurst, A.M.1    Hwang, S.H.2    Wang, A.3
  • 42
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006 203 : 553 61.
    • (2006) J Exp Med , vol.203 , pp. 553-61
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 43
    • 76249125968 scopus 로고    scopus 로고
    • IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus
    • Richez C, Yasuda K, Bonegio RG et al. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol 2010 184 : 796 806.
    • (2010) J Immunol , vol.184 , pp. 796-806
    • Richez, C.1    Yasuda, K.2    Bonegio, R.G.3
  • 44
    • 0037029604 scopus 로고    scopus 로고
    • Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice
    • Bolland S, Yim YS, Tus K, Wakeland EK, Ravetch JV. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 2002 195 : 1167 74.
    • (2002) J Exp Med , vol.195 , pp. 1167-74
    • Bolland, S.1    Yim, Y.S.2    Tus, K.3    Wakeland, E.K.4    Ravetch, J.V.5
  • 45
    • 31044440025 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling protects against murine lupus
    • Wu X, Peng SL. Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 2006 54 : 336 42.
    • (2006) Arthritis Rheum , vol.54 , pp. 336-42
    • Wu, X.1    Peng, S.L.2
  • 46
    • 33748465308 scopus 로고    scopus 로고
    • Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE
    • Yu P, Wellmann U, Kunder S et al. Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE. Int Immunol 2006 18 : 1211 19.
    • (2006) Int Immunol , vol.18 , pp. 1211-19
    • Yu, P.1    Wellmann, U.2    Kunder, S.3
  • 47
    • 13544254614 scopus 로고    scopus 로고
    • Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides
    • Brummel R, Lenert P. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J Immunol 2005 174 : 2429 34.
    • (2005) J Immunol , vol.174 , pp. 2429-34
    • Brummel, R.1    Lenert, P.2
  • 48
    • 15244349648 scopus 로고    scopus 로고
    • TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production
    • Lenert P, Brummel R, Field EH, Ashman RF. TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production. J Clin Immunol 2005 25 : 29 40.
    • (2005) J Clin Immunol , vol.25 , pp. 29-40
    • Lenert, P.1    Brummel, R.2    Field, E.H.3    Ashman, R.F.4
  • 49
    • 77952242576 scopus 로고    scopus 로고
    • Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice
    • doi:10.1016/j.jaut.2009.11.001
    • Santiago-Raber ML, Dunand-Sauthier I, Wu T et al. Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice. J Autoimmun 2009 doi:10.1016/j.jaut.2009.11.001.
    • (2009) J Autoimmun
    • Santiago-Raber, M.L.1    Dunand-Sauthier, I.2    Wu, T.3
  • 50
    • 23944497673 scopus 로고    scopus 로고
    • Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    • Patole PS, Gröne HJ, Segerer S et al. Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 2005 16 : 1326 38.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1326-38
    • Patole, P.S.1    Gröne, H.J.2    Segerer, S.3
  • 51
    • 67749135880 scopus 로고    scopus 로고
    • Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    • Kono DH, Haraldsson MK, Lawson BR et al. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 2009 106 : 12061 6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12061-6
    • Kono, D.H.1    Haraldsson, M.K.2    Lawson, B.R.3
  • 52
    • 40749098665 scopus 로고    scopus 로고
    • UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
    • Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 2008 452 : 234 8.
    • (2008) Nature , vol.452 , pp. 234-8
    • Kim, Y.M.1    Brinkmann, M.M.2    Paquet, M.E.3    Ploegh, H.L.4
  • 53
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • Tabeta K, Hoebe K, Janssen EM et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 2006 7 : 156 64.
    • (2006) Nat Immunol , vol.7 , pp. 156-64
    • Tabeta, K.1    Hoebe, K.2    Janssen, E.M.3
  • 54
    • 67449136127 scopus 로고    scopus 로고
    • Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
    • Fukui R, Saitoh S, Matsumoto F et al. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med 2009 206 : 1339 50.
    • (2009) J Exp Med , vol.206 , pp. 1339-50
    • Fukui, R.1    Saitoh, S.2    Matsumoto, F.3
  • 55
    • 67650600639 scopus 로고    scopus 로고
    • Glomerular expression of Toll-like receptor-9 in lupus nephritis but not in normal kidneys: Implications for the amplification of the inflammatory response
    • Papadimitraki ED, Tzardi M, Bertsias G, Sotsiou E, Boumpas DT. Glomerular expression of Toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response. Lupus 2009 18 : 831 5.
    • (2009) Lupus , vol.18 , pp. 831-5
    • Papadimitraki, E.D.1    Tzardi, M.2    Bertsias, G.3    Sotsiou, E.4    Boumpas, D.T.5
  • 56
    • 67049143142 scopus 로고    scopus 로고
    • Response to ODN-CpG by B Cells from patients with systemic lupus erythematosus correlates with disease activity
    • Zorro S, Arias M, Riaño F et al. Response to ODN-CpG by B Cells from patients with systemic lupus erythematosus correlates with disease activity. Lupus 2009 18 : 718 26.
    • (2009) Lupus , vol.18 , pp. 718-26
    • Zorro, S.1    Arias, M.2    Riaño, F.3
  • 57
    • 64049093899 scopus 로고    scopus 로고
    • The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population
    • Wu O, Chen GP, Chen H et al. The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population. Immunobiology 2009 214 : 392 402.
    • (2009) Immunobiology , vol.214 , pp. 392-402
    • Wu, O.1    Chen, G.P.2    Chen, H.3
  • 58
    • 43349094856 scopus 로고    scopus 로고
    • Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
    • Komatsuda A, Wakui H, Iwamoto K et al. Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 2008 152 : 482 7.
    • (2008) Clin Exp Immunol , vol.152 , pp. 482-7
    • Komatsuda, A.1    Wakui, H.2    Iwamoto, K.3
  • 59
    • 69449088671 scopus 로고    scopus 로고
    • Regression of systemic lupus erythematosus after development of an acquired Toll-like receptor signaling defect and antibody deficiency
    • Visentini M, Conti V, Cagliuso M et al. Regression of systemic lupus erythematosus after development of an acquired Toll-like receptor signaling defect and antibody deficiency. Arthritis Rheum 2009 60 : 2767 71.
    • (2009) Arthritis Rheum , vol.60 , pp. 2767-71
    • Visentini, M.1    Conti, V.2    Cagliuso, M.3
  • 60
    • 70350323680 scopus 로고    scopus 로고
    • Association study of a single nucleotide polymorphism in the exon 2 region of Toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese
    • Xu CJ, Zhang WH, Pan HF, Li XP, Xu JH, Ye DQ. Association study of a single nucleotide polymorphism in the exon 2 region of Toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. Mol Biol Rep 2009 36 : 2245 8.
    • (2009) Mol Biol Rep , vol.36 , pp. 2245-8
    • Xu, C.J.1    Zhang, W.H.2    Pan, H.F.3    Li, X.P.4    Xu, J.H.5    Ye, D.Q.6
  • 61
    • 67249107279 scopus 로고    scopus 로고
    • Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus
    • Sánchez E, Callejas-Rubio JL, Sabio JM et al. Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. Clin Exp Rheumatol 2009 27 : 267 71.
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 267-71
    • Sánchez, E.1    Callejas-Rubio, J.L.2    Sabio, J.M.3
  • 62
    • 0345447639 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
    • Spies B, Hochrein H, Vabulas M et al. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol 2003 171 : 5908 12.
    • (2003) J Immunol , vol.171 , pp. 5908-12
    • Spies, B.1    Hochrein, H.2    Vabulas, M.3
  • 63
    • 4444325043 scopus 로고    scopus 로고
    • TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine
    • Babiuk S, Mookherjee N, Pontarollo R et al. TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine. Immunology 2004 113 : 114 20.
    • (2004) Immunology , vol.113 , pp. 114-20
    • Babiuk, S.1    Mookherjee, N.2    Pontarollo, R.3
  • 64
    • 33744804308 scopus 로고    scopus 로고
    • TLR9-independent activation of B lymphocytes by bacterial DNA
    • Cortez-Gonzalez X, Pellicciotta I, Gerloni M et al. TLR9-independent activation of B lymphocytes by bacterial DNA. DNA Cell Biol 2006 25 : 253 61.
    • (2006) DNA Cell Biol , vol.25 , pp. 253-61
    • Cortez-Gonzalez, X.1    Pellicciotta, I.2    Gerloni, M.3
  • 65
    • 38949093002 scopus 로고    scopus 로고
    • TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    • Ishii KJ, Kawagoe T, Koyama S et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 2008 451 : 725 9.
    • (2008) Nature , vol.451 , pp. 725-9
    • Ishii, K.J.1    Kawagoe, T.2    Koyama, S.3
  • 66
    • 27944453599 scopus 로고    scopus 로고
    • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    • Okabe Y, Kawane K, Akira S, Taniguchi T, Nagata S. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med 2005 202 : 1333 9.
    • (2005) J Exp Med , vol.202 , pp. 1333-9
    • Okabe, Y.1    Kawane, K.2    Akira, S.3    Taniguchi, T.4    Nagata, S.5
  • 67
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    • Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 2005 6 : 49 56.
    • (2005) Nat Immunol , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 68
    • 47149108866 scopus 로고    scopus 로고
    • Interferon-inducible Ifi200-family genes in systemic lupus erythematosus
    • Choubey D, Panchanathan R. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol Lett 2008 119 : 32 41.
    • (2008) Immunol Lett , vol.119 , pp. 32-41
    • Choubey, D.1    Panchanathan, R.2
  • 69
    • 35748950430 scopus 로고    scopus 로고
    • Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders
    • Mondini M, Vidali M, Airò P et al. Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann NY Acad Sci 2007 1110 : 47 56.
    • (2007) Ann NY Acad Sci , vol.1110 , pp. 47-56
    • Mondini, M.1    Vidali, M.2    Airò, P.3
  • 70
    • 77649105762 scopus 로고    scopus 로고
    • Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene
    • Song LL, Ponomareva L, Shen H, Duan X, Alimirah F, Choubey D. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. PLoS One 2010 5 : e8569.
    • (2010) PLoS One , vol.5
    • Song, L.L.1    Ponomareva, L.2    Shen, H.3    Duan, X.4    Alimirah, F.5    Choubey, D.6
  • 71
    • 0344234427 scopus 로고    scopus 로고
    • Links between type i interferons and the genetic basis of disease in mouse lupus
    • Jørgensen TN, Gubbels MR, Kotzin BL. Links between type I interferons and the genetic basis of disease in mouse lupus. Autoimmunity 2003 36 : 491 502.
    • (2003) Autoimmunity , vol.36 , pp. 491-502
    • Jørgensen, T.N.1    Gubbels, M.R.2    Kotzin, B.L.3
  • 72
    • 60749104535 scopus 로고    scopus 로고
    • HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
    • Roberts TL, Idris A, Dunn JA et al. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 2009 323 : 1057 60.
    • (2009) Science , vol.323 , pp. 1057-60
    • Roberts, T.L.1    Idris, A.2    Dunn, J.A.3
  • 73
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • Hornung V, Ablasser A, Charrel-Dennis M et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009 458 : 514 18.
    • (2009) Nature , vol.458 , pp. 514-18
    • Hornung, V.1    Ablasser, A.2    Charrel-Dennis, M.3
  • 74
    • 0033568547 scopus 로고    scopus 로고
    • Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster
    • Wang H, Chatterjee G, Meyer JJ et al. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon- activatable gene 200 cluster. Genomics 1999 60 : 281 94.
    • (1999) Genomics , vol.60 , pp. 281-94
    • Wang, H.1    Chatterjee, G.2    Meyer, J.J.3
  • 75
    • 37349005293 scopus 로고    scopus 로고
    • The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function
    • Gubbels Bupp MR, Li M, Pashine A, Aud D, Peng SL. The candidate lupus susceptibility gene Ifi202a is largely dispensable for B-cell function. Rheumatology (Oxf) 2008 47 : 103 4.
    • (2008) Rheumatology (Oxf) , vol.47 , pp. 103-4
    • Gubbels Bupp, M.R.1    Li, M.2    Pashine, A.3    Aud, D.4    Peng, S.L.5
  • 77
    • 38549096975 scopus 로고    scopus 로고
    • Microarray analysis of glomerular gene expression in murine lupus nephritis
    • Teramoto K, Negoro N, Kitamoto K et al. Microarray analysis of glomerular gene expression in murine lupus nephritis. J Pharmacol Sci 2008 106 : 56 67.
    • (2008) J Pharmacol Sci , vol.106 , pp. 56-67
    • Teramoto, K.1    Negoro, N.2    Kitamoto, K.3
  • 78
    • 70349503643 scopus 로고    scopus 로고
    • Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR
    • Kimkong I, Avihingsanon Y, Hirankarn N. Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR. Lupus 2009 18 : 1066 72.
    • (2009) Lupus , vol.18 , pp. 1066-72
    • Kimkong, I.1    Avihingsanon, Y.2    Hirankarn, N.3
  • 79
    • 3042844142 scopus 로고    scopus 로고
    • Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli
    • Peterson KS, Huang JF, Zhu J et al. Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli. J Clin Invest 2004 113 : 1722 33.
    • (2004) J Clin Invest , vol.113 , pp. 1722-33
    • Peterson, K.S.1    Huang, J.F.2    Zhu, J.3
  • 80
    • 34548572051 scopus 로고    scopus 로고
    • Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells
    • Yamauchi M, Hashimoto M, Ichiyama K et al. Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells. Int Immunol 2007 19 : 935 42.
    • (2007) Int Immunol , vol.19 , pp. 935-42
    • Yamauchi, M.1    Hashimoto, M.2    Ichiyama, K.3
  • 81
    • 5644255667 scopus 로고    scopus 로고
    • Interferon-alpha-inducible proteins are novel autoantigens in murine lupus
    • Hueber W, Zeng D, Strober S, Utz PJ. Interferon-alpha-inducible proteins are novel autoantigens in murine lupus. Arthritis Rheum 2004 50 : 3239 49.
    • (2004) Arthritis Rheum , vol.50 , pp. 3239-49
    • Hueber, W.1    Zeng, D.2    Strober, S.3    Utz, P.J.4
  • 82
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • Takaoka A, Wang Z, Choi MK et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007 448 : 501 5.
    • (2007) Nature , vol.448 , pp. 501-5
    • Takaoka, A.1    Wang, Z.2    Choi, M.K.3
  • 83
    • 44449157593 scopus 로고    scopus 로고
    • Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
    • Wang Z, Choi MK, Ban T et al. Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci USA 2008 105 : 5477 82.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 5477-82
    • Wang, Z.1    Choi, M.K.2    Ban, T.3
  • 85
    • 68249113997 scopus 로고    scopus 로고
    • DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
    • Rebsamen M, Heinz LX, Meylan E et al. DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep 2009 10 : 916 22.
    • (2009) EMBO Rep , vol.10 , pp. 916-22
    • Rebsamen, M.1    Heinz, L.X.2    Meylan, E.3
  • 86
    • 58749100879 scopus 로고    scopus 로고
    • Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors
    • Kaiser WJ, Upton JW, Mocarski ES. Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors. J Immunol 2008 181 : 6427 34.
    • (2008) J Immunol , vol.181 , pp. 6427-34
    • Kaiser, W.J.1    Upton, J.W.2    Mocarski, E.S.3
  • 87
    • 55749088259 scopus 로고    scopus 로고
    • IFN beta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI)
    • Lippmann J, Rothenburg S, Deigendesch N et al. IFN beta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol 2008 10 : 2579 88.
    • (2008) Cell Microbiol , vol.10 , pp. 2579-88
    • Lippmann, J.1    Rothenburg, S.2    Deigendesch, N.3
  • 88
    • 35748967851 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2007 220 : 35 46.
    • (2007) Immunol Rev , vol.220 , pp. 35-46
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 89
    • 55549128746 scopus 로고    scopus 로고
    • High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease
    • Pisetsky DS, Erlandsson-Harris H, Andersson U. High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 2008 10 : 209.
    • (2008) Arthritis Res Ther , vol.10 , pp. 209
    • Pisetsky, D.S.1    Erlandsson-Harris, H.2    Andersson, U.3
  • 90
    • 34250837518 scopus 로고    scopus 로고
    • A novel role for HMGB1 in TLR9 mediated inflammatory responses to CpG-DNA
    • Ivanov S, Dragoi AM, Wang X et al. A novel role for HMGB1 in TLR9 mediated inflammatory responses to CpG-DNA. Blood 2007 110 : 1970 81.
    • (2007) Blood , vol.110 , pp. 1970-81
    • Ivanov, S.1    Dragoi, A.M.2    Wang, X.3
  • 91
    • 0024584528 scopus 로고
    • Specific recognition of cruciform DNA by nuclear protein HMG1
    • Bianchi ME, Beltrame M, Paonessa G. Specific recognition of cruciform DNA by nuclear protein HMG1. Science 1989 243 : 1056 9.
    • (1989) Science , vol.243 , pp. 1056-9
    • Bianchi, M.E.1    Beltrame, M.2    Paonessa, G.3
  • 92
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian J, Avalos AM, Mao SY et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007 8 : 487 96.
    • (2007) Nat Immunol , vol.8 , pp. 487-96
    • Tian, J.1    Avalos, A.M.2    Mao, S.Y.3
  • 93
    • 33747751590 scopus 로고    scopus 로고
    • Alarmin(g) news about danger: Workshop on innate danger signals and HMGB1
    • Harris HE, Raucci A. Alarmin(g) news about danger: workshop on innate danger signals and HMGB1. EMBO Rep 2006 7 : 774 8.
    • (2006) EMBO Rep , vol.7 , pp. 774-8
    • Harris, H.E.1    Raucci, A.2
  • 94
    • 75749158495 scopus 로고    scopus 로고
    • RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes
    • Avalos AM, Kiefer K, Tian J et al. RAGE-independent autoreactive B cell activation in response to chromatin and HMGB1/DNA immune complexes. Autoimmunity 2010 43 : 103 10.
    • (2010) Autoimmunity , vol.43 , pp. 103-10
    • Avalos, A.M.1    Kiefer, K.2    Tian, J.3
  • 96
    • 70749133481 scopus 로고    scopus 로고
    • The translocation of HMGB1 during cell activation and cell death
    • Gauley J, Pisetsky DS. The translocation of HMGB1 during cell activation and cell death. Autoimmunity 2009 42 : 299 301.
    • (2009) Autoimmunity , vol.42 , pp. 299-301
    • Gauley, J.1    Pisetsky, D.S.2
  • 97
    • 59649126956 scopus 로고    scopus 로고
    • Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: Implications for the pathogenesis of SLE
    • Urbonaviciute V, Fürnrohr BG, Meister S et al. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med 2008 205 : 3007 18.
    • (2008) J Exp Med , vol.205 , pp. 3007-18
    • Urbonaviciute, V.1    Fürnrohr, B.G.2    Meister, S.3
  • 98
    • 27744461020 scopus 로고    scopus 로고
    • Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus
    • Popovic K, Ek M, Espinosa A et al. Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus. Arthritis Rheum 2005 52 : 3639 45.
    • (2005) Arthritis Rheum , vol.52 , pp. 3639-45
    • Popovic, K.1    Ek, M.2    Espinosa, A.3
  • 99
    • 0027958019 scopus 로고
    • Antibodies to HMG proteins in patients with drug-induced autoimmunity
    • Ayer LM, Rubin RL, Dixon GH, Fritzler MJ. Antibodies to HMG proteins in patients with drug-induced autoimmunity. Arthritis Rheum 1994 37 : 98 103.
    • (1994) Arthritis Rheum , vol.37 , pp. 98-103
    • Ayer, L.M.1    Rubin, R.L.2    Dixon, G.H.3    Fritzler, M.J.4
  • 100
    • 42449084910 scopus 로고    scopus 로고
    • Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus
    • Jiang W, Pisetsky DS. Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus. Ann Rheum Dis 2008 67 : 727 8.
    • (2008) Ann Rheum Dis , vol.67 , pp. 727-8
    • Jiang, W.1    Pisetsky, D.S.2
  • 101
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I-dependent sensing of poly(dA : dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-I-dependent sensing of poly(dA : dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009 10 : 1065 72.
    • (2009) Nat Immunol , vol.10 , pp. 1065-72
    • Ablasser, A.1    Bauernfeind, F.2    Hartmann, G.3    Latz, E.4    Fitzgerald, K.A.5    Hornung, V.6
  • 102
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type i interferons through the RIG-I pathway
    • Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009 138 : 576 91.
    • (2009) Cell , vol.138 , pp. 576-91
    • Chiu, Y.H.1    MacMillan, J.B.2    Chen, Z.J.3
  • 103
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii KJ, Coban C, Kato H et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006 7 : 40 8.
    • (2006) Nat Immunol , vol.7 , pp. 40-8
    • Ishii, K.J.1    Coban, C.2    Kato, H.3
  • 104
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama M, Kikuchi M, Natsukawa T et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004 5 : 730 7.
    • (2004) Nat Immunol , vol.5 , pp. 730-7
    • Yoneyama, M.1    Kikuchi, M.2    Natsukawa, T.3
  • 105
    • 0037154176 scopus 로고    scopus 로고
    • Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
    • Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM, Fisher PB. mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc Natl Acad Sci USA 2002 99 : 637 42.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 637-42
    • Kang, D.C.1    Gopalkrishnan, R.V.2    Wu, Q.3    Jankowsky, E.4    Pyle, A.M.5    Fisher, P.B.6
  • 106
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006 441 : 101 5.
    • (2006) Nature , vol.441 , pp. 101-5
    • Kato, H.1    Takeuchi, O.2    Sato, S.3
  • 107
    • 46949097299 scopus 로고    scopus 로고
    • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    • Kato H, Takeuchi O, Mikamo-Satoh E et al. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 2008 205 : 1601 10.
    • (2008) J Exp Med , vol.205 , pp. 1601-10
    • Kato, H.1    Takeuchi, O.2    Mikamo-Satoh, E.3
  • 108
    • 59749101255 scopus 로고    scopus 로고
    • Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses
    • Allam R, Pawar RD, Kulkarni OP et al. Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses. Eur J Immunol 2008 38 : 3487 98.
    • (2008) Eur J Immunol , vol.38 , pp. 3487-98
    • Allam, R.1    Pawar, R.D.2    Kulkarni, O.P.3
  • 109
    • 0035423557 scopus 로고    scopus 로고
    • An etiopathogenic role for the type i IFN system in SLE
    • Ronnblom L, Alm GV. An etiopathogenic role for the type I IFN system in SLE. Trends Immunol 2001 22 : 427 31.
    • (2001) Trends Immunol , vol.22 , pp. 427-31
    • Ronnblom, L.1    Alm, G.V.2
  • 110
    • 4344617762 scopus 로고    scopus 로고
    • Interferon-alpha in systemic lupus erythematosus
    • Crow MK, Kirou KA. Interferon-alpha in systemic lupus erythematosus. Curr Opin Rheum 2004 16 : 541 7.
    • (2004) Curr Opin Rheum , vol.16 , pp. 541-7
    • Crow, M.K.1    Kirou, K.A.2
  • 111
    • 0345359586 scopus 로고    scopus 로고
    • Induction of clinical autoimmune disease by therapeutic interferon-alpha
    • Gota C, Calabrese L. Induction of clinical autoimmune disease by therapeutic interferon-alpha. Autoimmunity 2003 36 : 511 18.
    • (2003) Autoimmunity , vol.36 , pp. 511-18
    • Gota, C.1    Calabrese, L.2
  • 113
    • 0034533825 scopus 로고    scopus 로고
    • Activation of type i interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
    • Bengtsson AA, Sturfelt G, Truedsson L et al. Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies. Lupus 2000 9 : 664 71.
    • (2000) Lupus , vol.9 , pp. 664-71
    • Bengtsson, A.A.1    Sturfelt, G.2    Truedsson, L.3
  • 114
    • 0242456113 scopus 로고    scopus 로고
    • Microarray analysis of gene expression in lupus
    • Crow MK, Wohlgemuth J. Microarray analysis of gene expression in lupus. Arthritis Res Ther 2003 5 : 279 87.
    • (2003) Arthritis Res Ther , vol.5 , pp. 279-87
    • Crow, M.K.1    Wohlgemuth, J.2
  • 115
    • 0037451167 scopus 로고    scopus 로고
    • Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    • Bennett L, Palucka AK, Arce E et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003 97 : 711 23.
    • (2003) J Exp Med , vol.97 , pp. 711-23
    • Bennett, L.1    Palucka, A.K.2    Arce, E.3
  • 116
    • 33749331301 scopus 로고    scopus 로고
    • Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
    • Feng X, Wu H, Grossman JM et al. Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis Rheum 2006 54 : 2951 62.
    • (2006) Arthritis Rheum , vol.54 , pp. 2951-62
    • Feng, X.1    Wu, H.2    Grossman, J.M.3
  • 117
    • 70349505809 scopus 로고    scopus 로고
    • Longitudinal expression of type i interferon responsive genes in systemic lupus erythematosus
    • Petri M, Singh S, Tesfasyone H et al. Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus. Lupus 2009 18 : 980 9.
    • (2009) Lupus , vol.18 , pp. 980-9
    • Petri, M.1    Singh, S.2    Tesfasyone, H.3
  • 118
    • 70349254607 scopus 로고    scopus 로고
    • TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type i IFN
    • Di Domizio J, Blum A, Gallagher-Gambarelli M, Molens JP, Chaperot L, Plumas J. TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood 2009 114 : 1794 802.
    • (2009) Blood , vol.114 , pp. 1794-802
    • Di Domizio, J.1    Blum, A.2    Gallagher-Gambarelli, M.3    Molens, J.P.4    Chaperot, L.5    Plumas, J.6
  • 119
    • 0036855470 scopus 로고    scopus 로고
    • CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors
    • Takauji R, Iho S, Takatsuka H et al. CpG-DNA-induced IFN-alpha production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors. J Leukoc Biol 2002 72 : 1011 19.
    • (2002) J Leukoc Biol , vol.72 , pp. 1011-19
    • Takauji, R.1    Iho, S.2    Takatsuka, H.3
  • 120
    • 70349260404 scopus 로고    scopus 로고
    • Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes
    • Yasuda K, Richez C, Uccellini MB et al. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol 2009 183 : 3109 17.
    • (2009) J Immunol , vol.183 , pp. 3109-17
    • Yasuda, K.1    Richez, C.2    Uccellini, M.B.3
  • 121
    • 14044278824 scopus 로고    scopus 로고
    • IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black × New Zealand White) F1 but not in BALB/c mice
    • Mathian A, Weinberg A, Gallegos M, Banchereau J, Koutouzov S. IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black × New Zealand White) F1 but not in BALB/c mice. J Immunol 2005 174 : 2499 506.
    • (2005) J Immunol , vol.174 , pp. 2499-506
    • Mathian, A.1    Weinberg, A.2    Gallegos, M.3    Banchereau, J.4    Koutouzov, S.5
  • 122
    • 0037451124 scopus 로고    scopus 로고
    • Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice
    • Santiago-Raber ML, Baccala R, Haraldsson KM et al. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med 2003 197 : 777 88.
    • (2003) J Exp Med , vol.197 , pp. 777-88
    • Santiago-Raber, M.L.1    Baccala, R.2    Haraldsson, K.M.3
  • 123
    • 75749083254 scopus 로고    scopus 로고
    • Deficiency of type i IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease
    • Agrawal H, Jacob N, Carreras E et al. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol 2009 183 : 6021 9.
    • (2009) J Immunol , vol.183 , pp. 6021-9
    • Agrawal, H.1    Jacob, N.2    Carreras, E.3
  • 124
    • 68149126174 scopus 로고    scopus 로고
    • Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop
    • Green NM, Laws A, Kiefer K et al. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol 2009 183 : 1569 76.
    • (2009) J Immunol , vol.183 , pp. 1569-76
    • Green, N.M.1    Laws, A.2    Kiefer, K.3
  • 125
    • 33746238512 scopus 로고    scopus 로고
    • Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice
    • Brummel R, Roberts TL, Stacey KJ, Lenert P. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol 2006 36 : 1951 62.
    • (2006) Eur J Immunol , vol.36 , pp. 1951-62
    • Brummel, R.1    Roberts, T.L.2    Stacey, K.J.3    Lenert, P.4
  • 126
    • 0035900481 scopus 로고    scopus 로고
    • Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus
    • Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science 2001 294 : 1540 3.
    • (2001) Science , vol.294 , pp. 1540-3
    • Blanco, P.1    Palucka, A.K.2    Gill, M.3    Pascual, V.4    Banchereau, J.5
  • 127
    • 66449097622 scopus 로고    scopus 로고
    • Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase i trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus
    • Yao Y, Richman L, Higgs BW et al. Neutralization of interferon-alpha/ beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 2009 60 : 1785 96.
    • (2009) Arthritis Rheum , vol.60 , pp. 1785-96
    • Yao, Y.1    Richman, L.2    Higgs, B.W.3
  • 128
    • 44849085476 scopus 로고    scopus 로고
    • The innate immune system in SLE: Type i interferons and dendritic cells
    • Rönnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 2008 17 : 394 9.
    • (2008) Lupus , vol.17 , pp. 394-9
    • Rönnblom, L.1    Pascual, V.2
  • 129
    • 6844255888 scopus 로고    scopus 로고
    • A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group
    • Tsakonas E, Joseph L, Esdaile JM et al. A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study Group. Lupus 1998 7 : 80 5.
    • (1998) Lupus , vol.7 , pp. 80-5
    • Tsakonas, E.1    Joseph, L.2    Esdaile, J.M.3
  • 130
    • 0028832030 scopus 로고
    • In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers
    • Halpern MD, Pisetsky DS. In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers. Immunopharmacology 1995 29 : 47 52.
    • (1995) Immunopharmacology , vol.29 , pp. 47-52
    • Halpern, M.D.1    Pisetsky, D.S.2
  • 131
    • 0033843575 scopus 로고    scopus 로고
    • Inhibition of murine macrophage IL-12 production by natural and synthetic DNA
    • Pisetsky DS, Reich CF. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA. Clin Immunol 2000 96 : 198 204.
    • (2000) Clin Immunol , vol.96 , pp. 198-204
    • Pisetsky, D.S.1    Reich, C.F.2
  • 132
    • 0036913736 scopus 로고    scopus 로고
    • Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides
    • Zhu FG, Reich CF, Pisetsky DS. Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides. J Leukoc Biol 2002 72 : 1154 63.
    • (2002) J Leukoc Biol , vol.72 , pp. 1154-63
    • Zhu, F.G.1    Reich, C.F.2    Pisetsky, D.S.3
  • 133
    • 0032514616 scopus 로고    scopus 로고
    • Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
    • Krieg AM, Wu T, Weeratna R et al. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci USA 1998 95 : 12631 6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12631-6
    • Krieg, A.M.1    Wu, T.2    Weeratna, R.3
  • 134
    • 0034932263 scopus 로고    scopus 로고
    • Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs
    • Chen Y, Lenert P, Weeratna R et al. Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs. Gene Ther 2001 8 : 1024 32.
    • (2001) Gene Ther , vol.8 , pp. 1024-32
    • Chen, Y.1    Lenert, P.2    Weeratna, R.3
  • 135
    • 0034856551 scopus 로고    scopus 로고
    • CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kB activation
    • Lenert P, Stunz L, Yi AK, Krieg AM, Ashman RF. CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kB activation. Antisense Nucleic Acid Drug Dev 2001 11 : 247 56.
    • (2001) Antisense Nucleic Acid Drug Dev , vol.11 , pp. 247-56
    • Lenert, P.1    Stunz, L.2    Yi, A.K.3    Krieg, A.M.4    Ashman, R.F.5
  • 136
    • 24144476236 scopus 로고    scopus 로고
    • Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells
    • Lenert P, Yi AK, Krieg AM, Stunz LL, Ashman RF. Inhibitory oligonucleotides block the induction of AP-1 transcription factor by stimulatory CpG oligonucleotides in B cells. Antisense Nucleic Acid Drug Dev 2003 13 : 143 50.
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , pp. 143-50
    • Lenert, P.1    Yi, A.K.2    Krieg, A.M.3    Stunz, L.L.4    Ashman, R.F.5
  • 137
    • 0042346153 scopus 로고    scopus 로고
    • Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation
    • Gursel I, Gursel M, Yamada H, Ishii KJ, Takeshita F, Klinman DM. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 2003 171 : 1393 400.
    • (2003) J Immunol , vol.171 , pp. 1393-400
    • Gursel, I.1    Gursel, M.2    Yamada, H.3    Ishii, K.J.4    Takeshita, F.5    Klinman, D.M.6
  • 138
    • 0242288068 scopus 로고    scopus 로고
    • Structural characterization of the inhibitory DNA motif for the type A[D]-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells
    • Lenert P, Rasmussen W, Ashman RF, Ballas ZK. Structural characterization of the inhibitory DNA motif for the type A[D]-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells. DNA Cell Biol 2003 22 : 621 31.
    • (2003) DNA Cell Biol , vol.22 , pp. 621-31
    • Lenert, P.1    Rasmussen, W.2    Ashman, R.F.3    Ballas, Z.K.4
  • 139
    • 17644405409 scopus 로고    scopus 로고
    • Sequence requirements for oligodeoxyribonucleotide inhibitory activity
    • Ashman RF, Goeken JA, Drahos J, Lenert P. Sequence requirements for oligodeoxyribonucleotide inhibitory activity. Int Immunol 2005 17 : 411 20.
    • (2005) Int Immunol , vol.17 , pp. 411-20
    • Ashman, R.F.1    Goeken, J.A.2    Drahos, J.3    Lenert, P.4
  • 140
    • 76049114916 scopus 로고    scopus 로고
    • A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways
    • Sun R, Sun L, Bao M et al. A human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways. Clin Immunol 2010 134 : 262 76.
    • (2010) Clin Immunol , vol.134 , pp. 262-76
    • Sun, R.1    Sun, L.2    Bao, M.3
  • 141
    • 0036107449 scopus 로고    scopus 로고
    • Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells
    • Stunz LL, Lenert P, Peckham D et al. Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur J Immunol 2002 32 : 1212 22.
    • (2002) Eur J Immunol , vol.32 , pp. 1212-22
    • Stunz, L.L.1    Lenert, P.2    Peckham, D.3
  • 142
    • 16244423314 scopus 로고    scopus 로고
    • Inhibitory oligodeoxynucleotides - Therapeutic promise for systemic autoimmune diseases?
    • Lenert P. Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases? Clin Exp Immunol 2005 140 : 1 10.
    • (2005) Clin Exp Immunol , vol.140 , pp. 1-10
    • Lenert, P.1
  • 143
    • 17844383756 scopus 로고    scopus 로고
    • Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
    • Duramad O, Fearon KL, Chang B et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol 2005 174 : 5193 200.
    • (2005) J Immunol , vol.174 , pp. 5193-200
    • Duramad, O.1    Fearon, K.L.2    Chang, B.3
  • 144
    • 35348918191 scopus 로고    scopus 로고
    • Structural requirements and applications of inhibitory oligodeoxyribonucleotides
    • Ashman RF, Lenert P. Structural requirements and applications of inhibitory oligodeoxyribonucleotides. Immunol Res 2007 39 : 4 14.
    • (2007) Immunol Res , vol.39 , pp. 4-14
    • Ashman, R.F.1    Lenert, P.2
  • 145
    • 40249088259 scopus 로고    scopus 로고
    • The DNA sugar backbone 2′ deoxyribose determines Toll-like receptor 9 activation
    • Haas T, Metzger J, Schmitz F et al. The DNA sugar backbone 2′ deoxyribose determines Toll-like receptor 9 activation. Immunity 2008 28 : 315 23.
    • (2008) Immunity , vol.28 , pp. 315-23
    • Haas, T.1    Metzger, J.2    Schmitz, F.3
  • 147
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005 202 : 1131 9.
    • (2005) J Exp Med , vol.202 , pp. 1131-9
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3
  • 148
    • 37149024435 scopus 로고    scopus 로고
    • Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity
    • Peter M, Bode K, Lipford GB, Eberle F, Heeg K, Dalpke AH. Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity. Immunology 2008 123 : 118 28.
    • (2008) Immunology , vol.123 , pp. 118-28
    • Peter, M.1    Bode, K.2    Lipford, G.B.3    Eberle, F.4    Heeg, K.5    Dalpke, A.H.6
  • 149
    • 0027468768 scopus 로고
    • Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices
    • Pearson AM, Rich A, Krieger M. Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices. J Biol Chem 1993 268 : 3546 54.
    • (1993) J Biol Chem , vol.268 , pp. 3546-54
    • Pearson, A.M.1    Rich, A.2    Krieger, M.3
  • 151
    • 33144467291 scopus 로고    scopus 로고
    • Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
    • Lenert P. Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus. Arthritis Res Ther 2006 8 : R203.
    • (2006) Arthritis Res Ther , vol.8
    • Lenert, P.1
  • 152
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signaling for robust type-I interferon induction
    • Honda K, Ohba Y, Yannai H et al. Spatiotemporal regulation of MyD88-IRF-7 signaling for robust type-I interferon induction. Nature 2005 434 : 1035 40.
    • (2005) Nature , vol.434 , pp. 1035-40
    • Honda, K.1    Ohba, Y.2    Yannai, H.3
  • 153
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci C, Ott G, Chan JH et al. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med 2006 203 : 1999 2008.
    • (2006) J Exp Med , vol.203 , pp. 1999-2008
    • Guiducci, C.1    Ott, G.2    Chan, J.H.3
  • 154
    • 77953275701 scopus 로고    scopus 로고
    • Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides
    • Avalos AM, Latz E, Mousseau B et al. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J Immunol 2009 183 : 6262 8.
    • (2009) J Immunol , vol.183 , pp. 6262-8
    • Avalos, A.M.1    Latz, E.2    Mousseau, B.3
  • 155
    • 77953481282 scopus 로고    scopus 로고
    • A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naïve B cells and constitutive expression in memory B cells
    • Bernasconi NL, Onai N, Lanzavecchia A. A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naïve B cells and constitutive expression in memory B cells. Blood 2003 102 : 956 63.
    • (2003) Blood , vol.102 , pp. 956-63
    • Bernasconi, N.L.1    Onai, N.2    Lanzavecchia, A.3
  • 156
    • 33645956556 scopus 로고    scopus 로고
    • Toll-like receptor stimulation as a third signal required for activation of human naive B cells
    • Ruprecht CR, Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 2006 36 : 810 16.
    • (2006) Eur J Immunol , vol.36 , pp. 810-16
    • Ruprecht, C.R.1    Lanzavecchia, A.2
  • 157
    • 11144353781 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help
    • Poeck H, Wagner M, Battiany J et al. Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2004 103 : 3058 64.
    • (2004) Blood , vol.103 , pp. 3058-64
    • Poeck, H.1    Wagner, M.2    Battiany, J.3
  • 158
    • 38849175552 scopus 로고    scopus 로고
    • Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9
    • Busconi L, Bauer JW, Tumang JR et al. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J Immunol 2007 179 : 7397 405.
    • (2007) J Immunol , vol.179 , pp. 7397-405
    • Busconi, L.1    Bauer, J.W.2    Tumang, J.R.3
  • 159
    • 70349453647 scopus 로고    scopus 로고
    • Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides
    • Klinman DM, Tross D, Klaschik S, Shirota H, Sato T. Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides. Ann NY Acad Sci 2009 1175 : 80 8.
    • (2009) Ann NY Acad Sci , vol.1175 , pp. 80-8
    • Klinman, D.M.1    Tross, D.2    Klaschik, S.3    Shirota, H.4    Sato, T.5
  • 160
    • 6344262317 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma and IL-12-mediated signaling
    • Shirota H, Gursel M, Klinman DM. Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma and IL-12-mediated signaling. J Immunol 2004 173 : 5002 7.
    • (2004) J Immunol , vol.173 , pp. 5002-7
    • Shirota, H.1    Gursel, M.2    Klinman, D.M.3
  • 161
    • 0037637548 scopus 로고    scopus 로고
    • Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis
    • Zeuner RA, Verthelyi D, Gursel M, Ishii KJ, Klinman DM. Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis Rheum 2003 48 : 1701 7.
    • (2003) Arthritis Rheum , vol.48 , pp. 1701-7
    • Zeuner, R.A.1    Verthelyi, D.2    Gursel, M.3    Ishii, K.J.4    Klinman, D.M.5
  • 162
    • 13444302229 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice
    • Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice. Arthritis Rheum 2005 52 : 651 8.
    • (2005) Arthritis Rheum , vol.52 , pp. 651-8
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 163
    • 47249095737 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
    • Sato T, Shimosato T, Alvord WG, Klinman DM. Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. J Immunol 2008 180 : 7648 54.
    • (2008) J Immunol , vol.180 , pp. 7648-54
    • Sato, T.1    Shimosato, T.2    Alvord, W.G.3    Klinman, D.M.4
  • 164
    • 17044423406 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock
    • Shirota H, Gursel I, Gursel M, Klinman DM. Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock. J Immunol 2005 174 : 4579 83.
    • (2005) J Immunol , vol.174 , pp. 4579-83
    • Shirota, H.1    Gursel, I.2    Gursel, M.3    Klinman, D.M.4
  • 165
    • 0344984245 scopus 로고    scopus 로고
    • Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells
    • Jing N, Li Y, Xu X et al. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 2003 22 : 685 96.
    • (2003) DNA Cell Biol , vol.22 , pp. 685-96
    • Jing, N.1    Li, Y.2    Xu, X.3
  • 166
    • 4644325545 scopus 로고    scopus 로고
    • G-quartet oligonucleotides: A new class of signal transducers and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
    • Jing N, Li Y, Xiong W, Sha W, Jing L, Tweardy DJ. G-quartet oligonucleotides: a new class of signal transducers and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res 2004 64 : 6603 9.
    • (2004) Cancer Res , vol.64 , pp. 6603-9
    • Jing, N.1    Li, Y.2    Xiong, W.3    Sha, W.4    Jing, L.5    Tweardy, D.J.6
  • 167
    • 0033034413 scopus 로고    scopus 로고
    • High affinity interactions of nucleolin with G-G-aspired rDNA
    • Hanakahi LA, Sun H, Maizels N. High affinity interactions of nucleolin with G-G-aspired rDNA. J Biol Chem 1999 274 : 15908 12.
    • (1999) J Biol Chem , vol.274 , pp. 15908-12
    • Hanakahi, L.A.1    Sun, H.2    Maizels, N.3
  • 168
    • 0033597820 scopus 로고    scopus 로고
    • Ku binds telomeric DNA in vitro
    • Bianchi A, de Lange T. Ku binds telomeric DNA in vitro. J Biol Chem 1999 274 : 21223 7.
    • (1999) J Biol Chem , vol.274 , pp. 21223-7
    • Bianchi, A.1    De Lange, T.2
  • 169
    • 37549066665 scopus 로고    scopus 로고
    • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    • Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 2007 37 : 3582 6.
    • (2007) Eur J Immunol , vol.37 , pp. 3582-6
    • Barrat, F.J.1    Meeker, T.2    Chan, J.H.3    Guiducci, C.4    Coffman, R.L.5
  • 170
    • 77649289335 scopus 로고    scopus 로고
    • Treatment with a Toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice
    • Graham KL, Lee LY, Higgins JP, Steinman L, Utz PJ, Ho PP. Treatment with a Toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice. Autoimmunity 2010 43 : 140 55.
    • (2010) Autoimmunity , vol.43 , pp. 140-55
    • Graham, K.L.1    Lee, L.Y.2    Higgins, J.P.3    Steinman, L.4    Utz, P.J.5    Ho, P.P.6
  • 171
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation medicated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer J, Tluk S, Schmitz C et al. Immune stimulation medicated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005 202 : 1575 85.
    • (2005) J Exp Med , vol.202 , pp. 1575-85
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3
  • 172
    • 33746266273 scopus 로고    scopus 로고
    • Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides
    • Jurk M, Kritzler A, Schulte B et al. Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides. Eur J Immunol 2006 36 : 1815 26.
    • (2006) Eur J Immunol , vol.36 , pp. 1815-26
    • Jurk, M.1    Kritzler, A.2    Schulte, B.3
  • 173
    • 33751565283 scopus 로고    scopus 로고
    • Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines
    • Gorden KK, Qiu X, Batiste JJ, Wightman PP, Vasilakos JP, Alkan SS. Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. J Immunol 2006 177 : 8164 70.
    • (2006) J Immunol , vol.177 , pp. 8164-70
    • Gorden, K.K.1    Qiu, X.2    Batiste, J.J.3    Wightman, P.P.4    Vasilakos, J.P.5    Alkan, S.S.6
  • 174
    • 60549110710 scopus 로고    scopus 로고
    • Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9
    • Wang D, Bhagat L, Yu D et al. Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9. J Med Chem 2009 52 : 551 8.
    • (2009) J Med Chem , vol.52 , pp. 551-8
    • Wang, D.1    Bhagat, L.2    Yu, D.3
  • 176
    • 57349191215 scopus 로고    scopus 로고
    • The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    • Ewald SE, Lee BL, Lau L et al. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 2008 456 : 658 62.
    • (2008) Nature , vol.456 , pp. 658-62
    • Ewald, S.E.1    Lee, B.L.2    Lau, L.3
  • 177
    • 70449477746 scopus 로고    scopus 로고
    • Critical role for asparagine endopeptidase in endocytic toll-like receptor signaling in dendritic cells
    • Sepulveda FE, Maschalidi S, Colisson R et al. Critical role for asparagine endopeptidase in endocytic toll-like receptor signaling in dendritic cells. Immunity 2009 31 : 737 48.
    • (2009) Immunity , vol.31 , pp. 737-48
    • Sepulveda, F.E.1    Maschalidi, S.2    Colisson, R.3
  • 178
    • 34250698370 scopus 로고    scopus 로고
    • Ligand-induced conformational changes allosterically activate Toll-like receptor 9
    • Latz E, Verma A, Visintin A et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007 8 : 772 9.
    • (2007) Nat Immunol , vol.8 , pp. 772-9
    • Latz, E.1    Verma, A.2    Visintin, A.3
  • 179
    • 68149132205 scopus 로고    scopus 로고
    • Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type i IFN production in macrophages
    • Yao M, Liu X, Li D, Chen T, Cai Z, Cao X. Late endosome/lysosome- localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol 2009 183 : 1751 8.
    • (2009) J Immunol , vol.183 , pp. 1751-8
    • Yao, M.1    Liu, X.2    Li, D.3    Chen, T.4    Cai, Z.5    Cao, X.6
  • 180
    • 34249915031 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    • Pawar RD, Ramanjaneyulu A, Kulkarni OP, Lech M, Segerer S, Anders HJ. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 2007 18 : 1721 31.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1721-31
    • Pawar, R.D.1    Ramanjaneyulu, A.2    Kulkarni, O.P.3    Lech, M.4    Segerer, S.5    Anders, H.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.